Identification of ocular cicatricial pemphigoid antibody binding site(s) in human beta4 integrin.

abstract：PURPOSE:The degeneration of retinal pigment epithelial (RPE) cells is considered to be a crucial event in the pathophysiology of age-related macular degeneration (AMD). Cumulative oxidative damage has been implicated in the development of the changes seen in AMD. The present study was undertaken to evaluate the express...

journal_title：Investigative ophthalmology & visual science

authors： Alge CS,Priglinger SG,Neubauer AS,Kampik A,Zillig M,Bloemendal H,Welge-Lussen U

更新日期：2002-11-01 00:00:00

abstract：PURPOSE:To determine the role of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the response of the human retinal pigment epithelial cell line ARPE-19 to oxidative stress. METHODS:ARPE-19 cells were treated with the chemical oxidant tert-butyl hydroperoxide (t-BOOH), and cell viability was ...

journal_title：Investigative ophthalmology & visual science

authors： Hutnik CM,Pocrnich CE,Liu H,Laird DW,Shao Q

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:To assess the neuroprotective effects of different glutamate modulation strategies, with a nonselective (MK801) and a selective (ifenprodil) NMDA receptor antagonist and a metabotropic glutamate receptor agonist (mGluR Group II, LY354740), in glaucoma-related in vivo rat models of retinal ganglion cell (RGC) ap...

journal_title：Investigative ophthalmology & visual science

authors： Guo L,Salt TE,Maass A,Luong V,Moss SE,Fitzke FW,Cordeiro MF

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Several nonsyndromic high-grade myopia loci have been mapped primarily by microsatellite markers and a limited number of pedigrees. In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites. METHODS:G...

journal_title：Investigative ophthalmology & visual science

authors： Li YJ,Guggenheim JA,Bulusu A,Metlapally R,Abbott D,Malecaze F,Calvas P,Rosenberg T,Paget S,Creer RC,Kirov G,Owen MJ,Zhao B,White T,Mackey DA,Young TL

更新日期：2009-07-01 00:00:00

abstract：Purpose:To investigate changes of β-zone parapapillary atrophy (PPA) during axial elongation. Methods:Change of β-zone PPA was evaluated by spectral-domain optical coherence tomography (SD-OCT) in myopic children for 2 years, prospectively. Using the infrared images acquired by a fixed scan circle in the glaucoma prog...

journal_title：Investigative ophthalmology & visual science

authors： Lee KM,Choung HK,Kim M,Oh S,Kim SH

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Amblyopia is the commonest visual disorder of childhood. Yet the contributions of the two principal treatments (spectacle wear and occlusion) to outcome are unknown. This study was undertaken to investigate the dose-response relationship of amblyopia therapy. METHODS:The study comprised three distinct phases: ...

journal_title：Investigative ophthalmology & visual science

authors： Stewart CE,Moseley MJ,Stephens DA,Fielder AR

更新日期：2004-09-01 00:00:00

abstract：:An automated Minigel electrophoresis system (PhastSystem, Pharmacia, Uppsala, Sweden) was tested for human tear protein analysis. Tear samples were treated under nonreducing or reducing conditions before sodium dodecyl sulphate polyacryl amide gel electrophoresis (SDS-PAGE). Micro-amounts of tears (2 microliters) were...

journal_title：Investigative ophthalmology & visual science

authors： Kuizenga A,van Haeringen NJ,Kijlstra A

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the changes in tumor burden and hypoxia in the LH(BETA)T(AG) retinal tumors after treatment with a focal, single-modality, and combination therapy using periocular carboplatin and 2-deoxy-d-glucose (2-DG). METHODS:Seventeen-week-old LH(BETA)T(AG) transgenic mice (n = 25) w...

journal_title：Investigative ophthalmology & visual science

authors： Piña Y,Houston SK,Murray TG,Boutrid H,Celdran M,Feuer W,Shi W,Hernandez E,Lampidis TJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:We investigated the progressive degeneration of retinal and superior collicular functions in a mouse model of sustained ocular hypertension. METHODS:Focal laser illumination and injection of polystyrene microbeads were used to induce chronic ocular hypertension. Retinal ganglion cell (RGC) loss was characteriz...

journal_title：Investigative ophthalmology & visual science

authors： Chen H,Zhao Y,Liu M,Feng L,Puyang Z,Yi J,Liang P,Zhang HF,Cang J,Troy JB,Liu X

更新日期：2015-02-26 00:00:00

abstract：:Feline sarcoma virus (FeSV) is a naturally occurring virus that causes spontaneous tumors in cats. The immunologic and morphologic characteristics of these tumors have been studied extensively. It was recently observed in experiments undertaken to induce systemic malignancy with this virus, that severe uveitis and cli...

journal_title：Investigative ophthalmology & visual science

authors： Lubin JR,Albert DM,Essex M,de Noronha F,Riis R

更新日期：1983-08-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the hypothesis that quench-assisted 1/T1 magnetic resonance imaging (MRI) measures free radical production with laminar resolution in vivo without the need of a contrast agent. Here, we test this hypothesis further by examining the spatial and detection sensitivity of quench-assist...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Lewin AS,Biswal MR,Bredell BX,Davis C,Roberts R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS:Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-...

journal_title：Investigative ophthalmology & visual science

authors： Syed R,Sundquist SM,Ratnam K,Zayit-Soudry S,Zhang Y,Crawford JB,MacDonald IM,Godara P,Rha J,Carroll J,Roorda A,Stepien KE,Duncan JL

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Submucosal fibrosis due to excessive accumulation of collagens is an important histologic feature in the pathogenesis of ocular cicatricial pemphigoid (OCP). Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined ...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Foster CS,Ahmed AR

更新日期：2003-04-01 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:To determine whether polyamines are present in corneal cells, whether corneal cell polyamines can be depleted by blocking the first rate-limiting enzyme in the polyamine synthesis pathway, ornithine decarboxylase (ODC), and whether polyamines are required for proliferation in all three corneal cell types. METH...

journal_title：Investigative ophthalmology & visual science

authors： Du H,Viar MJ,Johnson LR,Watsky MA

更新日期：2003-06-01 00:00:00

abstract：:A single injection of an aqueous suspension of group A streptococcal peptidoglycan-polysaccharide complexes (PG-PS) when injected intraperitoneally into Lewis rats induced a self-limiting bilateral uveitis with associated perpetuating polyarthritis. The uveitis was characterized clinically during the first 72 h by iri...

journal_title：Investigative ophthalmology & visual science

authors： Wells A,Pararajasegaram G,Baldwin M,Yang CH,Hammer M,Fox A

更新日期：1986-06-01 00:00:00

abstract：PURPOSE:EGF-induced activation of the epigenetic CCCTC binding factor (CTCF) plays an important role in corneal epithelial cell proliferation by suppressing the Pax6 gene. The present study focused on further understanding the role of CTCF in mediating EGF-induced migration of immortalized human corneal epithelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Deng SX,Lu L

更新日期：2012-02-23 00:00:00

abstract：PURPOSE:To characterize in SV40-immortalized human corneal epithelial cells (tHCEC) osmosensitive taurine transporter gene and protein expression as well as its functional activity. To evaluate whether medium supplementation with taurine improves cell viability during a hypertonic challenge. METHODS:tHCEC were preincu...

journal_title：Investigative ophthalmology & visual science

authors： Shioda R,Reinach PS,Hisatsune T,Miyamoto Y

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:The use of patient-reported outcome (PRO) measures to assess self-reported difficulty in visual activities is common in patients with impaired vision. This study determines the visual and psychosocial factors influencing patients' responses to self-report measures, to aid in understanding what is being measured...

journal_title：Investigative ophthalmology & visual science

authors： Tabrett DR,Latham K

更新日期：2011-07-15 00:00:00

abstract：PURPOSE:Human adenovirus species D type 19 (HAdV-D19) has been associated with epidemic keratoconjunctivitis (EKC), a highly inflammatory infection of the ocular surface. Confusion exists regarding the origins of HAdV-D19. The prototype virus (HAdV-D19p) does not cause EKC, while a virus identified later with the ident...

journal_title：Investigative ophthalmology & visual science

authors： Zhou X,Robinson CM,Rajaiya J,Dehghan S,Seto D,Jones MS,Dyer DW,Chodosh J

更新日期：2012-05-14 00:00:00

abstract：PURPOSE:In an earlier study it was reported that thrombin significantly reduces the rate of Na,K-adenosine triphosphatase (ATPase)-mediated ion transport by porcine lens. Because thrombin stimulates the release of endogenous endothelin (ET)-1 stores from some tissues, and because ET-1 can cause Na,K-ATPase inhibition, ...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Mukhopadhyay P,Delamere NA

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：Purpose:To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). Methods:The qAF imaging was performed on eyes of 26 rhesus macaques (me...

journal_title：Investigative ophthalmology & visual science

authors： Tran TM,Kim S,Lin KH,Chung SH,Park S,Sazhnyev Y,Wang Y,Cunefare D,Farsiu S,Thomasy SM,Moshiri A,Yiu G

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To develop a modified adenoassociated viral (AAV) vector capable of efficient transfection of retinal ganglion cells (RGCs) and to test the hypothesis that use of this vector to express brain-derived neurotrophic factor (BDNF) could be protective in experimental glaucoma. METHODS:Ninety-three rats received one...

journal_title：Investigative ophthalmology & visual science

authors： Martin KR,Quigley HA,Zack DJ,Levkovitch-Verbin H,Kielczewski J,Valenta D,Baumrind L,Pease ME,Klein RL,Hauswirth WW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHOD...

journal_title：Investigative ophthalmology & visual science

authors： van den Berg TJ

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:We studied morphologic changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS:Major retinal vessels in 35 eyes from 35 consecutive patients with acute CRVO were examined prospectively and longitudinally with sequentia...

journal_title：Investigative ophthalmology & visual science

authors： Muraoka Y,Tsujikawa A,Kumagai K,Akagi-Kurashige Y,Ogino K,Murakami T,Miyamoto K,Yoshimura N

更新日期：2014-01-07 00:00:00

abstract：PURPOSE:To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on the photoreceptors, and whether it slows the rate of decrease of the electroretinogram (ERG) in rhodopsin P347L transgenic (Tg) rabbits. METHODS:Six-week-old Tg rabbits received TES through a contact lens electrode on...

journal_title：Investigative ophthalmology & visual science

authors： Morimoto T,Kanda H,Kondo M,Terasaki H,Nishida K,Fujikado T

更新日期：2012-06-28 00:00:00

abstract：PURPOSE:Trabecular meshwork (TM) cells appear to sense changes in intraocular pressure (IOP) as mechanical stretching. In response, they make homeostatic corrections in the aqueous humor outflow resistance, partially by increasing extracellular matrix (ECM) turnover initiated by the matrix metalloproteinases. To unders...

journal_title：Investigative ophthalmology & visual science

authors： Vittal V,Rose A,Gregory KE,Kelley MJ,Acott TS

更新日期：2005-08-01 00:00:00

abstract：Purpose:To evaluate the contribution of fixational saccades toward fixation instability in strabismic monkeys. Methods:Binocular eye movements were measured as six experimental monkeys (five strabismic monkeys and one monkey with downbeat nystagmus) and one normal monkey fixated targets of two shapes (Optotype, Disk) ...

journal_title：Investigative ophthalmology & visual science

authors： Upadhyaya S,Pullela M,Ramachandran S,Adade S,Joshi AC,Das VE

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00