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The effects of G-CSF on proliferation of mouse myocardial microvascular endothelial cells.

Abstract：

:This paper explores the effect of granulocyte colony-stimulating factor (G-CSF) on mouse myocardial microvascular endothelial cell (CMECs) proliferation. CMECs were harvested from C57/BL6 mice. CMECs were cultured in medium containing G-CSF (0 ng/mL, 20 ng/mL, 40 ng/mL, 60 ng/mL) for five days. Proliferative activity of CMECs was examined by CCK-8 method. Hypoxia inducible factor-1 (HIF-1) and p53 expression levels was determined from the mRNA obtained by reverse transcription polymerase chain reaction (RT-PCR). Results showed that the purity quotient of the CMECs, which were cultured by the method of modified myocardial tissue explant culture, was higher than 95%. Compared with control untreated cells, the proliferative activity of CMECs and the expression level of HIF-1 mRNA in these cells were enhanced by G-CSF treatment, whereas the expression level of p53 mRNA was markedly reduced. It may be concluded that G-CSF could promote the proliferative activity of CMECs, which might be mediated by upregulation of HIF-1 and downregulation of p53.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Li J,Zou Y,Ge J,Zhang D,Guan A,Wu J,Li L

doi

10.3390/ijms12021306

subject

Has Abstract

pub_date

2011-02-22 00:00:00

pages

1306-15

issue

2

issn

1422-0067

journal_volume

12

pub_type

杂志文章

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