abstract：OBJECTIVES:Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines. The goal of the study was to characterize the presentation, evaluation, histopathology, and outcomes of therapy in children with HAAA to guide future research and to develop standardize...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kemme S,Stahl M,Brigham D,Lovell MA,Nakano T,Feldman AG,Mack C

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:Pediatric high-resolution manometry (HRM) and 24-hour pH-impedance with/without ambulatory manometry (pH-MII+/-mano) tests are generally performed using adult-derived protocols. We aimed to assess the feasibility of these protocols in children, the occurrence of patient-related imperfections and their influe...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： van Lennep M,Leijdekkers ML,Oors JM,Benninga MA,van Wijk MP,Singendonk MMJ

更新日期：2021-02-01 00:00:00

abstract：ABSTRACT:Fructose is a highly abundant carbohydrate in western diet and may induce bowel symptoms in children as in adults. The main objective of this study is to describe the frequency of fructose malabsorption (FM) in symptomatic patients 18 years or younger undergoing fructose breath test in a single tertiary center...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Alliende F,Lucero Y,Jaime F,Ríos G,Arancibia ME,Rodriguez L

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Acute exacerbations of inflammatory bowel disease (IBD) may involve enteric pathogen. We aimed to assess the frequency and outcomes of Clostridium difficille toxin (CDT) and non-CDT enteric infections in symptomatic pediatric patients with IBD. METHODS:Patients' records were retrospectively searched for dis...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Melnik P,Soffair N,Matar M,Shamir R,Assa A

更新日期：2021-01-01 00:00:00

abstract：ABSTRACT:Neurogastroenterology and motility (NGM) disorders are common in childhood and are often very debilitating. Although pediatric gastroenterology fellows are expected to obtain training in the diagnosis and management of patients with these disorders, there is an ongoing concern for unmet needs and lack of expos...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Khlevner J,Rosen R,Ambartsumyan L,Lusman SS,Rosen JM,Yacob D,Mousa H,Nurko S,Di Lorenzo C,Boruta M,Ratcliffe EM,Feinstein L,Snyder J,Wood RJ,Graham K,Saps M,Gyawali CP,Rodriguez L,Belkind-Gerson J

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Current practice during pediatric colonoscopy is to obtain random colonic biopsies, even from normal appearing tissue. The majority of literature published on colonic biopsy practice analyzes adults; however, limited data examines the pediatric population. The lack of standardization regarding tissue sampling...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Glass J,Alcalá HE,Tobin M

更新日期：2020-12-30 00:00:00

abstract：ABSTRACT:Transgender and gender non-conforming (TGNC) individuals have a different gender identity than the sex they were assigned at birth. Despite an increase in provider awareness of TGNC health over the past decade, no original research or societal guidelines exist on TGNC patients with Inflammatory Bowel Disease (...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Schenker RB,Wilson E,Russell M,Cooke LC,Heyman MB,Verstraete SG

更新日期：2020-12-23 00:00:00

abstract：BACKGROUND:It is important to identify patients with monogenic IBD as management may differ from classical IBD. In this position statement we formulate recommendations for the use of genomics in evaluating potential monogenic causes of IBD across age groups. METHODS:The consensus included paediatric IBD specialists fr...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Uhlig HH,Charbit-Henrion F,Kotlarz D,Shouval DS,Schwerd T,Strisciuglio C,de Ridder L,van Limbergen J,Macchi M,Snapper SB,Ruemmele FM,Wilson DC,Travis SPL,Griffiths AM,Turner D,Klein C,Muise AM,Russell RK,Paediatric IB

更新日期：2020-12-16 00:00:00

abstract：OBJECTIVES:To assess the efficacy, safety and side-effect profile of ferric carboxymaltose (FCM) for correcting IDA in children and adolescents in paediatric gastroenterology, hepatology and nutrition. METHOD:This was a retrospective study of all gastroenterology patients <18years who had FCM (October 2015 to October ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Sasankan N,Duncan H,Curtis L,McGuckin C,Shannon C,Barclay A,Fraser S,Nair M,Russell RK,Hansen R

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVES:In this study, we investigated the role of the cannabinoid receptor type 2 (CB2) in the bone loss associated with celiac disease (CD) evaluating the effect of its pharmacological modulation on osteoclast activity. We previously demonstrated a significant association between the CB2 Q63R variant and CD, sugge...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Tortora C,Punzo F,Argenziano M,Di Paola A,Tolone C,Strisciuglio C,Rossi F

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:The aim of this systematic review and meta-analysis was to assess immune response to vaccination in children and young people with inflammatory bowel disease (IBD). In patients with IBDs, both the disease itself and its treatment can affect the vaccine response. METHODS:Medical databases were searched for r...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Dembiński Ł,Dziekiewicz M,Banaszkiewicz A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:Timed barium esophagram (TBE) is a fluoroscopic study that is widely employed as an adjunctive tool for diagnosing esophageal emptying disorders in adults (eg, achalasia, esophagogastric junction outflow obstruction [EGJOO]) and for following response to treatment. We aimed to describe the characteristics an...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Rosenwald KD,Hayes K,Menard-Katcher C,Belkind-Gerson J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The IMPACT-III measures health-related quality of life (HRQOL) in pediatric patients with Inflammatory Bowel Disease (IBD). The original IMPACT domain structure was developed based on expert opinion and was not psychometrically validated. This study developed a new domain structure based on the current IMPAC...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Grant A,MacIntyre B,Kappelman MD,Otley AR

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients. METHODS:Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kori M,Le Thi TG,Werkstetter K,Sustmann A,Bontems P,Lopes AI,Oleastro M,Iwanczak B,Kalach N,Misak Z,Cabral J,Homan M,Cilleruelo Pascual ML,Pehlivanoglu E,Casswall T,Urruzuno P,Martinez Gomez MJ,Papadopoulou A,Roma E,

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Recently, significant interest from families and healthcare providers has arisen to use blenderized tube feedings (BTF). Although many institutions are providing this nutritional option, literature documenting outcomes and safety is lacking. METHODS:A retrospective chart review was performed on pediatric ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kernizan D,Mintz D,Colin M,Lee M,Yoakam L,Chen YP,Iofel E,Koniaris S,Weidner M

更新日期：2020-10-01 00:00:00

abstract：ABSTRACT:Multisystem inflammatory syndrome in children (MIS-C) is a recently identified syndrome that appears to be temporally associated with novel coronavirus 2019 infection. MIS-C presents with fever and evidence of systemic inflammation, which can manifest as cardiovascular, pulmonary, neurologic, and gastrointesti...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Sahn B,Eze OP,Edelman MC,Chougar CE,Thomas RM,Schleien CL,Weinstein T

更新日期：2020-09-22 00:00:00

abstract：OBJECTIVES:The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. METHODS:A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Mack DR,Saul B,Boyle B,Griffiths A,Sauer C,Markowitz J,LeLeiko N,Keljo D,Rosh JR,Baker SS,Steiner S,Heyman MB,Patel AS,Baldassano R,Noe J,Rufo P,Kugathasan S,Walters T,Marquis A,Thomas SM,Denson L,Hyams J,PROT

更新日期：2020-09-01 00:00:00

abstract：:Ornithine transcarbamylase deficiency (OTCD) is the most common of the urea cycle disorders and follows an X-linked inheritance pattern. The classical form in male infants causes vomiting and lethargy in the neonatal period; if untreated the severe hyperammonaemia can cause acute neurotoxic complications and permanent...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Selvanathan A,Hertzog A,Lemberg DA,Ellaway C

更新日期：2020-08-01 00:00:00

abstract：:Parents and caretakers are increasingly feeding infants and young children plant-based "milk" (PBM) alternatives to cow milk (CM). The US Food and Drug Administration currently defines "milk" and related milk products by the product source and the inherent nutrients provided by bovine milk. Substitution of a milk that...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Merritt RJ,Fleet SE,Fifi A,Jump C,Schwartz S,Sentongo T,Duro D,Rudolph J,Turner J,NASPGHAN Committee on Nutrition.

更新日期：2020-08-01 00:00:00

abstract：:Quality training in pediatric gastroenterology, hepatology, and nutrition is essential for the future of our specialty from advancing the science through research to providing clinical care for children with gastrointestinal, hepatic and nutritional disorders. As educational theory has developed, both the American Boa...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Sauer CG,Robson J,Turmelle YP,Cerezo CS,Loomes KM,Huang JS,Quiros-Tejeira RE,Benkov KJ,Narkewicz MR,Leichtner A,Weinstein T

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Current pediatric guidelines allow noninvasive diagnosis of celiac disease in selected children. We investigated in a large cohort study whether the severity of villous atrophy at diagnosis is associated with clinical characteristics or long-term health outcomes, thus having a prognostic significance. METHO...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Kröger S,Kurppa K,Repo M,Huhtala H,Kaukinen K,Lindfors K,Arvola T,Kivelä L

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:Pediatric patients with inflammatory bowel diseases (IBD) require treatment, monitoring, and health maintenance services. We described patterns of primary, specialty, emergency department (ED) and urgent care delivery, and explored patient- and system-related variables that impact ED/urgent care utilization....

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Michel HK,Noll RB,Siripong N,Kim SC

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:The COVID-19 pandemic has drastically changed healthcare systems and training around the world. The Training Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition sought to understand how COVID-19 has affected pediatric gastroenterology fellowship training. METHODS...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Mallon D,Pohl JF,Phatak UP,Fernandes M,Rosen JM,Lusman SS,Nylund CM,Jump CS,Solomon AB,Srinath A,Singer A,Harb R,Rodriguez-Baez N,Whitfield Van Buren KL,Koyfman S,Bhatt R,Soler-Rodriguez DM,Sivagnanam M,Lee CK,NASPG

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:With the current coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised about the risk to children with inflammatory bowel diseases (IBD). We aimed to collate global experience and provide provisional guidance for managing paediatric IBD (PIBD) in the era of COVID-19. METHODS:An electroni...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Turner D,Huang Y,Martín-de-Carpi J,Aloi M,Focht G,Kang B,Zhou Y,Sanchez C,Kappelman MD,Uhlig HH,Pujol-Muncunill G,Ledder O,Lionetti P,Dias JA,Ruemmele FM,Russell RK,Paediatric IBD Porto group of ESPGHAN.

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:This study aims to develop a new prognostic score based on changes in serial laboratory data from patients with pediatric acute liver failure (PALF). METHODS:We retrospectively reviewed data on 146 patients with PALF at the Seoul National University Children Hospital (SNUCH) and the Asan Medical Center (AMC...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Lee EJ,Kim JW,Moon JS,Kim YB,Oh SH,Kim KM,Ko JS

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to quantify the differences in viscosity of over a range of commercial food-based formulas and home-prepared blenderized feeds used for enteral feeding in the clinical management of gastroesophageal reflux and gastroesophageal reflux-related aspiration in children with oropharyngeal d...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Hron B,Rosen R

更新日期：2020-06-01 00:00:00

abstract：:Commissioned by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN), we investigated how European physicians training in these fields are educated in nutrition. A survey on time spent in nutrition training, composition of multidisciplinary nutrition teams, and topics covered during...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Broekaert IJ,Jahnel J,Moes N,van der Doef H,Hojsak I,Tzivinikos C

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:This position paper written by the Hepatitis Expert Team of the Federation of International Societies of Pediatric Gastroenterology, Hepatology, and Nutrition aimed to systematically evaluate clinical practice guidelines (CPGs), medical consensus, and position papers on the use of direct-acting antivirals (DA...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Indolfi G,Fischler B,Gonzalez-Peralta RP,Ciocca M,Porta G,Neelam M,El-Guindi M,Kelly D,Ni YH,Sibal A,Leung DH,Chang MH,Hepatitis Expert Team of the Federation of International Societies of Pediatric Gastroenterology, Hepatology,

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVES:A minimally invasive biomarker to monitor disease activity is one of the greatest unmet clinical needs of the pediatric eosinophilic esophagitis (EoE) population. We aimed to determine whether circulating eosinophil progenitors (EoPs) could be used as a biomarker to identify pediatric patients with active Eo...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Henderson A,Magier A,Schwartz JT,Martin LJ,Collins MH,Putnam PE,Mukkada VA,Abonia JP,Rothenberg ME,Fulkerson PC

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Glucagon-like peptide 2 (GLP-2) is a 33 amino acid peptide hormone released from enteroendocrine L-cells following nutrient ingestion. It has been shown to exert trophic effects on the gut. We set out to measure GLP-2 concentrations in blood in children with diarrhoea and malnutrition. METHODS:GLP-2 levels ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Besa EC,Chandwe K,Banda R,Munalula L,Kalomo L,Amadi B,Kelly P

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:Functional dyspepsia (FD) is a functional abdominal pain disorder. There is paucity of data on the economic impact of FD in children. Primary aim of our study was to estimate annual evaluation cost ("diagnosis and visit" cost) and secondary aim was to identify potential prognostic factors of FD in children. ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Mani J,Madani S,Thomas R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The learning curve in paediatric oesophagogastroduodenoscopy (OGD) is unknown. Using ≥95% D2 (second part of the duodenum) intubation rates as a marker of technical competency, we conducted learning curve analyses to identify when trainees achieve competency in paediatric OGD. Factors associated with compete...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Barraclough H,Siau K,Ward ST,Dunckley P,Hawkes N,Thomson M,Narula P

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Vedolizumab (VDZ) is effective for treating both adult and pediatric onset inflammatory bowel disease (IBD). Clinical outcomes, however, have been reported to be superior in patients naïve to anti-tumor necrosis factor (TNF). With the growing interest in endoscopic endpoints, we aimed to describe rates of mu...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Jossen J,Kiernan BD,Pittman N,Dubinsky MC

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:The objective was to evaluate the efficacy and safety of sodium benzoate in the management of hyperammonemia and hepatic encephalopathy (HE) in decompensated chronic liver disease. METHODS:It was a prospective, interventional, double-blinded randomized controlled trial conducted from August 2017 to December ...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Snehavardhan P,Lal BB,Sood V,Khanna R,Alam S

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVES:Differentiation of Crohn disease (CD) from ulcerative colitis (UC) is challenging when inflammation is predominantly colonic. The paediatric inflammatory bowel disease (PIBD) classes algorithm was developed to bring consistency to labelling, but used physician-assigned diagnosis as the criterion standard. We...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Dhaliwal J,Siddiqui I,Muir J,Rinawi F,Church PC,Walters TD,Griffiths AM

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Infants with intestinal failure (IF) and IF-associated liver disease (IFALD) are at risk for poor somatic growth because of increased metabolic demands, inadequate intake, intestinal malabsorption, chronic liver disease and other comorbidities. There are limited data on the nutritional adequacy of intravenou...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Raphael BP,Mitchell PD,Gura KM,Potemkin AK,Squires RH,Puder M,Duggan CP

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Patients receiving home parenteral nutrition (HPN) are at high-risk for central line-associated bloodstream infections (CLABSI). There are no published management guidelines, however, for the antibiotic treatment of suspected CLABSI in this population. Historical microbiology data may help inform empiric ant...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Raphael BP,Fournier G,McLaughlin SR,Puder M,Jones S,Flett KB

更新日期：2020-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for live...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Cuzmar V,Alberti G,Uauy R,Pereira A,García C,De Barbieri F,Corvalán C,Santos JL,Mericq V,Villarroel L,Gana JC

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVES:Liver nodularity occurs across the spectrum of cystic fibrosis liver disease (CFLD), from regenerative nodules to cirrhosis, and can occur without liver enzyme abnormalities. Our aims were to determine if incorporating abdominal ultrasound (US) with annual laboratory testing improves the detection of CFLD an...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： Sellers ZM,Lee LW,Barth RA,Milla C

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVES:Inflammatory bowel disease (IBD) can be particularly challenging during the pediatric age with a relevant impact on patient's health-related quality of life (HRQoL). Disease activity accounts for only a small part of the variability in HRQoL, and psychological factors can play a significant role. We aimed to...

journal_title：Journal of pediatric gastroenterology and nutrition

authors： De Carlo C,Bramuzzo M,Canaletti C,Udina C,Cozzi G,Pavanello PM,Rampado S,Martelossi S,Giudici F,Di Leo G,Barbi E

更新日期：2019-10-01 00:00:00