Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.

Abstract:

PURPOSE:To systematically review and quantitatively synthesize associations between HLA genotypes and oxcarbazepine-induced cutaneous adverse drug reactions (OXC-cADRs), including Stevens-Johnson syndrome (SJS) and maculopapular rash. METHODS:Studies investigating associations between HLA genotypes and OXC-cADRs were systematically searched irrespective of language, in PubMed, HuGENet (Human Genome Epidemiology Network), and the Cochrane Library from their inception until January, 2017. Inclusion criteria were studies investigating associations between HLA genotypes and OXC-cADRs that reported sufficient data for calculating the frequency of HLA genotype carriers among cases and controls. Overall odds ratios (ORs) with corresponding 95%CIs were calculated using a random-effects model to determine the association between HLA genotypes and OXC-cADRs.  RESULTS: The initial searches identified 91 articles, of which 6 studies met the selection criteria. The studies included 229 patients with OXC-cADRs, 251 OXC-tolerant patients, and 2,358 participants from general populations of Han Chinese, Korean, and Thai ethnicities.  Associations between HLA-B*1502 and OXC-induced SJS were found in both the general population [OR=30.2 (95%CI=3.45-264)] and in OXC-tolerant individuals [OR=26.4 (95%CI=7.98-87.6)]. An association between the HLA-B*1502 and OXC-induced maculopapular rash was found in the general population [OR=5.67 (95%CI=2.03-15.9)] while HLA-A*3101 also associated with OXC-induced maculopapular rash [overall OR=29.2 (95%CI=6.70-128)].  CONCLUSIONS: Strong associations between the HLA-B*1502 and OXC-cADRs (SJS and maculopapular rash) were found in both controls from general population and OXC-tolerant groups. There was also an association between HLA-B*3101 and OXC-induced maculopapular rash. For patient safety, genetic screening especially for HLA-B*1502 prior to OXC therapy at least in these closely related ethnicities is warranted. Further studies need to better define other ethnicities at risk and a wider range of MHC gene subtypes. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

journal_name

J Pharm Pharm Sci

authors

Tangamornsuksan W,Scholfield N,Lohitnavy M

doi

10.18433/J36S7D

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1-18

issue

1

issn

1482-1826

journal_volume

21

pub_type

杂志文章,meta分析
  • Chemotherapy induced gastrointestinal toxicity in rats: involvement of mitochondrial DNA, gastrointestinal permeability and cyclooxygenase -2.

    abstract:PURPOSE:The gastrointestinal damage induced by xenobiotics is occurring more frequently and with greater toxicological significance than previously thought. Although there are some preliminary clinical studies and reports, there does not appear to be an extensive examination of gastrointestinal toxicity of various chem...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Yáñez JA,Teng XW,Roupe KA,Fariss MW,Davies NM

    更新日期:2003-09-01 00:00:00

  • Control of neonatal spinal networks by nociceptors: a potential role for TRP channel based therapies.

    abstract::Pediatric spinal cord injury (SCI) often leads to increased nociceptive input resulting in aberrant motor output like tremor and spasticity. Acute plasticity within spinal pain and motor networks following pediatric SCI may result in long-term sensorimotor disabilities. Despite this, pediatric SCI remains poorly under...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3w02s

    authors: Mandadi S,Hong P,Dhoopar AS,Whelan P

    更新日期:2013-01-01 00:00:00

  • The merits of a robot: a Dutch experience.

    abstract:PURPOSE:To determine the merits of a robot at the community pharmacy in a quasi-experiment. METHOD:The applied methods for data-collection were barcode-time measurements, direct observations, time-interval studies, and tally at a Dutch community pharmacy. The topics consisted of workload, waiting times, congestion, sl...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Mobach MP

    更新日期:2006-01-01 00:00:00

  • Different storing and processing conditions of human lymphocytes do not alter P-glycoprotein rhodamine 123 efflux.

    abstract::P-glycoprotein (Pgp), a protein codified by Multi Drug Resistance (MDR1) gene, has a detoxifying function and might influence the toxicity and pharmacokinetics and pharmacodynamics of drugs. Sampling strategies to improve Pgp studies could be useful to optimize the sensitivity and the reproducibility of efflux assays....

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j34g69

    authors: Chiva-Blanch G,Giménez-Bonafe P,Llaudó I,Torras J,Cruzado JM,Petriz J,Castaño E,Franquesa Ml,Herrero-Fresneda I,Tortosa A,Rama I,Bestard O,Grinyó JM,Lloberas N

    更新日期:2009-01-01 00:00:00

  • Understanding the Monoclonal Antibody Disposition after Subcutaneous Administration using a Minimal Physiologically based Pharmacokinetic Model.

    abstract:PURPOSE:Monoclonal antibodies (mAbs) are commonly administered by subcutaneous (SC) route. However, bioavailability is often reduced after SC administration. In addition, the sequential transfer of mAbs through the SC tissue and lymphatic system is not completely understood. Therefore, major objectives of this study we...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30028

    authors: Varkhede N,Forrest ML

    更新日期:2018-01-01 00:00:00

  • DRD3 Ser9Gly Polymorphism and Its Influence on Risperidone Response in Autistic Children.

    abstract:PURPOSE:Autism, a neuropsychiatric illness, is a complex ailment of mainly indefinite cause. Although precise pathophysiological mechanism is unclear but the role of genetics is undeniable therefore pharmacogenetics may assist to a better management of symptoms. Risperidone is widely used in autism. Considering the sig...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3H63T

    authors: Firouzabadi N,Nazariat A,Zomorrodian K

    更新日期:2017-01-01 00:00:00

  • Development of liposomal polyene antibiotics: an historical perspective.

    abstract:PURPOSE:The purpose of this review article is to review the development of a number of liposomal polyene antibiotics. BACKGROUND:In the past thirty years, the increase in life-threatening pre-systemic and systemic fungal infections within cancer, diabetic and AIDS patients have reached alarming proportions. A number o...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Ng AW,Wasan KM,Lopez-Berestein G

    更新日期:2003-01-01 00:00:00

  • Disodium Ascorbyl Phytostanyl Phosphates (FM-VP4) reduces plasma cholesterol concentration, body weight and abdominal fat gain within a dietary-induced obese mouse model.

    abstract:PURPOSE:The purpose of this study was to determine if Disodium Ascorbyl Phytostanol Phosphates (FM-VP4) alters animal body weight and plasma lipid levels in a dietary-induced obese mouse model. METHODS:Twenty-four C57BL6 mice (28 days old) were housed individually and fed a standard mouse diet for 2 weeks upon arrival...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Looije NA,Risovic V,Stewart DJ,Debeyer D,Kutney J,Wasan KM

    更新日期:2005-08-24 00:00:00

  • When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets.

    abstract:PURPOSE:Clinical studies have suggested that proton pump inhibitors may decrease levothyroxine absorption and an in vitro study suggested that the effect of pH on dissolution may differ with formulation. To determine the impact of formulation on the pharmacokinetics of levothyroxine in altered gastric pH conditions, th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j36p5m

    authors: Seng Yue C,Benvenga S,Scarsi C,Loprete L,Ducharme MP

    更新日期:2015-01-01 00:00:00

  • Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers.

    abstract:PURPOSE:To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS:An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 临床试验,杂志文章

    doi:10.18433/J3H03R

    authors: Todor I,Popa A,Neag M,Muntean D,Bocsan C,Buzoianu A,Vlase L,Gheldiu AM,Briciu C

    更新日期:2016-04-01 00:00:00

  • Effects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients.

    abstract:PURPOSE:Comparison of the effects of one year treatment with sibutramine compared to placebo on insulin resistance parameters, body weight, glycemic control, and lipid profile, in type 2 diabetic patients. METHODS:Two hundred and forty-six patients with uncontrolled type 2 diabetes mellitus in therapy with different o...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.18433/j3388p

    authors: Derosa G,Maffioli P,Ferrari I,Palumbo I,Randazzo S,D'Angelo A,Cicero AF

    更新日期:2010-01-01 00:00:00

  • Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.

    abstract::Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29895

    authors: Chan CC,Prokopich CL

    更新日期:2019-01-01 00:00:00

  • Stability of sulfadiazine oral liquids prepared from tablets and powder.

    abstract:PURPOSE:To assess the stability of sulfadiazine (SDZ) oral liquids prepared from tablets and powder at two temperatures. METHODS:Solutions of SDZ 200 mg/mL were prepared from commercially available 500 mg tablets and powder in sterile water for irrigation. They were stored in amber glass bottles at 4 degrees C and 23 ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Pathmanathan U,Halgrain D,Chiadmi F,Schlatter J,Vermerie N

    更新日期:2004-04-21 00:00:00

  • Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.

    abstract:PURPOSE:To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS:Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisting of oleate:palmitate (2:1) in the presence of 3% albumin. Cells ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3TS70

    authors: Chen Y,Li W,Wang G,Burczynski FJ

    更新日期:2017-01-01 00:00:00

  • Discovery of chlorogenic acid-based peptidomimetics as a novel class of antifungals. A success story in rational drug design.

    abstract::Life-threatening fungal infections have increased dramatically in recent decades in immunocompromised patients. An estimated 40% of all deaths from hospital-acquired infections are due to infections caused by opportunistic fungi. The current treatment options are either causing serious toxicity, or becoming inactive a...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3h010

    authors: Daneshtalab M

    更新日期:2008-07-06 00:00:00

  • Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide.

    abstract:PURPOSE:The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing. METHODS:Physical mixtures were processed by SCCO(2) at 30 MPa, 125 degrees C during 60 minutes in a static ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Barillaro V,Bertholet P,Henry de Hassonville S,Ziemon E,Evrard B,Delattre L,Piel G

    更新日期:2004-11-30 00:00:00

  • Alteration of rat hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities by Satureja khuzestanica Jamzad essential oil.

    abstract:PURPOSE:Regarding reported antidiabetic effect of Satureja khuzestanica essential oil (SKEO) and important role of liver on body glucose metabolism by glycogenolysis and gluconeogenesis, we were interested to examine effect of SKEO treatment on rat hepatic key enzymes of glycogenolysis and gluconeogenesis in vivo. MET...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Saadat M,Pournourmohammadi S,Donyavi M,Khorasani R,Amin G,Nazar Salehnia A,Abdollahi M

    更新日期:2004-09-24 00:00:00

  • Assessing bioequivalence of antiepileptic drugs: are the current requirements too permissive?

    abstract:PURPOSE:In order to evaluate the permissiveness of current bioequivalence requirements for antiepileptic drugs we investigated how accurate Cmax and AUC0-t of generic antiepileptic drugs approved in Brazil are in comparison to reference products. METHODS:Data collected from assessment reports of approved bioequivalenc...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3659z

    authors: Rediguieri CF,Zeredo JL

    更新日期:2014-01-01 00:00:00

  • A systematic review and meta-analysis of the risk of microbial contamination of aseptically prepared doses in different environments.

    abstract:PURPOSE:To review microbial contamination rates about preparation of individual and batch doses using aseptic techniques within pharmaceutical (controlled) and clinical (ward and theatre) environments. METHODS:Systematic review, involving amalgamation of data using a random effect model and metaanalysis. RESULTS:A to...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,meta分析,评审

    doi:10.18433/j3jp4b

    authors: Austin PD,Elia M

    更新日期:2009-01-01 00:00:00

  • A simple and efficient method for radiolabeling of preformed liposomes.

    abstract::A simple and efficient method for radiolabeling preformed liposomes was developed using hepatobiliary imaging agent (99m)Tc-diisopropyl iminodiacetic acid ((99m)Tc-DISIDA). Chloroform extraction of (99m)Tc-DISIDA from aqueous solutions results in 80% radioactivity in the organic phase due to its lipophilic properties....

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Suresh M,Cao Y

    更新日期:1998-01-01 00:00:00

  • Correlation of photosensitizer delivery to lipoproteins and efficacy in tumor and arthritis mouse models; comparison of lipid-based and Pluronic P123 formulations.

    abstract:PURPOSE:The purpose of this study was the use of animal models to demonstrate the importance of drug delivery (verteporfin) to plasma lipoproteins in order to attain efficacy of photodynamic therapy (PDT) in vivo. METHODS:Photosensitizers appropriately formulated in various vehicles such as pluronics and lipid-based s...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Chowdhary RK,Sharif I,Chansarkar N,Dolphin D,Ratkay L,Delaney S,Meadows H

    更新日期:2003-05-01 00:00:00

  • Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl.

    abstract:PURPOSE:To examine the impact of adding droperidol to fentanyl-based intravenous patient- controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS:Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30902

    authors: Hirata I,Iwamoto M,Matsui H,Yoshinuma H,Funakoshi R

    更新日期:2020-01-01 00:00:00

  • Antinociceptive effects of some synthetic delta-valerolactones.

    abstract:PURPOSE:A series of delta-valerolactones has been synthesized in good yields, by reaction of ethyl acetoacetate with several aldehydes in presence of LDA. METHODS AND RESULTS:The in vivo analgesic activity of these compounds has been evaluated. The results indicate that the lactones synthesized showed an important ant...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Amaral Pde A,Bergold AM,Eifler-Lima VL,Santos EM,Oliveira ER,Campos-Buzzi F,Cechinel-Filho V

    更新日期:2005-04-08 00:00:00

  • Biliary excretion of irinotecan and its metabolites.

    abstract:PURPOSE:The aim of this study was to investigate the excretion of irinotecan hydrochloride (CPT-11) and its metabolites into the gastrointestinal lumen via the biliary route after intravenous administration of lactone and carboxylate forms of CPT-11. METHODS:Biliary excretions of CPT-11 and its metabolites, SN-38 and ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Itoh T,Takemoto I,Itagaki S,Sasaki K,Hirano T,Iseki K

    更新日期:2004-01-23 00:00:00

  • Lack of evidence for involvement of P-glycoprotein in brain uptake of the centrally acting analgesic, tramadol in the rat.

    abstract:PURPOSE:Tramadol Hydrochloride is a widely-used centrally acting analgesic drug, which has some features of being a P-gp substrate. The present study evaluates the functional involvement of P-gp in CNS distribution of tramadol. METHODS:The possible involvement of P-glycoprotein in brain distribution of tramadol was ev...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3d60r

    authors: Sheikholeslami B,Hamidi M,Lavasani H,Sharifzadeh M,Rouini MR

    更新日期:2012-01-01 00:00:00

  • Alzheimer's Disease: Dawn of a New Era?

    abstract::Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by a progressive decline in cognition and memory, leading to significant impairment in daily activities and ultimately death. It is the most common cause of dementia, the prevalence of which increases with age; however, age is not the ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/J3VS8P

    authors: Amirrad F,Bousoik E,Shamloo K,Al-Shiyab H,Nguyen VV,Montazeri Aliabadi H

    更新日期:2017-01-01 00:00:00

  • Clinical trial risk in type-2 diabetes: importance of patient history.

    abstract:PURPOSE:To determine the risk of clinical trial failure for drugs developed for type-2 diabetes. METHODS:Drugs were investigated by reviewing phase I to phase III studies that were conducted between 1998 and February 2013. The clinical trial success rates were calculated and compared to the industry standard. The drug...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3hg73

    authors: Aiyere EO,Silverberg J,Ali S,Parker JL

    更新日期:2014-01-01 00:00:00

  • Methoxyflurane anesthesia augments the chronotropic and dromotropic effects of verapamil.

    abstract:INTRODUCTION:Inhalation anesthetics have been shown to have electrical suppressant effects on excitable membranes such as the cardiac conduction system. Therefore, the anesthetized patient or laboratory animal may respond differently to cardiac drugs when compared with their conscious counterparts. The purpose of this ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Jamali F,Mayo PR

    更新日期:1999-01-01 00:00:00

  • Can Pentoxifylline be used as Adjunct Therapy to ACE Inhibitors and ARBs in Preserving Kidney Function?

    abstract:PURPOSE:To determine if there is sufficient evidence to recommend the addition of pentoxifylline to standard ACE inhibitor and ARB therapy in chronic kidney disease patients to reduce proteinuria and preserve kidney function.  METHODS:A search of the literature was conducted using the PubMed.gov and ClinicalTrials.gov...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/J3K020

    authors: Carson C,Al-Makki A,Shepler B

    更新日期:2016-01-01 00:00:00

  • Carnitine and sepsis: a review of an old clinical dilemma.

    abstract:PURPOSE:The precise role of carnitine as the key regulator of lipid metabolism in sepsis is unclear. In this review, available experimental as well as clinical evidences regarding the probable beneficial effects of carnitine in sepsis were evaluated. METHOD:A comprehensive literature search was performed in the relate...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3js4c

    authors: Hatamkhani S,Karimzadeh I,Elyasi S,Farsaie S,Khalili H

    更新日期:2013-01-01 00:00:00