Abstract：
PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recordings of ICP, IOP, and retinal venous pulsation waveforms taken with constant timing relative to the cardiac cycle using pulse oximetry. Video frames of the maxima and minima of these parameters, including retinal vein diameter, were identified. The times from pulse oximetry "beep" to these parameters were measured and converted into a percentage of the respective cardiac cycle. RESULTS:A total of 338 measurements from nine subjects with a mean age of 39 years, mean ICP of 4.4 mm Hg and IOP 15.1 mm Hg were taken. Vein diameter minima occurred an insignificant 0.6% of cardiac cycle before ICP minima (P = 0.6620) and a significant 3.2% after IOP minima (P = 0.0097) and significantly later than IOP (51%) and ICP maxima (74%, all P < 0.0001). Maximum vein diameter occurred an insignificant 2.0% before IOP maxima (P = 0.2267) and was significantly different from IOP and ICP minima (P < 0.00001). Mean venous pulsation pressure between the two eyes was significantly associated with ICP (r = 0.89, P = 0.0075). CONCLUSIONS:During pulsation, central retinal vein collapse occurs in time with IOP and ICP diastole. Venous collapse is not induced by intraocular systole. These results suggest that ICP pulse pressure dominates the timing of venous pulsation.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DYdoi
10.1167/iovs.12-9837subject
Has Abstractpub_date
2012-07-10 00:00:00pages
4676-81issue
8eissn
0146-0404issn
1552-5783pii
iovs.12-9837journal_volume
53pub_type
杂志文章abstract：Purpose:Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular a...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.19-26759
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abstract：PURPOSE:This study was undertaken to improve understanding of the defective lens developmental changes induced by the transgenic overexpression of the Rho GDP dissociation inhibitor RhoGDIalpha. The study was focused on a single differentially expressed gene encoding ponsin, a cell adhesion interacting signaling adapto...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.08-2909
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abstract：PURPOSE:To quantify protein changes in the morphologically distinct remodeling zone (RZ) and adjacent regions of the human lens outer cortex using spatially directed quantitative proteomics. METHODS:Lightly fixed human lens sections were deparaffinized and membranes labeled with fluorescent wheat germ agglutinin (WGA-...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.16-19791
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:The accessory lacrimal glands are assumed to contribute to the production of tear fluid, but little is known about their function. The goal of this study was to conduct an analysis of gene expression by glands of Wolfring that would provide a more complete picture of the function of these glands. METHODS:Gland...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.12-10750
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:Recovery of photoreceptor cells after light damage is thought to involve the physiologic process of disk renewal. However, only indirect evidence is available to support this hypothesis. The present study sought to examine more directly the mechanisms of photoreceptor cell recovery by quantitatively assessing t...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
abstract：PURPOSE:To test whether retinal pigment epithelial (RPE) cells are able to induce myeloid-derived suppressor cell (MDSC) differentiation from bone marrow (BM) progenitors. METHODS:BM cells were cocultured with or without RPE cells in the presence of GM-CSF and IL-4. Numbers of resultant MDSCs were assessed by flow cyt...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.11-8377
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abstract：PURPOSE:Tests for ocular Chlamydia trachomatis have not been well characterized, because there is no gold standard test. Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard. METHODS:Individual data from pr...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章,随机对照试验
doi：10.1167/iovs.11-7419
更新日期：2011-08-03 00:00:00
abstract：PURPOSE:To identify the defective gene in the sex-linked, recessively inherited retinal dysplasia and degeneration (rdd) chicken and to search for the human equivalent disease. METHODS:Microsatellites from chicken chromosome Z were genotyped in 77 progeny of a carrier male (rdd/+) and an affected female (rdd/W), and c...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.11-7872
更新日期：2011-09-27 00:00:00
abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...
journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.19-27865
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.09-4108
更新日期：2010-09-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.17-22240
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...
journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.12-9656
更新日期：2012-05-14 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.13-12833
更新日期：2014-03-25 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.16-21302
更新日期：2017-03-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：10.1167/iovs.03-0822
更新日期：2004-12-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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doi：10.1167/iovs.10-5240
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
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journal_title：Investigative ophthalmology & visual science
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更新日期：2003-07-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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doi：
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journal_title：Investigative ophthalmology & visual science
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更新日期：2016-11-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to examine ocular surface and tear film, contact lens, care solution, medical, and patient-related factors that are associated with corneal staining in contact lens wearers. METHODS:In this cross-sectional/nested case-control study, in addition to the assessment of corneal stainin...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
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更新日期：2015-05-01 00:00:00
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journal_title：Investigative ophthalmology & visual science
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
