Reduction of apoptosis in ischemic retinas of two mouse models using hyperbaric oxygen treatment.

abstract：PURPOSE:To explore the maximum retinal vasodilation in response to repeated flicker light stimulation in relation to vasospastic propensity in healthy subjects. METHODS:Twenty-four young healthy women were grouped as vasospastic and nonvasospastic, based on their history of cold extremities and on the results of nailf...

journal_title：Investigative ophthalmology & visual science

authors： Gugleta K,Zawinka C,Rickenbacher I,Kochkorov A,Katamay R,Flammer J,Orgul S

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To investigate the role of macrophages in the development of laser-induced choroidal neovascularization (CNV) by selective depletion with liposomal clodronate (Cl(2)MDP-LIP). METHODS:Laser photocoagulation was used to induce CNV in wild-type C57BL/6J mice. Animals were treated with intravenous (IV) and/or su...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Anand A,Ambati BK,van Rooijen N,Ambati J

更新日期：2003-08-01 00:00:00

abstract：:The integrity of the RPE barrier function in retinal detachment was studied in vitro. The retinal pigment epithelium (RPE)-choroid tissue was isolated from cynomolgus monkey eyes with acute (less than 1 hr), subacute (1-2 weeks), and chronic (8-20 months) retinal detachments, and clamped between Ussing-type chambers. ...

journal_title：Investigative ophthalmology & visual science

authors： Tsuboi S,Pederson JE,Toris CB

更新日期：1987-11-01 00:00:00

abstract：:Voluntary vertical saccades were recorded in five normal human subjects with electro-oculography (EOG), an infrared, limbus tracking system (IR), and a magnetic scleral search coil method. The peak velocity-amplitude relationships of up and down saccades were measured during refixations across the center of the orbit ...

journal_title：Investigative ophthalmology & visual science

authors： Yee RD,Schiller VL,Lim V,Baloh FG,Baloh RW,Honrubia V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:Retinal injury induces Müller cell dedifferentiation by activating extracellular signal-regulated kinase (ERK) signaling. Stimulation of α2-adrenergic receptors protects against injury but also activates ERK in Müller cells. The purpose of this work was to study the effect of α2-adrenergic signaling on injury-i...

journal_title：Investigative ophthalmology & visual science

authors： Harun-Or-Rashid M,Díaz-DelCastillo M,Galindo-Romero C,Hallböök F

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to identify target antigens of autoimmune keratitis with a disease-prone mouse model. METHODS:BALB/c nude mice grafted with embryonic rat thymi (TG nude mice) develop various organ-localized autoimmune lesions, including keratitis. A hybridoma producing a monoclonal antibody (OT-2...

journal_title：Investigative ophthalmology & visual science

authors： Hattori T,Takeuchi M,Ohno K,Ogawara M,Asatani T,Usui Y,Muramatsu R,Inagaki M,Usui M,Taguchi O

更新日期：2006-01-01 00:00:00

abstract：:Hypothesis-driven science is expected to result in a continuum of studies and findings along a discrete path. By comparison, serendipity can lead to new directions that branch into different paths. Herein, I describe a diverse series of findings that were motivated by hypotheses, but driven by serendipity. I summarize...

journal_title：Investigative ophthalmology & visual science

authors： Fischer AJ

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Cystinosis is caused by a deficiency in the lysosomal cystine transporter, cystinosin (CTNS gene), resulting in cystine crystal accumulation in tissues. In eyes, crystals accumulate in the cornea causing photophobia and eventually blindness. Hematopoietic stem progenitor cells (HSPCs) rescue the kidney in a mou...

journal_title：Investigative ophthalmology & visual science

authors： Rocca CJ,Kreymerman A,Ur SN,Frizzi KE,Naphade S,Lau A,Tran T,Calcutt NA,Goldberg JL,Cherqui S

更新日期：2015-11-01 00:00:00

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:The selective muscarinic antagonist pirenzepine inhibits experimentally induced myopia in avian and mammalian species, including nonhuman primates and adolescent humans. Transient positive lens defocus has a potent inhibitory effect on negative-lens-induced myopia in avian and mammalian models. The purpose of t...

journal_title：Investigative ophthalmology & visual science

authors： Metlapally S,McBrien NA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:There is no consensus as how to calculate orbital soft tissue volume based on CT or MRI scans. The authors sought to validate their technique and to assess the intraobserver and interobserver variability of their calculations of bony orbital volume (OV), orbital fat volume (FV), and extraocular muscle volume (M...

journal_title：Investigative ophthalmology & visual science

authors： Regensburg NI,Kok PH,Zonneveld FW,Baldeschi L,Saeed P,Wiersinga WM,Mourits MP

更新日期：2008-05-01 00:00:00

abstract：Purpose:This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods:A total of 64 eyes (45 ED, 19 ...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Yang H,Reynaud J,Burgoyne CF,Smith B,Wang L,Downs JC

更新日期：2017-07-01 00:00:00

abstract：Purpose:Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods:Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, durati...

journal_title：Investigative ophthalmology & visual science

authors： Ferdousi M,Petropoulos IN,Kalteniece A,Azmi S,Ponirakis G,Efron N,Soran H,Malik RA

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra; Pfizer, New York, NY), a selective phosphodiesterase type-5 (PDE5) inhibitor, is widely used to treat impotence by improving penile blood flow via elevation of cGMP. However, its effect on ocular circulation is controversial and whether retinal arterioles are responsive to this drug remains ...

journal_title：Investigative ophthalmology & visual science

authors： Yuan Z,Hein TW,Rosa RH Jr,Kuo L

更新日期：2008-02-01 00:00:00

abstract：Purpose:To develop deep learning (DL) models for the automatic detection of optical coherence tomography (OCT) measures of diabetic macular thickening (MT) from color fundus photographs (CFPs). Methods:Retrospective analysis on 17,997 CFPs and their associated OCT measurements from the phase 3 RIDE/RISE diabetic macul...

journal_title：Investigative ophthalmology & visual science

authors： Arcadu F,Benmansour F,Maunz A,Michon J,Haskova Z,McClintock D,Adamis AP,Willis JR,Prunotto M

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Erythropoietin (EPO) modulates erythropoiesis by inhibiting apoptosis in erythrocyte progenitors. Recently, EPO has been shown to be protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial. However, little is known about EPO sign...

journal_title：Investigative ophthalmology & visual science

authors： Weishaupt JH,Rohde G,Pölking E,Siren AL,Ehrenreich H,Bähr M

更新日期：2004-05-01 00:00:00

abstract：Purpose:To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina and lamina cribrosa (LC) in vivo. Methods:Clinical data of 20 healthy, 20 ocular hypertensive (OHT), 20 primary open-angle glaucoma, and 16 primary angle-closure glaucoma eyes were analyzed. For ea...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Beotra MR,Baskaran M,Tun TA,Wang X,Perera SA,Strouthidis NG,Aung T,Boote C,Girard MJA

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:Nystagmus, head nodding, and anomalous head position are symptoms of spasmus nutans. This disorder appears in early childhood and is thought to be self-limited. However, the visual outcome of patients with spasmus nutans is unclear. The resolution of nystagmus has not been proven with quantitative eye movement ...

journal_title：Investigative ophthalmology & visual science

authors： Gottlob I,Wizov SS,Reinecke RD

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. Evidence suggests oxidative stress plays a role in the disease. To assess the potential contribution of epigenetic regulation of antioxidant genes relevant to AMD pathogenesis, we evaluated DNA methylation, a tissue-specifi...

journal_title：Investigative ophthalmology & visual science

authors： Hunter A,Spechler PA,Cwanger A,Song Y,Zhang Z,Ying GS,Hunter AK,Dezoeten E,Dunaief JL

更新日期：2012-04-24 00:00:00

abstract：PURPOSE:Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has be...

journal_title：Investigative ophthalmology & visual science

authors： Dieckow J,Brandt W,Hattermann K,Schob S,Schulze U,Mentlein R,Ackermann P,Sel S,Paulsen FP

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Targeted drug delivery to the ocular tissues remains a challenge. Biodegradable intraocular implants allow prolonged controlled release of drugs directly into the eye. In this study, we evaluated an anterior suprachoroidal polyurethane implant containing dexamethasone polyurethane dispersions (DX-PUD) as a drug...

journal_title：Investigative ophthalmology & visual science

authors： Barbosa Saliba J,Vieira L,Fernandes-Cunha GM,Rodrigues Da Silva G,Ligório Fialho S,Silva-Cunha A,Bousquet E,Naud MC,Ayres E,Oréfice RL,Tekaya M,Kowalczuk L,Zhao M,Behar-Cohen F

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To investigate the residual stereo function of a group of 15 patients with strabismic amblyopia, by using motion-in-depth stimuli that allow discrimination of contributions from local disparity as opposed to those from local velocity mechanisms as a function of the rate of depth change. METHODS:The stereo perf...

journal_title：Investigative ophthalmology & visual science

authors： Hess RF,Mansouri B,Thompson B,Gheorghiu E

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Many retinal imaging instruments use infrared wavelengths to reduce the risk of light damage. However, we have discovered that exposure to infrared illumination causes a long-lasting reduction in infrared autofluorescence (IRAF). We have characterized the dependence of this effect on radiant exposure and invest...

journal_title：Investigative ophthalmology & visual science

authors： Masella BD,Williams DR,Fischer WS,Rossi EA,Hunter JJ

更新日期：2014-05-20 00:00:00

abstract：PURPOSE:Research to restore some degree of vision to patients suffering from retinal degeneration is becoming increasingly more promising. Several groups have chosen electrical stimulation of the remaining network of a degenerate retina as a means to generate discrete light percepts (phosphenes). Approaches vary signif...

journal_title：Investigative ophthalmology & visual science

authors： Matteucci PB,Chen SC,Tsai D,Dodds CW,Dokos S,Morley JW,Lovell NH,Suaning GJ

更新日期：2013-06-21 00:00:00

abstract：Purpose:Corneal endothelial cells (CECs) are critical in maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cell (PBMC)-originated, induced pluripotent stem cell (iPSC)-derived CECs. Methods:We isolated PBMCs and programmed the mononuclear cells to generate iPSCs, which...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Khan SY,Vasanth S,Ahmed MR,Chen R,Na CH,Thomson JJ,Qiu C,Gottsch JD,Riazuddin SA

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:We assessed the association between complement pathway genes and age-related macular degeneration (AMD) in a Chinese population. METHODS:In a case-control study, 165 AMD patients and 216 unrelated controls were recruited from two hospitals in central China. We selected and genotyped six single nucleotide poly...

journal_title：Investigative ophthalmology & visual science

authors： Wu L,Tao Q,Chen W,Wang Z,Song Y,Sheng S,Li P,Zhou J

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis. METHODS:Corneal IL-33 mRNA and protein levels were tested in susceptible C57BL/6 (B6) and resistant BALB/c mice. B6 mice were injected with recombinant mouse IL-33 (rmIL-33) and disease severity, bacterial load, polymorphonuclear...

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Huang X,Zhang Y,Wu M,van Rooijen N,Szliter E

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To visualize and quantify the three-dimensional (3D) spatial relationships of the structures of the aqueous outflow system (AOS) within intact enucleated mouse eyes using spectral two-photon microscopy (TPM) techniques. METHODS:Spectral TPM, including two-photon autofluorescence (TPAF) and second-harmonic gene...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Liu N,Mak PU,Pun SH,Vai MI,Masihzadeh O,Kahook MY,Lei TC,Ammar DA

更新日期：2016-06-01 00:00:00

abstract：:The therapeutic effect of citrate on alkali-burned eyes is thought to be the result of inhibition of PMN activities while ascorbate apparently stimulates the production of new collagen by scorbutic fibroblasts. Attachment of PMNs to the vascular endothelium is the initial PMN response to mediators and must occur befor...

journal_title：Investigative ophthalmology & visual science

authors： Pfister RR,Haddox JL,Snyder TL

更新日期：1988-06-01 00:00:00

abstract：PURPOSE:This study was conducted to define whether pigment epithelial-derived growth factor (PEDF), together with docosahexaenoic acid (DHA), enhances the synthesis of neuroprotectin D1 (NPD1) and the regeneration of corneal nerves damaged after surgery. METHODS:Corneal stromal dissection was performed in the left eye...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Li N,Bazan NG,Bazan HE

更新日期：2010-02-01 00:00:00