Abstract：
:Obesity is a multifaceted pathophysiological condition that has been associated with lipid accumulation, adipocyte dysfunction, impaired mitochondrial biogenesis and an altered metabolic profile. Redox imbalance and excessive release of inflammatory mediators have been intricately linked in obesity-associated phenotypes. Hence, understanding the mechanisms of redox signaling pathways and molecular targets exacerbating oxidative stress is crucial in improving health outcomes. The activation of Na/K-ATPase/Src signaling, and its downstream pathways, by reactive oxygen species (ROS) has been recently implicated in obesity and subsequent nonalcoholic steatohepatitis (NASH), which causes further production of ROS creating an oxidant amplification loop. Apart from that, numerous studies have also characterized antioxidant properties of heme oxygenase 1 (HO-1), which is suppressed in an obese state. The induction of HO-1 restores cellular redox processes, which contributes to inhibition of the toxic milieu. The novelty of these independent mechanisms presents a unique opportunity to unravel their potential as molecular targets for redox regulation in obesity and NASH. The attenuation of oxidative stress, by understanding the underlying molecular mechanisms and associated mediators, with a targeted treatment modality may provide for improved therapeutic options to combat clinical disorders.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Pratt R,Lakhani HV,Zehra M,Desauguste R,Pillai SS,Sodhi Kdoi
10.3390/ijms21010087subject
Has Abstractpub_date
2019-12-21 00:00:00issue
1issn
1422-0067pii
ijms21010087journal_volume
21pub_type
杂志文章,评审abstract：:Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-02-24 00:00:00
abstract：:Glutamate (Glu)-mediated excitotoxicity is a major cause of amyotrophic lateral sclerosis (ALS) and our previous work highlighted that abnormal Glu release may represent a leading mechanism for excessive synaptic Glu. We demonstrated that group I metabotropic Glu receptors (mGluR1, mGluR5) produced abnormal Glu releas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-09-13 00:00:00
abstract：:The rhizome of Anemarrhena asphodeloides Bunge, used in Traditional Chinese Medicine as a brain function-improving herb, is a promising source of neuroprotective substances. The aim of this study was to evaluate the protective action of xanthones from A. asphodeloides rhizomes on the PC12 cell line exposed to the neur...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072510
更新日期：2020-04-04 00:00:00
abstract：:Pre-mRNA splicing is an essential mechanism for ensuring integrity of the transcriptome in eukaryotes. Therefore, splicing deficiency might cause a decrease in functional proteins and the production of nonfunctional, aberrant proteins. To prevent the production of such aberrant proteins, eukaryotic cells have several ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-11-20 00:00:00
abstract：:In this study, we investigated the anticancer effects of a new benzimidazole derivative, 1-benzyl-2-phenyl -benzimidazole (BPB), in human chondrosarcoma cells. BPB-mediated apoptosis was assessed by the MTT assay and flow cytometry analysis. The in vivo efficacy was examined in a JJ012 xenograft model. Here we found t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131216472
更新日期：2012-12-04 00:00:00
abstract：:Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is res...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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abstract：:Considering the undesirable attributes of synthetic fungicides and the availability of Ficus species in China, the stem of Ficus tikoua Bur. was investigated. One new antifungal pyranoisoflavone, 5,3',4'-trihydroxy-2″,2″-dimethylpyrano (5″,6″:7,8) isoflavone (1), together with two known isoflavones, wighteone (2) and ...
journal_title：International journal of molecular sciences
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更新日期：2012-01-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy where the immature leukemia cells communicate with neighboring cells through constitutive cytokine release and through their cell surface adhesion molecules. The primary AML cells express various integrins. These heterodimeric molecules containing an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19010251
更新日期：2018-01-15 00:00:00
abstract：:The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, k...
journal_title：International journal of molecular sciences
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更新日期：2016-01-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-11-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2009-12-08 00:00:00
abstract：:Trials using antisense oligonucleotide technology to lower Huntingtin levels in Huntington's disease (HD) are currently ongoing. This progress, taking place only 27 years after the identification of the Huntingtin gene (HTT) in 1993 reflects the enormous development in genetic engineering in the last decades. It is al...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141121727
更新日期：2013-11-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16022307
更新日期：2015-01-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15023287
更新日期：2014-02-21 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235928
更新日期：2019-11-25 00:00:00
abstract：:In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. More...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150916831
更新日期：2014-09-22 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20205055
更新日期：2019-10-11 00:00:00
abstract：:This study aimed to investigate the effects of cyclopamine, a specific inhibitor of Hedgehog signaling pathways, on the chondrogenic differentiation of mesenchymal stem cells (MSCs). During culture, the experimental groups were treated with cyclopamine and their cell proliferation status was assessed using the MTT tes...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms14035966
更新日期：2013-03-14 00:00:00
abstract：:Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chondrocyte senescence is thought to play a role in the initiation and progression o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-03-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-08-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-02-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122747
更新日期：2017-12-18 00:00:00
abstract：:Malignant gliomas are primary brain tumors with poor prognoses. These tumors are infiltrated by brain intrinsic microglia and peripheral monocytes which promote glioma cell invasion. In our previous studies, we discovered that the activation of Toll-like receptor 2 (TLR2) on microglia/brain macrophages converts them i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082959
更新日期：2020-04-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20235995
更新日期：2019-11-28 00:00:00
abstract：:Among the four immunoglobulin G (IgG) subclasses, IgG4 is the least represented in serum of a healthy human and it is considered an "odd" antibody. The IgG4 antibody has unique structural features that affect its biological function. These include the ability to undergo antigen-binding fragment (Fab)-arm exchange, to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145017
更新日期：2020-07-16 00:00:00
abstract：:The dried roots of Euphorbia kansui (kansui) have been used for centuries in China as a herbal medicine for edema, ascites, and asthma. The 95% ethanol extract showed a significant inhibition of cell proliferation against human normal cell lines L-O2 and GES-1. Bioassay-guided separation of the 95% ethanol extract fro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms130911247
更新日期：2012-01-01 00:00:00
abstract：:NW-G01, produced by Streptomyces alboflavus 313, is a novel cyclic hexapeptide antibiotic with many potential applications, including antimicrobial activity and antitumor agents. This study developed a system for optimizing medium components in order to enhance NW-G01 production. In this study, Plackett-Burman design ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13045230
更新日期：2012-01-01 00:00:00
abstract：:Forage legumes are an important livestock nutritional resource, which includes essential metals, such as copper. Particularly, the high prevalence of hypocuprosis causes important economic losses to Argentinian cattle agrosystems. Copper deficiency in cattle is partially due to its low content in forage produced by na...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-06-27 00:00:00
abstract：:The present work provides a comprehensive overview of the recent progress of research work toward developing new one dimensional (1-D) ceria (CeO(2)) nanomaterials. The review has been classified into three parts: the preparation procedures with identification of the existing different dimensional ceria nanomaterials,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11093226
更新日期：2010-09-13 00:00:00
