Regulation of Apoptosis by miR-122 in Pterygium via Targeting Bcl-w.

abstract：PURPOSE:To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS:There were two study days in an open design. On the first day, OPP was varied by elevating IOP during ...

journal_title：Investigative ophthalmology & visual science

authors： Polska E,Simader C,Weigert G,Doelemeyer A,Kolodjaschna J,Scharmann O,Schmetterer L

更新日期：2007-08-01 00:00:00

abstract：:Reduced quality of life and financial burden due to visual impairment and blindness begin to increase dramatically when individuals reach the age of 40. The major causes of age-related vision loss can be traced to changes to the structure and function of the lens, one of the tissues responsible for focusing light on t...

journal_title：Investigative ophthalmology & visual science

authors： Petrash JM

更新日期：2013-12-13 00:00:00

abstract：PURPOSE:To test the hypothesis that longitudinal differences between retinal nerve fiber layer (RNFL) birefringence, measured by scanning laser polarimetry (SLP), and RNFL thickness, measured by optical coherence tomography (OCT), are informative about the state of axonal degeneration. METHODS:Colchicine was injected ...

journal_title：Investigative ophthalmology & visual science

authors： Fortune B,Wang L,Cull G,Cioffi GA

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To determine transforming growth factor (TGF) beta effects on matrix metalloproteinases (MMPs) as a potential cause of the blood-retinal barrier breakdown at the onset of angiogenesis. Previously, glial cells were shown to play a role in the angiogenesis process and to express the angiogenic regulating factor T...

journal_title：Investigative ophthalmology & visual science

authors： Behzadian MA,Wang XL,Windsor LJ,Ghaly N,Caldwell RB

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To test the hypothesis that acute topical dorzolamide (DZ) decreases intraocular pressure (IOP) and increases retinal and choroidal blood flow in the DBA/2J mouse model of glaucoma. METHODS:Retinal and choroidal blood flow were measured in 4- and 9-month-old DBA/2J mice, and 4-month C57BL/6 (control) mice unde...

journal_title：Investigative ophthalmology & visual science

authors： Chandra S,Muir ER,Deo K,Kiel JW,Duong TQ

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in corneal epithelial cell proliferation by suppressing the Pax6 gene. The present study focused on further understanding the role of CTCF in mediating EGF-induced migration of immortalized human corneal epithelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Deng SX,Lu L

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:To define the inductive pathways leading to rat tear IgA antibody responses. METHODS:Fluoresceinated dinitrophenylated bovine serum albumin was encapsulated in poly(lactide-co-glycolide) microparticles and was administered by intranasal, ocular topical, or gastrointestinal routes. Histologic methods were used ...

journal_title：Investigative ophthalmology & visual science

authors： Ridley Lathers DM,Gill RF,Montgomery PC

更新日期：1998-05-01 00:00:00

abstract：:The morphologic effects on rabbit corneal endothelium of several common ophthalmic vehicle constituents were examined following subconjunctival administration. Profound dose-dependent changes consisting of intercellular vacuolization and thickening of the endothelial layer were noted within 1 day following administrat...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Wood I,Tomazzoli L,Alvarado J

更新日期：1986-04-01 00:00:00

abstract：PURPOSE:In corneal endothelial cells, intercellular Ca(2+) waves elicited by a mechanical stimulus involve paracrine intercellular communication, mediated by ATP release via connexin hemichannels, as well as gap junctional intercellular communication. Both mechanisms are inhibited by thrombin, which activates RhoA and ...

journal_title：Investigative ophthalmology & visual science

authors： D'hondt C,Srinivas SP,Vereecke J,Himpens B

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

journal_title：Investigative ophthalmology & visual science

authors： Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To investigate whether enzymatic collagen breakdown is an active process in the human vitreous. METHODS:Human donor eyes were used for immunohistochemistry to detect the possible presence of the matrix metalloproteinase (MMP)-induced type II collagen breakdown product col2-3/4C-short in the vitreous. Western b...

journal_title：Investigative ophthalmology & visual science

authors： van Deemter M,Pas HH,Kuijer R,van der Worp RJ,Hooymans JM,Los LI

更新日期：2009-10-01 00:00:00

abstract：:The laser Doppler technique was used to measure alterations in retinal blood flow in human subjects under dark-adapted conditions compared to light-adapted conditions. Retinal blood flow increased 40 to 70% after the transition from light to dark. We show quantitatively that the measured increases in retinal blood flo...

journal_title：Investigative ophthalmology & visual science

authors： Feke GT,Zuckerman R,Green GJ,Weiter JJ

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The ultrastructure of tight junctions in the corneal endothelium has been studied extensively, yet little is known about their molecular composition. Junctional adhesion molecule-A (JAM-A) is a tight junction-associated adhesion protein previously implicated in tight junction assembly and regulation of barrier ...

journal_title：Investigative ophthalmology & visual science

authors： Mandell KJ,Holley GP,Parkos CA,Edelhauser HF

更新日期：2006-06-01 00:00:00

abstract：PURPOSE:To evaluate the serum fatty acid changes in Chinese patients with Bietti crystalline dystrophy (BCD) in association with CYP4V2 mutation. METHODS:Sixteen Chinese patients with BCD confirmed with CYP4V2 mutation were recruited. Peripheral venous blood was obtained after fasting and serum fatty acid concentratio...

journal_title：Investigative ophthalmology & visual science

authors： Lai TY,Chu KO,Chan KP,Ng TK,Yam GH,Lam DS,Pang CP

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy commonly associated with elevated intraocular pressure (IOP), leading to optic nerve head (ONH) cupping, axon loss, and apoptosis of retinal ganglion cells (RGCs), which could ultimately result in blindness. Brn3b is a class-4 POU domain transcription factor that plays a key role...

journal_title：Investigative ophthalmology & visual science

authors： Stankowska DL,Minton AZ,Rutledge MA,Mueller BH 2nd,Phatak NR,He S,Ma HY,Forster MJ,Yorio T,Krishnamoorthy RR

更新日期：2015-01-13 00:00:00

abstract：PURPOSE:Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape. ME...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Chandrasekara K,Abbondandolo CJ,Coll TJ,Rutzen AR

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). METHODS:Radiolabeled recombinant human CTGF was used to determine the specificity and time course of binding to low-passage cultures of HCF. The affinity and number of receptors present wer...

journal_title：Investigative ophthalmology & visual science

authors： Blalock TD,Gibson DJ,Duncan MR,Tuli SS,Grotendorst GR,Schultz GS

更新日期：2012-06-05 00:00:00

abstract：PURPOSE:To examine the distribution of anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis for selective involvement of EOMs and muscle sp...

journal_title：Investigative ophthalmology & visual science

authors： Liu JX,Willison HJ,Pedrosa-Domellöf F

更新日期：2009-07-01 00:00:00

abstract：:The morphology of the apical surface of rabbit retinal pigment epithelium was studied by scanning electron microscopy from the first minute to several hours after making small nonrhegmatogenous retinal detachments (blebs). From 0 to 5 min, there were only slight changes in the homogeneous, dense mat of filamentous mic...

journal_title：Investigative ophthalmology & visual science

authors： Immel J,Negi A,Marmor MF

更新日期：1986-12-01 00:00:00

abstract：Purpose:To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. Methods:To establish the lower range of text luminances, we quantified the space-averaged luminance...

journal_title：Investigative ophthalmology & visual science

authors： Xu R,Gil D,Dibas M,Hare W,Bradley A

更新日期：2016-10-01 00:00:00

abstract：Purpose:Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells u...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Zhong Y,Demetriades AM,Shen J,Sui A,Yao Y,Gao Y,Zhu Y,Shen X,Xie B

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To improve the interpretation of Heidelberg Retina Flowmeter (HRF; Heidelberg Engineering GmBH, Dosselheim, Germany) flow maps by examining the influence of specific vascular structures and focus depth in the presence and absence of retinal blood flow. METHODS:HRF flow maps were recorded from the inferior reti...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Townsend R,Cringle SJ,Chauhan BC,Morgan WH

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Retinal injuries that affect the photoreceptors and/or the retinal pigment epithelium (RPE) may result in the leakage of retinal proteins into the systemic circulation. This study was designed to determine whether an immune response is elicited after an acute retinal injury resulting in circulating anti-retinal...

journal_title：Investigative ophthalmology & visual science

authors： Scott SE,Bouhenni RA,Chomyk AM,Dunmire JJ,Patil J,Nakamura H,Deepak P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:This study sought to examine the acute effects of ocular ischemia and reperfusion on retinal function and determine the extent to which recovery during reperfusion is improved by allopurinol (AP), a blocker of xanthine oxidase (XO). The latter is presumed to be a major factor in the formation of free radicals a...

journal_title：Investigative ophthalmology & visual science

authors： Peachey NS,Green DJ,Ripps H

更新日期：1993-01-01 00:00:00

abstract：:The therapeutic effect of citrate on alkali-burned eyes is thought to be the result of inhibition of PMN activities while ascorbate apparently stimulates the production of new collagen by scorbutic fibroblasts. Attachment of PMNs to the vascular endothelium is the initial PMN response to mediators and must occur befor...

journal_title：Investigative ophthalmology & visual science

authors： Pfister RR,Haddox JL,Snyder TL

更新日期：1988-06-01 00:00:00

abstract：:Cone electroretinograms were elicited with a full-field red flash after-45 min of dark adaptation from 16 patients with retinitis pigmentosa and from 17 normal subjects. The average latency and implicit time of the cone a-waves recorded from the patients were each significantly delayed (p less than 0.005) compared wit...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Sullivan PL,Berson EL

更新日期：1981-11-01 00:00:00

abstract：PURPOSE:Methylenetetrahydrofolate reductase (Mthfr) is a key enzyme in homocysteine-methionine metabolism. We investigated Mthfr expression in retina and asked whether mild hyperhomocysteinemia, due to Mthfr deficiency, alters retinal neurovascular structure and function. METHODS:Expression of Mthfr was investigated a...

journal_title：Investigative ophthalmology & visual science

authors： Markand S,Saul A,Roon P,Prasad P,Martin P,Rozen R,Ganapathy V,Smith SB

更新日期：2015-04-01 00:00:00

abstract：Purpose:We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT). Methods:Diabetic participants underwent VA testing and AO...

journal_title：Investigative ophthalmology & visual science

authors： Lammer J,Karst SG,Lin MM,Cheney M,Silva PS,Burns SA,Aiello LP,Sun JK

更新日期：2018-11-01 00:00:00