Abstract：
:The ankyrin repeat domain 1 (ANKRD1) protein is a cardiac-specific stress-response protein that is part of the muscle ankyrin repeat protein family. ANKRD1 is functionally pleiotropic, playing pivotal roles in transcriptional regulation, sarcomere assembly and mechano-sensing in the heart. Importantly, cardiac ANKRD1 has been shown to be highly induced in various cardiomyopathies and in heart failure, although it is still unclear what impact this may have on the pathophysiology of heart failure. This review aims at highlighting the known properties, functions and regulation of ANKRD1, with focus on the underlying mechanisms that may be involved. The current views on the actions of ANKRD1 in cardiovascular disease and its utility as a candidate cardiac biomarker with diagnostic and/or prognostic potential are also discussed. More studies of ANKRD1 are warranted to obtain deeper functional insights into this molecule to allow assessment of its potential clinical applications as a diagnostic or prognostic marker and/or as a possible therapeutic target.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ling SSM,Chen YT,Wang J,Richards AM,Liew OWdoi
10.3390/ijms18071362subject
Has Abstractpub_date
2017-06-26 00:00:00issue
7issn
1422-0067pii
ijms18071362journal_volume
18pub_type
杂志文章,评审abstract：:The quaternary transition between the relaxed (R) and tense (T) states of heme-binding proteins is a textbook example for the allosteric structural transition. Homodimeric hemoglobin (HbI) from Scapharca inaequivalvis is a useful model system for investigating the allosteric behavior because of the relatively simple q...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19113633
更新日期：2018-11-18 00:00:00
abstract：:In order to supply new information on the antioxidant function of selected beverages for nutritionists and the general public, total phenolic contents of 51 kinds of herbal and tea infusions made in China were measured by the Folin-Ciocalteu method, and their antioxidant capacities were evaluated using ferric reducing...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12042112
更新日期：2011-01-01 00:00:00
abstract：:Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer's disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13089615
更新日期：2012-01-01 00:00:00
abstract：:Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249720
更新日期：2020-12-19 00:00:00
abstract：:Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment is characterized by acidosis and hypoxia due to tumor heterogeneity, aerobic glycolysis (the "War...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020278
更新日期：2017-01-27 00:00:00
abstract：BACKGROUND:Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates. METHODS:Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61.6%...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123854
更新日期：2018-12-03 00:00:00
abstract：:It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151017333
更新日期：2014-09-29 00:00:00
abstract：:Clozapine (CLZ) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. Recently, the World Health Organization's (WHO) global database (VigiBase) reported the relative lethality of severe adverse reactions of CLZ. Agran...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197019
更新日期：2020-09-24 00:00:00
abstract：:Alzheimer's disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type calcium channel enhancer ethyl-8-methyl-2,4-dioxo-2-(piperidin-1-yl)-2H-spiro[cycl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020741
更新日期：2021-01-13 00:00:00
abstract：:Metacaspases, a class of cysteine-dependent proteases like caspases in animals, are important regulators of programmed cell death (PCD) during development and stress responses in plants. The present study was focused on comprehensive analyses of expression patterns of the rice metacaspase (OsMC) genes in response to a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160716216
更新日期：2015-07-17 00:00:00
abstract：:In recent decades, serious contamination of soils by heavy metals has been reported. It is therefore a matter of urgency to develop a new and efficient technology for removing contaminants from soil. Another aspect to this problem is that environmental pollution decreases the biological quality of soil, which is why p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12117760
更新日期：2011-01-01 00:00:00
abstract：:Working memory deficit is the core neurocognitive disorder in schizophrenia patients. To identify the factors underlying working memory deficit in schizophrenia patients and to explore the implication of possible genes in the working memory using genome-wide association study (GWAS) of schizophrenia, computerized dela...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16012145
更新日期：2015-01-20 00:00:00
abstract：:In this communication, lipase A from Candida antarctica (CALA) was immobilized by covalent bonding on magnetic nanoparticles coated with chitosan and activated with glutaraldehyde, labelled CALA-MNP, (immobilization parameters: 84.1% ± 1.0 for immobilization yield and 208.0 ± 3.0 U/g ± 1.1 for derivative activity). CA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20164018
更新日期：2019-08-17 00:00:00
abstract：:The microRNAs are small RNAs that regulate gene expression at the post-transcriptional level and can be involved in the onset of neurodegenerative diseases and cancer. They are emerging as possible targets for antisense-based therapy, even though the in vivo stability of miRNA analogues is still questioned. We tested ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21062001
更新日期：2020-03-15 00:00:00
abstract：:The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145170
更新日期：2020-07-21 00:00:00
abstract：:High levels of docosahexaenoic acid (DHA) in the phospholipids of mammalian brain have generated increasing interest in the search for its role in regulating brain functions. Recent studies have provided evidence for enhanced protective effects when DHA is administered in combination with phytochemicals, such as querc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040932
更新日期：2019-02-21 00:00:00
abstract：:Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful tool that enables the simultaneous detection and identification of biomolecules in analytes. MALDI-imaging mass spectrometry (MALDI-IMS) is a two-dimensional MALDI-mass spectrometric technique used to visualize the spatial distribut...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11125040
更新日期：2010-01-01 00:00:00
abstract：:Because angiogenesis is a major contributor to cancer progression and metastasis, it is an attractive target for cancer therapy. Although a diverse number of small compounds for anti-angiogenic therapy have been developed, severe adverse effects commonly occur, since small compounds can affect not only tumor endotheli...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20235819
更新日期：2019-11-20 00:00:00
abstract：:The aim of this work was to compare protective and anti-apoptotic effects of α-tocopherol at nanomolar and micromolar concentrations against 0.2 mM H(2)O(2)-induced toxicity in the PC12 neuronal cell line and to reveal protein kinases that contribute to α-tocopherol protective action. The protection by 100 nM α-tocoph...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms130911543
更新日期：2012-01-01 00:00:00
abstract：:Hybrid peptides integrating different functional domains of peptides have many advantages, such as remarkable antimicrobial activity, lower hemolysis and ideal cell selectivity, compared with natural antimicrobial peptides. FV7 (FRIRVRV-NH₂), a consensus amphiphilic sequence was identified as being analogous to host d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020339
更新日期：2017-02-06 00:00:00
abstract：:The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless, the monospecific IgG format is not optimal for ma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21207496
更新日期：2020-10-12 00:00:00
abstract：:While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in a much more sophisticated and nuanced manner than previously thought. Some aspects of this expanded repertoire of platelet function are mediate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176150
更新日期：2020-08-26 00:00:00
abstract：:Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal degeneration underlies the vision loss such as occurs with retinitis pigmentosa. Under these conditions, optogenetic the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020522
更新日期：2020-01-14 00:00:00
abstract：:Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225574
更新日期：2019-11-08 00:00:00
abstract：:Aphids are phloem feeders that cause large damage globally as pest insects. They induce a variety of responses in the host plant, but not much is known about which responses are promoting or inhibiting aphid performance. Here, we investigated whether one of the responses induced in barley by the cereal aphid, bird che...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061317
更新日期：2017-06-20 00:00:00
abstract：:The lignin-carbohydrate complex (LCC) was isolated from milled wood lignin of 2- and 24-month-old crude bamboo (Neosinocalamus affinis) culms using acetic acid (AcOH) and then characterized. The results have shown that the LCC preparation from 2-month-old bamboo (L₂) exhibited a slightly lower molecular weight than th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010001
更新日期：2017-12-21 00:00:00
abstract：:Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. Regulation of the TGFβ signaling pathway is of key importance to maintain tissue homeostasis. Perturbation of this signaling pathway has be...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020476
更新日期：2021-01-06 00:00:00
abstract：:The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155224
更新日期：2020-07-23 00:00:00
abstract：:Development of stimuli-responsive supramolecular micelles that enable high levels of well-controlled drug release in cancer cells remains a grand challenge. Here, we encapsulated the antitumor drug doxorubicin (DOX) and pro-photosensitizer 5-aminolevulinic acid (5-ALA) within adenine-functionalized supramolecular mice...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010154
更新日期：2020-12-25 00:00:00
abstract：:Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021269
更新日期：2012-01-01 00:00:00
