Abstract：
:Four-stranded DNA structures were structurally characterized in vitro by NMR, X-ray and Circular Dichroism spectroscopy in detail. Among the different types of quadruplexes (i-Motifs, minor groove quadruplexes, G-quadruplexes, etc.), the best described are G-quadruplexes which are featured by Hoogsteen base-paring. Sequences with the potential to form quadruplexes are widely present in genome of all organisms. They are found often in repetitive sequences such as telomeric ones, and also in promoter regions and 5' non-coding sequences. Recently, many proteins with binding affinity to G-quadruplexes have been identified. One of the initially portrayed G-rich regions, the human telomeric sequence (TTAGGG)n, is recognized by many proteins which can modulate telomerase activity. Sequences with the potential to form G-quadruplexes are often located in promoter regions of various oncogenes. The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins. A number of G-rich sequences are also present in promoter region of estrogen receptor alpha. In addition to DNA quadruplexes, RNA quadruplexes, which are critical in translational regulation, have also been predicted and observed. For example, the RNA quadruplex formation in telomere-repeat-containing RNA is involved in interaction with TRF2 (telomere repeat binding factor 2) and plays key role in telomere regulation. All these fundamental examples suggest the importance of quadruplex structures in cell processes and their understanding may provide better insight into aging and disease development.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Brázda V,Hároníková L,Liao JC,Fojta Mdoi
10.3390/ijms151017493subject
Has Abstractpub_date
2014-09-29 00:00:00pages
17493-517issue
10issn
1422-0067pii
ijms151017493journal_volume
15pub_type
杂志文章,评审abstract：:Many studies have addressed several plant-insect interaction topics at nutritional, molecular, physiological, and evolutionary levels. However, it is still unknown how flexible the metabolism and the nutritional content of specialist insect herbivores feeding on different closely related plants can be. We performed el...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010059
更新日期：2018-12-24 00:00:00
abstract：:Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada synd...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-09-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-11-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010046
更新日期：2012-12-20 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms19030865
更新日期：2018-03-15 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023901
更新日期：2013-02-14 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2015-04-30 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17121983
更新日期：2016-12-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030746
更新日期：2019-02-10 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-10-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms151121366
更新日期：2014-11-18 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122652
更新日期：2017-12-07 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246172
更新日期：2019-12-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19061744
更新日期：2018-06-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160613528
更新日期：2015-06-12 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071375
更新日期：2017-06-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030508
更新日期：2017-02-26 00:00:00
abstract：:Long noncoding RNA (lncRNA), circular RNA (circRNA), and microRNA (miRNA) are important in the regulation of life activities. However, their function is unclear in Paulownia fortunei. To identify lncRNAs, circRNAs, and miRNA, and investigate their roles in the infection progress of Paulownia witches' broom (PaWB) dise...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082463
更新日期：2018-08-20 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20133144
更新日期：2019-06-27 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms130810568
更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-12-10 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031020
更新日期：2020-02-04 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20164000
更新日期：2019-08-16 00:00:00
abstract：:The basal forebrain is home to the largest population of cholinergic neurons in the brain. These neurons are involved in a number of cognitive functions including attention, learning and memory. Basal forebrain cholinergic neurons (BFCNs) are particularly vulnerable in a number of neurological diseases with the most n...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2016-12-17 00:00:00
abstract：:Liver X receptors (LXRs) play a pivotal role in fatty acid (FA) metabolism. So far, the lipogenic consequences of in vivo LXR activation, as characterized by a major hepatic steatosis, has constituted a limitation to the clinical development of pharmacological LXR agonists. However, recent studies provided a different...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-08-02 00:00:00
abstract：:Histamine is a well-known mediator of inflammation that is released from mast cells and basophils. To date, many studies using histamine receptor antagonists have shown that histamine acts through four types of receptors: H1, H2, H3, and H4. Thus, histamine plays more roles in various diseases than had been predicted....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20020376
更新日期：2019-01-16 00:00:00
abstract：:Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloprot...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2020-07-13 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21155218
更新日期：2020-07-23 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145036
更新日期：2020-07-16 00:00:00
