Revalidating the Usefulness of a "Sector-Wise Regression" Approach to Predict Glaucomatous Visual Function Progression.

abstract：PURPOSE:To investigate the involvement of the p38 mitogen-activated protein (MAP) kinase and phosphatidylinositol-3 (PI-3) kinase-Akt signaling pathways after pathologic stimulation by N-methyl-D-aspartate (NMDA) receptors of retinal neurons in vivo. METHODS:NMDA (2-200 nmol), SB203580 (0.2-10 nmol, an inhibitor of p3...

journal_title：Investigative ophthalmology & visual science

authors： Manabe S,Lipton SA

更新日期：2003-01-01 00:00:00

abstract：:PURPOSE. Mitochondrial function and the presence of somatic mitochondrial DNA (mtDNA) defects were investigated in extraocular muscles (EOMs) collected from individuals covering a wide age range, to document the changes seen with normal aging. METHODS. Cytochrome c oxidase (COX) and succinate dehydrogenase (SDH) histo...

journal_title：Investigative ophthalmology & visual science

authors： Yu-Wai-Man P,Lai-Cheong J,Borthwick GM,He L,Taylor GA,Greaves LC,Taylor RW,Griffiths PG,Turnbull DM

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The pattern electroretinogram (PERG) is reduced in early glaucoma and in some eyes with ocular hypertension (OHT). This study was designed to test the ability of the PERG to predict the development of visual field loss in OHT eyes. METHODS:In 29 eyes of 18 patients with high-risk OHT, the visual fields were te...

journal_title：Investigative ophthalmology & visual science

authors： Pfeiffer N,Tillmon B,Bach M

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:We evaluated the clinical use of segmented macular layer thickness measurement in terms of glaucoma diagnosis and the ability to detect progression, and to compare such outcomes to those by circumpapillary retinal nerve fiber layer (cRNFLT) and total macular thickness (TMT) measurements. METHODS:The study incl...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Kim YJ,Durbin MK,Lee HJ,Kim HK,Sohn YH

更新日期：2012-06-20 00:00:00

abstract：Purpose:Neovascularization (NV) and retinal vascular leakage are major causes of impaired vision in ocular diseases. The purpose of this study was to identify novel phenylphthalimide analogs with therapeutic effects on NV and vascular leakage and to explore the mechanism of action. Methods:Antiangiogenic activities of...

journal_title：Investigative ophthalmology & visual science

authors： Wang B,Li PK,Ma JX,Chen D

更新日期：2018-07-02 00:00:00

abstract：Purpose:To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods:The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The...

journal_title：Investigative ophthalmology & visual science

authors： Xiong S,Zhang B,Hong Y,He X,Zhu J,Zou H,Xu X

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Previous work from the authors' laboratory has shown that Hsp27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation acts as a key cytoprotective factor in preventing retinal ischemic damage. The regulatory mechanisms involved in the upregulation of Hsp27 after IPC are...

journal_title：Investigative ophthalmology & visual science

authors： Whitlock NA,Agarwal N,Ma JX,Crosson CE

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:Compelling evidence suggests that alpha2 agonists, such as brimonidine, protect retinal ganglion cells (RGCs) from injury in a wide range of animal models. However, the mechanism of action for this protection and the physiological role of the alpha2 adrenergic system in the retina is not well understood. A majo...

journal_title：Investigative ophthalmology & visual science

authors： Dong CJ,Guo Y,Wheeler L,Hare WA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Intrastromal inlays for refractive correction of presbyopia are being adopted into clinical practice. An important concern is the effect of the inlay on the long-term health of the cornea due to disturbances in the concentration profiles of metabolic species. A three-dimensional metabolic model for the cornea i...

journal_title：Investigative ophthalmology & visual science

authors： Pinsky PM

更新日期：2014-05-15 00:00:00

abstract：PURPOSE:To investigate in impression cytology (IC) specimens the expression of inflammatory and apoptosis-related markers by conjunctival epithelial cells from patients with dry eye as a rationale for treatment with topical cyclosporine. METHODS:Immunologic anomalies were identified at baseline, before treatment with ...

journal_title：Investigative ophthalmology & visual science

authors： Brignole F,Pisella PJ,Goldschild M,De Saint Jean M,Goguel A,Baudouin C

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To investigate the role of the gap junction protein connexin43 (Cx43), which is predominantly expressed in lens epithelial cells in the control of lens development and organization. METHODS:Newborn mice in which the Cx43 gene was disrupted by homologous recombination were used. Lenses from Cx43 (-/-) mice and ...

journal_title：Investigative ophthalmology & visual science

authors： Gao Y,Spray DC

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:To quantify protein changes in the morphologically distinct remodeling zone (RZ) and adjacent regions of the human lens outer cortex using spatially directed quantitative proteomics. METHODS:Lightly fixed human lens sections were deparaffinized and membranes labeled with fluorescent wheat germ agglutinin (WGA-...

journal_title：Investigative ophthalmology & visual science

authors： Wenke JL,McDonald WH,Schey KL

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability to reproduce an organized matrix in vit...

journal_title：Investigative ophthalmology & visual science

authors： Kureshi AK,Funderburgh JL,Daniels JT

更新日期：2014-10-21 00:00:00

abstract：PURPOSE:A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by ...

journal_title：Investigative ophthalmology & visual science

authors： Li C,Ding XQ,O'Brien J,Al-Ubaidi MR,Naash MI

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity. METHODS:Newborn neural retinas of C57BL/6 mice were implanted into the su...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Jorquera M,Streilein JW

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:To assess the aqueous outflow pathway in primary open-angle glaucoma (POAG) through provocative gonioscopy and channelography with a flexible microcatheter and fluorescein tracer during canaloplasty. METHODS:One eye each was randomly selected from 28 consecutive black African POAG patients undergoing canalopla...

journal_title：Investigative ophthalmology & visual science

authors： Grieshaber MC,Pienaar A,Olivier J,Stegmann R

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00

abstract：Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

journal_title：Investigative ophthalmology & visual science

authors： Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To determine the fate of donor epithelial, stromal, and endothelial cells after corneal transplantation in humans. METHODS:Fifty-two transplanted corneal buttons were explanted over a 2-year period from patients who required regrafting and had received corneas from donors of opposite sex. Fluorescence in situ ...

journal_title：Investigative ophthalmology & visual science

authors： Lagali N,Stenevi U,Claesson M,Fagerholm P,Hanson C,Weijdegård B,Swedish Society of Corneal Surgeons.

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate in rabbits the relationship between nitric oxide and the noncholinergic vasodilation caused by facial nerve stimulation in the eye and some extraocular tissues. METHODS:Uveal vascular resistance was determined by measuring simultaneously the flow from a cannulated vorte...

journal_title：Investigative ophthalmology & visual science

authors： Nilsson SF

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:To examine whether Na(+)-K(+)-2Cl(-) cotransport has the potential to contribute to corneal endothelial ion and fluid transport in cultured and fresh bovine corneal endothelial cells. METHODS:Cl- and Na+ sensitive fluorescent dyes were used to measure furosemide-dependent ion fluxes in cultured and fresh endot...

journal_title：Investigative ophthalmology & visual science

authors： Jelamskii S,Sun XC,Herse P,Bonanno JA

更新日期：2000-02-01 00:00:00

abstract：:An ultrasonic pachometer was used to measure the central, mid-peripheral, and peripheral thickness in 17 locations across the corneas of 12 adult New Zealand Albino rabbit eyes. The mean thickness at each location was entered into a microcomputer to generate a three-dimensional plot of corneal thickness. The rabbit co...

journal_title：Investigative ophthalmology & visual science

authors： Chan T,Payor S,Holden BA

更新日期：1983-10-01 00:00:00

abstract：:Topical commercial phenylephrine HCl (Neo-Synephrine 10%) has been shown to cause an increase in corneal thickness and reversible vacuolization of corneal endothelial cells in rabbits. Using an in vivo model of regenerated corneal endothelial cells in the cat, we compared the cytotoxicity of phenylephrine-HCl 10% to r...

journal_title：Investigative ophthalmology & visual science

authors： Cohen KL,Van Horn DL,Edelhauser HF,Schultz RO

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:Elevated levels of extracellular glutamate have been implicated in the pathophysiology of neuronal loss in both central nervous system and ophthalmic disorders, including glaucoma. This increase in glutamate may result from a failure of glutamate transporters (molecules that ordinarily regulate extracellular gl...

journal_title：Investigative ophthalmology & visual science

authors： Vorwerk CK,Naskar R,Schuettauf F,Quinto K,Zurakowski D,Gochenauer G,Robinson MB,Mackler SA,Dreyer EB

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:In uveal melanoma, both tumor size and an inflammatory phenotype have been shown to correlate with a poor clinical prognosis. The purpose of this study was to identify whether inflammatory cytokines were present in the vitreous of eyes with uveal melanoma and to determine whether the vitreal concentration of cy...

journal_title：Investigative ophthalmology & visual science

authors： Nagarkatti-Gude N,Bronkhorst IH,van Duinen SG,Luyten GP,Jager MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To determine variations in eye volume, surface area, and shape with refractive error in young children using a three-dimensional magnetic resonance imaging (MRI) model. METHODS:A subset of Singaporean Chinese boys enrolled in the population-based Strabismus, Amblyopia, and Refractive Error in Singapore (STARS)...

journal_title：Investigative ophthalmology & visual science

authors： Lim LS,Yang X,Gazzard G,Lin X,Sng C,Saw SM,Qiu A

更新日期：2011-11-17 00:00:00

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00