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Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus Diseases.

Abstract：

:In the past 17 years, three novel coronaviruses have caused severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and the coronavirus disease 2019 (COVID-19). As emerging infectious diseases, they were characterized by their novel pathogens and transmissibility without available clinical drugs or vaccines. This is especially true for the newly identified COVID-19 caused by SARS coronavirus 2 (SARS-CoV-2) for which, to date, no specific antiviral drugs or vaccines have been approved. Similar to SARS and MERS, the lag time in the development of therapeutics is likely to take months to years. These facts call for the development of broad-spectrum anti-coronavirus drugs targeting a conserved target site. This review will systematically describe potential broad-spectrum coronavirus fusion inhibitors, including antibodies, protease inhibitors, and peptide fusion inhibitors, along with a discussion of their advantages and disadvantages.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Wang X,Xia S,Wang Q,Xu W,Li W,Lu L,Jiang S

doi

10.3390/ijms21113843

subject

Has Abstract

pub_date

2020-05-28 00:00:00

issue

11

issn

1422-0067

pii

ijms21113843

journal_volume

21

pub_type

杂志文章,评审

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