听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES期刊下所有文献
  • Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl.

    abstract:PURPOSE:To examine the impact of adding droperidol to fentanyl-based intravenous patient- controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS:Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30902

    authors: Hirata I,Iwamoto M,Matsui H,Yoshinuma H,Funakoshi R

    更新日期:2020-01-01 00:00:00

  • In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens.

    abstract:PURPOSE:The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical development. METHODS:The in vitro pharmacokinetic characterization...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30942

    authors: Chaira T,Barman T,Samuel Raj V

    更新日期:2020-01-01 00:00:00

  • Cannabis and the Gastrointestinal Tract.

    abstract::Cannabis has been used for its medicinal purposes since ancient times. Its consumption leads to the activation of Cannabis receptors CB1 and CB2 that, through specific mechanisms can lead to modulation and progression of inflammation or repair. The novel findings are linked to the medical use of Cannabis in gastrointe...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps31242

    authors: Cohen L,Neuman MG

    更新日期:2020-01-01 00:00:00

  • Population pharmacokinetic models of first choice beta-lactam antibiotics for severe infections treatment: What antibiotic regimen to prescribe in children?

    abstract:BACKGROUND:To perform a review describing the pharmacokinetic (PK) parameters and covariates of interest of the eight first choice β-lactams (BL) antibiotics for treatment of severe infections in pediatric population. Pediatric sepsis and septic shock reportedly affect 30% of children admitted to pediatric intensive ca...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30927

    authors: Marsot A

    更新日期:2020-01-01 00:00:00

  • miR-484: A Possible Indicator of Drug-Induced Pulmonary Fibrosis.

    abstract:BACKGROUND:Drug-induced lung injury leads to serious lung diseases, such as pulmonary fibrosis. We demonstrated in an alveolar epithelial cell line A549/ABCA3 that certain microRNAs were associated with bleomycin induced epithelial-mesenchymal transition (EMT) which is closely related to pulmonary fibrosis. In this stu...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps31448

    authors: Konaka T,Kawami M,Yamamoto A,Yumoto R,Takano M

    更新日期:2020-01-01 00:00:00

  • Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.

    abstract::Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29895

    authors: Chan CC,Prokopich CL

    更新日期:2019-01-01 00:00:00

  • Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.

    abstract::Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient Dark Agouti (DA) rats to determine the usefulness of prediction metho...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30237

    authors: Iwaki M,Niwa T,Tanaka H,Kawase A,Komura H

    更新日期:2019-01-01 00:00:00

  • Neuropeptide FF (FLFQPQRF-NH2) and its Fragments Bind to α2δ Subunit of Voltage-Gated Calcium Channels.

    abstract:PURPOSE:Gabapentin, a drug for neuropathic pain, exerts its therapeutic effect via inhibition of the a2d subunit of N-type Ca2+ channels. Thus, finding peptides that specifically displace gabapentin from its binding site may lead to the development of new drugs. METHODS:Displacement of bound [3H]-gabapentin in membran...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30358

    authors: Skubatz H

    更新日期:2019-01-01 00:00:00

  • Effects of Three Anti-Seizure Drugs on Cholinergic and Metabolic Activity in Experimental Status Epilepticus.

    abstract:PURPOSE:Status epilepticus (SE) is characterized by recurrent seizure activity and can be drug- resistant. Knowledge of neuronal and metabolic activity of the brain during SE may be helpful to improve medical care. We here report the effects of three anti-seizure drugs on changes of acetylcholine energy metabolites and...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30439

    authors: Imran I,Koch K,Schöfer H,Lau H,Klein J

    更新日期:2019-01-01 00:00:00

  • Multitarget Therapy: An Effective and Safe Therapeutic Regimen for Lupus Nephritis.

    abstract:INTRODUCTION:We evaluated the effectiveness and safety of various multitarget therapies for inducing remission in lupus nephritis patients. METHODS:Randomized controlled trials (RCT) were identified and extracted from the Embase, PubMed, Chinese Biomedical Literature Database (CBM), and the Cochrane Library until Oct ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,随机对照试验

    doi:10.18433/jpps30526

    authors: Zhou T,Zhang X,Lin W,Lin S

    更新日期:2019-01-01 00:00:00

  • Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.

    abstract:PURPOSE:The plasma membrane localization and transport activity of multidrug resistance- associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters are governed by transporter-associated proteins. Phosphatidylinositol 4,5-bisphosphate (PIP2) formed by phosphatidylinositol 4-phosphate 5-kinase...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30444

    authors: Kawase A,Inoue Y,Hirosoko M,Sugihara Y,Shimada H,Iwaki M

    更新日期:2019-01-01 00:00:00

  • Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:To systematically review and quantitatively synthesize associations between HLA genotypes and oxcarbazepine-induced cutaneous adverse drug reactions (OXC-cADRs), including Stevens-Johnson syndrome (SJS) and maculopapular rash. METHODS:Studies investigating associations between HLA genotypes and OXC-cADRs were ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,meta分析

    doi:10.18433/J36S7D

    authors: Tangamornsuksan W,Scholfield N,Lohitnavy M

    更新日期:2018-01-01 00:00:00

  • Microneedles as Enhancer of Drug Absorption Through the Skin and Applications in Medicine and Cosmetology.

    abstract::The microneedles technology has found applications in many health-related fields. For example, their application in drugs and vaccines delivery as well, as the determination of biomarkers, has been reported. They also have a place in the dermatology and cosmetic areas such as the treatment of wounds from burns, scars,...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29610

    authors: Serrano-Castañeda P,Escobar-Chavez JJ,Rodriguez-Cruz IM,Melgoza LM,Martinez-Hernandez J

    更新日期:2018-01-01 00:00:00

  • A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics.

    abstract:BACKGROUND:The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investigated in the early sta...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps29800

    authors: Galvão da Silva BAV,Chudzinski-Tavassi AM,Pasqualoto KFM

    更新日期:2018-01-01 00:00:00

  • Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model.

    abstract:PURPOSE:Monoclonal antibodies (mAbs) are commonly administered by subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major objectives of this study we...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30028

    authors: Varkhede N,Forrest ML

    更新日期:2018-01-01 00:00:00

  • Clearance Concepts: Fundamentals and Application to Pharmacokinetic Behavior of Drugs.

    abstract::Clearance concepts were introduced into the pharmacokinetics discipline in the 1970s and since then have played a major role in characterization of the pharmacokinetic behavior of drugs. These concepts are based on the relationship between organ extraction ratio or clearance and physiologic parameters such as the orga...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29896

    authors: Mehvar R

    更新日期:2018-01-01 00:00:00

  • Application of in Silico Tools in Clinical Practice using Ketoconazole as a Model Drug.

    abstract::Hypochlorhydria is a condition where the production of hydrochloric acid in the stomach is decreased. As a result, the intragastric pH is elevated. This condition can be due to a series of causes, such as disease (gastric mucosal infection caused by Helicobacter pylori and is prominent in AIDS patients), ethnicity, ag...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30227

    authors: Silva DA,Duque MD,Davies NM,Löbenberg R,Ferraz HG

    更新日期:2018-01-01 00:00:00

  • Rh-endostatin Concomitant with Chemotherapy Versus Single Agent Chemotherapy for Treating Soft Tissue and Bone Sarcomas: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non-small cell lung cancer (NSCLC). Recently, several studies have evaluated the efficacy of rh-endostatin combined with chemotherapy in the treatment of bone and soft t...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,meta分析

    doi:10.18433/jpps30034

    authors: Ma Z,Guo L,Cui X,Liu H,Liu L

    更新日期:2018-01-01 00:00:00

  • Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients.

    abstract:PURPOSE:The adrenoceptor family, as one of the main contributors in regulating the noradrenergic system, has been studied in involvement of depression and its treatment. A functional polymorphism of G1165C on beta adrenoceptor (βAR) enhances post receptor signalling and is assumed to be involved in pharmacotherapy of d...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3W31F

    authors: Firouzabadi N,Raeesi R,Zomorrodian K,Bahramali E,Yavarian I

    更新日期:2017-01-01 00:00:00

  • Alzheimer's Disease: Dawn of a New Era?

    abstract::Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by a progressive decline in cognition and memory, leading to significant impairment in daily activities and ultimately death. It is the most common cause of dementia, the prevalence of which increases with age; however, age is not the ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/J3VS8P

    authors: Amirrad F,Bousoik E,Shamloo K,Al-Shiyab H,Nguyen VV,Montazeri Aliabadi H

    更新日期:2017-01-01 00:00:00

  • Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.

    abstract:PURPOSE:To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS:Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisting of oleate:palmitate (2:1) in the presence of 3% albumin. Cells ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3TS70

    authors: Chen Y,Li W,Wang G,Burczynski FJ

    更新日期:2017-01-01 00:00:00

  • Assessment of Predicted Rate and Associated Factors of Dabigatran-induced Bleeding Events in Malaysian Patients with Non-Valvular Atrial Fibrillation.

    abstract:PURPOSE:To assess the predicted rate and the factors associated with bleeding events among patients with non-valvular atrial fibrillation (NVAF) receiving dabigatran therapy. METHODS:This retrospective cohort study includes adult patients of two tertiary hospitals in Malaysia. Potential study subjects were identified ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3TP9Q

    authors: Beshir SA,Yap LB,Sim S,Chee KH,Lo YL

    更新日期:2017-01-01 00:00:00

  • DRD3 Ser9Gly Polymorphism and Its Influence on Risperidone Response in Autistic Children.

    abstract:PURPOSE:Autism, a neuropsychiatric illness, is a complex ailment of mainly indefinite cause. Although precise pathophysiological mechanism is unclear but the role of genetics is undeniable therefore pharmacogenetics may assist to a better management of symptoms. Risperidone is widely used in autism. Considering the sig...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3H63T

    authors: Firouzabadi N,Nazariat A,Zomorrodian K

    更新日期:2017-01-01 00:00:00

  • Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers.

    abstract:PURPOSE:To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS:An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 临床试验,杂志文章

    doi:10.18433/J3H03R

    authors: Todor I,Popa A,Neag M,Muntean D,Bocsan C,Buzoianu A,Vlase L,Gheldiu AM,Briciu C

    更新日期:2016-04-01 00:00:00

  • Can Pentoxifylline be used as Adjunct Therapy to ACE Inhibitors and ARBs in Preserving Kidney Function?

    abstract:PURPOSE:To determine if there is sufficient evidence to recommend the addition of pentoxifylline to standard ACE inhibitor and ARB therapy in chronic kidney disease patients to reduce proteinuria and preserve kidney function.  METHODS:A search of the literature was conducted using the PubMed.gov and ClinicalTrials.gov...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/J3K020

    authors: Carson C,Al-Makki A,Shepler B

    更新日期:2016-01-01 00:00:00

  • Comparison of Cannabinoid Concentrations in Plasma, Oral Fluid and Urine in Occasional Cannabis Smokers After Smoking Cannabis Cigarette.

    abstract:PURPOSE:A randomized cross-over, double blind placebo controlled study of smoked cannabis was carried out on occasional cannabis smokers. The objective of this research was to describe the pharmacokinetic parameters of THC and its metabolites in plasma, oral fluid and urine, from samples obtained simultaneously to prov...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,随机对照试验

    doi:10.18433/J3F31D

    authors: Marsot A,Audebert C,Attolini L,Lacarelle B,Micallef J,Blin O

    更新日期:2016-01-01 00:00:00

  • Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?

    abstract::Purpose - The CEIBA cocktail consisting of caffeine (CAF), omeprazole (OZ), dextromethorphan (DM) and losartan (LOS) was previously proposed for the clinical phenotyping of five major human cytochrome P450 (CYP) isoenzymes. This work aimed to assess the usefulness of CEIBA cocktail to study non-clinical drug interacti...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3D313

    authors: Magalhães P,De Andrés F,Falcão A,LLerena A,Alves G

    更新日期:2016-01-01 00:00:00

  • Hantzsch-Type dihydropyridines and Biginelli-type tetra-hydropyrimidines: a review of their chemotherapeutic activities.

    abstract::Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis and the diverse pharmacologic properties that these scaffolds prese...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3q01v

    authors: Sepehri S,Sanchez HP,Fassihi A

    更新日期:2015-01-01 00:00:00

  • Phytoestrogens Modulate Breast Cancer Resistance Protein Expression and Function at the Blood-Cerebrospinal Fluid Barrier.

    abstract:PURPOSE:Breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter expressed at the blood cerebrospinal fluid barrier (BCSFB), and influences distribution of drugs into the central nervous systems (CNS). Current inhibitors have failed clinically due to neurotoxicity. Novel approaches are needed to ident...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3p31k

    authors: Kaur M,Badhan RK

    更新日期:2015-01-01 00:00:00

  • The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion.

    abstract::Cardiac ischemia-reperfusion stimulates the renin-angiotensin system (RAS) associated with elevated levels of circulating angiotensin II. Numerous studies demonstrate that the antagonist for the angiotensin II type 1 receptor, losartan improves cardiac function in animal models of ischemia-reperfusion. Molecular mecha...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3nw2k

    authors: Javadov S,Escobales N

    更新日期:2015-01-01 00:00:00

  • Interactions Between Nutraceutical Supplements and Standard Acute Myeloid Leukemia Chemotherapeutics.

    abstract:PURPOSE:Concomitant use of nutraceuticals with chemotherapy is very common. Cancer patients self-medicate to relieve the side effects associated with chemotherapy, improve disease outcome and to regain control of their medical care. However, there is limited empirical evidence on potential drug-nutraceutical interactio...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3m30k

    authors: Spagnuolo P

    更新日期:2015-01-01 00:00:00

  • Development and Evaluation of a Topical Anti-Inflammatory Preparation Containing Dodonaea polyandra Extract.

    abstract:PURPOSE:We have previously reported that the Australian Northern Kaanju (Kuuku I'yu) medicinal plant Dodonaea polyandra has anti-inflammatory activity. This is attributed largely to the presence of clerodane diterpenoids contained within the leaf resin. We envisaged developing a topical preparation to treat indications...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j38p57

    authors: Simpson BS,Luo X,Wang J,Song Y,Claudie D,Garg S,Smith N,McKinnon R,Semple S

    更新日期:2015-01-01 00:00:00

  • When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets.

    abstract:PURPOSE:Clinical studies have suggested that proton pump inhibitors may decrease levothyroxine absorption and an in vitro study suggested that the effect of pH on dissolution may differ with formulation. To determine the impact of formulation on the pharmacokinetics of levothyroxine in altered gastric pH conditions, th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j36p5m

    authors: Seng Yue C,Benvenga S,Scarsi C,Loprete L,Ducharme MP

    更新日期:2015-01-01 00:00:00

  • Alteration of pharmacokinetics of grepafloxacin in type 2 diabetic rats.

    abstract:PURPOSE:Patients with type 2 diabetes are generally treated with various pharmacological compounds and are exposed to a high risk of drug-drug interactions. However, alterations of pharmacokinetics in a type 2 diabetes model have been obscure. The present study was undertaken to investigate the effects of type 2 diabet...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3mc70

    authors: Watanabe M,Kobayashi M,Ogura J,Takahashi N,Yamaguchi H,Iseki K

    更新日期:2014-01-01 00:00:00

  • Assessing bioequivalence of antiepileptic drugs: are the current requirements too permissive?

    abstract:PURPOSE:In order to evaluate the permissiveness of current bioequivalence requirements for antiepileptic drugs we investigated how accurate Cmax and AUC0-t of generic antiepileptic drugs approved in Brazil are in comparison to reference products. METHODS:Data collected from assessment reports of approved bioequivalenc...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3659z

    authors: Rediguieri CF,Zeredo JL

    更新日期:2014-01-01 00:00:00

  • Clinical trial risk in type-2 diabetes: importance of patient history.

    abstract:PURPOSE:To determine the risk of clinical trial failure for drugs developed for type-2 diabetes. METHODS:Drugs were investigated by reviewing phase I to phase III studies that were conducted between 1998 and February 2013. The clinical trial success rates were calculated and compared to the industry standard. The drug...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3hg73

    authors: Aiyere EO,Silverberg J,Ali S,Parker JL

    更新日期:2014-01-01 00:00:00

  • Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.

    abstract:PURPOSE:Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of drug-uremic toxin interactions on OATP1B1 and OATP1B3 ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3m89q

    authors: Sato T,Yamaguchi H,Kogawa T,Abe T,Mano N

    更新日期:2014-01-01 00:00:00

  • Enhanced lactone stability of CZ48 in blood correlates to its lack of toxicity in mice.

    abstract:PURPOSE:The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48, a C20-propionate ester of camptothecin (CPT) in mice. METHODS:In this study, the safety and pharmacokinetics of oral doses of CZ48 were compared with th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3b604

    authors: Liu X,Wang Y,Cao Z,Zhan M,Vardeman D,Giovanella B

    更新日期:2013-01-01 00:00:00

  • Strategies for the discovery and development of anti-diabetic drugs from the natural products of traditional medicines.

    abstract::This review discusses issues largely from the biological point of view about the targeted approaches for the use of natural products for the discovery of anti-diabetic drugs in collaboration with medicinal chemists and computer-aided drug design. A major thrust of this review reflects the collaborative research of fou...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3t60g

    authors: Chan SM,Ye JM

    更新日期:2013-01-01 00:00:00

  • Control of neonatal spinal networks by nociceptors: a potential role for TRP channel based therapies.

    abstract::Pediatric spinal cord injury (SCI) often leads to increased nociceptive input resulting in aberrant motor output like tremor and spasticity. Acute plasticity within spinal pain and motor networks following pediatric SCI may result in long-term sensorimotor disabilities. Despite this, pediatric SCI remains poorly under...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3w02s

    authors: Mandadi S,Hong P,Dhoopar AS,Whelan P

    更新日期:2013-01-01 00:00:00

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