Aggregation in aqueous solutions of bovine lens gamma-crystallins: special role of gamma(s).

abstract：PURPOSE:To assess the scene gist recognition in eyes with age-related macular degeneration (AMD) and to study the relationship between scene recognition and macular function. METHODS:Twenty-seven patients with age-related macular degeneration with a visual acuity lower than 20/50 and 17 age-matched controls were inclu...

journal_title：Investigative ophthalmology & visual science

authors： Tran TH,Rambaud C,Despretz P,Boucart M

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the repeatability of manual measurements of choroidal thickness in healthy subjects imaged on spectral domain optical coherence tomography (OCT) using the enhanced depth imaging (EDI) technique. METHODS:Fifty consecutive, healthy, young, adult volunteers with no known e...

journal_title：Investigative ophthalmology & visual science

authors： Rahman W,Chen FK,Yeoh J,Patel P,Tufail A,Da Cruz L

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:To determine some of the mechanisms by which substance P (SP) induces contraction in the isolated rat iris. METHODS:Rings of rat iris were mounted in a 5-ml organ chamber containing Krebs solution at 37 degrees C under basal tension of 75 mg, and isometric tension was recorded. RESULTS:Substance P produced gr...

journal_title：Investigative ophthalmology & visual science

authors： Grumann-Júnior A,Dias MA,Alves RV,Boteon JE,Calixto JB

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:The inhibition of angiogenesis by angiostatic steroids has been demonstrated in a variety of systems, including rabbit and rat cornea. There is considerable interest in the therapeutic potential of this class of compounds for angiogenic ocular conditions such as diabetic retinopathy, macular degeneration, and r...

journal_title：Investigative ophthalmology & visual science

authors： Penn JS,Rajaratnam VS,Collier RJ,Clark AF

更新日期：2001-01-01 00:00:00

abstract：:The relationship between intraocular and systemic blood pressures was investigated in a prospective study of 572 middle-aged men. There was no consistent relationship between intraocular pressure at first visit and age. Subjects with an intraocular pressure greater than 20 mm Hg had a significantly higher systolic blo...

journal_title：Investigative ophthalmology & visual science

authors： McLeod SD,West SK,Quigley HA,Fozard JL

更新日期：1990-11-01 00:00:00

abstract：:The unscarified corneas of rabbits were inoculated with 50 microliter of 2-4 X 10(6) PFU/ml of herpes simplex virus, type 1 (HSV-1), McKrae strain in 10 separate experiments over a 12-month period. Sixty of 104 (57.7%) rabbits survived to postinoculation (PI) day 20. These sixty rabbits were swabbed with dacron-tipped...

journal_title：Investigative ophthalmology & visual science

authors： Berman EJ,Hill JM

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:To compare the prophylactic effects of intravenous moxifloxacin and vancomycin for Staphylococcus epidermidis endophthalmitis in a rabbit model. METHODS:Albino rabbits (n = 60) were divided into three groups. Intravenous moxifloxacin was injected into 20 animals (group 1), and intravenous vancomycin was inject...

journal_title：Investigative ophthalmology & visual science

authors： Kim JY,Kim SY

更新日期：2011-03-25 00:00:00

abstract：PURPOSE:The inner vasculature of the retina develops as a spreading network, which is preceded by spindle-shaped cells. These cells are alleged to be vascular precursor cells (angioblasts). This study was designed to test whether such angioblasts exist in neonatal mouse retina. METHODS:In situ hybridization and immuno...

journal_title：Investigative ophthalmology & visual science

authors： Fruttiger M

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To investigate the neuroprotective effects of brain-derived neurotrophic factor (BDNF) against potassium cyanide (KCN)-induced retinal damage. METHODS:Rats were injected intravitreally with iodinated BDNF. Two days later, eyeballs were dissected into various parts, and the level of radioactivity in each part w...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda K,Tanihara H,Honda Y,Tatsuno T,Noguchi H,Nakayama C

更新日期：1999-08-01 00:00:00

abstract：PURPOSE:To investigate the effect of hyperbaric oxygen (HBO) chamber treatment in mouse models of retinal ischemia. METHODS:Unilateral central retinal artery occlusion (CRAO) or optic nerve crush (ONC) was induced in 50 mice each, of which 30 were treated with 100% oxygen at 2 atm for 90 minutes immediately after inju...

journal_title：Investigative ophthalmology & visual science

authors： Gaydar V,Ezrachi D,Dratviman-Storobinsky O,Hofstetter S,Avraham-Lubin BC,Goldenberg-Cohen N

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Reports of lymphatics in the posterior human uvea are contradictory. We systematically analyzed the choroid by combining various lymphatic markers, following recently established guidelines for the immunohistochemical detection of ocular lymphatics. METHODS:Human choroids were prepared for flat mount serial cr...

journal_title：Investigative ophthalmology & visual science

authors： Schrödl F,Kaser-Eichberger A,Trost A,Strohmaier C,Bogner B,Runge C,Motloch K,Bruckner D,Laimer M,Heindl LM,Reitsamer HA

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:Lenses from selenite-treated animals develop reversible "cold cataract" at a lower temperature than is required for lenses from age-matched control animals. This unexplained, stabilized phase transition is readily observed in intact lenses 36 to 48 hours after treatment and occurs in lenses before the appearanc...

journal_title：Investigative ophthalmology & visual science

authors： Mitton KP,Hess JL,Bunce GE

更新日期：1995-04-01 00:00:00

abstract：Purpose:Retinal nonperfusion and hypoxia are important factors in human diabetic retinopathy, and these presumably inhibit energy production and lead to cell death. The purpose of this study was to elucidate the effect of diabetes on inner retinal oxygen delivery and metabolism in a mouse model of diabetes. Methods:Ph...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Wanek J,Felder AE,Brewer KC,Joslin CE,Shahidi M

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To determine the functional contribution of retinoic acid receptor (RAR)-alpha in the developing murine neural retina, through a phenotypic analysis of the corresponding null mutants. METHODS:RARalpha mutant (Rara(-/-)) mice were compared with wild-type littermates at several stages of pre- and postnatal devel...

journal_title：Investigative ophthalmology & visual science

authors： Cammas L,Trensz F,Jellali A,Ghyselinck NB,Roux MJ,Dollé P

更新日期：2010-06-01 00:00:00

abstract：:The metabolism of the polyunsaturated fatty acid, arachidonic acid (20:4, n-6) in rabbit cornea with varying severities of herpes simplex viral infection was investigated. The results indicate an active synthesis of the lipoxygenase and cyclooxygenase reaction products of arachidonic acid in central cornea and corneal...

journal_title：Investigative ophthalmology & visual science

authors： Birkle DL,Sanitato JJ,Kaufman HE,Bazan NG

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:Human brain generates miniature eye movements, such as microsaccades, to counteract image fading due to visual adaptation. Generation of microsaccade relies on the amount of retinal error or acuity demand for a desired visual task. The goal of this study was to assess the influence of visual blur, induced by un...

journal_title：Investigative ophthalmology & visual science

authors： Ghasia FF,Shaikh AG

更新日期：2015-04-01 00:00:00

abstract：:Horseradish peroxidase has been injected into the dorsal lateral geniculate nucleus of macaque monkeys to label ganglion cells of the retina by retrograde axoplasmic transport. Displaced ganglion cells, with somata in the inner nuclear layer and dendrites in the inner plexiform layer, were detected by virtue of their ...

journal_title：Investigative ophthalmology & visual science

authors： Bunt AH,Minckler DS

更新日期：1977-01-01 00:00:00

abstract：:Ocular adenoviral infections occur worldwide, and currently, there is no ocular animal model for evaluating new antivirals or studying pathogenesis. With a paired-eye design, an ocular model was developed in 32 New Zealand rabbits following topical and intrastromal inoculation with a clinical isolate of adenovirus typ...

journal_title：Investigative ophthalmology & visual science

authors： Gordon YJ,Romanowski E,Araullo-Cruz T

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:Age-related nuclear cataracts involve denaturation and aggregation of intracellular proteins. We have documented age-dependent changes in membrane transport in the mouse lens to see what might initiate changes in the intracellular milieu. METHODS:Microelectrode-based intracellular impedance studies of intact l...

journal_title：Investigative ophthalmology & visual science

authors： Gao J,Wang H,Sun X,Varadaraj K,Li L,White TW,Mathias RT

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:To map the spatiotemporal decline in retinally driven activity in the superior colliculus (SC) of transgenic S334ter-line-3 rats that express a mutated rhodopsin, which causes photoreceptor degeneration. To determine whether transplantation of fetal retinal sheets into the subretinal space of these rats can rec...

journal_title：Investigative ophthalmology & visual science

authors： Sagdullaev BT,Aramant RB,Seiler MJ,Woch G,McCall MA

更新日期：2003-04-01 00:00:00

abstract：Purpose:To assess changes in Schlemm's canal (SC), intraocular pressure (IOP), and autonomic nervous system activity in healthy individuals after performing the water-drinking test (WDT). Methods:The SC area (SCAR), trabecular meshwork (TM) thickness, IOP, high frequency (HF) of heart rate variability (HRV), heart rat...

journal_title：Investigative ophthalmology & visual science

authors： Chen W,Chen L,Chen Z,Xiang Y,Liu S,Zhang H,Wang J

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability to reproduce an organized matrix in vit...

journal_title：Investigative ophthalmology & visual science

authors： Kureshi AK,Funderburgh JL,Daniels JT

更新日期：2014-10-21 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal neovascularization. METHODS:C57BL/6 oxygen-induced retinopathy (OIR) mice and human retinal microvascular endothelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Hu J,Song X,He YQ,Freeman C,Parish CR,Yuan L,Yu H,Tang S

更新日期：2012-10-03 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence ...

journal_title：Investigative ophthalmology & visual science

authors： Moreira EF,Larrayoz IM,Lee JW,Rodríguez IR

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：Purpose:Mutations in the retinitis pigmentosa-1-like-1 (RP1L1) gene are the major cause of autosomal dominant occult macular dystrophy (OCMD), while recessive mutations have been linked to autosomal recessive retinitis pigmentosa (arRP). We present the clinical phenotype of a large German OCMD cohort, as well as four R...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Zobor G,Hipp S,Baumann B,Weisschuh N,Biskup S,Sliesoraityte I,Zrenner E,Kohl S

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To develop a novel in vitro model to study the formation of Staphylococcus epidermidis biofilm on intraocular lenses (IOLs) from the primary-attachment phase to the biofilm-accumulation phase. The model was designed to replicate intraocular conditions especially by taking into account intraocular hydrodynamics....

journal_title：Investigative ophthalmology & visual science

authors： Baillif S,Casoli E,Marion K,Roques C,Pellon G,Hartmann DJ,Freney J,Burillon C,Kodjikian L

更新日期：2006-08-01 00:00:00