During glaucoma, alpha2-macroglobulin accumulates in aqueous humor and binds to nerve growth factor, neutralizing neuroprotection.

abstract：PURPOSE:The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of ocular growth. METHODS:To induce accelerated growth a...

journal_title：Investigative ophthalmology & visual science

authors： Ashby RS,Zeng G,Leotta AJ,Tse DY,McFadden SA

更新日期：2014-07-22 00:00:00

abstract：PURPOSE:To study the damaging effect of UV-A irradiation on the chaperone-like properties of alpha-crystallin and the subsequent recovery process of young and old bovine lenses. METHODS:Young and old bovine lenses were kept in organ culture. After 24 hours of incubation they were irradiated with UV-A at 365 nm, and op...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb O,van Boekel MA,Dovrat A,Bloemendal H

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to use an in vivo model of retinal excitotoxicity to investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. METHODS:Adult Sprague-Dawley rats (weight range, 250-300 g) intravitreally received (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyd...

journal_title：Investigative ophthalmology & visual science

authors： Kiagiadaki F,Thermos K

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Juvenile open-angle glaucoma (JOAG) differs from primary open-angle glaucoma in that it is usually a more severe phenotype and has an earlier age of onset. Optineurin was recently associated with a variant of POAG that is characterized by intraocular pressure within normal limits: normal-tension glaucoma. The p...

journal_title：Investigative ophthalmology & visual science

authors： Willoughby CE,Chan LL,Herd S,Billingsley G,Noordeh N,Levin AV,Buys Y,Trope G,Sarfarazi M,Héon E

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To determine the involvement of rat kallikrein-binding protein (RKBP) in the development of diabetic retinopathy. METHODS:Diabetes was induced by streptozotocin (STZ) (55 mg/kg body weight in 0.05 M citrate buffer, pH 4.5) in male Sprague-Dawley rats (150 to 175 g, 6 weeks old) as confirmed by hyperglycemia an...

journal_title：Investigative ophthalmology & visual science

authors： Hatcher HC,Ma JX,Chao J,Chao L,Ottlecz A

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To investigate the protective effects of cobalt protoporphyrin (CoPP), a potent heme oxygenase (HO)-1 inducer, in a rat model of ischemia-reperfusion injury and to document the possible antiapoptotic and anti-inflammatory mechanisms underlying the protection. METHODS:Rats pretreated with intraperitoneal inject...

journal_title：Investigative ophthalmology & visual science

authors： Sun MH,Pang JH,Chen SL,Han WH,Ho TC,Chen KJ,Kao LY,Lin KK,Tsao YP

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To investigate the use of topically applied FK506, a new immunosuppressive compound, systemic and ocular absorption was determined in serum and various ocular tissues. METHODS:Two drops of 20 microliters FK506 were applied using oil dissolved (OD-FK506) or liposome-bound (LIP-FK506) drug. FK506 concentrations ...

journal_title：Investigative ophthalmology & visual science

authors： Pleyer U,Lutz S,Jusko WJ,Nguyen KD,Narawane M,Rückert D,Mondino BJ,Lee VH,Nguyen K

更新日期：1993-08-01 00:00:00

abstract：Purpose:Basement membrane degradation and macrophage aggregation at the optic fissure margins are crucial to optic fissure closure during normal murine eye development. Basement membrane degradation is also an essential step in cancer development, and matrix metalloproteinases (MMPs) play an important role. In this stu...

journal_title：Investigative ophthalmology & visual science

authors： Tsuji N,Matsuura T,Narama I,Yoshiki A,Ozaki K

更新日期：2018-03-01 00:00:00

abstract：:Iron is a potent generator of oxidative damage whose levels increase with age, potentially exacerbating age-related diseases. Several lines of evidence suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). AMD retinas have more iron within the photoreceptors, RPE, and drusen than do...

journal_title：Investigative ophthalmology & visual science

authors： Dunaief JL

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:To investigate the nature and reversibility of biochemical and functional changes in the retina encountered over a single generation of dietary n-3 polyunsaturated fatty acid deficiency in guinea pigs. METHODS:Dunkin-Hartley guinea pigs were fed for 16 weeks after weaning with diets supplemented with safflower...

journal_title：Investigative ophthalmology & visual science

authors： Weisinger HS,Vingrys AJ,Bui BV,Sinclair AJ

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:Severe ocular allergic diseases are characterized by pronounced conjunctival inflammation triggered by T helper 2 (Th2) cells and corneal epithelial damage induced by eosinophils. To examine the role of alarmins released by damaged corneal epithelial cells in tissue eosinophilia, we investigated the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Ishida W,Tanaka H,Harada Y,Matsuda A,Ebihara N,Fukushima A

更新日期：2013-08-27 00:00:00

abstract：PURPOSE:To model the photochemical kinetics of corneal cross-linking with riboflavin (Rf) and confirm the model through measured oxygen concentration experiments under varying energy input conditions by UV-A irradiance and temperature modulation in ex vivo porcine cornea. METHODS:A theoretical model was developed to d...

journal_title：Investigative ophthalmology & visual science

authors： Kamaev P,Friedman MD,Sherr E,Muller D

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Macrophages are thought to be the first line of defense in many infectious diseases and are present in high numbers in corneas with Acanthamoeba keratitis. Conjunctival macrophage depletion was performed in an animal model of Acanthamoeba infection to determine the importance of macrophages in this disease. ME...

journal_title：Investigative ophthalmology & visual science

authors： van Klink F,Taylor WM,Alizadeh H,Jager MJ,van Rooijen N,Niederkorn JY

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To map the spatiotemporal decline in retinally driven activity in the superior colliculus (SC) of transgenic S334ter-line-3 rats that express a mutated rhodopsin, which causes photoreceptor degeneration. To determine whether transplantation of fetal retinal sheets into the subretinal space of these rats can rec...

journal_title：Investigative ophthalmology & visual science

authors： Sagdullaev BT,Aramant RB,Seiler MJ,Woch G,McCall MA

更新日期：2003-04-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the impact of genetic deletion of NOS3 in CAV1-/- mice on aqueous humor outflow function using a mouse genetic double knockout model (DKO, NOS3-/- CAV1-/-). Methods:IOP was measured in DKO, NOS3 KO, CAV1 KO, and wild-type (WT) mice by rebound tonometry. Outflow faci...

journal_title：Investigative ophthalmology & visual science

authors： Song M,Wu J,Lei Y,Sun X

更新日期：2017-10-01 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：Purpose:Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs...

journal_title：Investigative ophthalmology & visual science

authors： Gottschalk HM,Wecker T,Khattab MH,Fischer CV,Callizo J,Rehfeldt F,Lubjuhn R,Russmann C,Hoerauf H,van Oterendorp C

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:During fixation and saccades, human eye movements obey Listing's law, which specifies the torsional eye position for each combination of horizontal and vertical eye positions. To study the mechanisms that implement Listing's law, the authors measured whether the law was violated in peripheral and central unilat...

journal_title：Investigative ophthalmology & visual science

authors： Wong AM,Tweed D,Sharpe JA

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS:An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Kaur K,Rao KN,Mandal AK,Kaur I,Parikh RS,Thomas R

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether clinical signs of infectious keratitis can be used to identify the causative organism. METHODS:Eighty photographs of eyes with culture-proven bacterial keratitis or smear-proven fungal keratitis were randomly selected from 2 clinical trials. Fifteen cornea spe...

journal_title：Investigative ophthalmology & visual science

authors： Dalmon C,Porco TC,Lietman TM,Prajna NV,Prajna L,Das MR,Kumar JA,Mascarenhas J,Margolis TP,Whitcher JP,Jeng BH,Keenan JD,Chan MF,McLeod SD,Acharya NR

更新日期：2012-04-02 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:This study investigated a novel motion-on-color paradigm to functionally isolate the magnocellular pathway and evaluate its diagnostic value in preperimetric glaucoma patients. METHODS:Thirty patients with preperimetric primary open-angle glaucoma and 30 controls participated in this study. They were tested in...

journal_title：Investigative ophthalmology & visual science

authors： Wen W,Zhang P,Liu T,Zhang T,Gao J,Sun X,He S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:The organization of scleral collagen helps to determine the eye's biomechanical response to intraocular pressure (IOP), and may therefore be important in glaucoma. This study provides a quantitative assessment of changes in scleral collagen fibril organization in bead-induced murine experimental glaucoma. METH...

journal_title：Investigative ophthalmology & visual science

authors： Pijanka JK,Kimball EC,Pease ME,Abass A,Sorensen T,Nguyen TD,Quigley HA,Boote C

更新日期：2014-09-16 00:00:00

abstract：PURPOSE:To evaluate a fully automated local fractal dimension method to quantify vessel density and foveal avascular zone (FAZ) area in optical coherence tomography angiography (OCTA) images. METHODS:Fifty-two healthy Asian Indian eyes underwent imaging prospectively with OCTA system. Superficial and deep retinal vasc...

journal_title：Investigative ophthalmology & visual science

authors： Gadde SG,Anegondi N,Bhanushali D,Chidambara L,Yadav NK,Khurana A,Sinha Roy A

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：Purpose:Growing evidence suggests the involvement of the macula even in early stages of glaucoma. However, little is known about the impact of glaucomatous macular damage on central pattern vision. Here we examine the contrast requirement for letter recognition and its relationship with retinal thickness in the macular...

journal_title：Investigative ophthalmology & visual science

authors： Chien L,Liu R,Girkin C,Kwon M

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:To test a newly developed tear evaporimetry system that detects real-time changes in tear evaporation rates and shows the tear film stability in patients with obstructive meibomian gland dysfunction (MGD). METHODS:A ventilated chamber system with high-sensitivity microbalance sensor was used to evaluate tear e...

journal_title：Investigative ophthalmology & visual science

authors： Goto E,Endo K,Suzuki A,Fujikura Y,Matsumoto Y,Tsubota K

更新日期：2003-02-01 00:00:00