Abstract：
:Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify the factors underlying working memory deficit in schizophrenia patients and to explore the implication of possible genes in the working memory using genome-wide association study (GWAS) of schizophrenia, computerized delay-matching-to-sample (DMS) and whole genome genotyping data were obtained from 100 first-episode, treatment-naïve patients with schizophrenia and 140 healthy controls from the Mental Health Centre of the West China Hospital, Sichuan University. A composite score, delay-matching-to-sample total correct numbers (DMS-TC), was found to be significantly different between the patients and control. On associating quantitative DMS-TC with interactive variables of groups × genotype, one SNP (rs1411832), located downstream of YWHAZP5 in chromosome 10, was found to be associated with the working memory deficit in schizophrenia patients with lowest p-value (p = 2.02 × 10(-7)). ConsensusPathDB identified that genes with SNPs for which p values below the threshold of 5 × 10(-5) were significantly enriched in GO:0007155 (cell adhesion, p < 0.001). This study indicates that working memory, as an endophenotype of schizophrenia, could improve the efficacy of GWAS in schizophrenia. However, further study is required to replicate the results from our study.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ren H,Zhang C,Huang C,Li N,Li M,Li Y,Deng W,Ma X,Xiang B,Wang Q,Li Tdoi
10.3390/ijms16012145subject
Has Abstractpub_date
2015-01-20 00:00:00pages
2145-61issue
1issn
1422-0067pii
ijms16012145journal_volume
16pub_type
杂志文章abstract：:The structure and function of an enzyme can be altered by nanoparticles (NPs). The interaction between enzyme and NPs is governed by the key properties of NPs, such as structure, size, surface chemistry, charge and surface shape. Recent representative studies on the NP-enzyme interactions and the regulation of enzyme ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10104198
更新日期：2009-11-20 00:00:00
abstract：:Follicular fluid (FF) accumulates in the antrum of the ovarian follicle and provides the microenvironment for oocyte development. FF plays an important role in follicle growth and oocyte maturation. The FF provides a unique window to investigate the processes occurring during buffalo follicular development. The observ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050618
更新日期：2016-04-29 00:00:00
abstract：:The western flower thrips, Frankliniella occidentalis (Pergande), is an invasive species and the most economically important pest within the insect order Thysanoptera. For a better understanding of the genetic makeup and migration patterns of F. occidentalis throughout the world, we characterized 18 novel polymorphic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13032863
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:A growing body of data indicates that the physiology of the liver is sex-hormone dependent, with some types of liver failure occurring more frequently in males, and some in females. In males, in physiological conditions, testosterone acts via androgen receptors (AR) to increase insulin receptor (IR) expressi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031242
更新日期：2021-01-27 00:00:00
abstract：:The removal of damaged or superfluous organelles from the cytosol by selective autophagy is required to maintain organelle function, quality control and overall cellular homeostasis. Precisely how substrate selectivity is achieved, and how individual substrates are degraded during selective autophagy in response to bo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21020578
更新日期：2020-01-16 00:00:00
abstract：:Silibinin, an effective anti-cancer and chemopreventive agent in various epithelial cancer models, has been reported to inhibit cancer cell growth through mitogenic signaling pathways. However, whether it can inhibit human pancreatic carcinoma growth and what are the underlying mechanisms is still not well elucidated....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12084861
更新日期：2011-01-01 00:00:00
abstract：:The growth arrest-specific transcript 5 (GAS5) is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, we reviewed the current literature on the expression of GAS5 in leukemia, cervical, breast, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21207633
更新日期：2020-10-15 00:00:00
abstract：:The availability of osteoinductive biomaterials has encouraged new therapies in bone regeneration and has potentially triggered paradigmatic shifts in the development of new implants in orthopedics and dentistry. Among several available synthetic biomaterials, bioceramics have gained attention for their ability to ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174080
更新日期：2019-08-21 00:00:00
abstract：:Zika virus (ZIKV) acquired a special relevance due to the pandemic that occurred in the Americas in 2015, when an important number of fetal microcephaly cases occurred. Since then, numerous studies have tried to elucidate the pathogenic mechanisms and the potential therapeutic approaches to combat the virus. Cellular ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010035
更新日期：2020-12-22 00:00:00
abstract：:Carvacrol is a natural compound known to be a highly effective antibacterial; however, it is a hydrophobic molecule, which is a limitation to its use within food packaging. Flaxseed gum (FG) films containing different contents of carvacrol (C) were produced by a film-casting method with sonication. The effects of sonic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051637
更新日期：2020-02-28 00:00:00
abstract：:At present, due to the growing attention focused on the issue of tendon-bone healing, we carried out an animal study of the use of genetic intervention combined with cell transplantation for the promotion of this process. Here, the efficacy of bone marrow stromal cells infected with bone morphogenetic protein-2 (BMP-2...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131013605
更新日期：2012-10-22 00:00:00
abstract：:Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,随机对照试验
doi：10.3390/ijms130912062
更新日期：2012-01-01 00:00:00
abstract：:Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enable...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18051075
更新日期：2017-05-17 00:00:00
abstract：:Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205105
更新日期：2019-10-15 00:00:00
abstract：:Atrazine, a member of the 2-chloro-s-triazine family of herbicides, is the most widely used pesticide in the world and often detected in agriculture watersheds. Although it was generally considered as an endocrine disruptor, posing a potential threat to human health, the molecular mechanisms of atrazine effects remain...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151017806
更新日期：2014-10-01 00:00:00
abstract：:Abnormalities in the melatonin signaling pathway and the involvement of melatonin receptor MT2 have been reported in patients with adolescent idiopathic scoliosis (AIS). Whether these abnormalities were involved in the systemic abnormal skeletal growth in AIS during the peripubertal period remain unknown. In this cros...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150917100
更新日期：2014-09-25 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are enzymes involved in periodontal tissue destruction. Hemagglutinin B (HagB) from the periodontal pathogen Porphyromonas gingivalis induces an elevated MMP response in dendritic cells, but responses from cultures of single-cell types do not reflect the local tissue environment. The o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123923
更新日期：2018-12-07 00:00:00
abstract：:The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In this study, we utiliz...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112686
更新日期：2019-05-31 00:00:00
abstract：:Chitosan nanoparticles (CS NPs) showed promising results in drug, vaccine and gene delivery for the treatment of various diseases. The considerable attention towards CS was owning to its outstanding biological properties, however, the main challenge in the application of CS NPs was faced during their size-controlled s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246212
更新日期：2019-12-09 00:00:00
abstract：:CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH was examined. The formation rate of camptothecin in human liver mic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13055498
更新日期：2012-01-01 00:00:00
abstract：:Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is underappreciated. Numerous lines of evidence now associate GPCRs and their downstream signaling targets in cancer growth and development. I...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17081320
更新日期：2016-08-12 00:00:00
abstract：:Glutamine synthetase 2 (GS2) is a key enzyme involved in the ammonium metabolism in plant leaves. In our previous study, we obtained GS2-cosuppressed plants, which displayed a normal growth phenotype at the seedling stage, while at the tillering stage they showed a chlorosis phenotype. In this study, to investigate th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160612713
更新日期：2015-06-04 00:00:00
abstract：:Pulmonary hypertension (PH) complicates bronchopulmonary dysplasia (BPD) in 25% of infants. Superoxide dismutase 2 (SOD2) is an endogenous mitochondrial antioxidant, and overexpression protects against acute lung injury in adult mice. Little is known about SOD2 in neonatal lung disease and PH. C57Bl/6 mice and isogeni...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16036373
更新日期：2015-03-19 00:00:00
abstract：:Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, impacts spindle assembly in human cells. Several studies have demonstrated that TPX2 is overexpressed in different types of human cancers and promotes tumor growth and metastasis. In this study, we found that the expression ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151018148
更新日期：2014-10-09 00:00:00
abstract：:Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021269
更新日期：2012-01-01 00:00:00
abstract：:Worldwide, women account for approximately 51% of human immunodeficiency virus-1 (HIV) seropositive individuals. The prevalence of neuropathic pain among individuals with HIV and a lack of preclinical data characterizing sex differences prompted us to address this knowledge gap. C57BL/6 male and female mice received m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051196
更新日期：2019-03-09 00:00:00
abstract：:Agricultural production continues to be constrained by a number of biotic and abiotic factors that can reduce crop yield quantity and quality. Potassium (K) is an essential nutrient that affects most of the biochemical and physiological processes that influence plant growth and metabolism. It also contributes to the s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14047370
更新日期：2013-04-02 00:00:00
abstract：:Autophagy is an important process by which pathogens and damaged or unused organelles are eliminated. The role of autophagy in development and the immune response to pathogens is well established. Autophagy-related protein 8 (Atg8) is involved in the formation of the autophagosome and, with the help of the serine prot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082944
更新日期：2020-04-22 00:00:00
abstract：:Hepatitis C virus (HCV) is an RNA virus that can efficiently establish chronic infection in humans. The overlap between the HCV replication cycle and lipid metabolism is considered to be one of the primary means by which HCV efficiently develops chronic infections. In the blood, HCV is complex with lipoproteins to for...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20082037
更新日期：2019-04-25 00:00:00
abstract：:MCP-1-induced protein (MCPIP, also known as Zc3h12a or Regnase-1), a newly identified suppressor of cytokine signaling, is expressed in endothelial cells (ECs). To investigate the role of endothelial MCPIP in vascular homeostasis and function, we deleted the MCPIP gene specifically in ECs using the Cre-LoxP system. EC...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010172
更新日期：2019-01-05 00:00:00
