Changes in the optic disc excavation of children affected by cerebral visual impairment: a tomographic analysis.

abstract：:Rabbit corneas were treated in vitro and in vivo with cholera toxin (CTX), a specific and irreversible activator of adenylate cyclase. Tissue pieces incubated in vitro in the presence of 10 mug/ml CTX for 15 min continuously synthesized adenosine 3',5'-monophosphate (cyclic AMP) at an increased rate for 3 hr in the ab...

journal_title：Investigative ophthalmology & visual science

authors： Jumblatt MM,Fogle JA,Neufeld AH

更新日期：1980-11-01 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：PURPOSE:The purposes of the present study were to assess the effect of a sympathetic inhibitory pharmacologic agent, timolol maleate, on the magnitude of nearwork-induced transient myopia (NITM) and its decay in different refractive groups for an extended near task duration and to determine the proportion of the young ...

journal_title：Investigative ophthalmology & visual science

authors： Vasudevan B,Ciuffreda KJ,Gilmartin B

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Stereoscopic displays challenge the neural cross-coupling between accommodation and vergence by inducing a constant accommodative demand and a varying vergence demand. Stereoscopic viewing calls for a decrease in the gain of vergence accommodation, which is the accommodation caused by vergence, quantified by us...

journal_title：Investigative ophthalmology & visual science

authors： Neveu P,Roumes C,Philippe M,Fuchs P,Priot AE

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to examine the roles of signaling pathways potentially activated by TGFbeta (i.e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cell migration and proliferation of healing mouse corneal epithelium. METHODS:Activation of Smads or p38MAPK was evaluated by im...

journal_title：Investigative ophthalmology & visual science

authors： Saika S,Okada Y,Miyamoto T,Yamanaka O,Ohnishi Y,Ooshima A,Liu CY,Weng D,Kao WW

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:It is thought that large perimetric stimuli are insensitive for demonstrating visual field defects. To test the hypothesis that there is no difference in the total number of abnormal test locations with total deviation empiric probability plots in glaucoma patients, we compared results of glaucoma patients test...

journal_title：Investigative ophthalmology & visual science

authors： Wall M,Doyle CK,Eden T,Zamba KD,Johnson CA

更新日期：2013-06-07 00:00:00

abstract：:Topical application of Prostaglandin F2 alpha (PGF2 alpha) to the eye reduces intraocular pressure (IOP) in all mammalian species studied thus far, including humans. The L-isopropylester derivative is currently the one most commonly used in experimental and clinical studies. Dose-response relationships were determined...

journal_title：Investigative ophthalmology & visual science

authors： Crawford KS,Kaufman PL

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To study the antineoplastic effect of vitamin D analogues in a xenograft model of human retinoblastoma. METHODS:Athymic mice were injected subcutaneously with Y79 cells and treated 5 days a week with either mineral oil (control group) or the vitamin D analogues calcitriol or 1,25-dihydroxy-16-ene-23-yne vitami...

journal_title：Investigative ophthalmology & visual science

authors： Audo I,Darjatmoko SR,Schlamp CL,Lokken JM,Lindstrom MJ,Albert DM,Nickells RW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Linkage intervals for erosive vitreoretinopathy (ERVR) and Wagner disease previously were found to overlap at 5q14.3. In a Japanese family with Wagner disease, a CSPG2/Versican splice site mutation (c.4004-2A-->G) was recently reported that resulted in a 39-nucleotide exon 8 in-frame deletion. We investigated w...

journal_title：Investigative ophthalmology & visual science

authors： Mukhopadhyay A,Nikopoulos K,Maugeri A,de Brouwer AP,van Nouhuys CE,Boon CJ,Perveen R,Zegers HA,Wittebol-Post D,van den Biesen PR,van der Velde-Visser SD,Brunner HG,Black GC,Hoyng CB,Cremers FP

更新日期：2006-08-01 00:00:00

abstract：:Electroretinographic studies of myctalopic Appaloosa horses demonstrated photopic and scotopic abnormalities similar to those in humans with congenital stationary night blindness (CSNB) of the Schubert-Bornschein type. The phototopic abnormalities consisted of reduced b-wave amplitudes and slower than normal b-wave im...

journal_title：Investigative ophthalmology & visual science

authors： Witzel DA,Smith EL,Wilson RD,Aguirre GD

更新日期：1978-08-01 00:00:00

abstract：:A recent hypothesis for the cellular mechanism of fluid secretion by lacrimal acini has been based, in part, on the results of subcellular fractionation analyses of lacrimal gland fragments which had been incubated for a brief period in vitro. An important assumption in those studies was that the ion transporters and ...

journal_title：Investigative ophthalmology & visual science

authors： Yiu SC,Wood RL,Mircheff AK

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cells play important roles in ophthalmologic diseases such as proliferative vitreoretinopathy, AMD, and diabetic retinopathy. MicroRNA-34a (miR-34a) has been reported to be important in the regulation of cell proliferation, migration, differentiation, and apoptosis. In this stud...

journal_title：Investigative ophthalmology & visual science

authors： Hou Q,Tang J,Wang Z,Wang C,Chen X,Hou L,Dong XD,Tu L

更新日期：2013-10-03 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：PURPOSE:Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell-mediated immune response is generated in the lymphoid compartment and to characterize the functional phenotype of the T c...

journal_title：Investigative ophthalmology & visual science

authors： El Annan J,Chauhan SK,Ecoiffier T,Zhang Q,Saban DR,Dana R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H stat...

journal_title：Investigative ophthalmology & visual science

authors： Hakobyan S,Harris CL,Tortajada A,Goicochea de Jorge E,García-Layana A,Fernández-Robredo P,Rodríguez de Córdoba S,Morgan BP

更新日期：2008-05-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Deposition of the macular pigment carotenoids lutein and zeaxanthin in the human retina occurs early in life. In this study, we examined the interrelationships of maternal carotenoid status and newborn infant macular pigment levels and systemic carotenoid status. As a secondary measure, we also evaluated the ef...

journal_title：Investigative ophthalmology & visual science

authors： Henriksen BS,Chan G,Hoffman RO,Sharifzadeh M,Ermakov IV,Gellermann W,Bernstein PS

更新日期：2013-08-15 00:00:00

abstract：PURPOSE:The goals of this study were to evaluate the safety of office-based vitreous sampling, and determine the utility of these samples with multiplex cytokine analysis. METHODS:Vitreous samples were collected from office-based needle aspiration and the rate of adverse events during follow-up was reviewed. The vitre...

journal_title：Investigative ophthalmology & visual science

authors： Ghodasra DH,Fante R,Gardner TW,Langue M,Niziol LM,Besirli C,Cohen SR,Dedania VS,Demirci H,Jain N,Jayasundera KT,Johnson MW,Kalyani PS,Rao RC,Zacks DN,Sundstrom JM

更新日期：2016-06-01 00:00:00

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：Purpose:The prevalence of age-related macular degeneration (AMD) increases dramatically with age. This large collaborative study investigates the effects of 51 late-AMD-associated genetic variants in different ages, focusing on individuals above the age of 90 years. Methods:The study included 27,996 individuals of the...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Lorés-Motta L,Altay L,Fritsche LG,den Hollander AI,Fauser S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Müller cells support retinal neurons with essential functions. Here, we aim to examine the impact of starvation and oxidative stress on glutamate uptake and mitochondrial function in Müller cells. METHODS:Cultured human retinal Müller cells (MIO-M1) were exposed to H2O2 and additional starvation for 24 hours. ...

journal_title：Investigative ophthalmology & visual science

authors： Toft-Kehler AK,Gurubaran IS,Desler C,Rasmussen LJ,Skytt DM,Kolko M

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Growth factors act through high-affinity cell surface receptors expressed by target cells and are critical modulators of cell function. Because aqueous humor is known to contain growth factors, these molecules may play a key role in maintaining the normal function of the human trabecular meshwork (HTM). Alterna...

journal_title：Investigative ophthalmology & visual science

authors： Wordinger RJ,Clark AF,Agarwal R,Lambert W,Wilson SE

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To investigate the role of the gap junction protein connexin43 (Cx43), which is predominantly expressed in lens epithelial cells in the control of lens development and organization. METHODS:Newborn mice in which the Cx43 gene was disrupted by homologous recombination were used. Lenses from Cx43 (-/-) mice and ...

journal_title：Investigative ophthalmology & visual science

authors： Gao Y,Spray DC

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00

abstract：Purpose:A shortage of human corneal endothelial cells (HCEC) for transplant and current methods of differentiation induction require chemical compounds, which might cast further influences after differentiation induction. Therefore, we developed a simple and straightforward approach to endothelial cell differentiation ...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Wu L,Li Z,Dong Y,Pei X,Huang Y,Wang L

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:To compare the distributional parameters for a series of ocular biometric traits between twins and their singleton siblings, to evaluate the generalizability of twin data, as used in heritability analyses to the general population. METHODS:A series of birth, anthropometric, and 13 ocular biometric traits were ...

journal_title：Investigative ophthalmology & visual science

authors： Sanfilippo PG,Medland SE,Hewitt AW,Kearns LS,Ruddle JB,Sun C,Hammond CJ,Young TL,Martin NG,Mackey DA

更新日期：2011-07-29 00:00:00