Normal square wave jerks.

abstract：:The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bi...

journal_title：Investigative ophthalmology & visual science

authors： Stern WH,Heath TD,Lewis GP,Guerin CJ,Erickson PA,Lopez NG,Hong KL

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To investigate the effects of reducing connexin (Cx) diversity in the lens when the amount of connexin protein is nearly constant. METHODS:Lenses in which the Cx50 coding region was replaced by that of Cx46 (knockin [KI]), were compared with wild type (WT) and Cx50-knockout (KO) lenses. Gap junctional conducta...

journal_title：Investigative ophthalmology & visual science

authors： Martinez-Wittinghan FJ,Sellitto C,White TW,Mathias RT,Paul D,Goodenough DA

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Amniotic membrane transplantation (AMT) reportedly improves herpetic stromal keratitis (HSK). Here we studied the role of the amniotic membrane (AM) on macrophages. METHODS:BALB/c mice with necrotizing HSK received an AMT or tarsorrhaphy (TAR) as control. Apoptosis of F4/80+ cells was determined using the anne...

journal_title：Investigative ophthalmology & visual science

authors： Bauer D,Hennig M,Wasmuth S,Baehler H,Busch M,Steuhl KP,Thanos S,Heiligenhaus A

更新日期：2012-02-21 00:00:00

abstract：PURPOSE:To compare current imaging methods with respect to their ability to detect the condition of the fovea in patients with geographic atrophy (GA). METHODS:The retinas of 176 eyes with GA were imaged using two spectral-domain optical coherence tomography (SD-OCT) systems, Cirrus HD-OCT and Spectralis HRA+OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Sayegh RG,Zotter S,Roberts PK,Kandula MM,Sacu S,Kreil DP,Baumann B,Pircher M,Hitzenberger CK,Schmidt-Erfurth U

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Placental growth factor (PlGF) has been implicated as a contributor to resistance against anti-VEGF therapy. The purpose of the present study was to analyze the systemic levels of PlGF, VEGF-A, and VEGF-B in patients with neovascular age-related macular degeneration (AMD) after treatment with aflibercept, ranib...

journal_title：Investigative ophthalmology & visual science

authors： Zehetner C,Bechrakis NE,Stattin M,Kirchmair R,Ulmer H,Kralinger MT,Kieselbach GF

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Posterior segment intraocular inflammation (PSII) is a putative Th1 CD4+ cell mediated autoimmune disorder. In experimental autoimmune uveoretinitis, neutralization of tumor necrosis factor (TNF)-alpha induces suppression of Th1 cells, macrophage activation, and target organ damage. Previous studies implicated ...

journal_title：Investigative ophthalmology & visual science

authors： Greiner K,Murphy CC,Willermain F,Duncan L,Plskova J,Hale G,Isaacs JD,Forrester JV,Dick AD

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To identify objective criteria to quantify visual function in the rat for developing therapeutic strategies to protect neuronal cells after ischemia. The impact of ocular ischemia on luminance and frequency-modulated contrast vision was compared with the function of outer retinal cells and the number of intact ...

journal_title：Investigative ophthalmology & visual science

authors： Jehle T,Wingert K,Dimitriu C,Meschede W,Lasseck J,Bach M,Lagrèze WA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) has features of chronic low-grade inflammation. The purpose of our study was to investigate whether the presence of inflammatory cells in fibrovascular membranes (FVMs) from patients with proliferative diabetic retinopathy (PDR) is associated with the activity of PDR and visual acuity ...

journal_title：Investigative ophthalmology & visual science

authors： Urbančič M,Štunf Š,Milutinović Živin A,Petrovič D,GlobočnikPetrovič M

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations. METHODS:Thirty-six subjects (19 male, 17 female; mean SD, age 51 13 years) were recruited into this single-masked placebo-controlled study, and were ...

journal_title：Investigative ophthalmology & visual science

authors： Loughman J,Nolan JM,Howard AN,Connolly E,Meagher K,Beatty S

更新日期：2012-11-29 00:00:00

abstract：PURPOSE:To assess the reproducibility of the ocular response analyzer (ORA) in nonoperated eyes and the impact of corneal biomechanical properties on intraocular pressure (IOP) measurements in normal and glaucomatous eyes. METHODS:In the reliability study, two independent examiners obtained repeated ORA measurements i...

journal_title：Investigative ophthalmology & visual science

authors： Moreno-Montañés J,Maldonado MJ,García N,Mendiluce L,García-Gómez PJ,Seguí-Gómez M

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supplementation evaluated. ...

journal_title：Investigative ophthalmology & visual science

authors： Feathers KL,Lyubarsky AL,Khan NW,Teofilo K,Swaroop A,Williams DS,Pugh EN Jr,Thompson DA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：PURPOSE:It is thought that large perimetric stimuli are insensitive for demonstrating visual field defects. To test the hypothesis that there is no difference in the total number of abnormal test locations with total deviation empiric probability plots in glaucoma patients, we compared results of glaucoma patients test...

journal_title：Investigative ophthalmology & visual science

authors： Wall M,Doyle CK,Eden T,Zamba KD,Johnson CA

更新日期：2013-06-07 00:00:00

abstract：PURPOSE:To measure the effects of cerebrospinal fluid pressure (CSFp) on retrolaminar tissue pressure (RLTp) and the translaminar pressure gradient (TLPG), particularly at low CSFp, which is the normal situation in erect posture. METHODS:Micropipettes coupled to a servonull pressure system were passed into eyes of ane...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Yu DY,Alder VA,Cringle SJ,Cooper RL,House PH,Constable IJ

更新日期：1998-07-01 00:00:00

abstract：PURPOSE:To investigate the specific role of myosin II, a critical biochemical determinant of cellular contraction, in modulation of aqueous humor outflow facility through the trabecular meshwork (TM) pathway. METHODS:Expression of the nonmuscle myosin II heavy chains (IIA, IIB, and IIC) in human TM and ciliary body (C...

journal_title：Investigative ophthalmology & visual science

authors： Zhang M,Rao PV

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Homocysteine (Hcys), a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM). LOX contributes to the...

journal_title：Investigative ophthalmology & visual science

authors： Coral K,Angayarkanni N,Gomathy N,Bharathselvi M,Pukhraj R,Rupak R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of genetic deletion of NOS3 in CAV1-/- mice on aqueous humor outflow function using a mouse genetic double knockout model (DKO, NOS3-/- CAV1-/-). Methods:IOP was measured in DKO, NOS3 KO, CAV1 KO, and wild-type (WT) mice by rebound tonometry. Outflow faci...

journal_title：Investigative ophthalmology & visual science

authors： Song M,Wu J,Lei Y,Sun X

更新日期：2017-10-01 00:00:00

abstract：:PURPOSE. To investigate the characteristics of a spectral-domain optical coherence tomography (SD-OCT) image phenomenon known as the mirror artifact, calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). METHODS. OCT macular...

journal_title：Investigative ophthalmology & visual science

authors： Ho J,Castro DP,Castro LC,Chen Y,Liu J,Mattox C,Krishnan C,Fujimoto JG,Schuman JS,Duker JS

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were obse...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DM

更新日期：2011-06-22 00:00:00

abstract：:Dog corneas were studied by indirect immunofluorescence with antibodies specific for pemphigus and pemphigoid antigens, laminin, and type IV collagen. The distribution of these antigens was similar to that observed in other squamous epithelia and skin. This study provides further evidence for close immunochemical simi...

journal_title：Investigative ophthalmology & visual science

authors： Cowen SJ,Anhalt GJ,Wicha MS,Sugar A,Labib RS,Diaz LA

更新日期：1981-12-01 00:00:00

abstract：PURPOSE:To demonstrate the potential use of subpixel image processing methods to perform automated Hirschberg measurements of strabismic deviations using relatively inexpensive personal computer hardware; to determine if the method might allow screening for strabismus using full-face video images obtained from a distan...

journal_title：Investigative ophthalmology & visual science

authors： Miller JM,Mellinger M,Greivenkemp J,Simons K

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:TGF-betas regulate cell proliferation and differentiation, and they play important roles in maintenance of corneal epithelium. However, the precise function of TGF-betas in the corneal epithelium remains unclear. In this study, cDNA expression array technology was used to demonstrate the effect of TGF-beta1 on ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashida-Hibino S,Watanabe H,Nishida K,Tsujikawa M,Tanaka T,Hori Y,Saishin Y,Tano Y

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To compare adult discrimination performance on nine pediatric visual acuity tests to determine the consistency of optotype design. METHODS:After their binocular acuity was measured with each test, eight adult observers (mean age, 27 years ± 6.3 SD; three emmetropes and five corrected myopes) were shown isolate...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Mishoulam SR,Nosofsky RM,Dobson V

更新日期：2011-06-16 00:00:00

abstract：:We present results from 64 glaucoma patients and glaucoma suspects followed up for a median period of 7.4 yr who had a median of seven examinations using Program 31 on the Octopus perimeter. The patients also had manual visual fields recorded on either the Tübinger or Goldmann perimeter during the same period. By exam...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:The values of Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany) stereometric parameters depend on the reference plane (RP), the instability of which results in parameter variability. Identification of change depends on RP stability. This study was undertaken to evaluate the influen...

journal_title：Investigative ophthalmology & visual science

authors： Poli A,Strouthidis NG,Ho TA,Garway-Heath DF

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:To investigate the neuroprotective effects of brain-derived neurotrophic factor (BDNF) against potassium cyanide (KCN)-induced retinal damage. METHODS:Rats were injected intravitreally with iodinated BDNF. Two days later, eyeballs were dissected into various parts, and the level of radioactivity in each part w...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda K,Tanihara H,Honda Y,Tatsuno T,Noguchi H,Nakayama C

更新日期：1999-08-01 00:00:00