Abstract：
PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were observed for ≥3 years with serial OCTs and stereo disc photographs. Subjects were divided into two groups according to the presence (n = 144) or absence of β-zone PPA (n = 58). The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined using linear regression and compared between groups. Logistic regression analysis was used to determine the factors associated with the rate of global RNFL thinning. RESULTS:The mean rate for global RNFL thinning over time was -1.03 ± 1.50 μm/year. Eyes with β-zone PPA showed a significantly faster rate of RNFL thinning than did eyes without β-zone PPA in the inferior quadrant and 7 o'clock sector (values of P < 0.0029). Multivariate analysis showed significant influence of the presence of β-zone PPA and the percentage increase in the PPA to disc area ratio during the follow-up on the rate of OCT RNFL thinning (odds ratio [OR], 3.314, P = 0.007; OR, 2.894, P = 0.003, respectively). CONCLUSIONS:Glaucomatous eyes with β-zone PPA are at increased risk for progressive RNFL thinning.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DMdoi
10.1167/iovs.10-6818subject
Has Abstractpub_date
2011-06-22 00:00:00pages
4422-7issue
7eissn
0146-0404issn
1552-5783pii
iovs.10-6818journal_volume
52pub_type
杂志文章abstract：:Retinal cone photoreceptors are polarized cells with discrete functional compartments. Little is known of the membrane-skeleton components in cones responsible for the maintenance of cellular morphology and compartmentalization of integral membrane proteins. The authors describe a high density of the membrane-skeleton...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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