The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress.

abstract：PURPOSE:This study describes the expression and distribution of arrestin, phosducin, and recoverin in the cone-dominant retina of the ground squirrel Spermophilus tridecemlineatus. METHODS:mRNA expression was studied by blot hybridization of ground squirrel retinal RNA, with human and murine RNA as controls. The distr...

journal_title：Investigative ophthalmology & visual science

authors： von Schantz M,Szél A,van Veen T,Farber DB

更新日期：1994-10-01 00:00:00

abstract：Purpose:Patients express their discomfort by subjective complaints, which may not clearly express the extent of their discomfort. This study noninvasively and objectively quantified ocular discomfort, a form of feeling, from the prefrontal cortex by functional near-infrared ray spectroscopy topography. Methods:This ca...

journal_title：Investigative ophthalmology & visual science

authors： Ono M,Takano Y,Haida M

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS:An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Kaur K,Rao KN,Mandal AK,Kaur I,Parikh RS,Thomas R

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the relationship between objectively measured ambient light exposure and longitudinal changes in axial eye growth in childhood. METHODS:A total of 101 children (41 myopes and 60 nonmyopes), 10 to 15 years of age participated in this prospective longitudinal observationa...

journal_title：Investigative ophthalmology & visual science

authors： Read SA,Collins MJ,Vincent SJ

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To investigate macular changes in acute retinopathy of prematurity (ROP). METHODS:Fifty-four premature infants with ROP and 20 controls underwent routine ROP screening with indirect ophthalmoscopy and imaging. A tabletop spectral domain optical coherence tomography (SD-OCT) scanner (Spectralis; Heidelberg Engi...

journal_title：Investigative ophthalmology & visual science

authors： Vinekar A,Avadhani K,Sivakumar M,Mahendradas P,Kurian M,Braganza S,Shetty R,Shetty BK

更新日期：2011-07-15 00:00:00

abstract：PURPOSE:Weak eye muscles can cause ophthalmic disorders, and in particular, strabismus. Exogenous trophic factors such as cardiotrophin (CT)-1 and insulin-like growth factor (IGF) have been shown to increase the contractile force of adult heart and skeletal muscles, respectively. In the current study, the effects of en...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,von Bartheld CS

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Stereoscopic displays challenge the neural cross-coupling between accommodation and vergence by inducing a constant accommodative demand and a varying vergence demand. Stereoscopic viewing calls for a decrease in the gain of vergence accommodation, which is the accommodation caused by vergence, quantified by us...

journal_title：Investigative ophthalmology & visual science

authors： Neveu P,Roumes C,Philippe M,Fuchs P,Priot AE

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin coh...

journal_title：Investigative ophthalmology & visual science

authors： Schäche M,Richardson AJ,Pertile KK,Dirani M,Scurrah K,Baird PN

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To investigate the effects of adhesion promoting surgical adjuncts in Descemets stripping automated endothelial keratoplasty (DSAEK). The effects of air-fill pressure, duration, use of venting incisions and stromal roughening on fluid dispersion, and donor adhesion strength were examined in theoretical, optical...

journal_title：Investigative ophthalmology & visual science

authors： Bhogal MS,Angunawela RI,Bilotti E,Eames I,Allan BD

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:In humans, mutations in the gene encoding myosin VIIa can cause Usher syndrome type 1b (USH1B), a disease characterized by deafness and retinitis pigmentosa. Myosin VIIa is also the gene responsible for the inner ear abnormalities at the shaker1 (sh1) locus in mice. To date, none of the sh1 alleles examined hav...

journal_title：Investigative ophthalmology & visual science

authors： Libby RT,Steel KP

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:To understand the involvement of the CYP1B1 gene in cases of primary open-angle (POAG) and primary angle-closure (PACG) glaucomas and obtain the haplotype background of these mutations. METHODS:The entire coding region of CYP1B1 was screened by resequencing in 224 unrelated cases of POAG (n = 134) and PACG (n ...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Devi KR,Komatireddy S,Kaur K,Parikh RS,Mandal AK,Chandrasekhar G,Thomas R

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dual-wavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS:Forty-three patients were divided into groups 1 (contro...

journal_title：Investigative ophthalmology & visual science

authors： Lima VC,Rosen RB,Maia M,Prata TS,Dorairaj S,Farah ME,Sallum J

更新日期：2010-11-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:In several retinal complications, such as age-dependent macular degeneration (AMD), oxidative stress is increased and cytokine level is elevated. These are shown to alter the activation and expression of matrix metalloproteinase (MMP) both in human primary and immortalized retinal pigment epithelial (RPE) cells...

journal_title：Investigative ophthalmology & visual science

authors： Juuti-Uusitalo K,Nieminen M,Treumer F,Ampuja M,Kallioniemi A,Klettner A,Skottman H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To assess cross-sectional and longitudinal associations between exposure to Chlamydia pneumoniae infection and age-related macular degeneration (AMD) in the nested case-control sample drawn from the Blue Mountains Eye Study (BMES) cohort. METHODS:The BMES examined 3654 persons aged 49 to 97 years during 1992 t...

journal_title：Investigative ophthalmology & visual science

authors： Robman L,Mahdi OS,Wang JJ,Burlutsky G,Mitchell P,Byrne G,Guymer R,Taylor H

更新日期：2007-09-01 00:00:00

abstract：:In recent years, there has been great interest in recording the pattern electroretinogram (PERG) in glaucomatous and diabetic populations. The Dawson, Trick, and Litzkow thread electrode (DTLTE) and the gold foil electrode (GFE), commonly used for recording PERGs, were compared for variations in amplitude of response,...

journal_title：Investigative ophthalmology & visual science

authors： Prager TC,Saad N,Schweitzer FC,Garcia CA,Arden GB

更新日期：1992-02-01 00:00:00

abstract：:Chloroquine was administered intramuscularly 5 days a week to rhesus monkeys for as long as 4 1/2 years. No clinical, fluorescein angiographic, or electrophysiological evidence of retinal damage was observed. Yet chloroquine/chloroquine byproduct analysis of the ocular tissues revealed an enormous binding capacity of ...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal AR,Kolb H,Bergsma D,Huxsoll D,Hopkins JL

更新日期：1978-12-01 00:00:00

abstract：Purpose:Tissue transglutaminase (TGM2) is elevated in glaucomatous trabecular meshwork (TM) tissues. We investigated whether increased expression of TGM2 increases extracellular matrix crosslinking in the TM, thereby increasing aqueous humor outflow resistance and elevating intraocular pressure (IOP) in mouse eyes. Me...

journal_title：Investigative ophthalmology & visual science

authors： Raychaudhuri U,Millar JC,Clark AF

更新日期：2017-12-01 00:00:00

abstract：:In vivo conjunctival epithelial healing in albino rabbits was investigated by light microscopy following both n-heptanol and trephined conjunctival wounding. Reepithelialization occurred faster following n-heptanol treatment (3 days) versus trephination (6-7 days). No goblet cells were present in the migrating epithel...

journal_title：Investigative ophthalmology & visual science

authors： Geggel HS,Friend J,Thoft RA

更新日期：1984-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of retinal eccentricity on the phenomenon of dichoptic suppression of the mfVEP amplitude and to examine the relationship between the degree of simulated unilateral visual impairment and the possible release of dichoptic suppression in the contralateral eye. METHOD:Eight subjects with...

journal_title：Investigative ophthalmology & visual science

authors： Leaney J,Klistorner A,Arvind H,Graham SL

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Previous reports indicated that pregnancy and corneal injury (CI) trigger alterations of lacrimal gland (LG) growth factor expression and redistributions of lymphocytes from periductal foci to acini. The purpose of this study was to test our hypothesis that pregnancy would exacerbate the changes induced by CI. ...

journal_title：Investigative ophthalmology & visual science

authors： Ding C,Chang N,Fong YC,Wang Y,Trousdale MD,Mircheff AK,Schechter JE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To investigate whether signaling pathways that incorporate protein tyrosine kinases and phosphatases regulate PKC-sensitive, volume-sensitive Cl(-) currents (I(Cl,vol)) in cultured rabbit nonpigmented ciliary epithelial cells. METHODS:Activation of I(Cl,vol) in response to hyposmotic stimulation was recorded w...

journal_title：Investigative ophthalmology & visual science

authors： Shi C,Barnes S,Coca-Prados M,Kelly ME

更新日期：2002-05-01 00:00:00

abstract：:In the 2-deoxyglucose technique, the rate of glucose utilization in small areas of the central nervous system is measured using a standard operational equation that assumes negligible glucose-6-phosphatase activity. Hoping to apply this technique in the mammalian retina, we sought to identify the extent of this enzyme...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Shaw WE,Yue B

更新日期：1989-10-01 00:00:00

abstract：:The profound visual deficits associated with early monocular form deprivation (MD) are caused largely by competitive binocular interactions in the visual cortex. We tested the hypothesis that disrupting normal cortical binocularity prior to the onset of MD would reduce the degree of form deprivation amblyopia compared...

journal_title：Investigative ophthalmology & visual science

authors： Smith EL 3rd,Harwerth RS,Siderov J,Wingard M,Crawford ML,von Noorden GK

更新日期：1992-04-01 00:00:00

abstract：:Ultrastructural morphometric techniques were used to quantify pericyte degeneration in retinal and uveal capillaries of streptozotocin-diabetic rats in order to assess the suitability of this small rodent model of diabetes for studies of the pathogenesis of microvascular eye disease in diabetic humans. Male, Sprague-D...

journal_title：Investigative ophthalmology & visual science

authors： Tilton RG,LaRose LS,Kilo C,Williamson JR

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:To investigate the role of angiopoietin-1 (Ang1) in choroidal neovascularization (CNV) and vascular leakage. METHODS:We generated laser-induced CNV in mice and measured the size of CNV and vascular leakage after intravitreal administration of Ang1. The expressions and distributions of endothelial junctional pr...

journal_title：Investigative ophthalmology & visual science

authors： Lee J,Park DY,Park DY,Park I,Chang W,Nakaoka Y,Komuro I,Yoo OJ,Koh GY

更新日期：2014-04-07 00:00:00

abstract：PURPOSE:This study examined the association between peripapillary choroidal thickness (PCT) with age and race in a group of African descent (AD) and European descent (ED) subjects with normal eyes. METHODS:Optic nerve head images from enhanced depth imaging spectral-domain optical coherence tomography of 166 normal ey...

journal_title：Investigative ophthalmology & visual science

authors： Rhodes LA,Huisingh C,Johnstone J,Fazio MA,Smith B,Wang L,Clark M,Downs JC,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2015-02-24 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore. METHODS:The authors undertook a population-based, cross-sectional ...

journal_title：Investigative ophthalmology & visual science

authors： Zheng Y,Lamoureux EL,Chiang PP,Cheng CY,Anuar AR,Saw SM,Aung T,Wong TY

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:To investigate the application of anterior corneal and ocular aberrations in detecting mildly ectatic corneas. METHODS:This study retrospectively reviewed the data of 220 eyes separated into three groups by the NIDEK Corneal Navigator System automated corneal classification software: normal (N) (n = 123); form...

journal_title：Investigative ophthalmology & visual science

authors： Saad A,Gatinel D

更新日期：2012-05-17 00:00:00