Correlation of aqueous humor ascorbate with intraocular pressure and outflow facility in hereditary buphthalmic rabbits.

abstract：:Gross correlation coefficient between light-scattering intensity and the optical parameters obtained for 48 sections of eight lenses with nuclear cataracts were evaluated. On the basis of these and other data in the literature, the structural elements, within the lens fiber are identified. These give rise to the optic...

journal_title：Investigative ophthalmology & visual science

authors： Bettelheim FA,Siew EL,Chylack LT Jr

更新日期：1981-03-01 00:00:00

abstract：PURPOSE:To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin, which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton of cultured bovine aortic endothelial cells (BAECs) and on outflow facility in living monkeys. METHODS:Latrunculin-A dose-time-response...

journal_title：Investigative ophthalmology & visual science

authors： Peterson JA,Tian B,Bershadsky AD,Volberg T,Gangnon RE,Spector I,Geiger B,Kaufman PL

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:To examine the effects of methylcobalamin on glutamate-induced neurotoxicity in the cultured retinal neurons. METHODS:Primary cultures obtained from the fetal rat retina (gestation days 16 to 19) were used for the experiment. The neurotoxicity was assessed quantitatively using the trypan blue exclusion method....

journal_title：Investigative ophthalmology & visual science

authors： Kikuchi M,Kashii S,Honda Y,Tamura Y,Kaneda K,Akaike A

更新日期：1997-04-01 00:00:00

abstract：PURPOSE:An alteration in corneal innervation has been described in dry eye associated with diabetes mellitus, contact lens use, and LASIK. The purpose of this study was to evaluate whether dry eye not related to Sjögren's syndrome (NSDE) and dry eye related to primary Sjögren's syndrome (PSDE) are associated with an al...

journal_title：Investigative ophthalmology & visual science

authors： Benítez-Del-Castillo JM,Acosta MC,Wassfi MA,Díaz-Valle D,Gegúndez JA,Fernandez C,García-Sánchez J

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To describe the variation in ocular biometry and its association with refraction in adult Mongolians. METHODS:The study included 1800 subjects, aged 40 years or more, who were selected in two Mongolian provinces-Hövsgöl and Omnögobi-to participate in this population survey. Axial length (AL) and its componen...

journal_title：Investigative ophthalmology & visual science

authors： Wickremasinghe S,Foster PJ,Uranchimeg D,Lee PS,Devereux JG,Alsbirk PH,Machin D,Johnson GJ,Baasanhu J

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:To study reading acuity in children and assess the reliability of its measurement using the Italian version of the MNREAD reading chart. METHODS:One hundred sixteen children from grades 3 to 8 with normal near vision were tested at a pediatric eye care institution in northeastern Italy. Visual acuity was evalu...

journal_title：Investigative ophthalmology & visual science

authors： Virgili G,Cordaro C,Bigoni A,Crovato S,Cecchini P,Menchini U

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation. METHODS:Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical ana...

journal_title：Investigative ophthalmology & visual science

authors： Ogawa Y,Kuwana M,Yamazaki K,Mashima Y,Yamada M,Mori T,Okamoto S,Oguchi Y,Kawakami Y

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine the details of the mechanism of K-115's neuroprotective effect in vivo and in vitro. METHODS:ROCK inhibitors, including K-115 and fasud...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto K,Maruyama K,Himori N,Omodaka K,Yokoyama Y,Shiga Y,Morin R,Nakazawa T

更新日期：2014-10-02 00:00:00

abstract：PURPOSE:Lens epithelial tissue does not normally express major histocompatibility complex (MHC) class I molecules. In addition, the mechanism of self-tolerance to intraocular antigens is unknown. To study the effect of class I expression in the lens, transgenic mice were produced that express an allo-MHC class I molecu...

journal_title：Investigative ophthalmology & visual science

authors： Martin WD,Egan RM,Stevens JL,Woodward JG

更新日期：1995-05-01 00:00:00

abstract：PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs ...

journal_title：Investigative ophthalmology & visual science

authors： Haymes SA,Johnston AW,Heyes AD

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:MRL/MpJ-+/+ (MRL/+) and MRL/MpJ-lpr/lpr (MRL/lpr) mice show spontaneous development of a T-cell-driven lacrimal gland inflammation that is a model for Sjögren syndrome. The lacrimal gland lesions in these mice were evaluated by quantitative RT-PCR for selected cytokine mRNA for the relative contributions of T-h...

journal_title：Investigative ophthalmology & visual science

authors： Jabs DA,Prendergast RA,Rorer EM,Hudson AP,Whittum-Hudson JA

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:The accessory lacrimal glands are assumed to contribute to the production of tear fluid, but little is known about their function. The goal of this study was to conduct an analysis of gene expression by glands of Wolfring that would provide a more complete picture of the function of these glands. METHODS:Gland...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Gipson IK,Spurr-Michaud SJ,Tisdale AS,Van Dyken RE,Hatton MP

更新日期：2012-10-01 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：:Iron is a potent generator of oxidative damage whose levels increase with age, potentially exacerbating age-related diseases. Several lines of evidence suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). AMD retinas have more iron within the photoreceptors, RPE, and drusen than do...

journal_title：Investigative ophthalmology & visual science

authors： Dunaief JL

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To provide a clinical and genetic description of a patient cohort with Stargardt disease (STGD1) with identifiable foveal sparing. METHODS:Patients with retinal atrophy (defined as an absence of autofluorescence) that surrounded the fovea by at least 180° and did not include the fovea were defined as having fo...

journal_title：Investigative ophthalmology & visual science

authors： van Huet RA,Bax NM,Westeneng-Van Haaften SC,Muhamad M,Zonneveld-Vrieling MN,Hoefsloot LH,Cremers FP,Boon CJ,Klevering BJ,Hoyng CB

更新日期：2014-10-16 00:00:00

abstract：PURPOSE:To assess corneal epithelial cell survival after keratoplasty. METHODS:Corneal impression cytology (CIC) was performed on sex-mismatched corneal transplants. Fluorescent in situ hybridization (FISH) with sex chromosome-specific probes was performed to identify epithelial cell mosaicism and therefore allocate t...

journal_title：Investigative ophthalmology & visual science

authors： Catanese M,Popovici C,Proust H,Hoffart L,Matonti F,Cochereau I,Conrath J,Gabison EE

更新日期：2011-02-22 00:00:00

abstract：:The adhesion complex of the corneal epithelium consists of the hemidesmosome and its associated structures, such as anchoring filaments, lamina densa of the basement membrane, and anchoring fibrils. It contributes to the adhesion of the corneal epithelium to Bowman's layer. To understand the adhesion complex better, a...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Kurpakus MA,Sambol B,Jones JC

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:Nonsyndromic high myopia, defined by a refractive error greater than -6 diopters (D), is associated with an increased risk of macular choroidal neovascularization (CNV), a vision-threatening complication. The aim of this study was to investigate whether genetic factors associated with age-related macular degene...

journal_title：Investigative ophthalmology & visual science

authors： Leveziel N,Yu Y,Reynolds R,Tai A,Meng W,Caillaux V,Calvas P,Rosner B,Malecaze F,Souied EH,Seddon JM

更新日期：2012-07-27 00:00:00

abstract：:Nineteen hundred and seventy-six immature human cataracts extracted intracapsularly were classified according to the Cooperative Cataract Research Group (CCRG) method of cataract classification. Data on cataract location and extent, nuclear color, preoperative visual acuity, age, and sex were organized and stored in t...

journal_title：Investigative ophthalmology & visual science

authors： Chylack LT Jr,Ransil BJ,White O

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:The goal was to establish an accurate method for measuring intraocular pressure (IOP) in living adult zebrafish and to determine the average IOPs of genetically different strains and mutants. The overall purpose was to develop the zebrafish system for studies of IOP and glaucoma. Elevated IOP and anterior segme...

journal_title：Investigative ophthalmology & visual science

authors： Link BA,Gray MP,Smith RS,John SW

更新日期：2004-12-01 00:00:00

abstract：:A stimulus consisting of 96 red LEDs mounted in the rear of a ganzfeld bowl was used to elicit focal electroretinograms (FERG) from the central 9 degrees of the retina in human subjects. The luminance of the stimulus was driven sinusoidally at frequencies from 10-60 Hz. The temporal responsiveness and response phase l...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM,Carr RE,Mayron C

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To quantify the spatial and temporal nature of congenital periodic alternating nystagmus (PAN) and to test the hypothesis that PAN results from a temporal shift in the null zone. METHODS:Twenty-five subjects with oculocutaneous albinism (16 tyrosinase negative and 9 tyrosinase positive) and 7 with ocular albin...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Pascal E

更新日期：1994-11-01 00:00:00

abstract：PURPOSE:To demonstrate the effectiveness of Hierarchical Bayesian (HB) approach in a modeling framework for association effects that accounts for SEs of vision-specific latent traits assessed using Rasch analysis. METHODS:A systematic literature review was conducted in four major ophthalmic journals to evaluate Rasch ...

journal_title：Investigative ophthalmology & visual science

authors： Wong WL,Li X,Li J,Wong TY,Cheng CY,Lamoureux EL

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response in Behçet's disease (BD) patients and the possible mechanisms involved. METHODS:Naive CD4(+) T cells from active BD patients and norm...

journal_title：Investigative ophthalmology & visual science

authors： Tian Y,Wang C,Ye Z,Xiao X,Kijlstra A,Yang P

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme ge...

journal_title：Investigative ophthalmology & visual science

authors： Görgün E,Güven M,Unal M,Batar B,Güven GS,Yenerel M,Tatlipinar S,Seven M,Yüksel A

更新日期：2010-09-01 00:00:00