Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA.

abstract：PURPOSE:To study binding of retinoids to human tear lipocalin (TL) to assess factors influencing ligand affinity and delivery. Mechanistic features of retinoid interactions with TL were investigated, including the influence of the retinoid functional group on ligand affinity, the relative affinity of retinol versus fat...

journal_title：Investigative ophthalmology & visual science

authors： Gasymov OK,Abduragimov AR,Yusifov TN,Glasgow BJ

更新日期：2002-10-01 00:00:00

abstract：:Feline sarcoma virus (FeSV) is a naturally occurring virus that causes spontaneous tumors in cats. The immunologic and morphologic characteristics of these tumors have been studied extensively. It was recently observed in experiments undertaken to induce systemic malignancy with this virus, that severe uveitis and cli...

journal_title：Investigative ophthalmology & visual science

authors： Lubin JR,Albert DM,Essex M,de Noronha F,Riis R

更新日期：1983-08-01 00:00:00

abstract：PURPOSE:Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene prod...

journal_title：Investigative ophthalmology & visual science

authors： Talahalli R,Zarini S,Sheibani N,Murphy RC,Gubitosi-Klug RA

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:To evaluate the utility of baseline Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) normative classification in the prediction of future visual field (VF) loss. METHODS:Eighty-eight eyes with suspected glaucoma with abnormal RNFL classification by Str...

journal_title：Investigative ophthalmology & visual science

authors： Sung KR,Kim S,Lee Y,Yun SC,Na JH

更新日期：2011-04-22 00:00:00

abstract：PURPOSE:Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG...

journal_title：Investigative ophthalmology & visual science

authors： Dias AC,Módulo CM,Jorge AG,Braz AM,Jordão AA Jr,Filho RB,de Paula JS,Rocha EM

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Genetic modification of cells before transplantation may allow the delivery of neuroprotective and other functional molecules to patients with neurodegenerative diseases. To avoid complications associated with virally transfected cells, we have explored the use of nonviral methods to insert genetic material int...

journal_title：Investigative ophthalmology & visual science

authors： Johnen S,Kazanskaya O,Armogan N,Stickelmann C,Stöcker M,Walter P,Thumann G

更新日期：2011-07-23 00:00:00

abstract：PURPOSE:Glaucoma is an optic neuropathy caused by the chronic and progressive death of retinal ganglion cells (RGCs), resulting in irreversible blindness. Ocular hypertension is a major risk factor, but RGC death often continues after ocular hypertension is normalized, and can take place with normal tension. Continuous...

journal_title：Investigative ophthalmology & visual science

authors： Bai Y,Sivori D,Woo SB,Neet KE,Lerner SF,Saragovi HU

更新日期：2011-07-15 00:00:00

abstract：PURPOSE:The purpose of this study was to examine ocular surface and tear film, contact lens, care solution, medical, and patient-related factors that are associated with corneal staining in contact lens wearers. METHODS:In this cross-sectional/nested case-control study, in addition to the assessment of corneal stainin...

journal_title：Investigative ophthalmology & visual science

authors： Nichols JJ,Sinnott LT

更新日期：2011-02-28 00:00:00

abstract：PURPOSE:Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity of acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number of immunogenetic factors including IL2RA, miR-27a, miR-182, and FoxO1 are associated with Treg cell function. In this study, we investig...

journal_title：Investigative ophthalmology & visual science

authors： Yu H,Liu Y,Zhang L,Wu L,Zheng M,Cheng L,Luo L,Kijlstra A,Yang P

更新日期：2014-11-20 00:00:00

abstract：PURPOSE:To determine the mechanism by which IL-1beta induces FGF-2 and to elucidate the signaling pathways of IL-1beta-induced FGF-2 in corneal endothelial cells (CECs). METHODS:Expression and/or activation of FGF-2, p38, ERK1/2, and Akt was analyzed by immunoblot analysis. Cell proliferation was measured by MTT assay...

journal_title：Investigative ophthalmology & visual science

authors： Lee JG,Kay EP

更新日期：2009-05-01 00:00:00

abstract：:Monoclonal antibody to HSV glycoprotein D was derivatized with palmitic acid and incorporated into liposomes. These immunoliposomes bound specifically to intact mouse corneas infected with HSV-1 in vitro. Furthermore, in yield reduction assays, anti-gD immunoliposomes loaded with acyclovir proved far more effective at...

journal_title：Investigative ophthalmology & visual science

authors： Norley SG,Sendele D,Huang L,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:FGF-2 stimulates cell proliferation of rabbit corneal endothelial cells (rCECs) by degrading the cyclin-dependent kinase inhibitor p27(Kip1) (p27) through its phosphorylation mechanism. The authors investigated whether the cell proliferation of human CECs (hCECs) is also induced by FGF-2 stimulation through the...

journal_title：Investigative ophthalmology & visual science

authors： Lee JG,Song JS,Smith RE,Kay EP

更新日期：2011-10-17 00:00:00

abstract：PURPOSE:Corneas with scars and certain chronic pathologic conditions contain highly sulfated dermatan sulfate, but little is known of the core proteins that carry these atypical glycosaminoglycans. In this study the proteoglycan proteins attached to dermatan sulfate in normal and pathologic human corneas were examined ...

journal_title：Investigative ophthalmology & visual science

authors： Funderburgh JL,Hevelone ND,Roth MR,Funderburgh ML,Rodrigues MR,Nirankari VS,Conrad GW

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To determine whether people with central visual field loss (CFL) show a smaller visual contribution to posture stabilization than people with normal vision and to determine the visual factors that predict the magnitude of visual stabilization in people with central visual field loss. METHODS:Posture informatio...

journal_title：Investigative ophthalmology & visual science

authors： Turano KA,Dagnelie G,Herdman SJ

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:To examine the waveform characteristics of 37 subjects with manifest latent nystagmus (MLN) and determine the manner in which visual feedback influences the nature of the waveform. METHODS:Binocular recordings of the eye movements of all subjects were undertaken using an infrared tracking system. Subjects view...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Scallan CJ

更新日期：2000-11-01 00:00:00

abstract：:A monoclonal antibody has been produced that binds to the apical squames (flattened cells) of the rat ocular surface epithelium and to the goblet cells of the conjunctiva. Immunoelectron microscopic localization of the antigen indicates that in apical cells it is present along the apical-microplical membrane in the re...

journal_title：Investigative ophthalmology & visual science

authors： Gipson IK,Yankauckas M,Spurr-Michaud SJ,Tisdale AS,Rinehart W

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Polypoidal choroidal vasculopathy (PCV) contains aneurismal morphologic and histopathologic feature and it is considered to be a possible distinct entity from neovascular age-related macular degeneration (AMD). In this study, the association of identified risk variants for intracranial aneurysm on chromosome 9p...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Wen F,Zuo C,Li M,Chen H,Wu K

更新日期：2011-10-17 00:00:00

abstract：Purpose:To examine the associations between nighttime driving performance of older drivers and photopic, mesopic, and glare-based tests of visual function. Methods:Participants included 26 older drivers (71.8 ± 6.3 years), with minimal or no eye disease, but who reported vision-related nighttime driving difficulties. ...

journal_title：Investigative ophthalmology & visual science

authors： Kimlin JA,Black AA,Wood JM

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:To quantify protein changes in the morphologically distinct remodeling zone (RZ) and adjacent regions of the human lens outer cortex using spatially directed quantitative proteomics. METHODS:Lightly fixed human lens sections were deparaffinized and membranes labeled with fluorescent wheat germ agglutinin (WGA-...

journal_title：Investigative ophthalmology & visual science

authors： Wenke JL,McDonald WH,Schey KL

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To identify risk factors for the development of high-risk proliferative diabetic retinopathy (PDR) and for the development of severe visual loss or vitrectomy (SVLV) in eyes assigned to deferral of photocoagulation in the Early Treatment Diabetic Retinopathy Study (ETDRS). METHODS:Multivariable Cox models were...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Fisher MR,Gangnon RE,Barton F,Aiello LM,Chew EY,Ferris FL 3rd,Knatterud GL

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS:Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; m...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Giudiceandrea A,Vaiano AS,Caputo CG,Gullà F,Salgarello T

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:RPE65 has been shown to be essential for the production of 11-cis retinal by the retinal pigment epithelium. Mutations in RPE65 are known to be associated with severe forms of early-onset retinal dystrophy. This project was designed to determine the amount of regenerable opsin in Rpe65-/- mice during developmen...

journal_title：Investigative ophthalmology & visual science

authors： Rohrer B,Goletz P,Znoiko S,Ablonczy Z,Ma JX,Redmond TM,Crouch RK

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K(+) currents in retinal pigment epithelial (RPE) cells. LPA receptor transduction was analyzed in human and rat RPE cells. METHODS:Cells were cultured with standard methods, and signalin...

journal_title：Investigative ophthalmology & visual science

authors： Thoreson WB,Ryan JS,Shi C,Kelly ME,Bryson EJ,Toews ML,Ediger TL,Chacko DM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To determine whether there is rod system dysfunction in the central retina of patients with age-related macular degeneration (AMD). METHODS:Dark-adapted sensitivity (500-nm stimulus) and light-adapted sensitivity (600 nm) were measured psychophysically at 52 loci in the central 38 degrees (diameter) of retina ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,Jackson GR,Cideciyan AV,Huang Y,Fine SL,Ho AC,Maguire MG,Lolley V,Jacobson SG

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expands on our p...

journal_title：Investigative ophthalmology & visual science

authors： Courtney DG,Poulsen ET,Kennedy S,Moore JE,Atkinson SD,Maurizi E,Nesbit MA,Moore CB,Enghild JJ

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Experimental autoimmune uveoretinitis (EAU) in mice is an important model for elucidating basic mechanisms in autoimmune eye disease. The need for pertussis toxin (PTX) as an additional adjuvant to elicit EAU has limited the usefulness of this model in some types of studies by introducing a pleiotropic factor w...

journal_title：Investigative ophthalmology & visual science

authors： Silver PB,Chan CC,Wiggert B,Caspi RR

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To determine whether the relative amounts of mucin mRNA in the conjunctival epithelium and mucin protein in the tears are altered in patients with Sjögren syndrome compared with healthy individuals. METHODS:Tear fluid was collected from the inferior fornix of normal subjects (n = 17) and patients with Sjögren ...

journal_title：Investigative ophthalmology & visual science

authors： Argüeso P,Balaram M,Spurr-Michaud S,Keutmann HT,Dana MR,Gipson IK

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:We examined the treatment period necessary to restore retinal and visual stability following trauma to the optic nerve. METHODS:Cats received unilateral optic nerve crush and no treatment (NT), treatment of the injured eye with brain-derived neurotrophic factor (BDNF), or treatment of the injured eye combined ...

journal_title：Investigative ophthalmology & visual science

authors： Weber AJ,Harman CD

更新日期：2013-10-09 00:00:00