Reduced accommodation in children with Down syndrome.

abstract：PURPOSE:To identify risk factors for the development of high-risk proliferative diabetic retinopathy (PDR) and for the development of severe visual loss or vitrectomy (SVLV) in eyes assigned to deferral of photocoagulation in the Early Treatment Diabetic Retinopathy Study (ETDRS). METHODS:Multivariable Cox models were...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Fisher MR,Gangnon RE,Barton F,Aiello LM,Chew EY,Ferris FL 3rd,Knatterud GL

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:Retinal basement membranes (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Müller cells (MCs) on the inner limiting membrane (ILM), providing polarity cues to adherent cells. The beta2 and gamma3 chains of laminin are key components of retinal BMs throughout developm...

journal_title：Investigative ophthalmology & visual science

authors： Pinzón-Duarte G,Daly G,Li YN,Koch M,Brunken WJ

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To quantify protein changes in the morphologically distinct remodeling zone (RZ) and adjacent regions of the human lens outer cortex using spatially directed quantitative proteomics. METHODS:Lightly fixed human lens sections were deparaffinized and membranes labeled with fluorescent wheat germ agglutinin (WGA-...

journal_title：Investigative ophthalmology & visual science

authors： Wenke JL,McDonald WH,Schey KL

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:The fibrotic lens disorder posterior capsule opacification (PCO) develops in millions of patients following cataract surgery. PCO characteristics are extensive extracellular matrix (ECM) production and contraction of the posterior lens capsule, resulting in light-scattering ECM modification (wrinkling). The pro...

journal_title：Investigative ophthalmology & visual science

authors： Eldred JA,Hodgkinson LM,Dawes LJ,Reddan JR,Edwards DR,Wormstone IM

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloproteinases (MMPs) also involve insulin-like gr...

journal_title：Investigative ophthalmology & visual science

authors： Lorenc VE,Jaldín-Fincati JR,Luna JD,Chiabrando GA,Sánchez MC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：PURPOSE:Corneas with scars and certain chronic pathologic conditions contain highly sulfated dermatan sulfate, but little is known of the core proteins that carry these atypical glycosaminoglycans. In this study the proteoglycan proteins attached to dermatan sulfate in normal and pathologic human corneas were examined ...

journal_title：Investigative ophthalmology & visual science

authors： Funderburgh JL,Hevelone ND,Roth MR,Funderburgh ML,Rodrigues MR,Nirankari VS,Conrad GW

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:Children with idiopathic infantile nystagmus (IIN) exhibit visual acuity deficits that have been modeled in terms of foveation characteristics of the nystagmus waveform. Here we present evidence for an additional component of acuity loss associated with the deprivation experienced during the sensitive period of...

journal_title：Investigative ophthalmology & visual science

authors： Felius J,Muhanna ZA

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In thi...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Beiboer SH,Jager MJ,Luyten GP,Gruis NA,van der Velden PA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To reconstruct the role played by vascular endothelium in the elevation of circulating von Willebrand factor (vWf) in diabetic patients with microangiopathy and, specifically, to determine whether storage and synthesis of vWf is altered in diabetic retinal vessels. METHODS:Trypsin digests were prepared from re...

journal_title：Investigative ophthalmology & visual science

authors： Boeri D,Cagliero E,Podestá F,Lorenzi M

更新日期：1994-02-01 00:00:00

abstract：:PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histo...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Lai-Cheong J,Borthwick GM,He L,Taylor GA,Greaves LC,Taylor RW,Griffiths PG,Turnbull DM

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficiency, cell specificity, stability, and toxicity of recombinant adeno-associated virus (rAAV)-mediated retinal transduction in vivo in the adult immunocompetent mouse. To assess the usefulness of green fluorescent protein (GFP) for real-time, noninvasive monitoring of retinal transgene expr...

journal_title：Investigative ophthalmology & visual science

authors： Bennett J,Duan D,Engelhardt JF,Maguire AM

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:To determine whether the lipid peroxidation inhibitor tirilazad mesylate can block the death of retinal ganglion cells induced by the inhibition of oxidative phosphorylation and glycolysis. METHODS:Rat retinal ganglion cells were labeled retrogradely with the fluorescent tracer DiI, and mixed cultures were pre...

journal_title：Investigative ophthalmology & visual science

authors： Levin LA,Clark JA,Johns LK

更新日期：1996-12-01 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:Nd:YAG laser photodisruption with nanosecond (ns) pulses in the millijoule range is an established tool for intraocular surgery. This study investigates tissue effects in cornea, lens, and retina to assess whether picosecond (ps) pulses with energies in the microjoule range can increase the surgical precision, ...

journal_title：Investigative ophthalmology & visual science

authors： Vogel A,Capon MR,Asiyo-Vogel MN,Birngruber R

更新日期：1994-06-01 00:00:00

abstract：:The adhesion complex of the corneal epithelium consists of the hemidesmosome and its associated structures, such as anchoring filaments, lamina densa of the basement membrane, and anchoring fibrils. It contributes to the adhesion of the corneal epithelium to Bowman's layer. To understand the adhesion complex better, a...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Kurpakus MA,Sambol B,Jones JC

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To assess whether saccadic eye movements show distinct changes in patients with early active Graves' ophthalmopathy (GO), which could serve as a diagnostic tool for early detection and treatment. METHODS:Each of two prospective studies included 10 patients with early acute GO and 10 age- and sex-matched contro...

journal_title：Investigative ophthalmology & visual science

authors： Schworm HD,Heufelder AE,Kunze A,Welge E,Boergen KP

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To map the spatiotemporal decline in retinally driven activity in the superior colliculus (SC) of transgenic S334ter-line-3 rats that express a mutated rhodopsin, which causes photoreceptor degeneration. To determine whether transplantation of fetal retinal sheets into the subretinal space of these rats can rec...

journal_title：Investigative ophthalmology & visual science

authors： Sagdullaev BT,Aramant RB,Seiler MJ,Woch G,McCall MA

更新日期：2003-04-01 00:00:00

abstract：:The properties of the oscillatory potentials (OPs) of the mudpuppy electroretinogram (ERG) were studied and compared with the properties of the b-wave of the ERG and the proximal negative response (PNR). Both transretinal and intraretinal ERGs were recorded in response to full-field as well as 200 and 500 microgram sp...

journal_title：Investigative ophthalmology & visual science

authors： Wachtmeister L,Dowling JE

更新日期：1978-12-01 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular gl...

journal_title：Investigative ophthalmology & visual science

authors： Vorwerk CK,Naskar R,Schuettauf F,Quinto K,Zurakowski D,Gochenauer G,Robinson MB,Mackler SA,Dreyer EB

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SD-OCT) in healthy individuals. METHODS:In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear ...

journal_title：Investigative ophthalmology & visual science

authors： Celebi AR,Mirza GE

更新日期：2013-12-11 00:00:00

abstract：PURPOSE:Recovery of photoreceptor cells after light damage is thought to involve the physiologic process of disk renewal. However, only indirect evidence is available to support this hypothesis. The present study sought to examine more directly the mechanisms of photoreceptor cell recovery by quantitatively assessing t...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Fisher PL,Dhindsa HS

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched control animals. METHODS:Two-month-old (group 1) and 8-month-old (group 2) normal control C57BL/6 mice and 2-month-old (group 3) and 8-month-old (group 4) A...

journal_title：Investigative ophthalmology & visual science

authors： Dithmar S,Curcio CA,Le NA,Brown S,Grossniklaus HE

更新日期：2000-07-01 00:00:00

abstract：Purpose:There is evidence that choroidal blood flow (ChBF) is regulated in a complex way during changes in ocular perfusion pressure (OPP). We hypothesized that ChBF regulates better in response to changes in mean arterial pressure (MAP) than in intraocular pressure (IOP). Methods:Eighteen volunteers (mean age, 26 yea...

journal_title：Investigative ophthalmology & visual science

authors： Popa-Cherecheanu A,Schmidl D,Werkmeister RM,Chua J,Garhöfer G,Schmetterer L

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00

abstract：:Fixation stability of the saccadic system was investigated by infrared reflection oculography in 29 normal subjects, young and elderly. Square wave jerks consisting of spontaneous horizontal saccadic excursions of 0.5 degree and over, followed some 200 msec later by corrective saccades, were recorded in 24% of subject...

journal_title：Investigative ophthalmology & visual science

authors： Herishanu YO,Sharpe JA

更新日期：1981-02-01 00:00:00

abstract：PURPOSE:Recently, it has been found that form deprivation myopia can be induced in fish (tilapia). This study examined the sensitivity of the tilapia eye to positive and negative lenses. It further investigated the sensitivity of the fish eye to form deprivation by examining the effect of fish weight. METHODS:Twenty-f...

journal_title：Investigative ophthalmology & visual science

authors： Shen W,Sivak JG

更新日期：2007-10-01 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00