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Analysis of DNA Methylation Status in Bodily Fluids for Early Detection of Cancer.

Abstract：

:Epigenetic alterations by promoter DNA hypermethylation and gene silencing in cancer have been reported over the past few decades. DNA hypermethylation has great potential to serve as a screening marker, a prognostic marker, and a therapeutic surveillance marker in cancer clinics. Some bodily fluids, such as stool or urine, were obtainable without any invasion to the body. Thus, such bodily fluids were suitable samples for high throughput cancer surveillance. Analyzing the methylation status of bodily fluids around the cancer tissue may, additionally, lead to the early detection of cancer, because several genes in cancer tissues are reported to be cancer-specifically hypermethylated. Recently, several studies that analyzed the methylation status of DNA in bodily fluids were conducted, and some of the results have potential for future development and further clinical use. In fact, a stool DNA test was approved by the U.S. Food and Drug Administration (FDA) for the screening of colorectal cancer. Another promising methylation marker has been identified in various bodily fluids for several cancers. We reviewed studies that analyzed DNA methylation in bodily fluids as a less-invasive cancer screening.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Yokoi K,Yamashita K,Watanabe M

doi

10.3390/ijms18040735

subject

Has Abstract

pub_date

2017-03-30 00:00:00

issue

4

issn

1422-0067

pii

ijms18040735

journal_volume

18

pub_type

杂志文章,评审

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