Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye.

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To examine the relation between grating acuity at age 1 year and Snellen acuity and grating acuity at 5.5 years, in preterm children with birth weights less than 1251 g. METHODS:Subjects were participants in the multicenter study of Cryotherapy for Retinopathy of Prematurity. The Teller acuity card (TAC; Viste...

journal_title：Investigative ophthalmology & visual science

authors： Dobson V,Quinn GE,Siatkowski RM,Baker JD,Hardy RJ,Reynolds JD,Trese MT,Tung B

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. METHODS:Hepc KO mice were given DFP in ...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Zhao L,Li Y,Hadziahmetovic M,Song Y,Connelly J,Spino M,Dunaief JL

更新日期：2014-06-26 00:00:00

abstract：Purpose:Diabetes causes dysfunction in the retinal mitochondria and increases base mismatches in their DNA (mtDNA). The enzyme responsible for repairing the base mismatches, MutL homolog 1 (Mlh1), is compromised. Diabetes also favors many epigenetic modifications and activates DNA methylation machinery, and Mlh1 has a ...

journal_title：Investigative ophthalmology & visual science

authors： Mohammad G,Radhakrishnan R,Kowluru RA

更新日期：2019-09-03 00:00:00

abstract：:Drusen are small, yellowish deposits that form under the retinal pigment epithelium (RPE) with senescence or under certain pathological conditions. The present study examined these structures under the scanning electron microscope. Tissue came from four eyes of 66- and 75-year-old donors who demonstrated widespread dr...

journal_title：Investigative ophthalmology & visual science

authors： Ulshafer RJ,Allen CB,Nicolaissen B Jr,Rubin ML

更新日期：1987-04-01 00:00:00

abstract：:Effects of substance P (SP) and vasoactive intestinal peptide (VIP) on motor function of bovine sphincter, dilator, and ciliary muscles were investigated pharmacologically, with and without field stimulation. SP contracted the sphincter and the maximum response was only about 25% of that in the presence of equimolar d...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki R,Kobayashi S

更新日期：1983-12-01 00:00:00

abstract：PURPOSE:Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthal...

journal_title：Investigative ophthalmology & visual science

authors： Jekle A,Abdul Rani S,Celeri C,Zuck M,Xu P,Wang L,Najafi-Tagol K,Anderson M,Stroman D,Debabov D

更新日期：2013-02-19 00:00:00

abstract：:In order to induce stereoscopic depth, retinal images in the right and left eyes must differ. Our experiments demonstrate that these uniocular differences for simple three-line configurations at stereo-threshold cannot usually be distinguished one from the other. We confirm that depth values are associated with indivi...

journal_title：Investigative ophthalmology & visual science

authors： Westheimer G,McKee SP

更新日期：1979-06-01 00:00:00

abstract：Purpose:To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods:Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Fov...

journal_title：Investigative ophthalmology & visual science

authors： Valkenburg D,van Cauwenbergh C,Lorenz B,van Genderen MM,Bertelsen M,Pott JR,Coppieters F,de Zaeytijd J,Thiadens AAHJ,Klaver CCW,Kroes HY,van Schooneveld MJ,Preising M,Hoyng CB,Leroy BP,van den Born LI,Collin RWJ

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degenerat...

journal_title：Investigative ophthalmology & visual science

authors： Marc RE,Jones BW,Anderson JR,Kinard K,Marshak DW,Wilson JH,Wensel T,Lucas RJ

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns. METHODS:Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol usi...

journal_title：Investigative ophthalmology & visual science

authors： McGowan A,Silvestri G,Moore E,Silvestri V,Patterson CC,Maxwell AP,McKay GJ

更新日期：2014-12-18 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Sensory imbalances in humans with amblyopia have been well documented using luminance-modulated (first-order) stimuli. However, little is known regarding whether there is a deficient binocular combination in amblyopes for stimuli defined by modulations in contrast (second-order stimuli). To address this, we ask...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Liu R,Feng L,Zhou Y,Hess RF

更新日期：2016-04-01 00:00:00

abstract：:Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the opt...

journal_title：Investigative ophthalmology & visual science

authors： Rao NA,Guy J,Sheffield PS

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：:On the assumption that myelin intrusion into the papilla and peripapillary region might occur with traumatic lesions of the optic nerve, a study was made of the clinical and histopathologic changes that might be expected. Nine monkey eyes were subjected to hemostat compression of the nerve close to the globe and studi...

journal_title：Investigative ophthalmology & visual science

authors： Cogan DG,Yee RD

更新日期：1977-05-01 00:00:00

abstract：PURPOSE:To assess whether saccadic eye movements show distinct changes in patients with early active Graves' ophthalmopathy (GO), which could serve as a diagnostic tool for early detection and treatment. METHODS:Each of two prospective studies included 10 patients with early acute GO and 10 age- and sex-matched contro...

journal_title：Investigative ophthalmology & visual science

authors： Schworm HD,Heufelder AE,Kunze A,Welge E,Boergen KP

更新日期：2000-06-01 00:00:00

abstract：Purpose:Asymmetry in disease progression between left and right eyes can occur in Stargardt disease (STGD1), and this needs to be considered in novel therapeutic trials with a fellow-eye paired controlled design. This study investigated the inter-eye discordance of best-corrected visual acuity (BCVA) and progression of...

journal_title：Investigative ophthalmology & visual science

authors： Lambertus S,Bax NM,Groenewoud JM,Cremers FP,van der Wilt GJ,Klevering BJ,Theelen T,Hoyng CB

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:Disruption of the normally antiangiogenic environment of the retina leads to aberrant angiogenesis, the major cause of vision loss throughout the world. Prolactin (PRL), the hormone originally associated with milk production, can be proteolytically processed to 16K-PRL, a 16 kDa N-terminal PRL fragment with pot...

journal_title：Investigative ophthalmology & visual science

authors： Aranda J,Rivera JC,Jeziorski MC,Riesgo-Escovar J,Nava G,López-Barrera F,Quiróz-Mercado H,Berger P,Martínez de la Escalera G,Clapp C

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To determine and compare gene expression patterns in the whole retina and retinal ganglion cell layer (RGCL) in a rodent glaucoma model. METHODS:IOP was unilaterally elevated in Brown Norway rats (N = 26) by injection of hypertonic saline and monitored for 5 weeks. A cDNA microarray was used on whole retinas f...

journal_title：Investigative ophthalmology & visual science

authors： Guo Y,Cepurna WO,Dyck JA,Doser TA,Johnson EC,Morrison JC

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Strabismic amblyopia is typically associated with several visual deficits, including loss of contrast sensitivity in the amblyopic eye and abnormal binocular vision. Binocular summation ratios (BSRs) are usually assessed by comparing contrast sensitivity for binocular stimuli (sens(BIN)) with that measured in t...

journal_title：Investigative ophthalmology & visual science

authors： Baker DH,Meese TS,Mansouri B,Hess RF

更新日期：2007-11-01 00:00:00

abstract：Purpose:To investigate the underlying mechanisms for how the mouse Cx50-R205G point mutation, a homologue of the human Cx50-R198W mutation that is linked to cataract-microcornea syndrome, affects proper lens growth and fiber cell differentiation to lead to severe lens phenotypes. Methods:EdU labeling, immunostaining, ...

journal_title：Investigative ophthalmology & visual science

authors： Tjahjono N,Xia CH,Li R,Chu S,Wang J,Gong X

更新日期：2020-03-09 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To determine the impact of substratum compliance and latrunculin-B (Lat-B), both alone and together, on fundamental human trabecular meshwork (HTM) cell behavior. Lat-B is a reversible actin cytoskeleton disruptor that decreases resistance to aqueous humor outflow and decreases intraocular pressure. METHODS:HT...

journal_title：Investigative ophthalmology & visual science

authors： Wood JA,McKee CT,Thomasy SM,Fischer ME,Shah NM,Murphy CJ,Russell P

更新日期：2011-12-02 00:00:00

abstract：PURPOSE:People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore. METHODS:The authors undertook a population-based, cross-sectional ...

journal_title：Investigative ophthalmology & visual science

authors： Zheng Y,Lamoureux EL,Chiang PP,Cheng CY,Anuar AR,Saw SM,Aung T,Wong TY

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Trefoil factor family (TFF) peptides, and in particular TFF3, are characteristic secretory products of mucous epithelia that promote antiapoptosis, epithelial migration, restitution, and wound healing. For a long time, a receptor for TFF3 had not yet been identified. However, the chemokine receptor CXCR4 has be...

journal_title：Investigative ophthalmology & visual science

authors： Dieckow J,Brandt W,Hattermann K,Schob S,Schulze U,Mentlein R,Ackermann P,Sel S,Paulsen FP

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:There is a correlation between cell volume changes and changes in the rate of aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate of aqueous humor outflow. This study investigated the effects of the nitric oxide (NO)-independent activators of soluble guanylate cycl...

journal_title：Investigative ophthalmology & visual science

authors： Dismuke WM,Sharif NA,Ellis DZ

更新日期：2009-07-01 00:00:00