Enhancement of ON-bipolar cell responses of cone electroretinograms in rabbits with the Pro347Leu rhodopsin mutation.

abstract：PURPOSE:To compare conventional pattern-reversal visual evoked potentials (cVEPs) with multifocal VEPs (mfVEPs). METHODS:mfVEPs and cVEPs were recorded during the same session in 12 normal subjects with an active electrode at Oz referenced to the inion (Oz-In) or to a midfrontal position, Fz (Oz-Fz). The mfVEP stimulu...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Hood DC

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human beta-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localization of HBD9 protein in different OS regions and to determine the ro...

journal_title：Investigative ophthalmology & visual science

authors： Mohammed I,Suleman H,Otri AM,Kulkarni BB,Chen P,Hopkinson A,Dua HS

更新日期：2010-09-01 00:00:00

abstract：Purpose:The study aimed to provide a quantitative description of aqueous humor dynamics in healthy rat eyes. Methods:One eye of 26 anesthetized adult Brown-Norway rats was cannulated with a needle connected to a perfusion pump and pressure transducer. Pressure-flow data were measured in live and dead eyes by varying p...

journal_title：Investigative ophthalmology & visual science

authors： Ficarrotta KR,Bello SA,Mohamed YH,Passaglia CL

更新日期：2018-05-01 00:00:00

abstract：:The rate of aqueous humor flow of 19 normal subjects was measured by a fluorescein clearance technique during the day, during sleep (at night) and during sleep deprivation (at night). Subjects engaged in routine activities during the daytime measurements and slept in comfortable quarters during the nighttime measureme...

journal_title：Investigative ophthalmology & visual science

authors： Reiss GR,Lee DA,Topper JE,Brubaker RF

更新日期：1984-06-01 00:00:00

abstract：PURPOSE:To address the consequences of visual deprivation paradigms in rat (dark rearing) and monkey (monocular deprivation) on extraocular muscle (EOM) development using genome-wide expression profiling. METHODS:Serial analysis of gene expression (SAGE) was used to determine alterations in the EOM transcriptome induc...

journal_title：Investigative ophthalmology & visual science

authors： Cheng G,Mustari MJ,Khanna S,Porter JD

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:This study determined whether adenovirus-mediated transfer of the murine interferon-beta (AdCMVIFN-beta) gene protects against liver metastases arising from intraocular melanomas in mice. METHODS:A replication-deficient adenovirus vector (AdCMVIFN-beta) was used for the in vivo transfer of the murine IFN-beta ...

journal_title：Investigative ophthalmology & visual science

authors： Alizadeh H,Howard K,Mellon J,Mayhew E,Rusciano D,Niederkorn JY

更新日期：2003-07-01 00:00:00

abstract：:Herpetic stromal disease often is treated with combinations of antiviral agents and corticosteroids. The addition of steroids to the antiviral treatment regimen frequently increases the efficacy of therapy in patients; however, many complications may arise as a result of corticosteroid therapy. Using a rabbit model, t...

journal_title：Investigative ophthalmology & visual science

authors： O'Brien WJ,Taylor JL

更新日期：1991-08-01 00:00:00

abstract：:Experiments were performed with a model of focal, thermal-induced ulceration to test the clinical impression that vascularization prevents ulceration of the corneal stroma. Slow-release polymers containing a vasoproliferase agent (tumor angiogenesis factor) were placed in corneal pockets 2 mm central to the limbus of ...

journal_title：Investigative ophthalmology & visual science

authors： Conn H,Berman M,Kenyon K,Langer R,Gage J

更新日期：1980-04-01 00:00:00

abstract：PURPOSE:To improve the 30-year-old "trypsin digestion" procedure for isolation of the complete retinal vasculature, which, in its time, was a revolutionary advance that allowed important discoveries about diabetic retinopathy; to provide a method that will yield more consistent results when applied to retinas represent...

journal_title：Investigative ophthalmology & visual science

authors： Laver NM,Robison WG Jr,Pfeffer BA

更新日期：1993-05-01 00:00:00

abstract：Purpose:To determine if cytokine tear levels before hematopoietic stem cell transplantation (HSCT) can help anticipate the occurrence of ocular chronic graft-versus-host disease (cGVHD). Methods:In this pilot study, 25 patients undergoing HSCT were followed prospectively for ≤43 months. After ocular examinations, tear...

journal_title：Investigative ophthalmology & visual science

authors： Cocho L,Fernández I,Calonge M,Sainz de la Maza M,Rovira M,Stern ME,Garcia-Vazquez C,Enríquez-de-Salamanca A

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To visualize changes in deep optic nerve head (ONH) structures following glaucoma surgery using (3-dimensional [3D]) swept-source optical coherence tomography (SS-OCT) and to determine the clinical and structural factors associated with postoperative lamina cribrosa (LC) and prelaminar neural tissue (PLT) chang...

journal_title：Investigative ophthalmology & visual science

authors： Yoshikawa M,Akagi T,Hangai M,Ohashi-Ikeda H,Takayama K,Morooka S,Kimura Y,Nakano N,Yoshimura N

更新日期：2014-01-23 00:00:00

abstract：PURPOSE:To investigate the interobserver agreement for the detection of optical coherence tomography (OCT) features of disease activity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a cross-sectional agreement study in which grading of OCT line scans from patients with nAMD was...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Browning AC,Chen FK,Da Cruz L,Tufail A

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The author...

journal_title：Investigative ophthalmology & visual science

authors： Sano Y,Ksander BR,Streilein JW

更新日期：1995-10-01 00:00:00

abstract：PURPOSE:Folic acid is essential for DNA, RNA, and protein synthesis, and deficiencies in folate can lead to nutritional amblyopia and optic neuropathy. The transport of folate from the choroidal blood supply to the retina is only now beginning to be understood. The reduced-folate transporter was reported recently to be...

journal_title：Investigative ophthalmology & visual science

authors： Smith SB,Kekuda R,Gu X,Chancy C,Conway SJ,Ganapathy V

更新日期：1999-04-01 00:00:00

abstract：:The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

journal_title：Investigative ophthalmology & visual science

authors： Efron N,Carney LG

更新日期：1979-01-01 00:00:00

abstract：PURPOSE:To estimate the relative importance of genes and environment in peripapillary atrophy type beta (beta-PPA) in a classic twin study. METHODS:Female twin pairs (n = 506) aged 49 to 79 years were recruited from the St. Thomas' UK Adult Twin Registry. Peripapillary atrophy was identified from masked grading of ste...

journal_title：Investigative ophthalmology & visual science

authors： Healey PR,Mitchell P,Gilbert CE,Lee AJ,Ge D,Snieder H,Spector TD,Hammond CJ

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To investigate whether mucosal immune responses directed against the ubiquitous parasite Toxoplasma gondii can be detected in tears of healthy humans. METHODS:Nonstimulated tears and blood were obtained from 62 healthy humans (mean age, 35 +/- 10 [SD] years). Serum anti-T. gondii immunoglobulin titers were det...

journal_title：Investigative ophthalmology & visual science

authors： Meek B,Klaren VN,van Haeringen NJ,Kijlstra A,Peek R

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS:The type IV collagen chains present in the normal retina were determined immunohistoche...

journal_title：Investigative ophthalmology & visual science

authors： Savige J,Liu J,DeBuc DC,Handa JT,Hageman GS,Wang YY,Parkin JD,Vote B,Fassett R,Sarks S,Colville D

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:This study was conducted to define whether pigment epithelial-derived growth factor (PEDF), together with docosahexaenoic acid (DHA), enhances the synthesis of neuroprotectin D1 (NPD1) and the regeneration of corneal nerves damaged after surgery. METHODS:Corneal stromal dissection was performed in the left eye...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Li N,Bazan NG,Bazan HE

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

journal_title：Investigative ophthalmology & visual science

authors： Gray LS,Winn B,Gilmartin B,Eadie AS

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility. METHODS:A system capable of tracking common fundus features based on reflectance changes was integrated into a commercial O...

journal_title：Investigative ophthalmology & visual science

authors： Ishikawa H,Gabriele ML,Wollstein G,Ferguson RD,Hammer DX,Paunescu LA,Beaton SA,Schuman JS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To examine whether Na(+)-K(+)-2Cl(-) cotransport has the potential to contribute to corneal endothelial ion and fluid transport in cultured and fresh bovine corneal endothelial cells. METHODS:Cl- and Na+ sensitive fluorescent dyes were used to measure furosemide-dependent ion fluxes in cultured and fresh endot...

journal_title：Investigative ophthalmology & visual science

authors： Jelamskii S,Sun XC,Herse P,Bonanno JA

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...

journal_title：Investigative ophthalmology & visual science

authors： Price BA,Sandoval IM,Chan F,Simons DL,Wu SM,Wensel TG,Wilson JH

更新日期：2011-12-28 00:00:00

abstract：PURPOSE:To determine whether ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) treatment leads to long-term photoreceptor survival in hereditary retinal degeneration. METHODS:An autosomal dominant feline model of rod-cone dystrophy was used throughout the study with two normal animals. In ...

journal_title：Investigative ophthalmology & visual science

authors： Chong NH,Alexander RA,Waters L,Barnett KC,Bird AC,Luthert PJ

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop lacrimal gland inflammatory lesions and are a model for the human disease Sjögren's syndrome. Therapy with monoclonal antibodies (mAb) to CD4 ameliorates the autoimmune renal, vasculitic, and intraocular inflammatory lesions in MRL/lpr mice. The effect of anti...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Burns WH,Prendergast RA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To identify the risk factors for having advanced glaucomatous visual field loss on the first visit at three hospital eye services. METHODS:This was a hospital-based, case-control study involving patients newly diagnosed with glaucoma at first visit to one of three ophthalmic departments in the United Kingdom. ...

journal_title：Investigative ophthalmology & visual science

authors： Fraser S,Bunce C,Wormald R

更新日期：1999-09-01 00:00:00

abstract：:Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus cornea...

journal_title：Investigative ophthalmology & visual science

authors： Panjwani N,Drysdale J,Clark B,Alberta J,Baum J

更新日期：1989-12-01 00:00:00

abstract：:Checkerboard reversal stimuli were used to evoke transient pattern electroretinograms (P-ERGs) from the eyes of 14 patients with amblyopia and 14 normal subjects. In the control group, and in normal eyes of patients, pattern electroretinograms were obtained with monocular central fixation. Amblyopic eyes were examined...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Welge-Lüssen L

更新日期：1987-01-01 00:00:00

abstract：:Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave im...

journal_title：Investigative ophthalmology & visual science

authors： Witzel DA,Smith EL,Wilson RD,Aguirre GD

更新日期：1978-08-01 00:00:00