Unscheduled DNA synthesis following excimer laser ablation of the cornea in vivo.

abstract：PURPOSE:Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell-mediated immune response is generated in the lymphoid compartment and to characterize the functional phenotype of the T c...

journal_title：Investigative ophthalmology & visual science

authors： El Annan J,Chauhan SK,Ecoiffier T,Zhang Q,Saban DR,Dana R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To demonstrate the potential use of subpixel image processing methods to perform automated Hirschberg measurements of strabismic deviations using relatively inexpensive personal computer hardware; to determine if the method might allow screening for strabismus using full-face video images obtained from a distan...

journal_title：Investigative ophthalmology & visual science

authors： Miller JM,Mellinger M,Greivenkemp J,Simons K

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:Weak eye muscles can cause ophthalmic disorders, and in particular, strabismus. Exogenous trophic factors such as cardiotrophin (CT)-1 and insulin-like growth factor (IGF) have been shown to increase the contractile force of adult heart and skeletal muscles, respectively. In the current study, the effects of en...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,von Bartheld CS

更新日期：2004-10-01 00:00:00

abstract：:The relative importance of the anterior ciliary arteries to blood flow to the anterior segment and the quadrant distribution of blood to the iris, ciliary body, and ciliary processes were determined in canines with the use of 15 +/- 3 mum 103Ru microspheres with the reference blood flow method. Recti muscles were isol...

journal_title：Investigative ophthalmology & visual science

authors： Keough EM,Wilcox LM,Connolly RJ,Hotte CE

更新日期：1980-11-01 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：Purpose:To assess the feasibility of macular integrity assessment (MAIA) microperimetry (MP) in children. Also to establish representative outcome measures (differential light sensitivity, fixation stability, test-retest reliability) for children without visual impairment. Methods:Thirty-three adults and 33 children (...

journal_title：Investigative ophthalmology & visual science

authors： Jones PR,Yasoubi N,Nardini M,Rubin GS

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To visualize and quantify the three-dimensional (3D) spatial relationships of the structures of the aqueous outflow system (AOS) within intact enucleated mouse eyes using spectral two-photon microscopy (TPM) techniques. METHODS:Spectral TPM, including two-photon autofluorescence (TPAF) and second-harmonic gene...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Liu N,Mak PU,Pun SH,Vai MI,Masihzadeh O,Kahook MY,Lei TC,Ammar DA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:The authors examine the effect of retinal branch vein occlusion (BVO), a common retinal vascular disorder, on protein tyrosine phosphorylation, production of angiogenic growth factors, and activation of signal proteins in the tyrosine kinase pathways in the retina. METHODS:Retinal branch vein occlusion was ind...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi A,Imai K,Kim HC,de Juan E Jr

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:To determine the prevalence, incidence, and progression of myopia of Chinese children in Hong Kong. METHODS:A cross-sectional survey was initially conducted. A longitudinal follow-up study was then conducted 12 months later. RESULTS:A total of 7560 children of mean age 9.33 (95% confidence interval [CI] = 9.1...

journal_title：Investigative ophthalmology & visual science

authors： Fan DS,Lam DS,Lam RF,Lau JT,Chong KS,Cheung EY,Lai RY,Chew SJ

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Because several polypeptide growth factors are known to influence capillary endothelial cell mitogenesis, the authors investigated the presence of some of these molecules in choroidal neovascular membranes (CNVMs) removed surgically from human subjects with age-related macular degeneration (ARMD). METHODS:The ...

journal_title：Investigative ophthalmology & visual science

authors： Amin R,Puklin JE,Frank RN

更新日期：1994-07-01 00:00:00

abstract：:Bovine rod outer segments (ROS) specifically stimulate DNA synthesis in lymphocyte cultures from guinea pigs preimmunized with ROS. At doses above 10 microgram/ml protein, however, preparations of ROS inhibit DNA and RNA synthesis by the sensitized lymphocytes or by normal lymphocytes reacting to mitogens. The inhibti...

journal_title：Investigative ophthalmology & visual science

authors： Gery I

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine the details of the mechanism of K-115's neuroprotective effect in vivo and in vitro. METHODS:ROCK inhibitors, including K-115 and fasud...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto K,Maruyama K,Himori N,Omodaka K,Yokoyama Y,Shiga Y,Morin R,Nakazawa T

更新日期：2014-10-02 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:There is some evidence to suggest that thrombolysis has a beneficial effect in retinal vessel occlusion. However, there is concern that this therapeutic approach carries the risk of hemorrhage. Retrograde cannulation of the supraorbital arteries followed by irrigation with fibrinolytic agents may have the poten...

journal_title：Investigative ophthalmology & visual science

authors： Schwenn OK,Wüstenberg EG,Konerding MA,Hattenbach LO

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To study the effect of aminoguanidine (AMG), an inhibitor of nitric oxide production, on the ocular infection of Balb/c mice with herpes simplex virus (HSV) type 1 strain F and HSV-2 strain G. METHODS:Animals were treated with different amounts of AMG (0.5, 0.1, and 0.05 mg/mouse) by topical application in the...

journal_title：Investigative ophthalmology & visual science

authors： Benencia F,Courrèges MC,Gamba G,Cavalieri H,Massouh EJ

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS:The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two in...

journal_title：Investigative ophthalmology & visual science

authors： Van de Veire S,Germonpre P,Renier C,Stalmans I,Zeyen T

更新日期：2008-12-01 00:00:00

abstract：:PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on the light-damaged retinal structure and the apoptosis of photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into the subretinal space of light-damaged Sprague-Dawley rats 10 days af...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Wang W

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:MRL/Mp-lpr/lpr mice (MRL/lpr) spontaneously develop lacrimal gland inflammatory lesions and are a model for the human disease Sjögren's syndrome. Therapy with monoclonal antibodies (mAb) to CD4 ameliorates the autoimmune renal, vasculitic, and intraocular inflammatory lesions in MRL/lpr mice. The effect of anti...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Burns WH,Prendergast RA

更新日期：1996-01-01 00:00:00

abstract：:We tested the state of retinal correspondence at different positions in the visual field of ten observers with strabismic and/or anisometropic amblyopia, four strabismic subjects with alternating fixation and three normal controls. Correspondence was evaluated by the subjective displacement of dichoptic stimuli; to es...

journal_title：Investigative ophthalmology & visual science

authors： Sireteanu R,Fronius M

更新日期：1989-09-01 00:00:00

abstract：PURPOSE:To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse. METHODS:Twenty-two patients with CRB1 mutations were studied. Function was assessed with perimetry and electroretinography (ERG) and retinal structure with optical coherence tomography (OCT). Cortical str...

journal_title：Investigative ophthalmology & visual science

authors： Aleman TS,Cideciyan AV,Aguirre GK,Huang WC,Mullins CL,Roman AJ,Sumaroka A,Olivares MB,Tsai FF,Schwartz SB,Vandenberghe LH,Limberis MP,Stone EM,Bell P,Wilson JM,Jacobson SG

更新日期：2011-08-29 00:00:00

abstract：Purpose:To characterize intraocular pressure (IOP) dynamics by identifying the sources of transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative IOP-related mechanical energy, and temporal distribution. Methods:IOP was monitored at 500 Hz for periods of 16 to 451 days in nine normal...

journal_title：Investigative ophthalmology & visual science

authors： Turner DC,Edmiston AM,Zohner YE,Byrne KJ,Seigfreid WP,Girkin CA,Morris JS,Downs JC

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:Vergence eye movements undergo adaptive recalibration in response to a training stimulus in which the initial disparity is changed just after vergence begins (the double-step paradigm). In the present study the changes in the dynamic properties of convergence, speed and acceleration, were examined by using this...

journal_title：Investigative ophthalmology & visual science

authors： Takagi M,Oyamada H,Abe H,Zee DS,Hasebe H,Miki A,Usui T,Hasegawa S,Bando T

更新日期：2001-06-01 00:00:00

abstract：Purpose:Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes. Me...

journal_title：Investigative ophthalmology & visual science

authors： Raychaudhuri U,Millar JC,Clark AF

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supplementation evaluated. ...

journal_title：Investigative ophthalmology & visual science

authors： Feathers KL,Lyubarsky AL,Khan NW,Teofilo K,Swaroop A,Williams DS,Pugh EN Jr,Thompson DA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:A human biovar of Chlamydia trachomatis was used to develop a murine model of ocular chlamydial infection. The inbred mouse model will allow detailed immunologic studies during ocular infection, and use of a human biovar for infection may aid in identification of appropriate vaccine strategies against chlamydia...

journal_title：Investigative ophthalmology & visual science

authors： Whittum-Hudson JA,O'Brien TP,Prendergast RA

更新日期：1995-09-01 00:00:00

abstract：PURPOSE:To assess the reactive changes of the corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment of myopia. METHODS:This prospective observational study included 46 eyes of 23 patients that were scheduled for myopic SMILE. High-resolution spectral-domain opti...

journal_title：Investigative ophthalmology & visual science

authors： Luft N,Ring MH,Dirisamer M,Mursch-Edlmayr AS,Kreutzer TC,Pretzl J,Bolz M,Priglinger SG

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Recoverin has been identified as a target autoantigen for antirecoverin antibodies found in the sera of some patients with cancer-associated retinopathy. The aim of this study was to investigate the role of antirecoverin antibodies in cancer-associated retinopathy. METHODS:Human, rat, and rabbit antirecoverin ...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Machnicki M,Seigel GM

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS:A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly f...

journal_title：Investigative ophthalmology & visual science

authors： Galli-Resta L,Piccardi M,Ziccardi L,Fadda A,Minnella A,Marangoni D,Placidi G,Resta G,Falsini B

更新日期：2013-10-09 00:00:00

abstract：PURPOSE:To determine the site of highest resistance to the movement of water across Bruch's membrane in humans. METHODS:A hydraulic conductivity chamber was designed that enabled us to measure flow across Bruch's membrane while ablating its subepithelial aspect using an excimer laser (193 nm). When resistance was lost...

journal_title：Investigative ophthalmology & visual science

authors： Starita C,Hussain AA,Patmore A,Marshall J

更新日期：1997-03-01 00:00:00