Phytoestrogens Modulate Breast Cancer Resistance Protein Expression and Function at the Blood-Cerebrospinal Fluid Barrier.

Abstract:

PURPOSE:Breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter expressed at the blood cerebrospinal fluid barrier (BCSFB), and influences distribution of drugs into the central nervous systems (CNS). Current inhibitors have failed clinically due to neurotoxicity. Novel approaches are needed to identify new modulators to enhance CNS delivery. This study examines 18 compounds (mainly phytoestrogens) as modulators of the expression/function of BCRP in an in vitro rat choroid plexus BCSFB model. METHODS:Modulators were initially subject to cytotoxicity (MTT) assessment to determine optimal non-toxic concentrations. Reverse-transcriptase PCR and confocal microscopy were used to identify the presence of BCRP in Z310 cells. Thereafter modulation of the intracellular accumulation of the fluorescent BCRP probe substrate Hoechst 33342 (H33342), changes in protein expression of BCRP (western blotting) and the functional activity of BCRP (membrane insert model) were assessed under modulator exposure. RESULTS:A 24 hour cytotoxicity assay (0.001 µM-1000 µM) demonstrated the majority of modulators possessed a cellular viability IC50 > 148 µM. Intracellular accumulation of H33342 was significantly increased in the presence of the known BCRP inhibitor Ko143 and, following a 24 hour pre-incubation, all modulators demonstrated statistically significant increases in H33342 accumulation (P < 0.001), when compared to control and Ko143. After a 24 hour pre-incubation with modulators alone, a 0.16-2.5 -fold change in BCRP expression was observed for test compounds. The functional consequences of this were confirmed in a permeable insert model of the BCSFB which demonstrated that 17-β-estradiol, naringin and silymarin (down-regulators) and baicalin (up-regulator) can modulate BCRP-mediated transport function at the BCSFB. CONCLUSION:We have successfully confirmed the gene and protein expression of BCRP in Z310 cells and demonstrated the potential for phytoestrogen modulators to influence the functionality of BCRP at the BCSFB and thereby potentially allowing manipulation of CNS drug disposition.

journal_name

J Pharm Pharm Sci

authors

Kaur M,Badhan RK

doi

10.18433/j3p31k

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

132-54

issue

2

issn

1482-1826

journal_volume

18

pub_type

杂志文章
  • Prediction of Hepatic Clearance of Stereoselective Metabolism of Carvedilol in Liver Microsomes and Hepatocytes of Sprague-Dawley and Cytochrome P450 2D-Deficient Dark Agouti Rats.

    abstract::Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient Dark Agouti (DA) rats to determine the usefulness of prediction metho...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30237

    authors: Iwaki M,Niwa T,Tanaka H,Kawase A,Komura H

    更新日期:2019-01-01 00:00:00

  • Alteration of rat hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities by Satureja khuzestanica Jamzad essential oil.

    abstract:PURPOSE:Regarding reported antidiabetic effect of Satureja khuzestanica essential oil (SKEO) and important role of liver on body glucose metabolism by glycogenolysis and gluconeogenesis, we were interested to examine effect of SKEO treatment on rat hepatic key enzymes of glycogenolysis and gluconeogenesis in vivo. MET...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Saadat M,Pournourmohammadi S,Donyavi M,Khorasani R,Amin G,Nazar Salehnia A,Abdollahi M

    更新日期:2004-09-24 00:00:00

  • A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability.

    abstract:PURPOSE:To determine the possible mechanism of poor bioavailability of bicyclol, and clarify the respective contribution of P- glycoprotein (P-gp) and Cytochrome 3A (CYP3A). METHODS:Rat in situ single-pass intestinal perfusion and Caco-2 cell monolayer model with selective inhibitors of CYP3A and P-gp were employed. ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3b88v

    authors: Tan W,Chen H,Zhao J,Hu J,Li Y

    更新日期:2008-01-01 00:00:00

  • How critical is the duration of the sampling scheme for the determination of half-life, characterization of exposure and assessment of bioequivalence?

    abstract::In noncompartmental analysis, poor characterization of the terminal elimination rate constant (Kel) will lead to biased results for half-life and total exposure (AUCinf), providing incorrect relative bioavailability and bioequivalence conclusions. We set out to determine if the sampling scheme duration was crucial for...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3fg63

    authors: Colucci P,Turgeon J,Ducharme MP

    更新日期:2011-01-01 00:00:00

  • Association Between HLA genotypes and Oxcarbazepine-induced Cutaneous Adverse Drug Reactions: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:To systematically review and quantitatively synthesize associations between HLA genotypes and oxcarbazepine-induced cutaneous adverse drug reactions (OXC-cADRs), including Stevens-Johnson syndrome (SJS) and maculopapular rash. METHODS:Studies investigating associations between HLA genotypes and OXC-cADRs were ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,meta分析

    doi:10.18433/J36S7D

    authors: Tangamornsuksan W,Scholfield N,Lohitnavy M

    更新日期:2018-01-01 00:00:00

  • Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties.

    abstract:PURPOSE:To investigate the suitability of an SCMC (sodium carboxymethyl cellulose/polyethylene glycol 400/carbopol 934P) and an HPMC (hydroxypropylmethyl cellulose/polyethylene glycol 400/carbopol 934P) films as drug vehicle for buccal delivery. METHODS:The mechanical and in vitro bioadhesive strength properties of th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Peh KK,Wong CF

    更新日期:1999-05-01 00:00:00

  • Predicting Caco-2 permeability using support vector machine and chemistry development kit.

    abstract:PURPOSE:To predict Caco-2 permeability is a valuable target for pharmaceutical research. Most of the Caco-2 prediction models are based on commercial or special software which limited their practical value. This study represents the relationship between Caco-2 permeability and molecular descriptors totally based on ope...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Guangli M,Yiyu C

    更新日期:2006-01-01 00:00:00

  • The merits of a robot: a Dutch experience.

    abstract:PURPOSE:To determine the merits of a robot at the community pharmacy in a quasi-experiment. METHOD:The applied methods for data-collection were barcode-time measurements, direct observations, time-interval studies, and tally at a Dutch community pharmacy. The topics consisted of workload, waiting times, congestion, sl...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Mobach MP

    更新日期:2006-01-01 00:00:00

  • Application of 12S rRNA gene for the identification of animal-derived drugs.

    abstract::PURPOSE. Animal-derived drugs are the major source of biological products and traditional medicine, but they are often difficult to identify, causing confusion in the clinical application. Among these medicinal animals, a number of animal species are endangered, leading to the destruction of biodiversity. The identifi...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3n017

    authors: Luo J,Yan D,Zhang D,Han Y,Dong X,Yang Y,Deng K,Xiao X

    更新日期:2011-01-01 00:00:00

  • Determination of pyridostigmine bromide and its metabolites in biological samples.

    abstract::Pyridostigmine bromide (PB) is a quartenary ammonium compound that inhibits the hydrolysis of acetylcholine by competitive reversible binding to acetylcholinesterase. PB is used for the symptomatic treatment of myasthenia gravis and has been applied as a prophylaxis against nerve agents. Many studies on PB have involv...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Zhao B,Moochhala SM,Lu J,Tan D,Lai MH

    更新日期:2006-01-01 00:00:00

  • Chemotherapy induced gastrointestinal toxicity in rats: involvement of mitochondrial DNA, gastrointestinal permeability and cyclooxygenase -2.

    abstract:PURPOSE:The gastrointestinal damage induced by xenobiotics is occurring more frequently and with greater toxicological significance than previously thought. Although there are some preliminary clinical studies and reports, there does not appear to be an extensive examination of gastrointestinal toxicity of various chem...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Yáñez JA,Teng XW,Roupe KA,Fariss MW,Davies NM

    更新日期:2003-09-01 00:00:00

  • A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics.

    abstract:BACKGROUND:The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investigated in the early sta...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps29800

    authors: Galvão da Silva BAV,Chudzinski-Tavassi AM,Pasqualoto KFM

    更新日期:2018-01-01 00:00:00

  • High performance liquid chromatography of mebudipine: application to pharmacokinetic study.

    abstract:PURPOSE:To develop a high performance liquid chromatography system for the determination of a new 1,4-dihydropyridine, mebudipine, in rabbit plasma. METHODS:To 1 ml of rabbit plasma was added internal standard (dibudipine) and 0.5 ml of 1 M NaOH. Mebudipine and internal standard were extracted to 5 ml ethyl acetate, e...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Bohlooli S,Keyhanfar F,Mahmoudian M

    更新日期:2001-09-01 00:00:00

  • Can Pentoxifylline be used as Adjunct Therapy to ACE Inhibitors and ARBs in Preserving Kidney Function?

    abstract:PURPOSE:To determine if there is sufficient evidence to recommend the addition of pentoxifylline to standard ACE inhibitor and ARB therapy in chronic kidney disease patients to reduce proteinuria and preserve kidney function.  METHODS:A search of the literature was conducted using the PubMed.gov and ClinicalTrials.gov...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/J3K020

    authors: Carson C,Al-Makki A,Shepler B

    更新日期:2016-01-01 00:00:00

  • Structural equation modeling of qualification of pharmacists to improve subjected quality of life in cancer patients.

    abstract:PURPOSE:To establish structural equation model (SEM) of subjected quality of life (QOL) in cancer patients taking into account qualification of pharmacists. METHOD:The SEM model was constructed from correlation matrix of the scores of answers of questions to both patients and pharmacists. Data were collected from 15 c...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Yamamura S,Takehira R,Kawada K,Katayama S,Nishizawa K,Hirano M,Momose Y

    更新日期:2005-10-04 00:00:00

  • Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Overview of Clinical Trial Program.

    abstract::Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifitegrast is well tolerated and effective in improving symptoms and...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29895

    authors: Chan CC,Prokopich CL

    更新日期:2019-01-01 00:00:00

  • Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers.

    abstract:PURPOSE:To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS:An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 临床试验,杂志文章

    doi:10.18433/J3H03R

    authors: Todor I,Popa A,Neag M,Muntean D,Bocsan C,Buzoianu A,Vlase L,Gheldiu AM,Briciu C

    更新日期:2016-04-01 00:00:00

  • When Bioequivalence in Healthy Volunteers May not Translate to Bioequivalence in Patients: Differential Effects of Increased Gastric pH on the Pharmacokinetics of Levothyroxine Capsules and Tablets.

    abstract:PURPOSE:Clinical studies have suggested that proton pump inhibitors may decrease levothyroxine absorption and an in vitro study suggested that the effect of pH on dissolution may differ with formulation. To determine the impact of formulation on the pharmacokinetics of levothyroxine in altered gastric pH conditions, th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j36p5m

    authors: Seng Yue C,Benvenga S,Scarsi C,Loprete L,Ducharme MP

    更新日期:2015-01-01 00:00:00

  • Clinical trial risk in type-2 diabetes: importance of patient history.

    abstract:PURPOSE:To determine the risk of clinical trial failure for drugs developed for type-2 diabetes. METHODS:Drugs were investigated by reviewing phase I to phase III studies that were conducted between 1998 and February 2013. The clinical trial success rates were calculated and compared to the industry standard. The drug...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3hg73

    authors: Aiyere EO,Silverberg J,Ali S,Parker JL

    更新日期:2014-01-01 00:00:00

  • Effects of in vivo hepatic ischemia-reperfusion injury on the hepatobiliary disposition of rhodamine 123 and its metabolites in isolated perfused rat livers.

    abstract:PURPOSE:A few studies have shown that normothermic hepatic ischemia-reperfusion (IR) injury may affect the mRNA and/or protein levels of canalicular transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (Mrp2). However, the effects of the injury on the functions of these canalicular transport...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3ms40

    authors: Parasrampuria R,Shaik IH,Mehvar R

    更新日期:2012-01-01 00:00:00

  • Effects of Three Anti-Seizure Drugs on Cholinergic and Metabolic Activity in Experimental Status Epilepticus.

    abstract:PURPOSE:Status epilepticus (SE) is characterized by recurrent seizure activity and can be drug- resistant. Knowledge of neuronal and metabolic activity of the brain during SE may be helpful to improve medical care. We here report the effects of three anti-seizure drugs on changes of acetylcholine energy metabolites and...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30439

    authors: Imran I,Koch K,Schöfer H,Lau H,Klein J

    更新日期:2019-01-01 00:00:00

  • A correlative model to predict in vivo AUC for nanosystem drug delivery with release rate-limited absorption.

    abstract:PURPOSE:Drug release from nanosystems at the sites of either absorption or effect biophase is a major determinant of its biological action. Thus, in vitro drug release is of paramount importance in gaining insight for the systems performance in vivo. METHODS:A novel in vitro in vivo correlation, IVIVC, model denoted a...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3np5n

    authors: Barzegar-Jalali M,Mohammadi K,Mohammadi G,Valizadeh H,Barzegar-Jalali A,Adibkia K,Nokhodchi A

    更新日期:2012-01-01 00:00:00

  • In vitro percutaneous permeation of the repellent DEET and the sunscreen oxybenzone across human skin.

    abstract:PURPOSE:DEET and oxybenzone are two essential active ingredients in repellent and sunscreen products. The percutaneous permeation of the two compounds across human skin from five commercially available repellent and sunscreen products was investigated in vitro. METHODS:Diffusion studies were carried out at 37 degrees ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Wang T,Gu X

    更新日期:2007-01-01 00:00:00

  • Control of neonatal spinal networks by nociceptors: a potential role for TRP channel based therapies.

    abstract::Pediatric spinal cord injury (SCI) often leads to increased nociceptive input resulting in aberrant motor output like tremor and spasticity. Acute plasticity within spinal pain and motor networks following pediatric SCI may result in long-term sensorimotor disabilities. Despite this, pediatric SCI remains poorly under...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3w02s

    authors: Mandadi S,Hong P,Dhoopar AS,Whelan P

    更新日期:2013-01-01 00:00:00

  • Effect of polaprezinc on healing of acetic acid-induced stomatitis in hamsters.

    abstract:PURPOSE:The purpose of this work was to investigate the potential effectiveness of polaprezinc in the treatment of stomatitis. Its effect on oral mucous membrane lesions was studied focusing on acetic acid-induced stomatitis in an animal model. METHOD:Stomatitis was induced in hamsters by local injection of 30 microL ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Katayama S,Nishizawa K,Hirano M,Yamamura S,Momose Y

    更新日期:2000-01-01 00:00:00

  • Development and Evaluation of a Topical Anti-Inflammatory Preparation Containing Dodonaea polyandra Extract.

    abstract:PURPOSE:We have previously reported that the Australian Northern Kaanju (Kuuku I'yu) medicinal plant Dodonaea polyandra has anti-inflammatory activity. This is attributed largely to the presence of clerodane diterpenoids contained within the leaf resin. We envisaged developing a topical preparation to treat indications...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j38p57

    authors: Simpson BS,Luo X,Wang J,Song Y,Claudie D,Garg S,Smith N,McKinnon R,Semple S

    更新日期:2015-01-01 00:00:00

  • Preparation and evaluation of a new nano pharmaceutical excipients and drug delivery system based in polyvinylpyrrolidone and silicate.

    abstract:PURPOSE:This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. METHODS:By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and t...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3hc72

    authors: Dornelas CB,da Silva AM,Dantas CB,Rodrigues CR,Coutinho SS,Sathler PC,Castro HC,Dias LR,de Sousa VP,Cabral LM

    更新日期:2011-01-01 00:00:00

  • Cannabis and the Gastrointestinal Tract.

    abstract::Cannabis has been used for its medicinal purposes since ancient times. Its consumption leads to the activation of Cannabis receptors CB1 and CB2 that, through specific mechanisms can lead to modulation and progression of inflammation or repair. The novel findings are linked to the medical use of Cannabis in gastrointe...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps31242

    authors: Cohen L,Neuman MG

    更新日期:2020-01-01 00:00:00

  • Relationship between LDL-C reduction after coronary revascularization and prevention of recurrence of cardiovascular events.

    abstract:PURPOSE:The purpose of our study was to optimize lipid-lowering therapy in patients undergoing coronary revascularization and to determine whether the percentage change in low-density lipoprotein-cholesterol (LDL-C) level in the 3 months after coronary revascularization could be used as a predictor of the time to recur...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3hg6q

    authors: Nishiwaki T,Kishi D,Yoshie F,Fukuda K,Ibuki C,Seino Y,Satoh M

    更新日期:2010-01-01 00:00:00

  • Droperidol Reduces Postoperative Nausea and Vomiting and Supports the Continuation of Intravenous Patient-Controlled Analgesia with Fentanyl.

    abstract:PURPOSE:To examine the impact of adding droperidol to fentanyl-based intravenous patient- controlled analgesia (IVPCA) on the discontinuation of IVPCA use due to postoperative nausea and vomiting (PONV). METHODS:Patients who underwent surgeries other than abdominal surgeries and used IVPCA between April 2014 and March...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30902

    authors: Hirata I,Iwamoto M,Matsui H,Yoshinuma H,Funakoshi R

    更新日期:2020-01-01 00:00:00