Abstract：
:Transforming growth factor (TGF)-βs are pluripotent cytokines with stimulatory and inhibitory properties for multiple types of immune cells. Analyses of genetic knockouts of each isoform of TGF-β have revealed differing expression patterns and distinct roles for the three mammalian isoforms of TGF-β. Considerable effort has been focused on understanding the molecular mechanisms of TGF-β1-mediated immune regulation, given its pivotal role in prohibiting systemic autoimmune disease. In recent years, functional similarities and differences between the TGF-β isoforms have delineated their distinct roles in the development of immunopathology and immune tolerance, with increased recent attention being focused on TGF-β3. In addition to the characteristic properties of each TGF-β isoform, recent progress has identified determinants of context-dependent functionality, including various cellular targets, cytokine concentrations, tissue microenvironments, and cytokine synergy, which combine to shape the physiological and pathophysiological roles of the TGF-βs in immunity. Controlling TGF-β production and signaling is being tested as a novel therapeutic strategy in multiple clinical trials for several human diseases. This review highlights advances in the understanding of the cellular sources, activation processes, contextual determinants, and immunological roles of TGF-β3 with comparisons to other TGF-β isoforms.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Komai T,Okamura T,Inoue M,Yamamoto K,Fujio Kdoi
10.3390/ijms19082261subject
Has Abstractpub_date
2018-08-01 00:00:00issue
8issn
1422-0067pii
ijms19082261journal_volume
19pub_type
杂志文章,评审abstract：:Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide hybrids by the immobilization, via i...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析,评审
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pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-07-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215289
更新日期：2019-10-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020665
更新日期：2021-01-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153731
更新日期：2019-07-31 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-02-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205097
更新日期：2019-10-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155245
更新日期：2020-07-24 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-06-03 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9122357
更新日期：2008-12-01 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-04-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-11-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-04-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2018-05-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2009-09-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2019-11-20 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2017-01-11 00:00:00
abstract：:The present work provides a comprehensive overview of the recent progress of research work toward developing new one dimensional (1-D) ceria (CeO(2)) nanomaterials. The review has been classified into three parts: the preparation procedures with identification of the existing different dimensional ceria nanomaterials,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11093226
更新日期：2010-09-13 00:00:00
