Abstract：
:Autophagy (particularly macroautophagy) is a bulk degradation process used by eukaryotic cells in order to maintain adequate energy levels and cellular homeostasis through the delivery of long-lived proteins and organelles to the lysosome, resulting in their degradation. It is becoming increasingly clear that many of the molecular requirements to fulfil autophagy intersect with those of conventional and unconventional membrane trafficking pathways. Of particular interest is the dependence of these processes on multiple members of the Rab family of small GTP binding proteins. Rab33b is a protein that localises to the Golgi apparatus and has suggested functions in both membrane trafficking and autophagic processes. Interestingly, mutations in the RAB33B gene have been reported to cause the severe skeletal disorder, Smith-McCort Dysplasia; however, the molecular basis for Rab33b in this disorder remains to be determined. In this review, we focus on the current knowledge of the participation of Rab33b and its interacting partners in membrane trafficking and macroautophagy, and speculate on how its function, and dysfunction, may contribute to human disease.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Morgan NE,Cutrona MB,Simpson JCdoi
10.3390/ijms20163916subject
Has Abstractpub_date
2019-08-12 00:00:00issue
16issn
1422-0067pii
ijms20163916journal_volume
20pub_type
杂志文章,评审abstract：:Intrinsically disordered proteins mediate crucial biological functions through their interactions with other proteins. Mutual synergistic folding (MSF) occurs when all interacting proteins are disordered, folding into a stable structure in the course of the complex formation. In these cases, the folding and binding pr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215460
更新日期：2019-11-01 00:00:00
abstract：:Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be potential biomarkers. Prediagnosis serum samples pooled according to f...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122670
更新日期：2017-12-09 00:00:00
abstract：:High-dose human recombinant erythropoietin (rEPO) is a promising potential neuroprotective treatment in preterm and full-term neonates with hypoxic-ischemic encephalopathy (HIE). There are limited data on the pharmacokinetics of high-dose rEPO in neonates. We examined the effects of body weight, gestation age, global ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093042
更新日期：2020-04-25 00:00:00
abstract：:The availability of osteoinductive biomaterials has encouraged new therapies in bone regeneration and has potentially triggered paradigmatic shifts in the development of new implants in orthopedics and dentistry. Among several available synthetic biomaterials, bioceramics have gained attention for their ability to ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174080
更新日期：2019-08-21 00:00:00
abstract：:Copy number variants (CNVs) detected by chromosomal microarray analysis (CMA) significantly contribute to understanding the etiology of autism spectrum disorder (ASD) and other related conditions. In recognition of the value of CMA testing and its impact on medical management, CMA is in medical guidelines as a first-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122070
更新日期：2016-12-09 00:00:00
abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is known to regulate mitochondrial biogenesis. Resveratrol is present in a variety of plants, including the skin of grapes, blueberries, raspberries, mulberries, and peanuts. It has been shown to offer protective effects against a number of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040998
更新日期：2019-02-25 00:00:00
abstract：:Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20112668
更新日期：2019-05-30 00:00:00
abstract：:Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020807
更新日期：2021-01-15 00:00:00
abstract：:Endocannabinoids are key-players of female fertility and potential biomarkers of reproductive dysfunctions. Here, we investigated localization and expression of cannabinoid receptor type-1 and -2 (CB1R and CB2R), G-protein coupled receptor 55 (GPR55), and transient receptor potential vanilloid type 1 channel (TRPV1) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20122866
更新日期：2019-06-12 00:00:00
abstract：:Dietary supplementation with polyunsaturated fatty acids (PUFA) n-3 can affect cutaneous wound healing; however, recent findings demonstrate the variable extent of their influence on the quality of healing. Here, we compare the effect of several dietary oils, containing different levels of PUFA n-3 and PUFA n-6, on wo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217911
更新日期：2020-10-24 00:00:00
abstract：:Fatty acid metabolism is important in the regulation of breast cancer progression. Some of the proteins involved in fatty acid transport have been demonstrated to promote the proliferation, migration, and invasion in breast cancer cells. Solute carrier family 27 member 4 (SLC27A4) is a fatty acid transporter protein a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113434
更新日期：2018-11-01 00:00:00
abstract：:The Cpi-17 (ppp1r14) gene family is an evolutionarily conserved, vertebrate specific group of protein phosphatase 1 (PP1) inhibitors. When phosphorylated, Cpi-17 is a potent inhibitor of myosin phosphatase (MP), a holoenzyme complex of the regulatory subunit Mypt1 and the catalytic subunit PP1. Myosin phosphatase deph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165709
更新日期：2020-08-09 00:00:00
abstract：:Colon cancer is an aggressive tumor form with a poor prognosis. This study reports a comparative proteomic analysis performed by using two-dimensional differential in-gel electrophoresis (2D-DIGE) between 26 pooled colon cancer surgical tissues and adjacent non-tumoral tissues, to identify potential target proteins co...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093096
更新日期：2020-04-28 00:00:00
abstract：:One of the major current trends in cancer immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved through antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological therapy and shown a new wa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228876
更新日期：2020-11-23 00:00:00
abstract：:Two-component systems (TCS) in plants have evolved into a more complicated multi-step phosphorelay (MSP) pathway, which employs histidine kinases (HKs), histidine-containing phosphotransfer proteins (HPts), and response regulators (RRs) to regulate various aspects of plant growth and development. How plants perceive t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21144898
更新日期：2020-07-11 00:00:00
abstract：:Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated by the receptor isoform with which it interacts. In order to gain a ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17020158
更新日期：2016-01-26 00:00:00
abstract：:Atherosclerosis is an arterial inflammatory disease. The circulating level of the C-C chemokine ligand (CCL4) is increased in atherosclerotic patients. This study aimed to investigate whether CCL4 inhibition could retard the progression of atherosclerosis. In ApoE knockout mice, CCL4 antibody treatment reduced circula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186567
更新日期：2020-09-08 00:00:00
abstract：:Tumor microenvironments are composed of a myriad of elements, both cellular (immune cells, cancer-associated fibroblasts, mesenchymal stem cells, etc.) and non-cellular (extracellular matrix, cytokines, growth factors, etc.), which collectively provide a permissive environment enabling tumor progression. In this revie...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020791
更新日期：2021-01-14 00:00:00
abstract：BACKGROUND:Due to current antibiotic resistance worldwide, there is an urgent need to find new alternative antibacterial approaches capable of dealing with multidrug-resistant pathogens. Most recent studies have demonstrated the antibacterial activity and non-cytotoxicity of carbon nanomaterials such as graphene oxide ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143603
更新日期：2019-07-23 00:00:00
abstract：:Reactive oxygen species (ROS) are not only harmful to cell survival but also essential to cell signaling through cysteine-based redox switches. In fact, ROS triggers the potential activation of mitogen-activated protein kinases (MAPKs). The 90 kDa ribosomal S6 kinase 1 (RSK1), one of the downstream mediators of the MA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228750
更新日期：2020-11-19 00:00:00
abstract：:Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215281
更新日期：2019-10-24 00:00:00
abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The neuropathological features of PD are selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta, deficiencies in striatal dopamine levels, and the presence of intracellular Lewy bodies. Interactions am...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197182
更新日期：2020-09-29 00:00:00
abstract：:The epithelial sodium channel (ENaC) has a key role in modulating endothelial cell stiffness and this in turn regulates nitric oxide (NO) synthesis. The physiological relevance of endothelial ENaC in pathological conditions where reduced NO bioavailability plays an essential role remains largely unexplored. Renal isch...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20133132
更新日期：2019-06-27 00:00:00
abstract：:The enzymatic condition for producing the anti-obesity hydrolysates from fish water-soluble protein was optimized with the aid of response surface methodology, which also derived a statistical model for experimental validation. Compared with neutral protease, papain and protamex, the porcine pancreas lipase inhibitory...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023124
更新日期：2013-02-01 00:00:00
abstract：:Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic dise...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14010226
更新日期：2012-12-21 00:00:00
abstract：:Bradysia odoriphaga (Diptera: Sciaridae) is the most important pest of Chinese chive. Insecticides are used widely and frequently to control B. odoriphaga in China. However, the performance of the insecticides chlorpyrifos and clothianidin in controlling the Chinese chive maggot is quite different. Using next generati...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112445
更新日期：2017-11-17 00:00:00
abstract：:This study was undertaken to test two therapies for acute kidney injury (AKI) prevention, IGF-1, which is renal protective, and BTP-2, which is a calcium entry (SOCE) inhibitor. We utilized lipopolysaccharide (LPS) IP, as a systemic model of AKI and studied in five groups of animals. Three experiments showed that at 7...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21114095
更新日期：2020-06-08 00:00:00
abstract：:In 1937, Sir H. A Krebs first published the Citric Acid Cycle, a unidirectional cycle with carboxylic acids. The original concept of the Citric Acid Cycle from Krebs' 1953 Nobel Prize lecture illustrates the unidirectional degradation of lactic acid to water, carbon dioxide and hydrogen. Here, we add the heart lactate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020604
更新日期：2021-01-09 00:00:00
abstract：:Melanin in the epidermis is known to ultimately regulate human skin pigmentation. Recently, we exploited a phenotypic-based screening system composed of ex vivo human skin cultures to search for effective materials to regulate skin pigmentation. Since a previous study reported the potent inhibitory effect of metformin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041451
更新日期：2020-02-20 00:00:00
abstract：:Many biological cellular processes occur at the micro- or millisecond time scale. With traditional all-atom molecular modeling techniques it is difficult to investigate the dynamics of long time scales or large systems, such as protein aggregation or activation. Coarse graining (CG) can be used to reduce the number of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11062393
更新日期：2010-06-09 00:00:00
