Gene expression in human accessory lacrimal glands of Wolfring.

abstract：:Contrast sensitivity functions for sinusoidal gratings of different spatial frequencies and stimulus durations have been determined for both eyes of amblyopic subjects. For both long and short stimulus durations, the entire contrast sensitivity function of the amblyopic eyes is lower than that of the nonamblyopic eyes...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:To develop a modified adenoassociated viral (AAV) vector capable of efficient transfection of retinal ganglion cells (RGCs) and to test the hypothesis that use of this vector to express brain-derived neurotrophic factor (BDNF) could be protective in experimental glaucoma. METHODS:Ninety-three rats received one...

journal_title：Investigative ophthalmology & visual science

authors： Martin KR,Quigley HA,Zack DJ,Levkovitch-Verbin H,Kielczewski J,Valenta D,Baumrind L,Pease ME,Klein RL,Hauswirth WW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice. METHODS:To ...

journal_title：Investigative ophthalmology & visual science

authors： Tang Y,Liu X,Zoltoski RK,Novak LA,Herrera RA,Richard I,Kuszak JR,Kumar NM

更新日期：2007-06-01 00:00:00

abstract：:Ultrastructural cytochemistry was used to localize a previously undescribed retinal enzyme activity, ie, "manganese-dependent pyrimidine 5'-nucleotidase" (MDPNase) activity in retinas from rats raised in cyclic light and killed at various times in the lighting cycle. In retinas fixed during the last 3 hr of darkness, ...

journal_title：Investigative ophthalmology & visual science

authors： Irons MJ

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

journal_title：Investigative ophthalmology & visual science

authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

更新日期：2006-06-01 00:00:00

abstract：:In order to investigate the effect of traction of the vasculature on induction or acceleration of neovascularization, the chorioallantoic membranes (CAMs) of the developing chick embryo were placed under tension with 10-0 nylon sutures and subsequently examined histologically. In the initial phase of the study, CAMs f...

journal_title：Investigative ophthalmology & visual science

authors： Yamashita H,Hori S,Yamamoto T

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:Bacillus cereus causes one of the most rapidly blinding forms of bacterial endophthalmitis. Migration of B. cereus throughout the eye during endophthalmitis is a unique aspect of this disease that may contribute to intraocular virulence. This study was conducted to analyze the contribution of swarming and intra...

journal_title：Investigative ophthalmology & visual science

authors： Callegan MC,Novosad BD,Ramirez R,Ghelardi E,Senesi S

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To investigate the effects of an imaginary and a visual target on torsional optokinetic nystagmus (tOKN) and directional symmetry of tOKN. METHODS:Torsional OKN was induced by a rotating random dot pattern (52 degrees in diameter, constant angular velocity: +/-30 deg/sec to +/-52 deg/sec) with an imaginary or ...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki Y,Shinmei Y,Nara H,Ifukube T

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To identify proteins secreted by the retinal pigment epithelium (RPE) and to analyze their cellular distribution in normal and pathologic rat retinas at various stages of eye development. METHODS:A cDNA library was constructed with RNA isolated from porcine RPE sheets and screened by using the yeast signal seq...

journal_title：Investigative ophthalmology & visual science

authors： Van Den Berghe L,Sainton K,Gogat K,Marchant D,Dufour E,Bonnel S,Gadin S,Menasche M,Abitbol M

更新日期：2004-05-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear m...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Löfgren S,Saether O,Mody V,Meyer L,Dong X,Söderberg PG,Midelfart A

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Adaptive optics scanning laser ophthalmoscopy (AOSLO) under optimized wavefront correction allows for routine imaging of foveal cone photoreceptors. The intersubject variability of foveal cone density was measured and its relation to eye length evaluated. METHODS:AOSLO was used to image 18 healthy eyes with ax...

journal_title：Investigative ophthalmology & visual science

authors： Li KY,Tiruveedhula P,Roorda A

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To evaluate by vector analysis the corneal astigmatic changes occurring in keratoconic corneas during a 3-year follow-up and to determine the relationship between these changes and other clinical changes. METHODS:Keratoconic eyes (n = 114) of 75 patients ranging in age from 14 to 70 years were retrospectively ...

journal_title：Investigative ophthalmology & visual science

authors： Piñero DP,Alio JL,Tomás J,Maldonado MJ,Teus MA,Barraquer RI

更新日期：2011-06-08 00:00:00

abstract：PURPOSE:To study age-related changes in the refractive index distribution of the human ocular lens. METHODS:Biometric data collected on 48 eyes in subjects ranging in age from 19 to 31 years and 48 eyes in subjects ranging in age from 49 to 61 years allowed estimation of a single parameter related to the refractive in...

journal_title：Investigative ophthalmology & visual science

authors： Hemenger RP,Garner LF,Ooi CS

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis. METHODS:Corneal IL-33 mRNA and protein levels were tested in susceptible C57BL/6 (B6) and resistant BALB/c mice. B6 mice were injected with recombinant mouse IL-33 (rmIL-33) and disease severity, bacterial load, polymorphonuclear...

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Huang X,Zhang Y,Wu M,van Rooijen N,Szliter E

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Corneas with scars and certain chronic pathologic conditions contain highly sulfated dermatan sulfate, but little is known of the core proteins that carry these atypical glycosaminoglycans. In this study the proteoglycan proteins attached to dermatan sulfate in normal and pathologic human corneas were examined ...

journal_title：Investigative ophthalmology & visual science

authors： Funderburgh JL,Hevelone ND,Roth MR,Funderburgh ML,Rodrigues MR,Nirankari VS,Conrad GW

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:To study the oxygen-saturation profiles in RP and macular dystrophies and compare them with age-matched healthy controls. METHODS:In a cross-sectional prospective study, 62 subjects with RP, 23 with macular dystrophies, and 78 controls were enrolled, and retinal oximetry was performed with the Oxymap T1 retina...

journal_title：Investigative ophthalmology & visual science

authors： Battu R,Mohan A,Khanna A,Kumar A,Shetty R

更新日期：2015-05-01 00:00:00

abstract：:The comparison of intracellular pH (pHi) regulation between fresh (FBCE) and cultured (CBCE) bovine corneal endothelium was extended to HCO3- transport mechanisms. Upon introduction of CO2/HCO3- Ringer's solution, there was a small, sharp acidification followed by an alkalinization .09 and .18 pH U above the HCO3- fre...

journal_title：Investigative ophthalmology & visual science

authors： Bonanno JA,Giasson C

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:To investigate feasibility and potential uses of flow cytometry in impression cytology as a new procedure to assess and quantify conjunctival inflammation. METHODS:Specimens for cytology were collected by impression from 30 patients with various chronic ocular surface disorders and from 10 normal subjects. Two...

journal_title：Investigative ophthalmology & visual science

authors： Baudouin C,Brignole F,Becquet F,Pisella PJ,Goguel A

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:We compared the reproducibility and mutual agreement of the subfoveal choroidal thickness measurements by expert raters and an automated algorithm in enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes with nonneovascular age-related macular degeneration (AMD). METHODS:We recruited 44 ...

journal_title：Investigative ophthalmology & visual science

authors： Lee S,Fallah N,Forooghian F,Ko A,Pakzad-Vaezi K,Merkur AB,Kirker AW,Albiani DA,Young M,Sarunic MV,Beg MF

更新日期：2013-04-23 00:00:00

abstract：PURPOSE:To identify the chromosomal location of the gene causing snowflake vitreoretinal degeneration (SVD), an autosomal dominant retinal degeneration characterized by small yellow-white dots in the retina, fibrillar anomaly of the vitreous humor, and retinal detachment. METHODS:Clinical data were collected on 31 fam...

journal_title：Investigative ophthalmology & visual science

authors： Jiao X,Ritter R 3rd,Hejtmancik JF,Edwards AO

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:We previously developed a method to measure visual function progression using "Progression sectors," which were derived from a clustering analysis of pointwise rates of glaucomatous visual field (VF) progression; however, only short series of VFs, where pointwise linear regression (PLR) is typically not reliabl...

journal_title：Investigative ophthalmology & visual science

authors： Hirasawa K,Murata H,Asaoka R

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence ...

journal_title：Investigative ophthalmology & visual science

authors： Moreira EF,Larrayoz IM,Lee JW,Rodríguez IR

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of coulomb-controlled iontophoresis (CCI) for delivery of riboflavin prior to corneal collagen cross-linking (CXL). METHODS:The eyes of 20 8-week-old Lewis rats, subject to epithelium-ON (epi-ON, n = 20 eyes) or epithelium-OFF (epi-OFF, n = 20 eyes) conditions, were used to evaluate th...

journal_title：Investigative ophthalmology & visual science

authors： Arboleda A,Kowalczuk L,Savoldelli M,Klein C,Ladraa S,Naud MC,Aguilar MC,Parel JM,Behar-Cohen F

更新日期：2014-04-28 00:00:00

abstract：PURPOSE:To examine the possibility that ocular surface epithelial cells might be grown in culture for use as grafts. METHODS:The proliferative capacity of epithelial cells cultured from the conjunctiva, limbus, and central cornea of normal human eyes was compared. Single cells disaggregated from approximately 1 mm2 bi...

journal_title：Investigative ophthalmology & visual science

authors： Lindberg K,Brown ME,Chaves HV,Kenyon KR,Rheinwald JG

更新日期：1993-08-01 00:00:00

abstract：Purpose:To assess the phenotypic variability and natural course of inherited retinal diseases (IRDs) caused by EYS mutations. Methods:Multiethnic cohort study (N = 30) with biallelic EYS variants from a clinical IRD database (retinitis pigmentosa [RP], N = 27; cone-rod dystrophy [CRD], N = 1; and macular dystrophy, N ...

journal_title：Investigative ophthalmology & visual science

authors： Pierrache LHM,Messchaert M,Thiadens AAHJ,Haer-Wigman L,de Jong-Hesse Y,van Zelst-Stams WAG,Collin RWJ,Klaver CCW,van den Born LI

更新日期：2019-05-01 00:00:00