Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina.

abstract：PURPOSE:The main purpose of this study was to develop a cell culture model of immortalized epithelium from the human cornea for drug permeability testing. METHODS:Immortalized human corneal epithelial (HCE) cells were grown on filters, with various filter materials and coating procedures. In the optimal case, HCE cell...

journal_title：Investigative ophthalmology & visual science

authors： Toropainen E,Ranta VP,Talvitie A,Suhonen P,Urtti A

更新日期：2001-11-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:Protein kinase C α (PKCα) is abundantly expressed in rod bipolar cells (RBCs) in the retina, yet the physiological function of PKCα in these cells is not well understood. To elucidate the role of PKCα in visual processing in the eye, we examined the effect of genetic deletion of PKCα on the ERG and on RBC light...

journal_title：Investigative ophthalmology & visual science

authors： Xiong WH,Pang JJ,Pennesi ME,Duvoisin RM,Wu SM,Morgans CW

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a history of cataract and cataract surgery (self-report and for a sibling), and to determine which demographic, cognitive, and medical factors are predictive of an accurate history. METHODS:All participants in the Salisbury Eye Evaluation (SEE) project and their locally resident si...

journal_title：Investigative ophthalmology & visual science

authors： Bowie H,Congdon NG,Lai H,West SK

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS:Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tis...

journal_title：Investigative ophthalmology & visual science

authors： Kadkol SS,Lin AY,Barak V,Kalickman I,Leach L,Valyi-Nagy K,Majumdar D,Setty S,Maniotis AJ,Folberg R,Pe'er J

更新日期：2006-03-01 00:00:00

abstract：:The morphology of the apical surface of rabbit retinal pigment epithelium was studied by scanning electron microscopy from the first minute to several hours after making small nonrhegmatogenous retinal detachments (blebs). From 0 to 5 min, there were only slight changes in the homogeneous, dense mat of filamentous mic...

journal_title：Investigative ophthalmology & visual science

authors： Immel J,Negi A,Marmor MF

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:To describe lacrimal gland involvement in a murine model of acute graft-versus-host disease (GVHD). METHODS:Histopathologic examination was performed on lacrimal glands of mice affected by GVHD at 1, 2, 4, and 6 weeks after allogeneic bone marrow transplantation (BMT). Histopathologic scoring, based on charact...

journal_title：Investigative ophthalmology & visual science

authors： Hassan AS,Clouthier SG,Ferrara JL,Stepan A,Mian SI,Ahmad AZ,Elner VM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00

abstract：PURPOSE:Intramuscular innervation of horizontal rectus extraocular muscle (EOMs) is segregated into superior and inferior (transverse) compartments, whereas all EOMs are also divided into global (GL) and orbital (OL) layers with scleral and pulley insertions, respectively. Mechanical independence between both types of ...

journal_title：Investigative ophthalmology & visual science

authors： Shin A,Yoo L,Demer JL

更新日期：2014-12-11 00:00:00

abstract：PURPOSE:To determine which components present in oxidized LDL are responsible for the cytotoxicity associated with its internalization by culture ARPE19 cells. METHODS:ARPE19 cells were grown in 24-well and 96-well plates. Cell viability was measured by MTT and/or adenosine triphosphate (ATP) content. LDL was oxidized...

journal_title：Investigative ophthalmology & visual science

authors： Rodriguez IR,Alam S,Lee JW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model. METHODS:Scrape injury was induced in the corneal endothelium, and immunolabeling (ZO-1, alpha-SMA, Cx43) was performed to analyze changes in Cx43 expression during woun...

journal_title：Investigative ophthalmology & visual science

authors： Nakano Y,Oyamada M,Dai P,Nakagami T,Kinoshita S,Takamatsu T

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS:Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of ...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Siemers E,Abel LA,Yee RD

更新日期：2000-07-01 00:00:00

abstract：:Purpose. To establish a theoretical model to determine the relationship between retinal coverage and tamponade shape in relation to tamponade volume, for a variety of tamponades, and to test these relationships with a physical analogue of the human eye. Methods. The theoretical model was based on a static balance betw...

journal_title：Investigative ophthalmology & visual science

authors： Eames I,Angunawela RI,Aylward GW,Azarbadegan A

更新日期：2010-04-01 00:00:00

abstract：:The extracellular matrix of retinal pigment epithelial (RPE) cells is an important component of the fibroelastic membranes formed in proliferative vitreoretinopathy (PVR). These membranes consist of cells intermingled with fibrillar proteins, such as elastin and collagen. Because RPE cells may be exposed to vitreous a...

journal_title：Investigative ophthalmology & visual science

authors： Martini B,Pandey R,Ogden TE,Ryan SJ

更新日期：1992-03-01 00:00:00

abstract：:Exposure of adult male and female albino rats to high-intensity illumination for 17.5 hr results in a marked, transient exophthalmos, which persists for approximately 48 hr after the light exposure. Upon examination of the Harderian glands in these rats, a significant glandular weight increase was observed up to 2 day...

journal_title：Investigative ophthalmology & visual science

authors： Johnson DD,Rudeen PK,O'Steen WK

更新日期：1979-12-01 00:00:00

abstract：PURPOSE:To evaluate the short- and long-term changes of focal macular electroretinograms (fmERGs) after macular translocation with 360 degrees retinotomy. METHODS:This was a retrospective study. fmERGs were recorded in 19 eyes of 19 consecutive patients who underwent macular translocation with 360 degrees retinotomy f...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Ishikawa K,Niwa Y,Piao CH,Niwa T,Kondo M,Ito Y,Miyake Y

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. METHODS:The binding affinities and agonistic activities of ONO-AG-367, a carboxy...

journal_title：Investigative ophthalmology & visual science

authors： Yamane S,Karakawa T,Nakayama S,Nagai K,Moriyuki K,Neki S,Suto F,Kambe T,Hirota Y,Kawabata K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the express...

journal_title：Investigative ophthalmology & visual science

authors： Alge CS,Priglinger SG,Neubauer AS,Kampik A,Zillig M,Bloemendal H,Welge-Lussen U

更新日期：2002-11-01 00:00:00

abstract：Purpose:To test the hypothesis that emmetropization buffers against genetic and environmental risk factors for myopia by investigating whether risk factor effect sizes vary depending on children's position in the refractive error distribution. Methods:Refractive error was assessed in participants from two birth cohort...

journal_title：Investigative ophthalmology & visual science

authors： Pozarickij A,Enthoven CA,Ghorbani Mojarrad N,Plotnikov D,Tedja MS,Haarman AEG,Tideman JWL,Polling JR,Northstone K,Williams C,Klaver CCW,Guggenheim JA

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment and can be modeled by optic nerve transection, which causes the death of 90% of RGCs within 14 days postaxotomy. We performed a proteomic study to identify and quantify proteins in the rat retina after optic nerve transection. O...

journal_title：Investigative ophthalmology & visual science

authors： Hollander A,D'Onofrio PM,Magharious MM,Lysko MD,Koeberle PD

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. METHODS:Hepc KO mice were given DFP in ...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Zhao L,Li Y,Hadziahmetovic M,Song Y,Connelly J,Spino M,Dunaief JL

更新日期：2014-06-26 00:00:00

abstract：PURPOSE:The majority of patients with X chromosome-linked retinitis pigmentosa (XlRP) carry mutations in the RPGR gene. The authors studied whether patients with RPGR mutations show additional splice defects that may interfere with RPGR properties. METHODS:Patient-derived cell lines with RPGR mutations were raised in ...

journal_title：Investigative ophthalmology & visual science

authors： Schmid F,Glaus E,Cremers FP,Kloeckener-Gruissem B,Berger W,Neidhardt J

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate in rabbits the relationship between nitric oxide and the noncholinergic vasodilation caused by facial nerve stimulation in the eye and some extraocular tissues. METHODS:Uveal vascular resistance was determined by measuring simultaneously the flow from a cannulated vorte...

journal_title：Investigative ophthalmology & visual science

authors： Nilsson SF

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

journal_title：Investigative ophthalmology & visual science

authors： Burroughs SL,Kaja S,Koulen P

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear m...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Löfgren S,Saether O,Mody V,Meyer L,Dong X,Söderberg PG,Midelfart A

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:There are two human 15-lipoxygenases (LOX), 15-LOX-1 and -2, which convert arachidonic acid to 15S-hydroxyeicosatetraenoic acid (15S-HETE). The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium. METHODS:Human corneal epithelia from donor c...

journal_title：Investigative ophthalmology & visual science

authors： Chang MS,Schneider C,Roberts RL,Shappell SB,Haselton FR,Boeglin WE,Brash AR

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Retinal ganglion cells (RGCs) die as a result of axonal injury in a variety of optic neuropathies, including glaucoma. Reactive oxygen species (ROS) act as intracellular signaling molecules and initiate apoptosis in nerve growth factor-deprived sympathetic neurons and axotomized RGCs. Determination of the role ...

journal_title：Investigative ophthalmology & visual science

authors： Schlieve CR,Lieven CJ,Levin LA

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure. METHODS:Sixty OCT image sets (of six radial lines each) were independently analyzed...

journal_title：Investigative ophthalmology & visual science

authors： Joeres S,Tsong JW,Updike PG,Collins AT,Dustin L,Walsh AC,Romano PW,Sadda SR

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European populati...

journal_title：Investigative ophthalmology & visual science

authors： Beatty S,Murray IJ,Henson DB,Carden D,Koh H,Boulton ME

更新日期：2001-02-01 00:00:00