Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.

abstract：:Voluntary vertical saccades were recorded in five normal human subjects with electro-oculography (EOG), an infrared, limbus tracking system (IR), and a magnetic scleral search coil method. The peak velocity-amplitude relationships of up and down saccades were measured during refixations across the center of the orbit ...

journal_title：Investigative ophthalmology & visual science

authors： Yee RD,Schiller VL,Lim V,Baloh FG,Baloh RW,Honrubia V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS:There were two study days in an open design. On the first day, OPP was varied by elevating IOP during ...

journal_title：Investigative ophthalmology & visual science

authors： Polska E,Simader C,Weigert G,Doelemeyer A,Kolodjaschna J,Scharmann O,Schmetterer L

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Throughout adulthood, Bruch membrane (BrM) accumulates esterified cholesterol (EC) associated with abundant 60- to 80-nm-diameter lipoprotein-like particles (LLP), putative apolipoprotein B (apoB) lipoproteins secreted by the retinal pigment epithelium (RPE). In the present study, neutral lipid, phospholipids, ...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Li CM,Rudolf M,Belyaeva OV,Chung BH,Messinger JD,Kedishvili NY,Curcio CA

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To investigate corneal sensitivity to selective mechanical, chemical, heat, and cold stimulation in patients with fibromyalgia (FM). METHODS:Twenty patients with FM (18 women, 2 men; 51.9 +/- 2.3 years old) and 18 control subjects (16 women, 2 men; 51.7 +/- 2.4 years) participated voluntarily in the study. Sub...

journal_title：Investigative ophthalmology & visual science

authors： Gallar J,Morales C,Freire V,Acosta MC,Belmonte C,Duran JA

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To obtain quantitative data on the optic disc excavation in children affected by cerebral visual impairment (CVI) by using the Heidelberg Retinal Tomograph (HRT)-II (Heidelberg Engineering, Heidelberg, Germany). METHODS:A total of 24 subjects affected by CVI (mean age, 7.28 years) were examined: 16 in alert co...

journal_title：Investigative ophthalmology & visual science

authors： Ruberto G,Salati R,Milano G,Bertone C,Tinelli C,Fazzi E,Guagliano R,Signorini S,Borgatti R,Bianchi A,Bianchi PE

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To examine the waveform characteristics of 37 subjects with manifest latent nystagmus (MLN) and determine the manner in which visual feedback influences the nature of the waveform. METHODS:Binocular recordings of the eye movements of all subjects were undertaken using an infrared tracking system. Subjects view...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Scallan CJ

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the mutational incidence and spectrum of mitochondrial ND1 gene in subjects with Leber's hereditary optic neuropathy (LHON). METHODS:A cohort of 1281 Han Chinese probands and 478 control subjects underwent sequence analysis of mitochondrial (mt)DNA. Resultant varian...

journal_title：Investigative ophthalmology & visual science

authors： Ji Y,Liang M,Zhang J,Zhu L,Zhang Z,Fu R,Liu X,Zhang M,Fu Q,Zhao F,Tong Y,Sun Y,Jiang P,Guan MX

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To test the effects of genistein on choriocapillaris regeneration and retinal pigment epithelial (RPE) wound healing in a surgical model in the rabbit. METHODS:Intravitreal injections of either 0.1 ml of a 90-microM concentration of genistein, dimethyl sulfoxide (DMSO; negative control), or 2 microg cyclohexim...

journal_title：Investigative ophthalmology & visual science

authors： Majji AB,Hayashi A,Kim HC,Grebe RR,de Juan E Jr

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To evaluate immunohistochemical staining of the endothelia of corneas from patients with clinical diagnoses of iridocorneal endothelial (ICE) syndrome. METHODS:Corneas diagnosed with ICE syndrome and removed during corneal transplantation were freshly frozen, sectioned, and stained with monoclonal antibodies t...

journal_title：Investigative ophthalmology & visual science

authors： Hirst LW,Bancroft J,Yamauchi K,Green WR

更新日期：1995-04-01 00:00:00

abstract：PURPOSE:To explore the roles of ZO-1 in corneal fibroblasts and myofibroblasts in a model of wounding. METHODS:Antibodies were used to identify ZO-1 in cultured rabbit corneal fibroblasts by immunocytochemistry, Western blot analysis, and immunoprecipitation. For colocalization studies, antibodies to beta-catenin, cad...

journal_title：Investigative ophthalmology & visual science

authors： Taliana L,Benezra M,Greenberg RS,Masur SK,Bernstein AM

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To study the distribution and predominant orientations of fibrillar collagen at different depths throughout the entire thickness of the human cornea. This information will form the basis of a full three-dimensional reconstruction of the preferred orientations of corneal lamellae. METHODS:Femtosecond laser tech...

journal_title：Investigative ophthalmology & visual science

authors： Abahussin M,Hayes S,Knox Cartwright NE,Kamma-Lorger CS,Khan Y,Marshall J,Meek KM

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To determine the morphologic changes in the retina in the macula and around the optic disc in patients with autosomal dominant optic atrophy (ADOA) associated with a mutation in the OPA1 gene. METHODS:Cross-sectional images of the macular area of the retina were obtained by optical coherence tomography (OCT) i...

journal_title：Investigative ophthalmology & visual science

authors： Ito Y,Nakamura M,Yamakoshi T,Lin J,Yatsuya H,Terasaki H

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To investigate the role of Toll-like receptors (TLRs) 2, 3, 4, and 8 in the pathogenesis of Behcet's disease (BD). METHODS:Sixteen patients with active ocular BD and 16 healthy volunteers were included in this study. Total RNA was isolated from PBMCs to determine mRNA levels of TLRs, including TLR2, TLR3, TLR4...

journal_title：Investigative ophthalmology & visual science

authors： Liu X,Wang C,Ye Z,Kijlstra A,Yang P

更新日期：2013-09-05 00:00:00

abstract：:Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epi...

journal_title：Investigative ophthalmology & visual science

authors： Brightwell JR,Riddle SL,Eiferman RA,Valenzuela P,Barr PJ,Merryweather JP,Schultz GS

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Solessio E

更新日期：2013-02-28 00:00:00

abstract：PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

journal_title：Investigative ophthalmology & visual science

authors： Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：:Experimental esotropia was produced surgically in infant rhesus monkeys (Macaca mulatta) for brief periods of time. Electrophysiological studies of the visual cortex showed that esotropia of only 2 weeks duration in an infant monkey is sufficient to cause a marked shift of dominance in favor of the fixating eye and to...

journal_title：Investigative ophthalmology & visual science

authors： Crawford ML,von Noorden GK

更新日期：1979-05-01 00:00:00

abstract：PURPOSE:To investigate the responses of retinal ganglion cells (RGCs) to electrical stimulation, using electrodes comparable in size to those used in human studies investigating the feasibility of an electronic retinal prosthesis. METHODS:Rabbit retinas were stimulated in vitro with current pulses applied to the inner...

journal_title：Investigative ophthalmology & visual science

authors： Jensen RJ,Ziv OR,Rizzo JF 3rd

更新日期：2005-04-01 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To measure changes in nuclear gene expression resulting from mitochondrial dysfunction in retinal pigment epithelial cells. METHODS:ARPE-19 retinal pigment epithelial cells were depleted of their mitochondrial (mt)DNA by passaging in a low concentration of ethidium bromide. Loss of mitochondrial DNA was determ...

journal_title：Investigative ophthalmology & visual science

authors： Miceli MV,Jazwinski SM

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:Adhesion molecules play a critical role in leukocyte emigration to wound sites, but differences are evident in different vascular beds. In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated. METHODS:Re-epithelialization, neut...

journal_title：Investigative ophthalmology & visual science

authors： Li Z,Rumbaut RE,Burns AR,Smith CW

更新日期：2006-11-01 00:00:00

abstract：:The life history of melanin and lipofuscin granules of human retinal pigment epithelium (RPE) was studied in 30 human eyes spanning nine decades of life. Autofluorescent granules in the cytoplasm of eye over 30 years of age were shown, ultrastructurally and through lipid solvent extraction, to be lipofuscin granules. ...

journal_title：Investigative ophthalmology & visual science

authors： Feeney L

更新日期：1978-07-01 00:00:00

abstract：PURPOSE:Glaucoma is a distinct neuropathy characterized by the chronic and progressive death of retinal ganglion cells (RGCs). The etiology of RGC death remains unknown. Risk factors for glaucomatous RGC death are elevated intraocular pressure and glial production of tumor necrosis factor-alpha (TNF-α). Previously, the...

journal_title：Investigative ophthalmology & visual science

authors： Bai Y,Shi Z,Zhuo Y,Liu J,Malakhov A,Ko E,Burgess K,Schaefer H,Esteban PF,Tessarollo L,Saragovi HU

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：:Scanning electron microscopic (SEM) observations of the rabbit retinal pigment epithelium (RPE) are reported both for normal tissue and for tissue subjected to laser radiation. In normal RPE, cells were observed to be closely packed and to have the characteristic hexagonal shape. The microvilli were abundant and of tw...

journal_title：Investigative ophthalmology & visual science

authors： Borwein B,Sanwal M,Medeiros JA,McGowan JW

更新日期：1977-08-01 00:00:00

abstract：Purpose:Ocular structural and functional changes, collectively termed spaceflight-associated neuro-ocular syndrome (SANS), have been described in astronauts undergoing long-duration missions in the microgravity environment of the International Space Station. We tested the hypothesis that retinal vascular remodeling, pa...

journal_title：Investigative ophthalmology & visual science

authors： Vyas RJ,Young M,Murray MC,Predovic M,Lim S,Jacobs NM,Mason SS,Zanello SB,Taibbi G,Vizzeri G,Parsons-Wingerter P

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:To determine the efficacy of a new formulation of topical dexamethasone 0.1%/povidone-iodine 0.4% (FST-100) in reducing clinical symptoms and infectious viral titers in a rabbit model of adenoviral keratoconjunctivitis. METHODS:Rabbit corneas were inoculated bilaterally with 2×10(6) plaque-forming-units (PFU) ...

journal_title：Investigative ophthalmology & visual science

authors： Clement C,Capriotti JA,Kumar M,Hobden JA,Foster TP,Bhattacharjee PS,Thompson HW,Mahmud R,Liang B,Hill JM

更新日期：2011-01-21 00:00:00

abstract：PURPOSE:To assess the impact of a novel visual field spatial filtering technique on the detection of glaucomatous progression. METHODS:One hundred ninety-eight ocular hypertensive (OHT) and 21 control subjects were examined prospectively (1994-2001) with regular full-threshold Humphrey visual field (VF) testing. VF pr...

journal_title：Investigative ophthalmology & visual science

authors： Strouthidis NG,Scott A,Viswanathan AC,Crabb DP,Garway-Heath DF

更新日期：2007-01-01 00:00:00

abstract：:Chloride ion (Cl-) secretion by the rabbit corneal epithelium involves a catecholamine-stimulated Cl- conductance at the apical membrane, but the characteristics of the ion channel(s) responsible are unknown. A primary cell culture system was developed that induces stratified epithelial differentiation of rat and rabb...

journal_title：Investigative ophthalmology & visual science

authors： Marshall WS,Hanrahan JW

更新日期：1991-04-01 00:00:00