当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Macular and retinal nerve fiber layer thickness: which is more helpful in the diagnosis of glaucoma?

Macular and retinal nerve fiber layer thickness: which is more helpful in the diagnosis of glaucoma?

Abstract：

PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating healthy from glaucomatous eyes was determined using 10 macular thickness and 16 cRNFL thickness parameters. Glaucomatous eyes were categorized into two groups using four criteria according to whether cRNFL thickness or macular thickness measurement was better for glaucoma detection (cRNFL better group [RBG], macula better group [MBG], respectively). The clinical characteristics were compared between RBG and MBG. ROC regression analysis was conducted to identify variables affecting diagnostic capability using either macular thickness or cRNFL thickness measurements. RESULTS:Four hundred twenty-four glaucomatous patients and 297 healthy subjects were analyzed. Of all cRNFL parameters, average thickness showed the largest AUC (0.958). Of macular parameters, the inferior outer sector showed the largest AUC (0.880). More eyes were placed into the RBG than the MBG, making use of all four criteria (90 vs. 24, 143 vs. 46, 76 vs. 18, and 103 vs. 36, respectively). RBG patients had a smaller optic disc area than did MBG patients in 3 of the 4 criteria. Signal strength affected the diagnostic performance of cRNFL thickness measurement (P = 0.043), whereas that of macular thickness was not affected by any covariate analyzed. CONCLUSIONS:Overall, cRNFL thickness measurements were generally superior to those of macular thickness when used to diagnose glaucoma. Macular thickness parameters were of greater value in eyes with larger optic discs.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Na JH,Sung KR,Baek S,Sun JH,Lee Y

doi

10.1167/iovs.11-7833

subject

Has Abstract

pub_date

2011-10-11 00:00:00

pages

8094-101

issue

11

eissn

0146-0404

issn

1552-5783

pii

iovs.11-7833

journal_volume

52

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Prevention of ornithine cytotoxicity by proline in human retinal pigment epithelial cells.

    abstract：PURPOSE:To investigate the relationship between ornithine-delta-aminotransferase (OAT) deficiency and ornithine accumulation and the specific degeneration of retinal pigment epithelial (RPE) cells in gyrate atrophy. METHODS:Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromet...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Ueda M,Masu Y,Ando A,Maeda H,Del Monte MA,Uyama M,Ito S

    更新日期：1998-04-01 00:00:00

  • Unilateral deafferentation and eye position misdirect the initial vestibulo-ocular reflex: a model-based study.

    abstract：PURPOSE:Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined. METHODS:Initial VOR direction and magnitude were examined in six normal human subjec...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-0784

    authors： Crane BT,Tian J,Ishiyama A,Demer JL

    更新日期：2007-12-01 00:00:00

  • Tropomyosin 3.1 Association With Actin Stress Fibers is Required for Lens Epithelial to Mesenchymal Transition.

    abstract：Purpose:Epithelial to mesenchymal transition (EMT) is a cause of anterior and posterior subcapsular cataracts. Central to EMT is the formation of actin stress fibers. Selective targeting of actin stress fiber-associated tropomyosin (Tpm) in epithelial cells may be a means to prevent stress fiber formation and repress l...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.6.2

    authors： Parreno J,Amadeo MB,Kwon EH,Fowler VM

    更新日期：2020-06-03 00:00:00

  • Surface-modified electrospun poly(epsilon-caprolactone) scaffold with improved optical transparency and bioactivity for damaged ocular surface reconstruction.

    abstract：PURPOSE:The purpose of this study was to modify and functionalize the surface of synthetic poly-ε-caprolactone (PCL) nanofibrous scaffolds to improve their biocompatibility in order to provide better "cell-substrate" interaction. METHODS:Poly-ε-caprolactone solution was electrospun and its surface functionality was mo...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-12727

    authors： Sharma S,Gupta D,Mohanty S,Jassal M,Agrawal AK,Tandon R

    更新日期：2014-02-12 00:00:00

  • Corneal epithelial basement membrane changes in diabetes.

    abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Taylor HR,Kimsey RA

    更新日期：1981-04-01 00:00:00

  • Enhancement of ON-bipolar cell responses of cone electroretinograms in rabbits with the Pro347Leu rhodopsin mutation.

    abstract：PURPOSE:To determine how the different stages of retinal processing change after photoreceptor degeneration in rabbits carrying the Pro347Leu rhodopsin mutation (Tg rabbits). METHODS:Cone electroretinograms (ERGs) were elicited by 150-ms duration stimuli from 13 Tg rabbits at 12 and 24 weeks of age. The ERG recordings...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7611

    authors： Nishimura T,Machida S,Kondo M,Terasaki H,Yokoyama D,Kurosaka D

    更新日期：2011-09-29 00:00:00

  • Molecular polymorphism of lumican during corneal development.

    abstract：PURPOSE:To evaluate the expression of lumican and decorin, the major proteoglycans of the adult corneal stroma, during the acquisition of corneal transparency in developing chick embryos. METHODS:mRNA levels of decorin and lumican were measured in total RNA extracted from corneas of days 9 to 18 of development by Nort...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Cornuet PK,Blochberger TC,Hassell JR

    更新日期：1994-03-01 00:00:00

  • Involvement of the Erk-MAP kinase pathway in TNFalpha regulation of trabecular matrix metalloproteinases and TIMPs.

    abstract：PURPOSE:TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor (TIMP). Laser trabeculoplasty appears to rely on this process to restore normal aqueous humor outflow facility. Thus, studies were conducted to determine whether the extracellular signal-reg...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.01-1201

    authors： Alexander JP,Acott TS

    更新日期：2003-01-01 00:00:00

  • Alterations in serum fatty acid concentrations and desaturase activities in Bietti crystalline dystrophy unaffected by CYP4V2 genotypes.

    abstract：PURPOSE:To evaluate the serum fatty acid changes in Chinese patients with Bietti crystalline dystrophy (BCD) in association with CYP4V2 mutation. METHODS:Sixteen Chinese patients with BCD confirmed with CYP4V2 mutation were recruited. Peripheral venous blood was obtained after fasting and serum fatty acid concentratio...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.09-3665

    authors： Lai TY,Chu KO,Chan KP,Ng TK,Yam GH,Lam DS,Pang CP

    更新日期：2010-02-01 00:00:00

  • A biometric study of the eye, orbit, and face in 205 normal human fetuses.

    abstract：PURPOSE:To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye. METHODS:Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follow...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Denis D,Burguière O,Burillon C

    更新日期：1998-11-01 00:00:00

  • Retinal Structure Measurements as Inclusion Criteria for Stem Cell-Based Therapies of Retinal Degenerations.

    abstract：PURPOSE:We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS:Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.15-17654

    authors： Jacobson SG,Matsui R,Sumaroka A,Cideciyan AV

    更新日期：2016-04-01 00:00:00

  • Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w.

    abstract：PURPOSE:To identify the differently expressed micro (mi) RNAs in pterygium compared with normal conjunctiva and investigate the potential role of miRNAs in the pathogenesis of pterygium. METHODS:With microRNA microarray and quantitative RT-PCR, we identified that microRNA-122 (miR-122) was significantly decreased in p...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-19402

    authors： Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

    更新日期：2016-07-01 00:00:00

  • Molecular characterization of the skate peripherin/rds gene: relationship to its orthologues and paralogues.

    abstract：PURPOSE:A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.02-1152

    authors： Li C,Ding XQ,O'Brien J,Al-Ubaidi MR,Naash MI

    更新日期：2003-06-01 00:00:00

  • Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes.

    abstract：Purpose:The purpose of this study was to measure change in anterior lamina cribrosa depth (ALD) globally and regionally in glaucoma eyes at different intraocular pressures (IOP). Methods:Twenty-seven glaucoma patients were imaged before and after IOP-lowering procedures using optical coherence tomography. The anterior...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-21321

    authors： Quigley H,Arora K,Idrees S,Solano F,Bedrood S,Lee C,Jefferys J,Nguyen TD

    更新日期：2017-05-01 00:00:00

  • Optical coherence tomographic correlates of angiographic subtypes of occult choroidal neovascularization.

    abstract：PURPOSE:To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). METHODS:We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who underwent both fluorescein angiography (FA) and volu...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,随机对照试验

    doi：10.1167/iovs.13-12302

    authors： Hariri A,Heussen FM,Nittala MG,Sadda SR

    更新日期：2013-12-09 00:00:00

  • Voluntary Exercise Suppresses Choroidal Neovascularization in Mice.

    abstract：Purpose:To determine the effect of voluntary exercise on choroidal neovascularization (CNV) in mice. Methods:Age-matched wild-type C57BL/6J mice were housed in cages equipped with or without running wheels. After four weeks of voluntary running or sedentariness, mice were subjected to laser injury to induce CNV. After...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.5.52

    authors： Makin RD,Argyle D,Hirahara S,Nagasaka Y,Zhang M,Yan Z,Kerur N,Ambati J,Gelfand BD

    更新日期：2020-05-11 00:00:00

  • Amniotic membrane induces peroxisome proliferator-activated receptor-γ positive alternatively activated macrophages.

    abstract：PURPOSE:Amniotic membrane transplantation (AMT) reportedly improves herpetic stromal keratitis (HSK). Here we studied the role of the amniotic membrane (AM) on macrophages. METHODS:BALB/c mice with necrotizing HSK received an AMT or tarsorrhaphy (TAR) as control. Apoptosis of F4/80+ cells was determined using the anne...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7617

    authors： Bauer D,Hennig M,Wasmuth S,Baehler H,Busch M,Steuhl KP,Thanos S,Heiligenhaus A

    更新日期：2012-02-21 00:00:00

  • Periodic alternating nystagmus in humans with albinism.

    abstract：PURPOSE:To quantify the spatial and temporal nature of congenital periodic alternating nystagmus (PAN) and to test the hypothesis that PAN results from a temporal shift in the null zone. METHODS:Twenty-five subjects with oculocutaneous albinism (16 tyrosinase negative and 9 tyrosinase positive) and 7 with ocular albin...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Abadi RV,Pascal E

    更新日期：1994-11-01 00:00:00

  • The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathy.

    abstract：PURPOSE:The angiopoietin (Ang) system plays an important role in vascular stabilization and pathologic neovascularization. The hypothesis for the study was that, in addition to modulating endothelial cell behavior, the angiopoietin/Tie-2 system also regulates the pericyte apoptosis and/or the vessel maturation associat...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1206

    authors： Cai J,Kehoe O,Smith GM,Hykin P,Boulton ME

    更新日期：2008-05-01 00:00:00

  • A population-based assessment of presbyopia in the state of Andhra Pradesh, south India: the Andhra Pradesh Eye Disease Study.

    abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-1192

    authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

    更新日期：2006-06-01 00:00:00

  • Correlation of pseudoexfoliative material and optic nerve damage in pseudoexfoliation syndrome.

    abstract：PURPOSE:To determine whether the severity of glaucomatous damage in eyes with pseudoexfoliative (PEX) glaucoma is related to the amount of PEX material in the trabecular meshwork. METHODS:Trabecular meshwork and optic nerves from 19 eyes (11 donors) with PEX syndrome were studied. Eyes were chosen to represent all sta...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Gottanka J,Flügel-Koch C,Martus P,Johnson DH,Lütjen-Drecoll E

    更新日期：1997-11-01 00:00:00

  • Retinoid effects in purified cultures of chick embryo retina neurons and photoreceptors.

    abstract：PURPOSE:To investigate the effects of retinoic acid, retinol, and 11-cis retinaldehyde on proliferation, differentiation, and survival of cultured embryonic chick neural retina cells; to describe the metabolic transformations of these retinoids by the cultured cells. METHODS:Retinoids were added to glia-free, low-dens...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Stenkamp DL,Gregory JK,Adler R

    更新日期：1993-07-01 00:00:00

  • Screening tests for detecting open-angle glaucoma: systematic review and meta-analysis.

    abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,meta分析,评审

    doi：10.1167/iovs.07-1501

    authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

    更新日期：2008-12-01 00:00:00

  • Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.

    abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8654

    authors： Price BA,Sandoval IM,Chan F,Simons DL,Wu SM,Wensel TG,Wilson JH

    更新日期：2011-12-28 00:00:00

  • IMI - Clinical Myopia Control Trials and Instrumentation Report.

    abstract：:The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes wer...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,评审

    doi：10.1167/iovs.18-25955

    authors： Wolffsohn JS,Kollbaum PS,Berntsen DA,Atchison DA,Benavente A,Bradley A,Buckhurst H,Collins M,Fujikado T,Hiraoka T,Hirota M,Jones D,Logan NS,Lundström L,Torii H,Read SA,Naidoo K

    更新日期：2019-02-28 00:00:00

  • Role of small GTPase Rho in regulating corneal epithelial wound healing.

    abstract：PURPOSE:To determine the role of small GTPase Rho and its relation with epidermal growth factor receptor (EGFR) in mediating corneal epithelial wound healing. METHODS:Rho activity in THCE cells, an SV40-immortalized human corneal epithelial cell (HCEC) line, and primary HCECs was assessed by pull-down assay followed b...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.07-1122

    authors： Yin J,Lu J,Yu FS

    更新日期：2008-03-01 00:00:00

  • Prenatal ethanol exposure alters scotopic and photopic components of adult rat electroretinograms.

    abstract：:Ocular malformations and visual deficits are pathognomic of fetal alcohol syndrome (FAS). However, there are no reports on retinal visual function. To determine if prenatal (human second-trimester equivalent) or prenatal plus 10 days of postnatal (human third-trimester equivalent) ethanol exposure produced scotopic an...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Katz LM,Fox DA

    更新日期：1991-10-01 00:00:00

  • A prototype antifungal contact lens.

    abstract：PURPOSE:To design a contact lens to treat and prevent fungal ocular infections. METHODS:Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in p...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-6935

    authors： Ciolino JB,Hudson SP,Mobbs AN,Hoare TR,Iwata NG,Fink GR,Kohane DS

    更新日期：2011-08-09 00:00:00

  • Optic disc swelling in Vogt-Koyanagi-Harada disease.

    abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8984

    authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

    更新日期：2012-04-18 00:00:00

  • Effect of Fas and Fas ligand deficiency in resistance of C57BL/6 mice to HSV-1 keratitis and chorioretinitis.

    abstract：PURPOSE:To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS:Anterior chamber inoculation of the right ey...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Nguyen QD,Uy HS,Merchant A,Medina CA,Baltatzis S,Zhao T,Zhao ZS,Cantor H,Foster CS

    更新日期：2001-10-01 00:00:00