Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.

abstract：:The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bi...

journal_title：Investigative ophthalmology & visual science

authors： Stern WH,Heath TD,Lewis GP,Guerin CJ,Erickson PA,Lopez NG,Hong KL

更新日期：1987-05-01 00:00:00

abstract：:Tissue culture of retinal vessels from fetal calf eyes produced colonies of endothelium, pericytes, and smooth muscle. Identification of endothelial cells was based upon culture morphology, [3H]thymidine labeling of isolated vessels, and factor VIII immunofluorescence. Thimerosal added to the culture medium destroyed ...

journal_title：Investigative ophthalmology & visual science

authors： Buzney SM,Massicotte SJ

更新日期：1979-11-01 00:00:00

abstract：Purpose:To investigate transepidermal water loss (TEWL) from the ocular area in dry eye disease (DED) and evaluate the correlation between ocular TEWL and other DED parameters. Methods:Transepidermal water loss from the ocular area in 56 eyes with DED and 38 healthy eyes was measured using a Tewameter TM300 that was e...

journal_title：Investigative ophthalmology & visual science

authors： Jeon HS,Youn SW,Jeon HE,Kim JH,Hyon JY

更新日期：2016-09-01 00:00:00

abstract：:Demeclocycline, tetracycline and other tetracycline derivatives lowered intraocular pressure (IOP) in rabbits following intravitreal injection, but the onset of this effect was not evident until 1 or more days after drug administration. Of the drugs tested, demeclocycline was the most active ocular hypotensive agent. ...

journal_title：Investigative ophthalmology & visual science

authors： Wallace I,Krupin T,Stone RA,Moolchandani J

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS:Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extr...

journal_title：Investigative ophthalmology & visual science

authors： Thalamuthu A,Khor CC,Venkataraman D,Koh LW,Tan DT,Aung T,Mehta JS,Vithana EN

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery. METHODS:A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was incr...

journal_title：Investigative ophthalmology & visual science

authors： Minguini N,Monteiro de Carvalho KM,Akaishi PM,De Luca IM

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of corneal trauma on gene expression in the lacrimal gland and to assess how many genes and what specific genes are regulated in response to corneal trauma. METHODS:A mouse model with acute corneal trauma was created with a chemical burn to the cornea with silver nitrate. Sixty-four f...

journal_title：Investigative ophthalmology & visual science

authors： Fang Y,Choi D,Searles RP,Mathers WD

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：:Sodium removal from the solution bathing the isolated rabbit corneal endothelium caused a reduction in both unidirectional and net flux of bicarbonate, whereas chloride withdrawal from the solution had no effect on the net bicarbonate flux but increased the unidirectional fluxes. These data correlate with previously p...

journal_title：Investigative ophthalmology & visual science

authors： Green K,Simon S,Kelly GM Jr,Bowman KA

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:The authors compared the efficacy of two different forms of flicker perimetry: temporal modulation perimetry (TMP), which measures contrast thresholds for a fixed temporal frequency, and critical flicker frequency (CFF), which measures the highest frequency for which flicker is detected at a fixed contrast. ME...

journal_title：Investigative ophthalmology & visual science

authors： Yoshiyama KK,Johnson CA

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:To determine the kinetics of tumor necrosis factor (TNF) and interleukin-6 (IL-6) in serum and aqueous humor of rats with different susceptibilities to endotoxin-induced uveitis (EIU), after footpad injection of lipopolysaccharide (LPS). METHODS:Samples were collected from EIU-susceptible Lewis rats and EIU-re...

journal_title：Investigative ophthalmology & visual science

authors： de Vos AF,van Haren MA,Verhagen C,Hoekzema R,Kijlstra A

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Abnormalities in the distribution of long-chain polyunsaturated fatty acids (LCPUFA) have been documented in plasma of patients with X-linked retinitis pigmentosa (XLRP). In this study, fatty acid profiles of red blood cells (RBC) were used as an index for LCPUFA metabolism in patients with XLRP because RBC lip...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman DR,Birch DG

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:TGF-betas regulate cell proliferation and differentiation, and they play important roles in maintenance of corneal epithelium. However, the precise function of TGF-betas in the corneal epithelium remains unclear. In this study, cDNA expression array technology was used to demonstrate the effect of TGF-beta1 on ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashida-Hibino S,Watanabe H,Nishida K,Tsujikawa M,Tanaka T,Hori Y,Saishin Y,Tano Y

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:To evaluate the functional treatment response 3 months and 12 months after monthly ranibizumab in neovascular age-related macular degeneration (NAMD). METHODS:Twenty-six eyes showing treatment-naïve NAMD were examined with the Heidelberg Spectralis OCT (SD-OCT) and the Nidek MP-1 microperimeter (MP) at baselin...

journal_title：Investigative ophthalmology & visual science

authors： Sulzbacher F,Kiss C,Kaider A,Roberts P,Munk M,Kroh ME,Sayegh R,Schmidt-Erfurth U

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS:We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), ...

journal_title：Investigative ophthalmology & visual science

authors： Akashi A,Kanamori A,Nakamura M,Fujihara M,Yamada Y,Negi A

更新日期：2013-07-10 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：:The amount of unscheduled DNA synthesis (UDS) produced in the cells adjacent to excimer laser ablations in the cornea was compared for 193-nm and 248-nm laser wavelengths. UDS is interpreted to indicate the process of excision repair of pyrimidine dimers formed in DNA. 193-nm laser ablation did not produce a statistic...

journal_title：Investigative ophthalmology & visual science

authors： Nuss RC,Puliafito CA,Dehm E

更新日期：1987-02-01 00:00:00

abstract：PURPOSE:Oxidative stress has been proposed as a major pathogenic factor in age-related macular degeneration (AMD), the leading cause of vision loss among elderly people of western European ancestry. Lutein (LUT) and zeaxanthin (ZEA), major components in macular pigment, are among the retinal antioxidants. Though xantho...

journal_title：Investigative ophthalmology & visual science

authors： Chucair AJ,Rotstein NP,Sangiovanni JP,During A,Chew EY,Politi LE

更新日期：2007-11-01 00:00:00

abstract：Purpose:To analyze the anti-inflammatory and antioxidative effects of Camellia japonica (CJ) on human corneal epithelial (HCE) cells and its therapeutic effects in a mouse model of experimental dry eye (EDE). Methods:Camellia japonica extracts of varying concentrations (0.001%, 0.01%, and 0.1%) were used to treat HCE ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HS,Choi JH,Cui L,Li Y,Yang JM,Yun JJ,Jung JE,Choi W,Yoon KC

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:This retrospective observational study was designed to evaluate the frequency of, and the factors associated with, optic disc swelling in Vogt-Koyanagi-Harada disease (VKH). METHODS:A retrospective observational study was conducted. We analyzed 116 eyes of 58 patients with VKH. Demographic and clinical differe...

journal_title：Investigative ophthalmology & visual science

authors： Nakao K,Abematsu N,Mizushima Y,Sakamoto T

更新日期：2012-04-18 00:00:00

abstract：PURPOSE:Patients with sickle cell disease have elevated circulating levels of cytokines including tumor necrosis factor (TNF) alpha. TNF-alpha stimulates expression by endothelial cells of adhesion molecules, including vascular cell adhesion molecule (VCAM) 1. Others have demonstrated that VLA-4 (alpha(4)beta(1)), a li...

journal_title：Investigative ophthalmology & visual science

authors： Lutty GA,Taomoto M,Cao J,McLeod DS,Vanderslice P,McIntyre BW,Fabry ME,Nagel RL

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Müller cells are the principal glial cells of the retina. They span the entire thickness of the neural retina, and they are in close contact with neurons. Müller cells grow very slowly, and they undergo senescence with increasing passages. Moreover, successful primary cultures of Müller cells can be obtained on...

journal_title：Investigative ophthalmology & visual science

authors： Lupien CB,Salesse C

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:To evaluate the feasibility of introducing exogenous genes and phosphorothioate oligonucleotides into the anterior chamber tissues of rats and monkeys using the authors' fusogenic liposomes. METHODS:Hemagglutinating virus of Japan liposomes containing LacZ DNA-high-mobility group 1 complexes or fluorescein iso...

journal_title：Investigative ophthalmology & visual science

authors： Hangai M,Tanihara H,Honda Y,Kaneda Y

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

journal_title：Investigative ophthalmology & visual science

authors： Ono M,Takano Y,Haida M

更新日期：2018-09-04 00:00:00

abstract：:Extracellular matrix (ECM) turnover and remodeling are initiated, at least in part, by the regulated secretion of members of a family of matrix metalloproteinases. Human and bovine trabecular mesh-work in culture secrete interstitial collagenase, both the 72- and the 92-kD forms of type IV collagenase (gelatinases) an...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Samples JR,Van Buskirk EM,Acott TS

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Mutations in the frizzled-4 gene (FZD4) have recently been associated with autosomal dominant familial exudative vitreoretinopathy (FEVR) in families linking to the EVR1 locus on the long arm of chromosome 11. The purpose of this study was to screen FZD4 in a panel of 40 patients with FEVR to identify the types...

journal_title：Investigative ophthalmology & visual science

authors： Toomes C,Bottomley HM,Scott S,Mackey DA,Craig JE,Appukuttan B,Stout JT,Flaxel CJ,Zhang K,Black GC,Fryer A,Downey LM,Inglehearn CF

更新日期：2004-07-01 00:00:00