Depth-dependent forward light scattering by donor lenses.

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00

abstract：PURPOSE:To test the hypothesis that the robust expansion of bovine corneal endothelial cells (BCECs) in vitro is due to the presence of individual endothelial cells with various levels of proliferative potential. METHODS:BCECs and bovine vascular endothelial cells (ECs) derived from aorta, coronary artery, and pulmona...

journal_title：Investigative ophthalmology & visual science

authors： Huang L,Harkenrider M,Thompson M,Zeng P,Tanaka H,Gilley D,Ingram DA,Bonanno JA,Yoder MC

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat. METHODS:Retinal ischemia was induced by increasing intraocular pressure. Glutamate release from the rat retina and intravitreal PO(2) (partia...

journal_title：Investigative ophthalmology & visual science

authors： Fujita T,Hirooka K,Nakamura T,Itano T,Nishiyama A,Nagai Y,Shiraga F

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To determine if there is endothelin-mediated regulation of cell signaling and proliferation in rabbit corneal epithelium. METHODS:Endothelin-1 (ET-1) gene and protein expression by the rabbit corneal epithelial (RCE) cells were analyzed by polymerase chain reaction, sequence analysis, and enzyme immunoassay. D...

journal_title：Investigative ophthalmology & visual science

authors： Takagi H,Reinach PS,Tachado SD,Yoshimura N

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To determine the effect of intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) on optic disc movement and lamina cribrosa displacement using confocal scanning laser tomography (CSLT). METHODS:The anterior chamber and lateral ventricles were cannulated in mixed-breed dogs (n = 8) to allow modulat...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Chauhan BC,Yu DY,Cringle SJ,Alder VA,House PH

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:To assess the suitability of human donor corneas maintained in long-term organ culture for the isolation and expansion of viable and functional corneal stromal stem cells (CSSCs). These cells display properties similar to mesenchymal stem cells and demonstrate the ability to reproduce an organized matrix in vit...

journal_title：Investigative ophthalmology & visual science

authors： Kureshi AK,Funderburgh JL,Daniels JT

更新日期：2014-10-21 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether a better IOP reduction can be observed in conscious, normotensive monkeys treated with ONO-9054, a novel dual EP3 and FP receptor agonist, compared with prostaglandin F2α analogs. METHODS:The binding affinities and agonistic activities of ONO-AG-367, a carboxy...

journal_title：Investigative ophthalmology & visual science

authors： Yamane S,Karakawa T,Nakayama S,Nagai K,Moriyuki K,Neki S,Suto F,Kambe T,Hirota Y,Kawabata K

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study w...

journal_title：Investigative ophthalmology & visual science

authors： Sivaprasad S,Chong NV,Bailey TA

更新日期：2005-09-01 00:00:00

abstract：:Photoreceptor-mediated mechanisms were studied in patients with a recently identified retinopathy typified by night blindness, cystoid maculopathy, and similar scotopic and photopic electroretinograms (ERGs). Dark-adapted spectral sensitivity functions were only partly explained as composites of rod and cone curves sh...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Marmor MF,Kemp CM,Knighton RW

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:To characterize the spectrum of mutations in the OPA1 gene in a large international panel of patients with autosomal dominant optic atrophy (adOA), to improve understanding of the range of functional deficits attributable to sequence variants in this gene, and to assess any genotype-phenotype correlations. MET...

journal_title：Investigative ophthalmology & visual science

authors： Thiselton DL,Alexander C,Taanman JW,Brooks S,Rosenberg T,Eiberg H,Andreasson S,Van Regemorter N,Munier FL,Moore AT,Bhattacharya SS,Votruba M

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:To investigate the relationship between percentage of body fat and macular pigment (MP) optical density. METHODS:One hundred healthy subjects of ages between 22 and 60 years volunteered to participate in this study. MP optical density was measured psychophysically, serum lutein and zeaxanthin were quantified b...

journal_title：Investigative ophthalmology & visual science

authors： Nolan J,O'Donovan O,Kavanagh H,Stack J,Harrison M,Muldoon A,Mellerio J,Beatty S

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS:Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathi...

journal_title：Investigative ophthalmology & visual science

authors： Takeda A,Yoshikawa H,Fukuhara T,Hikita S,Hijioka K,Otomo T,Arita R,Hisatomi T,Kimura K,Yoshida S,Kawano Y,Sonoda KH,Ishibashi T

更新日期：2015-11-01 00:00:00

abstract：:The evidence-basis based on existing myopia control trials along with the supporting academic literature were reviewed; this informed recommendations on the outcomes suggested from clinical trials aimed at slowing myopia progression to show the effectiveness of treatments and the impact on patients. These outcomes wer...

journal_title：Investigative ophthalmology & visual science

authors： Wolffsohn JS,Kollbaum PS,Berntsen DA,Atchison DA,Benavente A,Bradley A,Buckhurst H,Collins M,Fujikado T,Hiraoka T,Hirota M,Jones D,Logan NS,Lundström L,Torii H,Read SA,Naidoo K

更新日期：2019-02-28 00:00:00

abstract：PURPOSE:To characterize in SV40-immortalized human corneal epithelial cells (tHCEC) osmosensitive taurine transporter gene and protein expression as well as its functional activity. To evaluate whether medium supplementation with taurine improves cell viability during a hypertonic challenge. METHODS:tHCEC were preincu...

journal_title：Investigative ophthalmology & visual science

authors： Shioda R,Reinach PS,Hisatsune T,Miyamoto Y

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Cornea confocal microscopy is emerging as a clinical tool to evaluate the development and progression of diabetic neuropathy. The purpose of these studies was to characterize the early changes in corneal sensitivity and innervation in a rat model of type 1 diabetes in relation to standard peripheral neuropathy ...

journal_title：Investigative ophthalmology & visual science

authors： Davidson EP,Coppey LJ,Yorek MA

更新日期：2012-12-07 00:00:00

abstract：PURPOSE:Changes in blood vessel barrier properties contribute to retinal edema in diabetic retinopathy (DR). However, limited data are available to describe the routes of transport for fluids and solutes across the inner blood-retinal barrier (iBRB). In this study, a three-pore model was developed to characterize such ...

journal_title：Investigative ophthalmology & visual science

authors： Lopez-Quintero SV,Ji XY,Antonetti DA,Tarbell JM

更新日期：2011-02-28 00:00:00

abstract：:Exposure of denuded rabbit corneal stromal carriers for 24 hr at 37 degrees C to suspensions of rabbit corneal epithelial cells grown in tissue culture resulted in the establishment of a cell layer on the carriers. The cell layers persisted for at least 1 week of incubation and were one to three cells thick. They cons...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kinoshita S,Thoft RA,Eliason JA

更新日期：1982-07-01 00:00:00

abstract：Purpose:In many individuals with pattern strabismus, the vertical misalignment varies with horizontal eye position. It has been proposed that these cross-axis effects result from abnormal cross-talk between brainstem structures that would normally encode horizontal and vertical eye position and velocity. The nucleus pr...

journal_title：Investigative ophthalmology & visual science

authors： Pallus A,Walton MMG

更新日期：2020-05-11 00:00:00

abstract：Purpose:Hyaluronan (HA) overproduction by orbital fibroblasts (OFs) is a major factor in the pathogenesis of Graves' orbitopathy (GO). 4-methylumbelliferone (4-MU) is an inhibitor of HA synthesis in different cell types in vitro and has beneficial effects in animal models of autoimmune diseases. Methods:HA production ...

journal_title：Investigative ophthalmology & visual science

authors： Galgoczi E,Jeney F,Katko M,Erdei A,Gazdag A,Sira L,Bodor M,Berta E,Ujhelyi B,Steiber Z,Gyory F,Nagy EV

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with A...

journal_title：Investigative ophthalmology & visual science

authors： Guzman CP,Gong T,Nongpiur ME,Perera SA,How AC,Lee HK,Cheng L,He M,Baskaran M,Aung T

更新日期：2013-08-07 00:00:00

abstract：Purpose:To validate the Liverpool Uveal Melanoma Prognosticator Online (LUMPO) in a cohort of patients treated at the University of California-San Francisco (UCSF). Methods:A retrospective chart review was performed of 390 patients treated between 2002 and 2007 for choroidal melanoma at UCSF. Similar patients (n = 117...

journal_title：Investigative ophthalmology & visual science

authors： DeParis SW,Taktak A,Eleuteri A,Enanoria W,Heimann H,Coupland SE,Damato B

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To develop and apply microarray-based resequencing technology to detect sequence alterations in multiple autosomal recessive retinal disease genes on a single high-throughput platform. METHODS:Oligonucleotides corresponding to both strands of the target exons and the flanking intron sequences of 29,214 bp from...

journal_title：Investigative ophthalmology & visual science

authors： Mandal MN,Heckenlively JR,Burch T,Chen L,Vasireddy V,Koenekoop RK,Sieving PA,Ayyagari R

更新日期：2005-09-01 00:00:00

abstract：Purpose:Structural retinal microvascular changes have been identified as risk markers of diabetic retinopathy (DR). In order to estimate the retinal response of neuroprotective eye drops, we aimed to evaluate the effect of topical retinal neuroprotection on retinal microvascular changes in early DR. Methods:Patients w...

journal_title：Investigative ophthalmology & visual science

authors： Grauslund J,Frydkjaer-Olsen U,Peto T,Fernández-Carneado J,Ponsati B,Hernández C,Cunha-Vaz J,Simó R,EUROCONDOR.

更新日期：2019-05-01 00:00:00

abstract：Purpose:To investigate the underlying mechanisms for how the mouse Cx50-R205G point mutation, a homologue of the human Cx50-R198W mutation that is linked to cataract-microcornea syndrome, affects proper lens growth and fiber cell differentiation to lead to severe lens phenotypes. Methods:EdU labeling, immunostaining, ...

journal_title：Investigative ophthalmology & visual science

authors： Tjahjono N,Xia CH,Li R,Chu S,Wang J,Gong X

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:To investigate immediate and long-term changes in static ocular alignment with acute acquired superior oblique palsy (SOP) in monkeys. METHODS:The trochlear nerve was severed intracranially in two rhesus monkeys. After the surgery, the paretic eye was patched for 6 to 9 days, and then binocular viewing was all...

journal_title：Investigative ophthalmology & visual science

authors： Shan X,Tian J,Ying HS,Quaia C,Optican LM,Walker MF,Tamargo RJ,Zee DS

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:To investigate the effects of adhesion promoting surgical adjuncts in Descemets stripping automated endothelial keratoplasty (DSAEK). The effects of air-fill pressure, duration, use of venting incisions and stromal roughening on fluid dispersion, and donor adhesion strength were examined in theoretical, optical...

journal_title：Investigative ophthalmology & visual science

authors： Bhogal MS,Angunawela RI,Bilotti E,Eames I,Allan BD

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye. METHODS:Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follow...

journal_title：Investigative ophthalmology & visual science

authors： Denis D,Burguière O,Burillon C

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

journal_title：Investigative ophthalmology & visual science

authors： Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

更新日期：2002-07-01 00:00:00