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Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.

Abstract：

:Ganoderma lucidum polysaccharide (GLP) is a biologically active substance reported to possess anti-tumor ability. Nonetheless, the mechanisms of GLP-stimulated apoptosis are still unclear. This study aims to determine the inhibitory and apoptosis-inducing effects of GLP on HCT-116 cells. We found that GLP reduced cell viability on HCT-116 cells in a time- and dose-dependent manner, which in turn, induced cell apoptosis. The observed apoptosis was characterized by morphological changes, DNA fragmentation, mitochondrial membrane potential decrease, S phase population increase, and caspase-3 and -9 activation. Furthermore, inhibition of c-Jun N-terminal kinase (JNK) by SP600125 led to a dramatic decrease of the GLP-induced apoptosis. Western blot analysis unveiled that GLP up-regulated the expression of Bax/Bcl-2, caspase-3 and poly (ADP-ribose) polymerase (PARP). These results demonstrate that apoptosis stimulated by GLP in human colorectal cancer cells is associated with activation of mitochondrial and mitogen-activated protein kinase (MAPK) pathways.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Liang Z,Yi Y,Guo Y,Wang R,Hu Q,Xiong X

doi

10.3390/ijms15059103

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

9103-16

issue

5

issn

1422-0067

pii

ijms15059103

journal_volume

15

pub_type

杂志文章

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