Ferric Carboxymaltose Across all Ages in Paediatric Gastroenterology Shows Efficacy Without Increased Safety Concerns.

Abstract:

OBJECTIVES:To assess the efficacy, safety and side-effect profile of ferric carboxymaltose (FCM) for correcting IDA in children and adolescents in paediatric gastroenterology, hepatology and nutrition. METHOD:This was a retrospective study of all gastroenterology patients <18years who had FCM (October 2015 to October 2017). Haematological and biochemical parameters were recorded pre-infusion, at 4 weeks, 3 months, 6 months and 1 year post-infusion. Recognised side-effects were documented. RESULTS:66 children received FCM during this period. Data was analysed on 61 children, 5 excluded due to inadequate data. The median age at administration was 14 years (IQR-7). 32 (52%) were male. 26 (42%) were <14 years old. 7 (11.5%) were <5 years old. 17 (28%) were switched from oral iron supplements to FCM. The median dose of FCM delivered was 19 mg/kg. The median haemoglobin increased from 108 g/l to 126 g/l at 1 month post-infusion (P value <0.00001). The mean cell volume also improved from 80 fl to 84 fl at 1 month post-infusion (P value = 0.0007). 48 (94%) children corrected their anaemia after receiving FCM. Two patients (3%) reported side-effects with skin bruising and staining. CONCLUSION:FCM appears to be effective in correcting IDA in children across a wide range of GI indications and all ages. It is effective and generally well tolerated including in very young patients. Potential side-effects can be avoided by careful monitoring during infusions.

authors

Sasankan N,Duncan H,Curtis L,McGuckin C,Shannon C,Barclay A,Fraser S,Nair M,Russell RK,Hansen R

doi

10.1097/MPG.0000000000003003

subject

Has Abstract

pub_date

2020-11-20 00:00:00

eissn

0277-2116

issn

1536-4801

pub_type

杂志文章
  • Effects of neonatal undernutrition and subsequent nutritional rehabilitation or administration of thyroxine and hydrocortisone on the inositol phosphatase activities in rat intestine.

    abstract::Undernutrition during the suckling period imposed by maternal protein deficiency during lactation resulted in elevated inositol triphosphatase activity (units per gram of wet tissue) in the ileum and lower phytase activity in the duodenum and jejunum. Activities of inositol triphosphatase in the duodenum and jejunum a...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198609000-00021

    authors: Rao RK,Ramakrishnan CV

    更新日期:1986-09-01 00:00:00

  • The double-wire technique as an aid to selective cannulation of the common bile duct during pediatric endoscopic retrograde cholangiopancreatography.

    abstract:BACKGROUND:Selective cannulation of the common bile duct (CBD) during endoscopic retrograde cholangiopancreatography (ERCP) can be difficult. Several techniques have been described to assist endoscopists in obtaining access when initial cannulation fails. The objective of this report is to describe our initial experien...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e318054e1f4

    authors: Kramer RE,Azuaje RE,Martinez JM,Dunkin BJ

    更新日期:2007-10-01 00:00:00

  • Esophageal endoscopic dilations.

    abstract:OBJECTIVE:Esophageal strictures in children are serious and require specialized care. Peptic stricture is most common in our context, whereas caustic and congenital strictures are rare. The present study reports our experience in esophageal endoscopic dilation while specifying the causes of esophageal strictures as wel...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31824b16b2

    authors: Lakhdar-Idrissi M,Khabbache K,Hida M

    更新日期:2012-06-01 00:00:00

  • Role of the colon in short bowel syndrome and intestinal transplantation.

    abstract::Colon is a crucial partner for small intestinal adaptation and function in patients who underwent extensive small intestinal resection or transplantation. This short review deals with the different properties and roles of the colon in these settings, involving fluid and electrolytes absorption, absorption of medium-ch...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/MPG.0b013e3181a118ef

    authors: Goulet O,Colomb-Jung V,Joly F

    更新日期:2009-04-01 00:00:00

  • Chronic gastroenteritis in a patient with histiocytosis-X.

    abstract::We describe a 5-year-old white girl who presented at 18 months of age with an ileal perforation and radiographic evidence of segmental intestinal narrowing. Her initial diagnosis was Crohn's disease; however, on subsequent microscopic review, her lesion consisted of mixed histiocytic and eosinophilic infiltration char...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:

    authors: Sutphen JL,Fechner RE

    更新日期:1986-03-01 00:00:00

  • The prevalence of encopresis in a multicultural population.

    abstract:BACKGROUND:Population-based studies on the prevalence of encopresis in children are scarce and generally outdated. Prevalence estimates based on clinical studies are unreliable because parents tend to be reticent to seek medical help for this problem. Professional help is necessary, however, because encopresis can lead...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000149964.77418.27

    authors: van der Wal MF,Benninga MA,Hirasing RA

    更新日期:2005-03-01 00:00:00

  • Effects of dietary zinc deficiency on hepatic ornithine carbamoyltransferase and alcohol dehydrogenase activities in rats.

    abstract::Hepatic ornithine carbamoyltransferase (OCT) and alcohol dehydrogenase (ADH) activities were measured in six groups of rats: (A) fed a severe zinc-(Zn-) deficient diet (1.98 ppm) for 5 weeks; (B) pair-fed control for group (A); (C) fed a less severe Zn-deficient diet (6.10 ppm) for 5 weeks; (D) pair-fed control for gr...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198504000-00019

    authors: Indo Y,Nagata N,Higashi A,Matsuda I,Kashiwabara N,Nakashima I

    更新日期:1985-04-01 00:00:00

  • Euro-Growth references for breast-fed boys and girls: influence of breast-feeding and solids on growth until 36 months of age. Euro-Growth Study Group.

    abstract:BACKGROUND:The World Health Organization (WHO) recommends exclusive breast-feeding during the first 4 to 6 months of life, but limited information is available regarding the growth performance of infants fed according to the recommendation. The present study used data from the Euro-Growth study to determine the growth ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00005176-200007001-00006

    authors: Haschke F,van't Hof MA

    更新日期:2000-01-01 00:00:00

  • Tissue transglutaminase antibodies are a useful serological marker for the diagnosis of celiac disease in patients with Down syndrome.

    abstract:BACKGROUND:Celiac disease (CD) is overrepresented among patients with Down syndrome (DS), who frequently lack any typical symptoms. Therefore, screening for CD is recommended in this high-risk group. The aim of the study was to determine the prevalence of CD in Arab children with DS and evaluate the contribution of imm...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3180320679

    authors: Shamaly H,Hartman C,Pollack S,Hujerat M,Katz R,Gideoni O,Shamir R

    更新日期:2007-05-01 00:00:00

  • Reduced bile output with chronic enteral and parenteral infusion of amino acids, glucose, and fat emulsion in rabbits.

    abstract::To assess the effect of chronic administration of amino acids, glucose, and fat on hepatic excretory function, bile flow and bile salt secretion were directly measured in adult rabbits alimented either intravenously or intragastrically. Five groups of animals were studied after 9-11 days on different nutritional regim...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198510000-00023

    authors: Zahavi I,Shaffer EA,Kelly J,Gall DG

    更新日期:1985-10-01 00:00:00

  • Immunoglobulin levels in human colostrum and milk.

    abstract::The levels of secretory IgA and of IgM and IgG in colostrums and milks obtained at various times postpartum were measured by radial immunodiffusion. Immunoglobulin A was the dominant immunoglobulin in all samples, and concentrations in colostrum ranged from 1.5 to 83.7 g/L (mean 32 g/L). Immunoglobulin M and IgG had m...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198201030-00018

    authors: Mickleson KN,Moriarty KM

    更新日期:1982-01-01 00:00:00

  • Well Preserved Renal Function in Children With Untreated Chronic Liver Disease.

    abstract:OBJECTIVES:On the basis of studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease (CLD). Therefore, we investigated renal function in children with CLD. METHODS:In a retrospective study of 277 children with CLD, renal function was investigated as glomerular fi...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000001862

    authors: Berg UB,Németh A

    更新日期:2018-04-01 00:00:00

  • Outcomes of Severe Seronegative Hepatitis-associated Aplastic Anemia: A Pediatric Case Series.

    abstract:OBJECTIVES:Hepatitis-associated aplastic anemia (HAAA) is a potentially life-threatening diagnosis without clear treatment guidelines. The goal of the study was to characterize the presentation, evaluation, histopathology, and outcomes of therapy in children with HAAA to guide future research and to develop standardize...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002940

    authors: Kemme S,Stahl M,Brigham D,Lovell MA,Nakano T,Feldman AG,Mack C

    更新日期:2021-02-01 00:00:00

  • Cerebral thromboembolic disease in pediatric and adult inflammatory bowel disease: case report and review of the literature.

    abstract::Cerebral and retinal vascular disease are rare complications of inflammatory bowel disease. Most reports are of adult patients, with only seven instances described in children. The eighth case, a 14-year-old boy with ulcerative colitis and cerebral venous thrombosis is reported in whom the diagnosis was confirmed by m...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-198904000-00028

    authors: Markowitz RL,Ment LR,Gryboski JD

    更新日期:1989-04-01 00:00:00

  • Cytokine release of peripheral blood mononuclear cells in children with chronic hepatitis B virus infection.

    abstract:BACKGROUND:Immune response to hepatitis B virus (HBV) antigens or mitogens in Asian children with chronic HBV infection who are mainly perinatally infected has not been studied in connection with the production of various cytokines, although these patients are considered to be less responsive to antiviral therapy. MET...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199911000-00013

    authors: Hsu HY,Chang MH,Ni YH,Lee PI

    更新日期:1999-11-01 00:00:00

  • Discriminant analysis for the diagnosis of childhood celiac disease.

    abstract::A new statistical approach to the analysis of laboratory data has been introduced to optimize the use of absorption tests and gliadin antibody measurement for the diagnosis of childhood celiac disease. Serum antigliadin antibodies, as well as blood xylose, iron, and tryglycerides after oral load, were evaluated in 40 ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-198707000-00008

    authors: Greco L,Troncone R,De Vizia B,Poggi V,Mayer M,Grimaldi M

    更新日期:1987-07-01 00:00:00

  • Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility S

    abstract:ABSTRACT:Neurogastroenterology and motility (NGM) disorders are common in childhood and are often very debilitating. Although pediatric gastroenterology fellows are expected to obtain training in the diagnosis and management of patients with these disorders, there is an ongoing concern for unmet needs and lack of expos...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000002965

    authors: Khlevner J,Rosen R,Ambartsumyan L,Lusman SS,Rosen JM,Yacob D,Mousa H,Nurko S,Di Lorenzo C,Boruta M,Ratcliffe EM,Feinstein L,Snyder J,Wood RJ,Graham K,Saps M,Gyawali CP,Rodriguez L,Belkind-Gerson J

    更新日期:2021-01-01 00:00:00

  • Development and subsequent refinement of the inflammatory bowel disease questionnaire: a quality-of-life instrument for adult patients with inflammatory bowel disease.

    abstract:BACKGROUND:Health-related quality of life (HRQOL) describes the physical, social, and emotional attitudes and behavior of people in relation to health status. By the 1980s, HRQOL was noted to be impaired in chronic diseases but inflammatory bowel disease, had not been extensively described. METHODS:This review summari...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章,评审

    doi:10.1097/00005176-199904001-00003

    authors: Irvine EJ

    更新日期:1999-04-01 00:00:00

  • Development and validation of a pediatric IBD knowledge inventory device: the IBD-KID.

    abstract:OBJECTIVES:Questionnaires exist to assess inflammatory bowel disease (IBD)-related knowledge of adults. Owing to wording and content concerns, these were believed to be inappropriate for use in pediatric patients. The aim of this study was to develop a questionnaire to assess disease-related knowledge of pediatric pati...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0000000000000210

    authors: Haaland D,Day AS,Otley A

    更新日期:2014-03-01 00:00:00

  • A metabolic bed for collecting excreta in premature infants.

    abstract::A mattress and plastic bed for collection of urine and feces in premature infants housed in isolettes is described. The dimensions of the bed are 65.5 x 34.4 x 13.5 cm. A drainage hole is located 18 cm from the foot of the bed and midway (16.5 cm) from either side. The angle of the depression in the bed for the draina...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199005000-00011

    authors: Kien CL

    更新日期:1990-05-01 00:00:00

  • Manometric variations following spiral myotomy for long-gap esophageal atresia.

    abstract::We have previously demonstrated that a spiral myotomy and delayed definitive procedure is a viable alternative for esophageal reconstruction in long-gap esophageal atresia. In this study we sought to determine whether this procedure leads to esophageal motility disturbances and to compare the manometric findings with ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199004000-00019

    authors: Levine JJ,Shoshany G,Davidson M,Kimura K

    更新日期:1990-04-01 00:00:00

  • Treatment of recurrent abdominal pain: components analysis of four treatment protocols.

    abstract:BACKGROUND:Recurrent abdominal pain (RAP) affects up to 34% of the world's population of children. Medical management has been limited, but behavioral strategies have been shown to be effective. In this study several components of published treatment protocols were adapted and/or improved and then compared using a pret...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200007000-00011

    authors: Humphreys PA,Gevirtz RN

    更新日期:2000-07-01 00:00:00

  • Primary sclerosing cholangitis in Arab children: report of four cases and literature review.

    abstract:BACKGROUND:The prevalence of primary sclerosing cholangitis, a rare progressive liver disorder, is increasing with the advent of endoscopic retrograde cholangiography in the investigation of children with obscure liver disease. The etiology of primary sclerosing cholangitis is not known, clinical presentation is variab...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/00005176-199702000-00007

    authors: Kagalwalla AF,Altraif I,Shamsan L,Omojola M,Khan H,Kagalwalla YA

    更新日期:1997-02-01 00:00:00

  • Biliary atresia in Canada: the effect of centre caseload experience on outcome.

    abstract:OBJECTIVES:: Biliary atresia (BA) is a leading cause of end-stage paediatric liver disease. Standard BA treatment is sequential surgery with an initial Kasai procedure (KP) followed by liver transplant (LT) for patients who progress to liver failure. A key determinant for the post-KP patient survival with their native ...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e3181d67e5e

    authors: Schreiber RA,Barker CC,Roberts EA,Martin SR,Canadian Pediatric Hepatology Research Group.

    更新日期:2010-07-01 00:00:00

  • Long-term treatment of primary sclerosing cholangitis in children with oral vancomycin: an immunomodulating antibiotic.

    abstract:BACKGROUND:Primary sclerosing cholangitis is a rare chronic cholestatic condition of unknown etiology, frequently associated with inflammatory bowel disease and characterized by diffuse fibrosing and inflammatory destruction of the intra- and/or extrahepatic biliary duct system. PATIENTS AND METHODS:The study involved...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/MPG.0b013e31816fee95

    authors: Davies YK,Cox KM,Abdullah BA,Safta A,Terry AB,Cox KL

    更新日期:2008-07-01 00:00:00

  • Serum leptin and cytokines in whole blood in relation to clinical and nutritional status in cystic fibrosis.

    abstract:OBJECTIVES:Leptin plays an important role in the energy balance and may be affected by hormonal and metabolic derangement associated with chronic disease. The aim of this study was to assess the correlation between leptin, proinflammatory cytokines and nutritional status with regard to clinical status in homozygous del...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000228096.81831.a2

    authors: Schmitt-Grohé S,Hippe V,Igel M,von Bergmann K,Posselt HG,Krahl A,Smaczny C,Wagner TO,Nikolaizik W,Lentze MJ,Zielen S

    更新日期:2006-08-01 00:00:00

  • Electrogastrography, Near-infrared Spectroscopy, and Acoustics to Measure Gastrointestinal Development in Preterm Babies.

    abstract:OBJECTIVES:The aim of the study was to obtain objective measures indicative of gastrointestinal maturity using 3 noninvasive technologies. METHODS:Electrogastrography (EGG), abdominal near-infrared spectroscopy (NIRS), and bowel sound/acoustics (AC) monitoring were used simultaneously to obtain physiologic measures of...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章

    doi:10.1097/MPG.0000000000001867

    authors: Ortigoza EB,Cagle J,Chien JH,Oh S,Brown LS,Neu J

    更新日期:2018-06-01 00:00:00

  • Efficacy of bismuth-based triple therapy in children with abdominal pain and Helicobacter pylori gastritis.

    abstract:BACKGROUND:To evaluate the effect of a therapeutic regimen of 7 days versus 14 days on the clinical manifestations of Helicobacter pylori gastritis in children. METHODS:Ninety children (age 2-19 years) who had abdominal pain and/or recurrent vomiting were determined to have H. pylori gastritis by endoscopy, histology,...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-200002000-00018

    authors: Shamaly H,Berkowitz D,Rosenthal E,Naveh Y

    更新日期:2000-02-01 00:00:00

  • Exocrine pancreatic function in children with progressive familial intrahepatic cholestasis type 2.

    abstract::In progressive familial intrahepatic cholestasis type 2 (PFIC-2), severe steatorrhea is often documented. However, pancreatic exocrine secretion has not yet been studied. In 14 children with PFIC-2, pancreatic function was assessed using standard fecal tests. Normal fecal lipase concentrations excluded isolated lipase...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 杂志文章

    doi:10.1097/01.mpg.0000218154.26792.6a

    authors: Walkowiak J,Jankowska I,Pawlowska J,Strautnieks S,Bull L,Thompson R,Herzig KH,Socha J

    更新日期:2006-04-01 00:00:00

  • Dietary fiber in weaning cereals: a study of the effect on stool characteristics and absorption of energy, nitrogen, and minerals in healthy infants.

    abstract::We evaluated the effect of increased dietary fiber (DF) content in weaning cereals based on wheat/soy (8.0 and 1.8% DF) and wheat/milk (5.3 and 2.0% DF) in healthy, formula-fed infants 7-17 weeks old. The study had a cross-over design, each infant acting as his or her own control. Stool characteristics and anthropomet...

    journal_title:Journal of pediatric gastroenterology and nutrition

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00005176-199602000-00008

    authors: Davidsson L,Mackenzie J,Kastenmayer P,Rose A,Golden BE,Aggett PJ,Hurrell RF

    更新日期:1996-02-01 00:00:00