Objective Ocular Discomfort: Noninvasive Evaluation by Functional Near-Infrared Ray Spectroscopy.

abstract：PURPOSE:In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloproteinases (MMPs) also involve insulin-like gr...

journal_title：Investigative ophthalmology & visual science

authors： Lorenc VE,Jaldín-Fincati JR,Luna JD,Chiabrando GA,Sánchez MC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Amblyopia is the commonest visual disorder of childhood. Yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken to investigate the dose-response relationship of amblyopia therapy. METHODS:The study comprised three distinct phases: ...

journal_title：Investigative ophthalmology & visual science

authors： Stewart CE,Moseley MJ,Stephens DA,Fielder AR

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To study the topography of photoreceptor loss early in the course of Leber congenital amaurosis (LCA) caused by RPE65 mutations. METHODS:Young patients with RPE65-LCA (n = 9; ages, 6-17 years) were studied with optical coherence tomography (OCT) in a wide region of central retina. Outer nuclear layer (ONL) thi...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Aleman TS,Sumaroka A,Windsor EA,Schwartz SB,Heon E,Stone EM

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To assess the impact of zinc finger E-box binding homeobox 1 (ZEB1) gene mutations associated with posterior polymorphous corneal dystrophy 3 (PPCD3) and Fuchs' endothelial corneal dystrophy (FECD). METHODS:Thirteen of the 27 previously reported ZEB1 truncating mutations associated with PPCD3 and the six previ...

journal_title：Investigative ophthalmology & visual science

authors： Chung DW,Frausto RF,Ann LB,Jang MS,Aldave AJ

更新日期：2014-09-04 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:We studied morphologic changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS:Major retinal vessels in 35 eyes from 35 consecutive patients with acute CRVO were examined prospectively and longitudinally with sequentia...

journal_title：Investigative ophthalmology & visual science

authors： Muraoka Y,Tsujikawa A,Kumagai K,Akagi-Kurashige Y,Ogino K,Murakami T,Miyamoto K,Yoshimura N

更新日期：2014-01-07 00:00:00

abstract：PURPOSE:To evaluate the immunosuppressive and antiangiogenic activities of an intraocular rapamycin (RAPA) drug delivery system (DDS) in a rabbit model of high-risk penetrating keratoplasty. METHODS:Forty New Zealand White rabbits with corneal neovascularization underwent allograft cornea transplantation and were rand...

journal_title：Investigative ophthalmology & visual science

authors： Shi W,Gao H,Xie L,Wang S

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). METHODS:Paired explants were used as control versus VIP (10 nM)-treated before storage in corne...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Gloria D,Molloy J

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To describe and evaluate a new experimental reference plane for measuring rim area in scanning laser tomography. METHODS:The experimental reference plane was positioned so that (1) it always lay entirely below the margin of the optic nerve head (ONH), (2) it remained at a set z-axis distance below the ONH in i...

journal_title：Investigative ophthalmology & visual science

authors： Tan JC,Hitchings RA

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:The majority of patients with X chromosome-linked retinitis pigmentosa (XlRP) carry mutations in the RPGR gene. The authors studied whether patients with RPGR mutations show additional splice defects that may interfere with RPGR properties. METHODS:Patient-derived cell lines with RPGR mutations were raised in ...

journal_title：Investigative ophthalmology & visual science

authors： Schmid F,Glaus E,Cremers FP,Kloeckener-Gruissem B,Berger W,Neidhardt J

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：:Increased vascular permeability, one of the characteristic features of immediate hypersensitivity (Type I), is mediated through a variety of compounds, including histamine and platelet-activating factor (PAF), a phospholipid inflammatory mediator. The effects on vascular permeability of histamine, PAF, and ethanol, th...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Roth SI,Kim ED,Walsh MK,Thamman R

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes. METHODS:Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age- and sex-matched nondiabetic, nonglauc...

journal_title：Investigative ophthalmology & visual science

authors： Jeon SJ,Kwon JW,La TY,Park CK,Choi JA

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), which involves ocular, dental, and umbilical abnormalities. Identification of cis-regulatory elements of PITX2 is important to better understand the mechanisms of disease. METHODS:Conserved noncoding elements surrounding PITX2/pitx2 were id...

journal_title：Investigative ophthalmology & visual science

authors： Volkmann BA,Zinkevich NS,Mustonen A,Schilter KF,Bosenko DV,Reis LM,Broeckel U,Link BA,Semina EV

更新日期：2011-03-18 00:00:00

abstract：PURPOSE:To test the effects of genistein on choriocapillaris regeneration and retinal pigment epithelial (RPE) wound healing in a surgical model in the rabbit. METHODS:Intravitreal injections of either 0.1 ml of a 90-microM concentration of genistein, dimethyl sulfoxide (DMSO; negative control), or 2 microg cyclohexim...

journal_title：Investigative ophthalmology & visual science

authors： Majji AB,Hayashi A,Kim HC,Grebe RR,de Juan E Jr

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To determine whether blood pressure and subclinical atherosclerosis are associated with incident age-related maculopathy (ARM). METHODS:The study was performed within the Rotterdam Study, a population-based, prospective cohort study in Rotterdam, The Netherlands. A total of 4822 subjects who at baseline were a...

journal_title：Investigative ophthalmology & visual science

authors： van Leeuwen R,Ikram MK,Vingerling JR,Witteman JC,Hofman A,de Jong PT

更新日期：2003-09-01 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：Purpose:To investigate the effects of tear film instability (TFI) induced by sustained tear exposure (STARE) on sensory responses to corneal cold, mechanical, and chemical stimuli. Methods:Fifteen normal subjects were enrolled. TFI was induced during 10 repeated trials of STARE. Pneumatic cold, mechanical, and chemica...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Begley CG,Simpson TL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To assess if the in vivo mechanical displacement of the anterior laminar cribrosa surface (ALCS) as a response of an acute elevation in intraocular pressure (IOP) differs in individuals of European (ED) and African descent (AD). METHODS:Spectral-domain optical coherence tomography (SDOCT) scans were obtained f...

journal_title：Investigative ophthalmology & visual science

authors： Fazio MA,Johnstone JK,Smith B,Wang L,Girkin CA

更新日期：2016-06-01 00:00:00

abstract：Purpose:Rose bengal (RB)-photosensitized protein crosslinking has been proposed for several applications in the eye. This study identifies oxygen-dependent and oxygen-independent mechanistic pathways in cornea for RB-photosensitized crosslinking to enhance its efficiency for ocular treatments. Methods:Rabbit corneas e...

journal_title：Investigative ophthalmology & visual science

authors： Wertheimer CM,Elhardt C,Kaminsky SM,Pham L,Pei Q,Mendes B,Afshar S,Kochevar IE

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:The RAS association domain family 1 (RASSF1) gene is a tumor-suppressor gene located on chromosome 3p21.3. The alternative transcript (RASSF1a) has been shown to be inactivated by hypermethylation in several human malignancies, including breast, prostate, and lung cancer, and in cutaneous melanoma. The purpose ...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,van der Velden PA,Out-Luiting C,Plug M,Dirks-Mulder A,Jager MJ,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:To evaluate a porcine anterior chamber perfusion model and to test the transferability of data obtained with this model to the human system. METHODS:Porcine eyes were obtained from a local abattoir and processed within 2 hours after death. Anterior chambers of 42 pairs of eyes were dissected with removal of le...

journal_title：Investigative ophthalmology & visual science

authors： Bachmann B,Birke M,Kook D,Eichhorn M,Lütjen-Drecoll E

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response in Behçet's disease (BD) patients and the possible mechanisms involved. METHODS:Naive CD4(+) T cells from active BD patients and norm...

journal_title：Investigative ophthalmology & visual science

authors： Tian Y,Wang C,Ye Z,Xiao X,Kijlstra A,Yang P

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To evaluate the refractive status and optical components in school age children born prematurely and to examine the risk factors associated with refractive errors. METHODS:The participants were a cohort of children aged 7 to 9 years with gestational age less than 35 weeks or birth weight less than 1500 g. The ...

journal_title：Investigative ophthalmology & visual science

authors： Chen TC,Tsai TH,Shih YF,Yeh PT,Yang CH,Hu FC,Lin LL,Yang CM

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：:The rhodopsin content of the human retina was determined spectrophotometrically. Retinas were removed completely by using an in vitro technique based on a simulation of retinal detachment. This method provides a total recovery of rod outer segments which contain the rhodopsin visual pigment or its apoprotein, opsin. U...

journal_title：Investigative ophthalmology & visual science

authors： van Kuijk FJ,Lewis JW,Buck P,Parker KR,Kliger DS

更新日期：1991-06-01 00:00:00

abstract：:Visual thresholds and rhodopsin levels were determined in nine subjects with autosomal dominant retinitis pigmentosa. The subjects fell into two groups, corresponding to two subtypes of the disease revealed by two-color, dark-adapted static perimetry. In the first of these subtypes, rod-mediated function was variably ...

journal_title：Investigative ophthalmology & visual science

authors： Kemp CM,Jacobson SG,Faulkner DJ

更新日期：1988-08-01 00:00:00