Ocular ischemia and the effects of allopurinol on functional recovery in the retina of the arterially perfused cat eye.

abstract：Purpose:To investigate the roles and pathways of microRNAs 143 and 145 in transforming growth factor (TGF)-β1-induced human subconjunctival fibrosis. Methods:Human tenon's capsule fibroblasts (HTFs) were obtained from a healthy eye. After treating cultured HTFs with TGF-β1, the expression of microRNAs 143 and 145 was ...

journal_title：Investigative ophthalmology & visual science

authors： Hwang YH,Jung SA,Lyu J,Kim YY,Lee JH

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:Slow oscillatory eye movements (SOMs) occur simultaneously with tremor, drifts, and microsaccades during visual fixation. In a previous study, the amplitude of SOM was found to be affected by the visual characteristics of the stimuli. This indicates a perceptual influence on the control of the movement. However...

journal_title：Investigative ophthalmology & visual science

authors： Zhang B,Bolzani R,Öqvist Seimyr G,Ygge J,Pansell T

更新日期：2013-12-11 00:00:00

abstract：:In their IOVS article "Rejuvenating Clinician-Scientist Training" (published March 28, 2014), Balamurali Ambati and Judd Cahoon rightly point out the dearth of new clinician-scientists in ophthalmology. Within the context of their suggestions for increasing the number of successful clinician-scientists, they claim tha...

journal_title：Investigative ophthalmology & visual science

authors： Culican SM,Rupp JD,Margolis TP

更新日期：2014-05-27 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Using a scanning laser ophthalmoscope, it was found that some patients with relative central scotomas reliably used two different preferred retinal loci (PRLs) at different stimulus illuminances. This article describes adaptations in a patient's PRL for fixation when dimming the stimulus increased the relative ...

journal_title：Investigative ophthalmology & visual science

authors： Lei H,Schuchard RA

更新日期：1997-08-01 00:00:00

abstract：:Quantitative autoradiography was used to study the incorporation of 3H-thymidine into the retina of albino rats following in vivo exposure to 300-nm radiation. Relative to background labeling in unexposed eyes, there was 8-20 times as much label per unit area in the outer nuclear layer, inner nuclear layer, and gangli...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Jose JG,Pitts DG

更新日期：1985-03-01 00:00:00

abstract：:Reaching a consensus in terms of interchangeability and utility (i.e., disease detection/monitoring) of a medical device is the eventual aim of repeatability and agreement studies. The aim of the tolerance and relative utility indices described in this report is to provide a methodology to compare change in clinical m...

journal_title：Investigative ophthalmology & visual science

authors： Bergin C,Guber I,Hashemi K,Majo F

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To investigate the potential use of amniotic membrane transplantation (AMT) in the construction of glaucoma filtering blebs. METHODS:Twenty-four albino rabbits underwent glaucoma filtration surgery in one eye. In alternate cases, the conjunctival flap was replaced with AMT. Postoperative examination data were ...

journal_title：Investigative ophthalmology & visual science

authors： Barton K,Budenz DL,Khaw PT,Tseng SC

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：Purpose:To compare the hemifield asymmetry of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) across all severity levels. Methods:A total of 522 eyes of 327 patients with POAG (mean age ± SD, 54.1 ± 12.4 years) and 375 eyes of 204 patients with PACG (67.3 ± 8.9 ye...

journal_title：Investigative ophthalmology & visual science

authors： Yousefi S,Sakai H,Murata H,Fujino Y,Garway-Heath D,Weinreb R,Asaoka R

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To determine whether dexamethasone (DEX)-induced ocular hypertension (OHT) in mice mimics the hallmarks of steroid-induced glaucoma (SIG) in humans, including reduced conventional outflow facility (C), increased extracellular matrix (ECM), and myofibroblasts within the outflow pathway. METHODS:Osmotic mini-pum...

journal_title：Investigative ophthalmology & visual science

authors： Overby DR,Bertrand J,Tektas OY,Boussommier-Calleja A,Schicht M,Ethier CR,Woodward DF,Stamer WD,Lütjen-Drecoll E

更新日期：2014-07-15 00:00:00

abstract：PURPOSE:This study aims to determine the in vivo effectiveness of low-frequency ultrasound in mediating the transport of macromolecules to the posterior segment of the eye via transscleral route. It investigates if damage is caused by ultrasound at the tested operation parameters on the posterior ocular tissues and vis...

journal_title：Investigative ophthalmology & visual science

authors： Suen WL,Wong HS,Yu Y,Lau LC,Lo AC,Chau Y

更新日期：2013-06-26 00:00:00

abstract：Purpose:To investigate whether rapamycin protects tear production and the ocular surface during endoplasmic reticulum (ER) stress-induced dry eye syndrome in mice. Methods:Tunicamycin was injected intraperitoneally in BALB/c mice without or with rapamycin (TM or RM5 group). Peritoneal injection of PBS performed in veh...

journal_title：Investigative ophthalmology & visual science

authors： Cho BJ,Hwang JS,Shin YJ,Kim JW,Chung TY,Hyon JY

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:The link between nasal-temporal motion asymmetries and anomalous binocular sensory function in infantile esotropia (ET) has led to the idea that visual evoked potential responses to horizontal motion (mVE) is an alternative measure of sensory binocularity to stereopsis. A second hypothesis is that the mVEP resp...

journal_title：Investigative ophthalmology & visual science

authors： Fawcett SL,Birch EE

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To determine the fate of donor epithelial, stromal, and endothelial cells after corneal transplantation in humans. METHODS:Fifty-two transplanted corneal buttons were explanted over a 2-year period from patients who required regrafting and had received corneas from donors of opposite sex. Fluorescence in situ ...

journal_title：Investigative ophthalmology & visual science

authors： Lagali N,Stenevi U,Claesson M,Fagerholm P,Hanson C,Weijdegård B,Swedish Society of Corneal Surgeons.

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:A prior study showed that cholinergic agonists activate phospholipase D (PLD). The purpose of this study was to determine whether cholinergic agonists use the PLD pathway to alter protein secretion and to identify the molecular signaling components of this pathway in rat lacrimal gland acini. METHODS:Rat lacri...

journal_title：Investigative ophthalmology & visual science

authors： Hodges RR,Guilbert E,Shatos MA,Natarajan V,Dartt DA

更新日期：2011-04-06 00:00:00

abstract：Purpose:To define the functional roles of Grk1 and Grk7 in zebrafish cones in vivo. Methods:Genome editing was used to generate grk7a and grk1b knockout zebrafish. Electroretinogram (ERG) analyses of the isolated cone mass receptor potential and the b-wave were performed in dark-adapted zebrafish using a paired flash ...

journal_title：Investigative ophthalmology & visual science

authors： Chrispell JD,Dong E,Osawa S,Liu J,Cameron DJ,Weiss ER

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Rabbits are used commonly for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The authors compared the accuracy and variability of three tonometers for measuring IOP in rabbits. METHODS:The anterior chamber of adult rabbits was cannulated with a 25-gauge needle connected to an elevated...

journal_title：Investigative ophthalmology & visual science

authors： Abrams LS,Vitale S,Jampel HD

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00

abstract：PURPOSE:To test whether eliprodil (SL 82.0715), a unique antagonist for the N-methyl-D-aspartate (NMDA) receptor, is protective in the glutamate-induced cytotoxicity model in cultured rat retinal ganglion cells (RGCs). METHODS:Two to four days after a fluorescent dye, Di-I, was injected near the superior colliculi, ne...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Wexler EM,Nawy S,DeSantis L,Kapin MA

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to use Raman spectra of tears to differentiate between infectious and noninfectious ulcerative keratitis. METHODS:Raman microspectroscopy was applied using the drop-coating deposition method on Ti/Au-coated glass slides to obtain sample spectra from different human tear groups, includ...

journal_title：Investigative ophthalmology & visual science

authors： Kuo MT,Lin CC,Liu HY,Yang MY,Chang HC

更新日期：2012-03-15 00:00:00

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro. METHODS:A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice t...

journal_title：Investigative ophthalmology & visual science

authors： Grimaldo S,Yuen D,Ecoiffier T,Chen L

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS:Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey ...

journal_title：Investigative ophthalmology & visual science

authors： Tham YC,Cheng CY,Zheng Y,Aung T,Wong TY,Cheung CY

更新日期：2013-11-05 00:00:00

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, ...

journal_title：Investigative ophthalmology & visual science

authors： Vera-Diaz FA,McGraw PV,Strang NC,Whitaker D

更新日期：2005-02-01 00:00:00

abstract：:The elastic fiber consists of several components: a central core of alpha-elastin and a microfibrillar sheath containing three components: fibrillin, microfibril-associated glycoprotein, and a 35-kD protein with amine oxidase activity. Elastin is a major component of the elastic fibers of the extracellular matrix (ECM...

journal_title：Investigative ophthalmology & visual science

authors： Hernandez MR

更新日期：1992-09-01 00:00:00

abstract：PURPOSE:The objective of the study was to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on the multifocal electroretinogram (mfERG) following an induced branch retinal vein occlusion (BRVO) in pigs. METHODS:Electrophysiological examination of the retina was performed in 20 pigs with stan...

journal_title：Investigative ophthalmology & visual science

authors： Ejstrup R,Cour Ml,Kyhn MV,Heegaard S,Kiilgaard JF

更新日期：2012-09-14 00:00:00