abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：Purpose:To characterize inheritance, penetrance, and trinucleotide repeat expansion stability in Fuchs endothelial corneal dystrophy (FECD). Methods:One thousand unrelated and related subjects with and without FECD were prospectively recruited. CTG18.1 repeat length (CTG18.1L) was determined via short tandem repeat as...

journal_title：Investigative ophthalmology & visual science

authors： Xu TT,Li YJ,Afshari NA,Aleff RA,Rinkoski TA,Patel SV,Maguire LJ,Edwards AO,Brown WL,Fautsch MP,Wieben ED,Baratz KH

更新日期：2021-01-04 00:00:00

abstract：Purpose:The purpose of this study was to describe the cellular architecture of normal human peripapillary sclera (PPS) and evaluate surface topography's role in fibroblast behavior. Methods:PPS cryosections from nonglaucomatous eyes were labelled for nuclei, fibrillar actin (FA), and alpha smooth muscle actin (αSMA) a...

journal_title：Investigative ophthalmology & visual science

authors： Szeto J,Chow A,McCrea L,Mozzer A,Nguyen TD,Quigley HA,Pitha I

更新日期：2021-01-04 00:00:00

abstract：Purpose:Endophthalmitis models have reported the virulent role of Panton-Valentine leucocidin (PVL) secreted by Staphylococcus aureus on the retina. PVL targets retinal ganglion cells (RGCs), expressing PVL membrane receptor C5aR. Interactions between PVL and retinal cells lead to glial activation, retinal inflammation...

journal_title：Investigative ophthalmology & visual science

authors： Wurtz M,Ruhland E,Liu X,Namer IJ,Mazzoleni V,Lipsker D,Keller D,Prévost G,Gaucher D

更新日期：2021-01-04 00:00:00

abstract：Purpose:To investigate the effect of short-wavelength light (SL) on guinea pigs with lens-induced myopia (LIM) and the possible retinoic acid (RA)-related mechanisms. Methods:Two-week-old guinea pigs (n = 60) with monocular -5D lenses were reared under white light (WL, 580 lux) or SL (440 nm, 500 lux). The left eyes w...

journal_title：Investigative ophthalmology & visual science

authors： Yu M,Liu W,Wang B,Dai J

更新日期：2021-01-04 00:00:00

abstract：Purpose:The three-dimensional configurations of rod and cone bipolar cell (BC) dendrites and horizontal cell (HC) processes outside rod and cone synaptic terminals have not been fully elucidated. We reveal how these neurites are mutually arranged to coordinate formation and maintenance of the postsynaptic complex of ri...

journal_title：Investigative ophthalmology & visual science

authors： Tsukamoto Y,Iseki K,Omi N

更新日期：2021-01-04 00:00:00

abstract：Purpose:The purpose of this work was to test whether palisade endings express structural and molecular features of exocytotic machinery, and are associated with acetylcholine receptors, and enzymes for neurotransmitter breakdown. Methods:Extraocular rectus muscles from six cats were studied. Whole-mount preparations o...

journal_title：Investigative ophthalmology & visual science

authors： Blumer R,Streicher J,Carrero-Rojas G,Calvo PM,de la Cruz RR,Pastor AM

更新日期：2020-12-01 00:00:00

abstract：Purpose:Ocular structural and functional changes, collectively termed spaceflight-associated neuro-ocular syndrome (SANS), have been described in astronauts undergoing long-duration missions in the microgravity environment of the International Space Station. We tested the hypothesis that retinal vascular remodeling, pa...

journal_title：Investigative ophthalmology & visual science

authors： Vyas RJ,Young M,Murray MC,Predovic M,Lim S,Jacobs NM,Mason SS,Zanello SB,Taibbi G,Vizzeri G,Parsons-Wingerter P

更新日期：2020-12-01 00:00:00

abstract：Purpose:The prevalence of age-related macular degeneration (AMD) increases dramatically with age. This large collaborative study investigates the effects of 51 late-AMD-associated genetic variants in different ages, focusing on individuals above the age of 90 years. Methods:The study included 27,996 individuals of the...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Lorés-Motta L,Altay L,Fritsche LG,den Hollander AI,Fauser S

更新日期：2020-12-01 00:00:00

abstract：Purpose:Activation of proteolytic enzymes, calpains and caspases, have been observed in many models of retinal disease. We previously demonstrated calpain activation in monkey retinal explants cultured under hypoxia. However, cellular responses are often species-specific. The purpose of the present study was to determi...

journal_title：Investigative ophthalmology & visual science

authors： Kobayashi-Otsugu M,Orihara K,Nakajima E,Shearer TR,Azuma M

更新日期：2020-11-02 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：Purpose:Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, the effect of Yap1 haplodeficiency on the lens epithelium and its role ...

journal_title：Investigative ophthalmology & visual science

authors： Lu Q,Zhang Y,Kasetti RB,Gaddipati S,Cvm NK,Borchman D,Li Q

更新日期：2020-10-01 00:00:00

abstract：Purpose:Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma, acting through the translaminar pressure (TLP = IOP - CSFP), which directly affects the optic nerve head. In this study, IOP and intracranial pressure (ICP; a surrogate ...

journal_title：Investigative ophthalmology & visual science

authors： Jasien JV,Samuels BC,Johnston JM,Downs JC

更新日期：2020-10-01 00:00:00

abstract：Purpose:Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Overexpression of Tmem1...

journal_title：Investigative ophthalmology & visual science

authors： Landowski M,Grindel S,Shahi PK,Johnson A,Western D,Race A,Shi F,Benson J,Gao M,Santoirre E,Lee WH,Ikeda S,Pattnaik BR,Ikeda A

更新日期：2020-10-01 00:00:00

abstract：Purpose:The purpose of this paper was to discuss manifestations of primary mitochondrial dysfunctions and whether the retinal pigment epithelium or the photoreceptors are preferentially affected. Methods:A retrospective analysis was performed of patients with clinically and laboratory confirmed diagnoses of maternally...

journal_title：Investigative ophthalmology & visual science

authors： Oh JK,Lima de Carvalho JR Jr,Nuzbrokh Y,Ryu J,Chemudupati T,Mahajan VB,Sparrow JR,Tsang SH

更新日期：2020-10-01 00:00:00

abstract：Purpose:Patients with diabetes mellitus are reported to have ocular surface defects, impaired ocular surface barrier function, and a higher incidence of corneal and conjunctival infections. Tight junctions are critical for ocular surface barrier function. The present study was designed to investigate the effect of high...

journal_title：Investigative ophthalmology & visual science

authors： Alfuraih S,Barbarino A,Ross C,Shamloo K,Jhanji V,Zhang M,Sharma A

更新日期：2020-09-01 00:00:00

abstract：Purpose:Candida remains the leading cause of fungal endophthalmitis. However, the pathobiology and innate immune responses in this disease are not well characterized. Here, we developed two murine models of candida endophthalmitis and evaluated their disease susceptibility and differential immune response. Methods:End...

journal_title：Investigative ophthalmology & visual science

authors： Rottmann BG,Singh PK,Singh S,Revankar SG,Chandrasekar PH,Kumar A

更新日期：2020-09-01 00:00:00

abstract：Purpose:To determine whether high glucose (HG) or diabetes alters mitochondrial morphology and promotes mitochondrial fragmentation in retinal vascular cells and thereby triggers apoptosis associated with diabetic retinopathy. Methods:To assess whether diabetes promotes mitochondrial fragmentation and thereby triggers...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Roy S

更新日期：2020-08-03 00:00:00

abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

journal_title：Investigative ophthalmology & visual science

authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

更新日期：2020-08-03 00:00:00

abstract：Purpose:To evaluate the incidence, visual prognosis, and mortality in retinopathy of prematurity (ROP) in Korea. Methods:We used the National Health Insurance and the Korean Disability Registry database, which covers the entire newborn population in 2006 to 2014 and includes information on all newborns diagnosed with ...

journal_title：Investigative ophthalmology & visual science

authors： Na KH,Kim KH,Kang TU,Hann HJ,Ahn HS,Kim HJ

更新日期：2020-08-03 00:00:00

abstract：Purpose:To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods:Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected to unilateral injection of hypertonic saline into a limbal vein, causing sclerosis of the outflow pathway and su...

journal_title：Investigative ophthalmology & visual science

authors： Nettesheim A,Dixon A,Shim MS,Coyne A,Walsh M,Liton PB

更新日期：2020-08-03 00:00:00

abstract：Purpose:To determine the effects of narrowband light exposure on choroidal thickness and the pupil response in humans. Methods:Twenty subjects, ages 21 to 43 years, underwent 1 hour of exposure to broadband, short wavelength "blue," or long wavelength "red" light, or darkness. Choroidal thickness, imaged with spectral...

journal_title：Investigative ophthalmology & visual science

authors： Lou L,Ostrin LA

更新日期：2020-08-03 00:00:00

abstract：Purpose:The present study investigated retinal glia and choroidal vessels in flatmounts and sections from individuals with clinically diagnosed Stargardt disease (STGD). Methods:Eyes from three donors clinically diagnosed with STGD were obtained through the Foundation Fighting Blindness (FFB). Genetic testing was perf...

journal_title：Investigative ophthalmology & visual science

authors： Edwards MM,Bonilha VL,Bhutto IA,Bell BA,McLeod DS,Hollyfield JG,Lutty GA

更新日期：2020-07-01 00:00:00

abstract：Purpose:To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). Methods:The qAF imaging was performed on eyes of 26 rhesus macaques (me...

journal_title：Investigative ophthalmology & visual science

authors： Tran TM,Kim S,Lin KH,Chung SH,Park S,Sazhnyev Y,Wang Y,Cunefare D,Farsiu S,Thomasy SM,Moshiri A,Yiu G

更新日期：2020-07-01 00:00:00

abstract：Purpose:To quantify organelles impacting imaging in the cell body and intact apical processes of human retinal pigment epithelium (RPE), including melanosomes, lipofuscin-melanolipofuscin (LM), mitochondria, and nuclei. Methods:A normal perifovea of a 21-year-old white male was preserved after rapid organ recovery. An...

journal_title：Investigative ophthalmology & visual science

authors： Pollreisz A,Neschi M,Sloan KR,Pircher M,Mittermueller T,Dacey DM,Schmidt-Erfurth U,Curcio CA

更新日期：2020-07-01 00:00:00

abstract：Purpose:To evaluate the relationship between refractive error, circadian phase, and melatonin with consideration of prior light exposure, physical activity, and sleep. Methods:Healthy young myopic (spherical equivalent refraction [SER] ≤-0.50DS) and emmetropic adults underwent noncycloplegic autorefraction and axial l...

journal_title：Investigative ophthalmology & visual science

authors： Flanagan SC,Cobice D,Richardson P,Sittlington JJ,Saunders KJ

更新日期：2020-07-01 00:00:00

abstract：Purpose:This study is to investigate the corneal anomaly caused by excess transforming growth factor-α (TGF-α) during mouse development. Methods:Bitransgenic KeraRT/TGF-α mice, generated via cross-mating tetO-TGF-α and KeraRT mice, were induced to overexpress TGF-α by doxycycline commencing at embryonic day 0 or postn...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Yuan Y,Yeh LK,Dong F,Zhang J,Okada Y,Kao WWY,Liu CY,Zhang Y

更新日期：2020-07-01 00:00:00

abstract：Purpose:To describe the pathology of AMD in eyes with geographic atrophy (GA) using confocal scanning laser ophthalmoscopy (SLO) blue light autofluorescence (BAF), and near-infrared (IR) AF and to correlate it with the histology and immunohistochemistry analysis at the margins of the GA lesion. Methods:Enucleated, fix...

journal_title：Investigative ophthalmology & visual science

authors： Bonilha VL,Bell BA,Hu J,Milliner C,Pauer GJ,Hagstrom SA,Radu RA,Hollyfield JG

更新日期：2020-07-01 00:00:00

abstract：Purpose:To elucidate the molecular events in solute carrier family 4 member 11 (SLC4A11)-deficient corneal endothelium that lead to the endothelial dysfunction that characterizes the dystrophies associated with SLC4A11 mutations, congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy...

journal_title：Investigative ophthalmology & visual science

authors： Zhang W,Frausto R,Chung DD,Griffis CG,Kao L,Chen A,Azimov R,Sampath AP,Kurtz I,Aldave AJ

更新日期：2020-07-01 00:00:00

abstract：Purpose:Epithelial to mesenchymal transition (EMT) is a cause of anterior and posterior subcapsular cataracts. Central to EMT is the formation of actin stress fibers. Selective targeting of actin stress fiber-associated tropomyosin (Tpm) in epithelial cells may be a means to prevent stress fiber formation and repress l...

journal_title：Investigative ophthalmology & visual science

authors： Parreno J,Amadeo MB,Kwon EH,Fowler VM

更新日期：2020-06-03 00:00:00

abstract：Purpose:To evaluate the nature and extent of functional abnormality in X-linked retinoschisis (XLRS) by comparing three dark-adapted, full-field measures: the electroretinogram (ERG), pupillary light reflex (PLR), and luminance threshold. Methods:ERGs, PLRs (pupil constriction due to light stimulation), and luminance ...

journal_title：Investigative ophthalmology & visual science

authors： McAnany JJ,Park JC,Fishman GA,Collison FT

更新日期：2020-06-03 00:00:00

abstract：Purpose:Synucleinopathies such as multiple system atrophy (MSA) and Parkinson's disease are associated with a variety of visual symptoms. Functional and morphological retinal aberrations are therefore supposed to be valuable biomarkers for these neurodegenerative diseases. This study examined the retinal morphology and...

journal_title：Investigative ophthalmology & visual science

authors： Kaehler K,Seitter H,Sandbichler AM,Tschugg B,Obermair GJ,Stefanova N,Koschak A

更新日期：2020-06-03 00:00:00

abstract：Purpose:Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma, is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP homeostasis relies on TM responses to mechanical stretch. To model the effects of elevated IOP on the TM, this study sought to identify co...

journal_title：Investigative ophthalmology & visual science

authors： Youngblood H,Cai J,Drewry MD,Helwa I,Hu E,Liu S,Yu H,Mu H,Hu Y,Perkumas K,Aboobakar IF,Johnson WM,Stamer WD,Liu Y

更新日期：2020-05-11 00:00:00

abstract：Purpose:To determine the effect of voluntary exercise on choroidal neovascularization (CNV) in mice. Methods:Age-matched wild-type C57BL/6J mice were housed in cages equipped with or without running wheels. After four weeks of voluntary running or sedentariness, mice were subjected to laser injury to induce CNV. After...

journal_title：Investigative ophthalmology & visual science

authors： Makin RD,Argyle D,Hirahara S,Nagasaka Y,Zhang M,Yan Z,Kerur N,Ambati J,Gelfand BD

更新日期：2020-05-11 00:00:00

abstract：Purpose:Global motion and global form perception have been found to be abnormal in the presence of amblyopia. How such deficits manifest in visual function reliant on the interactions between these two visual processing mechanisms has not been adequately explored. In the current study, we use dynamic Glass patterns (dG...

journal_title：Investigative ophthalmology & visual science

authors： Joshi MR,Simmers AJ,Jeon ST

更新日期：2020-05-11 00:00:00

abstract：Purpose:Aging affects a variety of visual functions. In this study, we aim to quantitatively investigate the temporal characteristics of visual processing in aging. Methods:Twelve younger (24.1 ± 1.6 years) and 12 older observers (58.4 ± 3.6 years) participated in the study. All participants had normal or corrected-to...

journal_title：Investigative ophthalmology & visual science

authors： He X,Shen M,Cui R,Zheng H,Ruan X,Lu ZL,Hou F

更新日期：2020-05-11 00:00:00

abstract：Purpose:In many individuals with pattern strabismus, the vertical misalignment varies with horizontal eye position. It has been proposed that these cross-axis effects result from abnormal cross-talk between brainstem structures that would normally encode horizontal and vertical eye position and velocity. The nucleus pr...

journal_title：Investigative ophthalmology & visual science

authors： Pallus A,Walton MMG

更新日期：2020-05-11 00:00:00

abstract：Purpose:The purpose of this study was to evaluate macular preganglionic function and to verify its relationship with retinal and choroidal morphology in patients with intermediate age-related macular degeneration (iAMD) patients. Methods:All included patients performed multifocal electroretinogram (mfERG) for investig...

journal_title：Investigative ophthalmology & visual science

authors： Parisi V,Ziccardi L,Costanzo E,Tedeschi M,Barbano L,Manca D,Di Renzo A,Giorno P,Varano M,Parravano M

更新日期：2020-05-11 00:00:00

abstract：Purpose:The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. Methods:The two guide RNAs specific to the target sites in the KCNJ13 gene were designe...

journal_title：Investigative ophthalmology & visual science

authors： Kanzaki Y,Fujita H,Sato K,Hosokawa M,Matsumae H,Shiraga F,Morizane Y,Ohuchi H

更新日期：2020-05-11 00:00:00