Scleral plug of biodegradable polymers containing ganciclovir for experimental cytomegalovirus retinitis.

abstract：PURPOSE:To determine and compare gene expression patterns in the whole retina and retinal ganglion cell layer (RGCL) in a rodent glaucoma model. METHODS:IOP was unilaterally elevated in Brown Norway rats (N = 26) by injection of hypertonic saline and monitored for 5 weeks. A cDNA microarray was used on whole retinas f...

journal_title：Investigative ophthalmology & visual science

authors： Guo Y,Cepurna WO,Dyck JA,Doser TA,Johnson EC,Morrison JC

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：:The properties of the oscillatory potentials (OPs) of the mudpuppy electroretinogram (ERG) were studied and compared with the properties of the b-wave of the ERG and the proximal negative response (PNR). Both transretinal and intraretinal ERGs were recorded in response to full-field as well as 200 and 500 microgram sp...

journal_title：Investigative ophthalmology & visual science

authors： Wachtmeister L,Dowling JE

更新日期：1978-12-01 00:00:00

abstract：:One hypothesized cause of low-tension glaucoma is chronic or intermittent ischemia of the optic nerve. Since the optic nerve and brain are both parts of the central nervous system and share a common blood supply, the authors wondered if patients with low-tension glaucoma might also have clinical or radiographic eviden...

journal_title：Investigative ophthalmology & visual science

authors： Corbett JJ,Phelps CD,Eslinger P,Montague PR

更新日期：1985-08-01 00:00:00

abstract：Purpose:Melanopsin expressing intrinsically photosensitive retinal ganglion cells (ipRGC) input to multiple brain regions including those for pupil control, circadian rhythms, sleep and mood regulation. Here we measured ipRGC function and its relationship to sleep quality and depression in patients with advanced AMD. ...

journal_title：Investigative ophthalmology & visual science

authors： Maynard ML,Zele AJ,Kwan AS,Feigl B

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:This study sought to examine the acute effects of ocular ischemia and reperfusion on retinal function and determine the extent to which recovery during reperfusion is improved by allopurinol (AP), a blocker of xanthine oxidase (XO). The latter is presumed to be a major factor in the formation of free radicals a...

journal_title：Investigative ophthalmology & visual science

authors： Peachey NS,Green DJ,Ripps H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS:Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Matsui R,Sumaroka A,Cideciyan AV

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding. METHODS:Antibodies were used to identify ZO-1 in cultured rabbit corneal fibroblasts by immunocytochemistry, Western blot analysis, and immunoprecipitation. For colocalization studies, antibodies to beta-catenin, cad...

journal_title：Investigative ophthalmology & visual science

authors： Taliana L,Benezra M,Greenberg RS,Masur SK,Bernstein AM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To identify the defective gene in the sex-linked, recessively inherited retinal dysplasia and degeneration (rdd) chicken and to search for the human equivalent disease. METHODS:Microsatellites from chicken chromosome Z were genotyped in 77 progeny of a carrier male (rdd/+) and an affected female (rdd/W), and c...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Hocking PM,McKibbin M,Finnegan S,Shires M,Poulter JA,Prescott K,Booth A,Raashid Y,Jafri H,Ruddle JB,Mackey DA,Jacobson SG,Toomes C,Lester DH,Burt DW,Curry WJ,Inglehearn CF

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:To assess the effects of diabetes mellitus on corneal structure and function. METHODS:The authors measured endothelial permeability to fluorescein and corneal deswelling for 7.5 hours after 2 hours of hypoxic contact lens wear in 20 patients with diabetes who had nonproliferative retinopathy and 21 age-matched...

journal_title：Investigative ophthalmology & visual science

authors： Weston BC,Bourne WM,Polse KA,Hodge DO

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To investigate the nature and reversibility of biochemical and functional changes in the retina encountered over a single generation of dietary n-3 polyunsaturated fatty acid deficiency in guinea pigs. METHODS:Dunkin-Hartley guinea pigs were fed for 16 weeks after weaning with diets supplemented with safflower...

journal_title：Investigative ophthalmology & visual science

authors： Weisinger HS,Vingrys AJ,Bui BV,Sinclair AJ

更新日期：1999-02-01 00:00:00

abstract：:PURPOSE. To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). The authors postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid ...

journal_title：Investigative ophthalmology & visual science

authors： Kupersmith MJ,Sibony P,Mandel G,Durbin M,Kardon RH

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate the roles of caspase 1 and extracellular signal-regulated kinase (ERK) in inflammation-induced inhibition of lacrimal gland secretion. METHODS:Lacrimal gland inflammation was induced by injection of lipopolysaccharide (LPS; to study the role of caspase 1) or ...

journal_title：Investigative ophthalmology & visual science

authors： Zoukhri D,Ko S,Stark PC,Kublin CL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical...

journal_title：Investigative ophthalmology & visual science

authors： Taylor L,Moran D,Arnér K,Warrant E,Ghosh F

更新日期：2013-03-13 00:00:00

abstract：PURPOSE:To evaluate the contribution that fixation errors make to the overall variability of perimetric responses in patients with glaucoma. METHODS:Frequency of seeing curves were established, with and without fixation error correction, at two locations in each of 14 patients with glaucoma and good visual acuity. One...

journal_title：Investigative ophthalmology & visual science

authors： Henson DB,Evans J,Chauhan BC,Lane C

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:To assess the impact of glaucoma-related vision loss on measures of out-loud reading, including time to say individual words, interval time between consecutive words, lexical errors, skipped words, and repetitions. METHODS:Glaucoma subjects (n = 63) with bilateral visual field loss and glaucoma suspect control...

journal_title：Investigative ophthalmology & visual science

authors： Mathews PM,Rubin GS,McCloskey M,Salek S,Ramulu PY

更新日期：2015-03-03 00:00:00

abstract：PURPOSE:Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), which involves ocular, dental, and umbilical abnormalities. Identification of cis-regulatory elements of PITX2 is important to better understand the mechanisms of disease. METHODS:Conserved noncoding elements surrounding PITX2/pitx2 were id...

journal_title：Investigative ophthalmology & visual science

authors： Volkmann BA,Zinkevich NS,Mustonen A,Schilter KF,Bosenko DV,Reis LM,Broeckel U,Link BA,Semina EV

更新日期：2011-03-18 00:00:00

abstract：PURPOSE:Intraocular pressure (IOP) is dynamic and can be influenced by the use of tonometers. The authors developed a technique to implant a telemetric pressure transducer to measure IOP continuously in unrestrained rabbits. METHODS:A commercial telemetric pressure transducer was implanted subcutaneously on the dorsal...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF,FitzSimon JS

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population. METHODS:In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide poly...

journal_title：Investigative ophthalmology & visual science

authors： Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:Recently, it has been found that form deprivation myopia can be induced in fish (tilapia). This study examined the sensitivity of the tilapia eye to positive and negative lenses. It further investigated the sensitivity of the fish eye to form deprivation by examining the effect of fish weight. METHODS:Twenty-f...

journal_title：Investigative ophthalmology & visual science

authors： Shen W,Sivak JG

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To use a theoretical model of the observer on the Farnsworth-Munsell 100-hue test to estimate the magnitude of random variation in 100-Hue test error scores. METHODS:The model was based upon classical signal detection theory. Results from the model were obtained by computer simulation. RESULTS:There is a fair...

journal_title：Investigative ophthalmology & visual science

authors： Craven BJ

更新日期：1993-03-01 00:00:00

abstract：PURPOSE:To determine, with the use of optical coherence tomography (OCT), the peripapillary retinal nerve fiber layer (RNFL) thickness among patients with retinitis pigmentosa (RP) of different degrees of disease severity. METHODS:One eye in each of 25 RP patients was included. All patients underwent complete ocular e...

journal_title：Investigative ophthalmology & visual science

authors： Walia S,Fishman GA,Edward DP,Lindeman M

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:The virulence of any given strain of herpes simplex virus (HSV) is probably due to the effects of the constellation of genes in that strain and how they act in concert to promote disease. The goal of this work was to develop a system to identify and study the role of multiple genes in HSV disease. METHODS:Mixe...

journal_title：Investigative ophthalmology & visual science

authors： Brandt CR,Kolb AW,Shah DD,Pumfery AM,Kintner RL,Jaehnig E,Van Gompel JJ

更新日期：2003-06-01 00:00:00

abstract：Purpose:To compare in vivo lamina cribrosa (LC) strains (deformations) following acute IOP elevation in healthy, glaucoma, and ocular hypertensive subjects. Methods:There were 20 healthy, 20 high-tension primary open-angle glaucoma (POAG), 16 primary angle-closure glaucoma (PACG), and 20 ocular hypertensive (OHT; with...

journal_title：Investigative ophthalmology & visual science

authors： Beotra MR,Wang X,Tun TA,Zhang L,Baskaran M,Aung T,Strouthidis NG,Girard MJA

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To identify major gangliosides - the sialated glycolipids - of corneal epithelium; to determine which specific gangliosides, if any, are synthesized in a higher amount or are downregulated during corneal epithelial cell migration; and to determine what role, if any, they play in the modulation of corneal epithe...

journal_title：Investigative ophthalmology & visual science

authors： Yang Z,Zhao Z,Panjwani N

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:Autoimmune uveitis is a sight-threatening disease in which autoreactive T cells cross the blood-retinal barrier. Molecular mechanisms contributing to the loss of eye immune privilege in this autoimmune disease are not well understood. In this study, the authors investigated the changes in the matrix metalloprot...

journal_title：Investigative ophthalmology & visual science

authors： Hofmaier F,Hauck SM,Amann B,Degroote RL,Deeg CA

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00

abstract：PURPOSE:To study retinal microstructure in Usher Syndrome type 1B (USH1B) caused by MYO7A mutations as a prelude to treatment initiatives. METHODS:Patients with MYO7A-USH1B (n=17; ages 5-61) were studied with optical coherence tomography. Retinal laminae across horizontal and vertical meridians were measured. Colocali...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Aleman TS,Sumaroka A,Cideciyan AV,Roman AJ,Windsor EA,Schwartz SB,Rehm HL,Kimberling WJ

更新日期：2009-04-01 00:00:00