Helical Fasciculation of Bipolar and Horizontal Cell Neurites for Wiring With Photoreceptors in Macaque and Mouse Retinas.

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：:Albino rabbits were exposed to repeated microwave irradiations once daily for a month. Clinical examination was carried out for a period up to one year. No changes occurred below 300 mW./cm.2. At and above this level posterior subcapsular iridescence and posterior cortical cataracts were produced. The histologic findi...

journal_title：Investigative ophthalmology & visual science

authors： Hirsch SE,Appleton B,Fine BS,Brown PV

更新日期：1977-04-01 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic ...

journal_title：Investigative ophthalmology & visual science

authors： Hirano Y,Sakurai E,Matsubara A,Ogura Y

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape. ME...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Chandrasekara K,Abbondandolo CJ,Coll TJ,Rutzen AR

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations. METHODS:Thirty-six subjects (19 male, 17 female; mean SD, age 51 13 years) were recruited into this single-masked placebo-controlled study, and were ...

journal_title：Investigative ophthalmology & visual science

authors： Loughman J,Nolan JM,Howard AN,Connolly E,Meagher K,Beatty S

更新日期：2012-11-29 00:00:00

abstract：Purpose:Mutations in the retinitis pigmentosa-1-like-1 (RP1L1) gene are the major cause of autosomal dominant occult macular dystrophy (OCMD), while recessive mutations have been linked to autosomal recessive retinitis pigmentosa (arRP). We present the clinical phenotype of a large German OCMD cohort, as well as four R...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Zobor G,Hipp S,Baumann B,Weisschuh N,Biskup S,Sliesoraityte I,Zrenner E,Kohl S

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. METH...

journal_title：Investigative ophthalmology & visual science

authors： Chalasani ML,Radha V,Gupta V,Agarwal N,Balasubramanian D,Swarup G

更新日期：2007-04-01 00:00:00

abstract：:The sequential electrophysiologic and pathologic changes in the retina in ceroid-lipofuscinosis were recorded in a time-course study in the ovine model. Over a relatively short period in the course of the disease, a severe reduction in both rod and cone b-wave amplitudes developed with rod b-wave changes preceeding th...

journal_title：Investigative ophthalmology & visual science

authors： Graydon RJ,Jolly RD

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：PURPOSE:To investigate immediate and long-term changes in static ocular alignment with acute acquired superior oblique palsy (SOP) in monkeys. METHODS:The trochlear nerve was severed intracranially in two rhesus monkeys. After the surgery, the paretic eye was patched for 6 to 9 days, and then binocular viewing was all...

journal_title：Investigative ophthalmology & visual science

authors： Shan X,Tian J,Ying HS,Quaia C,Optican LM,Walker MF,Tamargo RJ,Zee DS

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To test whether triamcinolone acetonide (TA) inhibits angiogenesis induced by IL-6 or VEGF and whether this inhibition is through antagonism of the IL-6 or the VEGF receptor 2. METHODS:A rat cornea micropocket assay was used to initiate IL-6- and VEGF-mediated angiogenesis. The ability of TA or neutralizing VE...

journal_title：Investigative ophthalmology & visual science

authors： Ebrahem Q,Minamoto A,Hoppe G,Anand-Apte B,Sears JE

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Juvenile open-angle glaucoma (JOAG) differs from primary open-angle glaucoma in that it is usually a more severe phenotype and has an earlier age of onset. Optineurin was recently associated with a variant of POAG that is characterized by intraocular pressure within normal limits: normal-tension glaucoma. The p...

journal_title：Investigative ophthalmology & visual science

authors： Willoughby CE,Chan LL,Herd S,Billingsley G,Noordeh N,Levin AV,Buys Y,Trope G,Sarfarazi M,Héon E

更新日期：2004-09-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) can infect the cornea and achieve ganglionic latency. HSV-1 can later be activated by a variety of effectors although the exact mechanism of reactivation is unknown. Rabbits harboring latent HSV-1 strain McKrae can be induced to shed virus by ocular iontophoresis of epinephrine to t...

journal_title：Investigative ophthalmology & visual science

authors： Rootman DS,Haruta Y,Hill JM,Kaufman HE

更新日期：1988-03-01 00:00:00

abstract：:The entoptic phenomenon by which one can observe leukocytes flowing in one's own parafoveal capillaries has been used to study the effect of changes in perfusion pressure on blood flow. Our measurements in humans with normal ocular fundi indicate that the retinal circulation of the parafovea is autoregulated in relati...

journal_title：Investigative ophthalmology & visual science

authors： Riva CE,Loebl M

更新日期：1977-06-01 00:00:00

abstract：:Horseradish peroxidase has been injected into the dorsal lateral geniculate nucleus of macaque monkeys to label ganglion cells of the retina by retrograde axoplasmic transport. Displaced ganglion cells, with somata in the inner nuclear layer and dendrites in the inner plexiform layer, were detected by virtue of their ...

journal_title：Investigative ophthalmology & visual science

authors： Bunt AH,Minckler DS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

journal_title：Investigative ophthalmology & visual science

authors： Burroughs SL,Kaja S,Koulen P

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：:Extraocular muscle represents a distinctive class among mammalian skeletal musculature in exhibiting the full range of muscle fiber type variability found in vertebrate species. To better understand the basis for the unique structural/functional diversity of extraocular muscle, the ontogeny of lateral rectus muscles w...

journal_title：Investigative ophthalmology & visual science

authors： Porter JD,Baker RS

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:To determine whether resolvin E1 (RvE1), an endogenous oxygenation product of eicosapentaenoic acid (EPA), induces increases in migration in human corneal epithelial cells (HCECs) and to identify signal pathways mediating this response. METHODS:Migration was measured with the scratch wound assay. Western blot ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang F,Yang H,Pan Z,Wang Z,Wolosin JM,Gjorstrup P,Reinach PS

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate (Cl(2)MDP-LIP). METHODS:Laser photocoagulation was used to induce CNV in wild-type C57BL/6J mice. Animals were treated with intravenous (IV) and/or su...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Anand A,Ambati BK,van Rooijen N,Ambati J

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS:In an earlier study, it was shown that a model using vB-ICA-mm...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Boden C,Zhang Z,Pascual J,Lee TW,Zangwill LM,Weinreb RN,Crowston JG,Hoffmann EM,Medeiros FA,Sejnowski T,Goldbaum M

更新日期：2005-10-01 00:00:00

abstract：Purpose:To investigate the impact of the rates of change of anterior lamina cribrosa surface depth (ALCSD) and optic nerve head surface depth (ONHSD) on visual field (VF) progression in glaucoma. Methods:One hundred forty-six eyes of 95 glaucoma patients had optical coherence tomography ONH imaging and VF testing at a...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Lin C,Crowther M,Mak H,Yu M,Leung CK

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To study the topography of photoreceptor loss early in the course of Leber congenital amaurosis (LCA) caused by RPE65 mutations. METHODS:Young patients with RPE65-LCA (n = 9; ages, 6-17 years) were studied with optical coherence tomography (OCT) in a wide region of central retina. Outer nuclear layer (ONL) thi...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Aleman TS,Sumaroka A,Windsor EA,Schwartz SB,Heon E,Stone EM

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration is a common form of vision loss affecting older adults. The etiology of AMD is multifactorial and is influenced by environmental and genetic risk factors. In this study, we examine how 19 common risk variants contribute to drusen progression, a hallmark of AMD pathogenesis. MET...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman JD,van Grinsven MJ,Li C,Brantley M Jr,McGrath J,Agarwal A,Scott WK,Schwartz SG,Kovach J,Pericak-Vance M,Sanchez CI,Haines JL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

journal_title：Investigative ophthalmology & visual science

authors： Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:To investigate whether enzymatic collagen breakdown is an active process in the human vitreous. METHODS:Human donor eyes were used for immunohistochemistry to detect the possible presence of the matrix metalloproteinase (MMP)-induced type II collagen breakdown product col2-3/4C-short in the vitreous. Western b...

journal_title：Investigative ophthalmology & visual science

authors： van Deemter M,Pas HH,Kuijer R,van der Worp RJ,Hooymans JM,Los LI

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:To determine the toxicity of various doses of intravitreal amphotericin B deoxycholate, amphotericin B lipid complex (ABLC), and liposomal amphotericin B (L-AmB). METHODS:Fifty-two rabbits were divided into two treatment groups (groups A and B). Thirteen treatments were administered intravitreally to the 104 r...

journal_title：Investigative ophthalmology & visual science

authors： Cannon JP,Fiscella R,Pattharachayakul S,Garey KW,De Alba F,Piscitelli S,Edward DP,Danziger LH

更新日期：2003-05-01 00:00:00