Abstract:
:In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kolmas J,Sobczak M,Olędzka E,Nałęcz-Jawecki G,Dębek Cdoi
10.3390/ijms150916831subject
Has Abstractpub_date
2014-09-22 00:00:00pages
16831-47issue
9issn
1422-0067pii
ijms150916831journal_volume
15pub_type
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