Serum elastin-derived peptides in age-related macular degeneration.

abstract：PURPOSE:Gangliosides are normal components of cell membranes, contribute to structural rigidity and membrane function, and have been shown to protect against various insults to the brain. This study evaluates the effect of exogenously administered monosialoganglioside GM1 on retinal damage induced by transient retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Weber M,Mohand-Said S,Hicks D,Dreyfus H,Sahel JA

更新日期：1996-02-01 00:00:00

abstract：:Electroretinograms (ERGs) were elicited by hemicircular (half-disc) stimuli to the upper, lower, temporal and nasal maculas of 26 normal subjects, and the amplitudes and implicit times of the ERGs from opposing macular regions were compared. The amplitudes of a-wave, b-wave and oscillatory potentials (OPs) were signif...

journal_title：Investigative ophthalmology & visual science

authors： Miyake Y,Shiroyama N,Horiguchi M,Ota I

更新日期：1989-08-01 00:00:00

abstract：PURPOSE:The goals of this study were to evaluate the safety of office-based vitreous sampling, and determine the utility of these samples with multiplex cytokine analysis. METHODS:Vitreous samples were collected from office-based needle aspiration and the rate of adverse events during follow-up was reviewed. The vitre...

journal_title：Investigative ophthalmology & visual science

authors： Ghodasra DH,Fante R,Gardner TW,Langue M,Niziol LM,Besirli C,Cohen SR,Dedania VS,Demirci H,Jain N,Jayasundera KT,Johnson MW,Kalyani PS,Rao RC,Zacks DN,Sundstrom JM

更新日期：2016-06-01 00:00:00

abstract：Purpose:To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. Methods:To establish the lower range of text luminances, we quantified the space-averaged luminance...

journal_title：Investigative ophthalmology & visual science

authors： Xu R,Gil D,Dibas M,Hare W,Bradley A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:We used a rabbit model to evaluate the interface embedded between the recipient corneas and transplanted donor corneal discs after non-Descemet's stripping automated endothelial keratoplasty (nDSAEK). METHODS:Unilateral DSAEK and nDSAEK surgeries were performed on New Zealand white rabbits. In vivo confocal mi...

journal_title：Investigative ophthalmology & visual science

authors： Sun JP,Hu FR,Chen YM,Chu HS,Chen WL

更新日期：2014-11-18 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:Generate site-specific somatic mutations selectively in the retinal pigment epithelium (RPE) in mice. METHODS:A transgenic mouse line expressing the Cre recombinase under the control of the tyrosinase-related protein (TRP)-1 promoter was generated. The presence of Cre was determined by in situ hybridization, a...

journal_title：Investigative ophthalmology & visual science

authors： Mori M,Metzger D,Garnier JM,Chambon P,Mark M

更新日期：2002-05-01 00:00:00

abstract：:Hypothesis-driven science is expected to result in a continuum of studies and findings along a discrete path. By comparison, serendipity can lead to new directions that branch into different paths. Herein, I describe a diverse series of findings that were motivated by hypotheses, but driven by serendipity. I summarize...

journal_title：Investigative ophthalmology & visual science

authors： Fischer AJ

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:Metabolism and transport of glutathione (GSH), the endogenous thiol antioxidant, in conjunctival tissue to date are poorly understood. The purpose of the present study was to define transport characteristics of GSH in primary cultured rabbit conjunctival epithelial cells (RCECs). METHODS:RCECs were grown on me...

journal_title：Investigative ophthalmology & visual science

authors： Gukasyan HJ,Lee VH,Kim KJ,Kannan R

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

journal_title：Investigative ophthalmology & visual science

authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:In uveal melanoma, both tumor size and an inflammatory phenotype have been shown to correlate with a poor clinical prognosis. The purpose of this study was to identify whether inflammatory cytokines were present in the vitreous of eyes with uveal melanoma and to determine whether the vitreal concentration of cy...

journal_title：Investigative ophthalmology & visual science

authors： Nagarkatti-Gude N,Bronkhorst IH,van Duinen SG,Luyten GP,Jager MJ

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To identify the differently expressed micro (mi) RNAs in pterygium compared with normal conjunctiva and investigate the potential role of miRNAs in the pathogenesis of pterygium. METHODS:With microRNA microarray and quantitative RT-PCR, we identified that microRNA-122 (miR-122) was significantly decreased in p...

journal_title：Investigative ophthalmology & visual science

authors： Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:(Photo)-oxidative stress is believed to play a role in the pathogenesis of age-related macular degeneration (AMD), with the threshold for retinal damage being lowest for short-wavelength (blue) light. Macular pigment (MP), consisting of the carotenoids lutein (L), zeaxanthin (Z) and meso-Z, has a maximum absorp...

journal_title：Investigative ophthalmology & visual science

authors： Nolan JM,O'Reilly P,Loughman J,Stack J,Loane E,Connolly E,Beatty S

更新日期：2009-10-01 00:00:00

abstract：Purpose:Because there is a paucity of population-based data on retinal nerve fiber layer thickness (RNFLT) for children, we measured the RNFLT and its associations in schoolchildren. Methods:The population-based Gobi Desert Children Eye Study included all schoolchildren aged 6 to 21 years living in Ejina, Inner Mongol...

journal_title：Investigative ophthalmology & visual science

authors： Wang CY,Zheng YF,Liu B,Meng ZW,Hong F,Wang XX,Wang XJ,Du L,Wang IY,Zhu D,Tao Y,You QS,Jonas JB

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Macrophages are thought to be the first line of defense in many infectious diseases and are present in high numbers in corneas with Acanthamoeba keratitis. Conjunctival macrophage depletion was performed in an animal model of Acanthamoeba infection to determine the importance of macrophages in this disease. ME...

journal_title：Investigative ophthalmology & visual science

authors： van Klink F,Taylor WM,Alizadeh H,Jager MJ,van Rooijen N,Niederkorn JY

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:Connexin50 (Cx50) is absolutely essential for normal postnatal lens growth. Deletion of Cx50 or replacement with Cx46 by knockin resulted in smaller lenses containing fewer cells. To determine why Cx50-deficient lenses fail to grow normally, cell proliferation was assayed during the period of growth failure. M...

journal_title：Investigative ophthalmology & visual science

authors： Sellitto C,Li L,White TW

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:To determine whether the relative amounts of mucin mRNA in the conjunctival epithelium and mucin protein in the tears are altered in patients with Sjögren syndrome compared with healthy individuals. METHODS:Tear fluid was collected from the inferior fornix of normal subjects (n = 17) and patients with Sjögren ...

journal_title：Investigative ophthalmology & visual science

authors： Argüeso P,Balaram M,Spurr-Michaud S,Keutmann HT,Dana MR,Gipson IK

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Anti-vascular endothelial growth factor (anti-VEGF) drugs have dramatically improved the treatment of neovascular AMD. In pivotal studies, almost 90% of patients maintain vision, with approximately 30% showing significant improvement. Despite these successes, 10% to 15% of patients continue to lose vision, even...

journal_title：Investigative ophthalmology & visual science

authors： Wickremasinghe SS,Xie J,Lim J,Chauhan DS,Robman L,Richardson AJ,Hageman G,Baird PN,Guymer R

更新日期：2011-06-08 00:00:00

abstract：:Reaching a consensus in terms of interchangeability and utility (i.e., disease detection/monitoring) of a medical device is the eventual aim of repeatability and agreement studies. The aim of the tolerance and relative utility indices described in this report is to provide a methodology to compare change in clinical m...

journal_title：Investigative ophthalmology & visual science

authors： Bergin C,Guber I,Hashemi K,Majo F

更新日期：2015-08-01 00:00:00

abstract：Purpose:To investigate the effects of tear film instability (TFI) induced by sustained tear exposure (STARE) on sensory responses to corneal cold, mechanical, and chemical stimuli. Methods:Fifteen normal subjects were enrolled. TFI was induced during 10 repeated trials of STARE. Pneumatic cold, mechanical, and chemica...

journal_title：Investigative ophthalmology & visual science

authors： Situ P,Begley CG,Simpson TL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To determine the efficacy and safety of naked plasmid gene therapy to the corneal stroma and epithelium. METHODS:Naked plasmid DNA was injected under pressure into the cornea of mice. The expression of genes coding for beta galactosidase (beta-gal), enhanced green fluorescent protein (EGFP), vascular endotheli...

journal_title：Investigative ophthalmology & visual science

authors： Stechschulte SU,Joussen AM,von Recum HA,Poulaki V,Moromizato Y,Yuan J,D'Amato RJ,Kuo C,Adamis AP

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:To observe the spatial distribution of households with high loads of ocular chlamydia infection in children, before and after mass treatment with azithromycin to determine whether there exists spatial clustering of households with high loads of infection and the spatial scale of the clustering. METHODS:All res...

journal_title：Investigative ophthalmology & visual science

authors： Broman AT,Shum K,Munoz B,Duncan DD,West SK

更新日期：2006-01-01 00:00:00

abstract：:The effect of systemic hypoxia on the maintained firing rate (MFR) of single retinal ganglion cells has been measured in the cat at a constant luminance level. Systemic hypoxia was produced by reducing the percentage of oxygen in the respiratory mixture under forced ventilation so that arterial PCO2 and pH were consta...

journal_title：Investigative ophthalmology & visual science

authors： Alder VA,Constable IJ

更新日期：1981-09-01 00:00:00

abstract：PURPOSE:To investigate whether myopia is present in a breed of domestic dog, the Labrador retriever, and how the ocular components are related to refractive error in this breed. METHODS:Cycloplegic refractive error was measured in 75 Labrador retrievers by retinoscopy. Corneal and crystalline lens radii of curvature w...

journal_title：Investigative ophthalmology & visual science

authors： Mutti DO,Zadnik K,Murphy CJ

更新日期：1999-06-01 00:00:00

abstract：PURPOSE:To identify the genetic cause in five families with autosomal recessive retinitis pigmentosa, a genetic disorder involving retinal degeneration and visual loss with high genetic heterogeneity. METHODS:We performed whole-genome single nucleotide polymorphism genotyping on 35 members from the five families to ma...

journal_title：Investigative ophthalmology & visual science

authors： Wang NH,Chen SJ,Yang CF,Chen HW,Chuang HP,Lu YH,Chen CH,Wu JY,Niu DM,Chen YT

更新日期：2016-07-01 00:00:00