Implied Motion From Form Shows Motion Aids the Perception of Global Form in Amblyopia.

abstract：PURPOSE:CD40 antigen is a membrane receptor that plays a role in the regulation of immune reactions. The expressions of CD40 and CD40 ligand (CD40L) were investigated ex vivo and in vitro in conjunctival epithelial cells, in correlation with HLA DR class H antigen, previously shown to be upregulated in conjunctival inf...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,De Saint-Jean M,Brignole F,Goguel A,Baudouin C

更新日期：2000-01-01 00:00:00

abstract：:Posterior eye cups of the frog Rana ridibunda were prefixed in the presence of tannic acid, osmicated and stained en bloc with uranyl acetate. Electron microscopy revealed the following features of membrane traffic in cells of the retinal pigment epithelium (RPE): (1) intracellular membranes with increased electron de...

journal_title：Investigative ophthalmology & visual science

authors： Rungger-Brändle E,Englert U,Leuenberger PM

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:To determine the effect of pyrrolidine dithiocarbamate (PDTC), a nuclear factor (NF)-kappaB inhibitor, on chemokine and chemokine receptor expression and thus elucidate the role of NF-kappaB in the pathogenesis of experimental autoimmune anterior uveitis (EAAU). METHODS:Uveitis was induced in Lewis rats with t...

journal_title：Investigative ophthalmology & visual science

authors： Yang CH,Fang IM,Lin CP,Yang CM,Chen MS

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by ...

journal_title：Investigative ophthalmology & visual science

authors： Li C,Ding XQ,O'Brien J,Al-Ubaidi MR,Naash MI

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To compare the ability of several machine learning classifiers to predict development of abnormal fields at follow-up in ocular hypertensive (OHT) eyes that had normal visual fields in baseline examination. METHODS:The visual fields of 114 eyes of 114 patients with OHT with four or more visual field tests with...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Goldbaum MH,Chan K,Boden C,Lee TW,Vasile C,Boehm AG,Sejnowski T,Johnson CA,Weinreb RN

更新日期：2002-08-01 00:00:00

abstract：Purpose:To investigate the role of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in ocular surface damage of dry eye. Methods:MK2 inhibition was performed in mice subjected to desiccating stress (DS) by topical application of MK2 inhibitor (MK2i) or vehicle eye drops. The total and phosphorylated M...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Bu J,Yang Y,Lin X,Cai X,Huang C,Zheng X,Ouyang W,Li W,Zhang X,Liu Z

更新日期：2017-09-01 00:00:00

abstract：Purpose:To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods:Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedi...

journal_title：Investigative ophthalmology & visual science

authors： Tan NYQ,Leong YY,Lang SS,Htoon ZM,Young SM,Sundar G

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00

abstract：PURPOSE:The increase in intraocular pressure in primary open-angle glaucoma (POAG) may involve transforming growth factor (TGF)-beta2 signaling, as TGF-beta2 is found in higher amounts than normal in the aqueous humor of patients with POAG. In vitro, TGF-beta2 causes an accumulation of extracellular matrix (ECM) in the...

journal_title：Investigative ophthalmology & visual science

authors： Fuchshofer R,Yu AH,Welge-Lüssen U,Tamm ER

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major cause of visual handicap in the pediatric population. To date, this disorder is thought to stem from deficient retinal vascularization. Intriguingly, functional electrophysiological studies in patients with mild or moderate ROP and in the oxygen-induced retinopathy (O...

journal_title：Investigative ophthalmology & visual science

authors： Shao Z,Dorfman AL,Seshadri S,Djavari M,Kermorvant-Duchemin E,Sennlaub F,Blais M,Polosa A,Varma DR,Joyal JS,Lachapelle P,Hardy P,Sitaras N,Picard E,Mancini J,Sapieha P,Chemtob S

更新日期：2011-08-05 00:00:00

abstract：:Using a freezing point depression method, requiring volumes of only 200 nanoliters, the osmolalities of 324 tear samples collected at consecutive 10-minute intervals throughout 8.5-hour periods from each of six healthy young adults were measured. The population mean was found to be 318 mOsm/kg, with a population media...

journal_title：Investigative ophthalmology & visual science

authors： Benjamin WJ,Hill RM

更新日期：1983-12-01 00:00:00

abstract：PURPOSE:To investigate corneal nerve damage and its subsequent regeneration after excimer laser photokeratectomy in rabbit eyes. METHODS:Corneal photokeratectomy was performed on the right eyes of 34 pigmented rabbits, while the left eyes were used as a control. A Summit UV 200 excimer laser (Summit Technology, Waltha...

journal_title：Investigative ophthalmology & visual science

authors： Trabucchi G,Brancato R,Verdi M,Carones F,Sala C

更新日期：1994-01-01 00:00:00

abstract：Purpose:Because there is a paucity of population-based data on retinal nerve fiber layer thickness (RNFLT) for children, we measured the RNFLT and its associations in schoolchildren. Methods:The population-based Gobi Desert Children Eye Study included all schoolchildren aged 6 to 21 years living in Ejina, Inner Mongol...

journal_title：Investigative ophthalmology & visual science

authors： Wang CY,Zheng YF,Liu B,Meng ZW,Hong F,Wang XX,Wang XJ,Du L,Wang IY,Zhu D,Tao Y,You QS,Jonas JB

更新日期：2018-10-01 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:In Graves' orbitopathy (GO), inflammation and expansion of the retrobulbar tissue are the result of a pathophysiologic process in which orbital fibroblasts (GO-Fs) are considered the central cell type. However, in a previous study we observed that GO-Fs expressed some of the consensus surface markers described ...

journal_title：Investigative ophthalmology & visual science

authors： Brandau S,Bruderek K,Hestermann K,Görtz GE,Horstmann M,Mattheis S,Lang S,Eckstein A,Berchner-Pfannschmidt U

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：Purpose:To investigate the underlying mechanisms for how the mouse Cx50-R205G point mutation, a homologue of the human Cx50-R198W mutation that is linked to cataract-microcornea syndrome, affects proper lens growth and fiber cell differentiation to lead to severe lens phenotypes. Methods:EdU labeling, immunostaining, ...

journal_title：Investigative ophthalmology & visual science

authors： Tjahjono N,Xia CH,Li R,Chu S,Wang J,Gong X

更新日期：2020-03-09 00:00:00

abstract：Purpose:Global analyses using mean deviation (MD) assess visual field progression, but can miss localized changes. Pointwise analyses are more sensitive to localized progression, but more variable so require confirmation. This study assessed whether cluster trend analysis, averaging information across subsets of locati...

journal_title：Investigative ophthalmology & visual science

authors： Gardiner SK,Mansberger SL,Demirel S

更新日期：2017-05-01 00:00:00

abstract：:The pattern reversal visual evoked response (VER) was recorded under conditions of artificially unbalanced visual input between two eyes, an aniseikonia induced by size lenses that alter the perceived retinal image size without changing refraction. At 3.0% aniseikonia binocular summation started to decrease, and at 5....

journal_title：Investigative ophthalmology & visual science

authors： Katsumi O,Tanino T,Hirose T

更新日期：1986-04-01 00:00:00

abstract：PURPOSE:To investigate immediate and long-term changes in static ocular alignment with acute acquired superior oblique palsy (SOP) in monkeys. METHODS:The trochlear nerve was severed intracranially in two rhesus monkeys. After the surgery, the paretic eye was patched for 6 to 9 days, and then binocular viewing was all...

journal_title：Investigative ophthalmology & visual science

authors： Shan X,Tian J,Ying HS,Quaia C,Optican LM,Walker MF,Tamargo RJ,Zee DS

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:We investigated the neuroprotective effect of human serum albumin nanoparticles (HSA-NPs) and their conjugation with brimonidine (HSA-Br-NPs) on retinal ganglion cells (RGCs) in optic nerve crush (ONC) model. METHODS:We fabricated HSA-Br-NPs by ethanol precipitation, including 0.18% brimonidine (Br) and 3.5% h...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Jang I,Moon H,Kim YJ,Jeoung JW,Park KH,Kim H

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Many retinal imaging instruments use infrared wavelengths to reduce the risk of light damage. However, we have discovered that exposure to infrared illumination causes a long-lasting reduction in infrared autofluorescence (IRAF). We have characterized the dependence of this effect on radiant exposure and invest...

journal_title：Investigative ophthalmology & visual science

authors： Masella BD,Williams DR,Fischer WS,Rossi EA,Hunter JJ

更新日期：2014-05-20 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To investigate the residual stereo function of a group of 15 patients with strabismic amblyopia, by using motion-in-depth stimuli that allow discrimination of contributions from local disparity as opposed to those from local velocity mechanisms as a function of the rate of depth change. METHODS:The stereo perf...

journal_title：Investigative ophthalmology & visual science

authors： Hess RF,Mansouri B,Thompson B,Gheorghiu E

更新日期：2009-10-01 00:00:00

abstract：:Three congenic Royal College of Surgeons (RCS) strains of rats have been developed: the RCS-p+ strain, which is a black-eyed dystrophic strain; the pink-eyed RCS-rdy+ strain, which is wild-type (+/+) at the retinal dystrophy (rdy) genetic locus and serves as the control for the inbred, pink-eyed RCS strain; and the bl...

journal_title：Investigative ophthalmology & visual science

authors： LaVail MM

更新日期：1981-05-01 00:00:00

abstract：PURPOSE:To characterize photoreceptor cell apoptosis and cell loss in a mouse model of experimental retinal detachment (RD), and to use the technology of mouse genetics to study the molecular mechanisms underlying RD-associated photoreceptor degeneration. METHODS:Retinal detachments were created in adult wild-type and...

journal_title：Investigative ophthalmology & visual science

authors： Yang L,Bula D,Arroyo JG,Chen DF

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

journal_title：Investigative ophthalmology & visual science

authors： Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:Previous sequence analyses of hemidesmosomal BP 180/collagen XVII cDNA from human skin and of a similar chicken corneal cDNA showed some similarities, but major differences as well. The authors examined whether, in one species, the same mRNA is present in cornea and skin. They also studied the developmental exp...

journal_title：Investigative ophthalmology & visual science

authors： Gordon MK,Fitch JM,Foley JW,Gerecke DR,Linsenmayer C,Birk DE,Linsenmayer TF

更新日期：1997-01-01 00:00:00