Abstract：
:Serum microRNAs are emerging as a clinically useful tool for early and non-invasive detection of various cancer types including renal cell carcinoma (RCC). Based on our previous results, we performed the study to analyze circulating serum miR-378 and miR-210 in patients with various histological subtypes of RCC. RNA was purified from blood serum samples of 195 RCC patients and 100 healthy controls. The levels of miR-378 and miR-210 in serum were determined absolutely using quantitative real-time PCR. Pre- and postoperative levels of both microRNAs were compared in 20 RCC patients. Significantly increased serum levels of both miR-378 and miR-210 enabled to clearly distinguish RCC patients and healthy controls with 80% sensitivity and 78% specificity if analyzed in combination (p<0.0001), and their levels significantly decreased in the time period of three months after radical nephrectomy (p<0.0001). Increased level of miR-378 positively correlates with disease-free survival (p=0.036) and clinical stage (p=0.0476). The analysis of serum miR-378 and miR-210 proved their potential to serve as powerful non-invasive diagnostic and prognostic biomarkers in RCC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Fedorko M,Stanik M,Iliev R,Redova-Lojova M,Machackova T,Svoboda M,Pacik D,Dolezel J,Slaby Odoi
10.3390/ijms161023382subject
Has Abstractpub_date
2015-09-29 00:00:00pages
23382-9issue
10issn
1422-0067pii
ijms161023382journal_volume
16pub_type
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