Retinal Nerve Fiber Layer Thickness in Children: The Gobi Desert Children Eye Study.

abstract：Purpose:To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods:Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Fov...

journal_title：Investigative ophthalmology & visual science

authors： Valkenburg D,van Cauwenbergh C,Lorenz B,van Genderen MM,Bertelsen M,Pott JR,Coppieters F,de Zaeytijd J,Thiadens AAHJ,Klaver CCW,Kroes HY,van Schooneveld MJ,Preising M,Hoyng CB,Leroy BP,van den Born LI,Collin RWJ

更新日期：2018-09-04 00:00:00

abstract：PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Mutations in the coding region of the OPTN gene are associated with certain glaucomas. Although the function of the optineurin protein is yet to be elucidated, the most common mutation, E50K, is associated with a severe phenotype. This study explores some functional features of optineurin and its mutants. METH...

journal_title：Investigative ophthalmology & visual science

authors： Chalasani ML,Radha V,Gupta V,Agarwal N,Balasubramanian D,Swarup G

更新日期：2007-04-01 00:00:00

abstract：Purpose:To investigate the molecular pathways that drive thyroid stimulating hormone receptor (TSHR)-induced cellular proliferation in orbital fibroblasts (OFs) from thyroid eye disease (TED) patients. Methods:Orbital fibroblasts from TED and non-TED patients were treated with TSH and changes in gene expression and pr...

journal_title：Investigative ophthalmology & visual science

authors： Woeller CF,Roztocil E,Hammond C,Feldon SE

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Late infantile neuronal ceroid lipofuscinosis (NCL) is an inherited disorder characterized by progressive vision loss. The disease results from mutations in the TPP1 (CLN2) gene. Studies were undertaken to characterize the effects of a TPP1 frameshift mutation on the retina in Dachshunds. METHODS:A litter of f...

journal_title：Investigative ophthalmology & visual science

authors： Katz ML,Coates JR,Cooper JJ,O'Brien DP,Jeong M,Narfström K

更新日期：2008-06-01 00:00:00

abstract：:Three monoclonal antibodies against lens crystallin have been used to study the accumulation of specific polypeptides during development of the human lens. One antibody which recognizes an antigen common to three polypeptides with molecular weights close to 31,000 reacted equally well to the human lens cortex and nucl...

journal_title：Investigative ophthalmology & visual science

authors： Russell P,Carper DA,Chiogioji A,Reddy V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic PRRs during retinal...

journal_title：Investigative ophthalmology & visual science

authors： Qi Y,Zhao M,Bai Y,Huang L,Yu W,Bian Z,Zhao M,Li X

更新日期：2014-08-05 00:00:00

abstract：PURPOSE:To establish the regulatory roles that pericytes have in coordinating retinal endothelial cell (EC) growth and angiogenic potential. METHODS:Pericytes were derived from donor diabetic (DHuRP) or normal (NHuRP) human retinae, and characterized using vascular markers, coculture, contraction, morphogenesis, and p...

journal_title：Investigative ophthalmology & visual science

authors： Durham JT,Dulmovits BM,Cronk SM,Sheets AR,Herman IM

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:Angioscotomas are scotomata caused by vessel shadows. Their extent may be influenced by physiological and pharmacologic conditions and disease. In this study, the authors quantified angioscotomas in normal subjects using a fundus perimetry technique with a scanning laser ophthalmoscope. They further investigate...

journal_title：Investigative ophthalmology & visual science

authors： Remky A,Beausencourt E,Elsner AE

更新日期：1996-10-01 00:00:00

abstract：PURPOSE:To determine whether polyamines are present in corneal cells, whether corneal cell polyamines can be depleted by blocking the first rate-limiting enzyme in the polyamine synthesis pathway, ornithine decarboxylase (ODC), and whether polyamines are required for proliferation in all three corneal cell types. METH...

journal_title：Investigative ophthalmology & visual science

authors： Du H,Viar MJ,Johnson LR,Watsky MA

更新日期：2003-06-01 00:00:00

abstract：:Topical administration of biosynthetic human epidermal growth factor (h-EGF), given in combination with an antibiotic and synthetic steroid (Neodecadron) accelerated the rate of corneal epithelial regeneration and significantly increased the strength of full-thickness stromal incisions in primates. The regenerated epi...

journal_title：Investigative ophthalmology & visual science

authors： Brightwell JR,Riddle SL,Eiferman RA,Valenzuela P,Barr PJ,Merryweather JP,Schultz GS

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To assess the repeatability, intersession and interobserver reproducibility, and agreement of central corneal thickness (CCT) measurements obtained by scanning-slit topography (SST) and noncontact specular microscopy (NCSM) after advanced surface ablation (ASA). METHODS:To analyze repeatability, one examiner m...

journal_title：Investigative ophthalmology & visual science

authors： López-Miguel A,Martínez-Almeida L,Mateo ME,Coco-Martín MB,Alió JL,Maldonado MJ

更新日期：2013-02-05 00:00:00

abstract：:N-formimidoyl thienamycin (MK-787) is a new beta-lactam with potent activity against both aerobic and anaerobic gram-positive and gram-negative bacteria. Its spectrum and activity suggest it may be useful in treatment of complicated intraocular infections. Its ocular penetration was studied in New Zealand white rabbit...

journal_title：Investigative ophthalmology & visual science

authors： Finlay KR,Carlson CL,Chow AW

更新日期：1983-08-01 00:00:00

abstract：PURPOSE:To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse pressure (PP). METHODS:The ALIENOR study is a population-based study on age-related eye diseases in 963 residents of Bordeaux, France, aged 73 years or older. AMD was graded from nonmydriatic color retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Cougnard-Grégoire A,Delyfer MN,Korobelnik JF,Rougier MB,Malet F,Le Goff M,Dartigues JF,Colin J,Barberger-Gateau P,Delcourt C

更新日期：2013-03-28 00:00:00

abstract：PURPOSE:To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutation. METHODS:Ophthalmic examination and mutation screening by direct sequencing of the ELOVL4 gene was per...

journal_title：Investigative ophthalmology & visual science

authors： Maugeri A,Meire F,Hoyng CB,Vink C,Van Regemorter N,Karan G,Yang Z,Cremers FP,Zhang K

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Point and null mutations in interphotoreceptor retinoid-binding protein (IRBP) cause retinal dystrophy in affected patients and IRBP-deficient mice with unknown mechanism. This study investigated whether IRBP protects cells from damages induced by all-trans-retinal (atRAL), which was increased in the Irbp(-/-) ...

journal_title：Investigative ophthalmology & visual science

authors： Lee M,Li S,Sato K,Jin M

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To determine the mechanism by which basic fibroblast growth factor (bFGF) exerts its neuroprotective effects on degenerating or injured photoreceptors. METHODS:Confocal immunofluorescence microscopy was used to identify sites of bFGF and FGF receptor 1 (FGFR1) expression after focal injury or experimental reti...

journal_title：Investigative ophthalmology & visual science

authors： Ozaki S,Radeke MJ,Anderson DH

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To evaluate the effects of 5-fluorouracil (5-FU) on ocular cells in vitro and the effects of degradable 5-FU-loaded poly(DL-lactide-co-glycolide; PDLGA) 50:50 implant in the rabbit eye in vivo. METHODS:Cytotoxicity was assessed with a tetrazolium salt WST-1 cell proliferation/viability test and a lactate dehyd...

journal_title：Investigative ophthalmology & visual science

authors： Huhtala A,Rönkkö S,Teräsvirta M,Puustjärvi T,Sihvola R,Vehanen K,Laukkanen A,Anttila J,Urtti A,Pohjonen T,Uusitalo H

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of σ receptor 1 (σR1) neuroprotection in retinal neurons. METHODS:Oxidative stress, which is implicated in diabetic retinopathy, was induced in mouse primary ganglion cells (GCs) and RGC-5 cells, and the effect of the σR1 ligand (+)-pentazocine on pro- and anti-apoptotic and endopl...

journal_title：Investigative ophthalmology & visual science

authors： Ha Y,Dun Y,Thangaraju M,Duplantier J,Dong Z,Liu K,Ganapathy V,Smith SB

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:The epidermal growth factor receptor (EGFR) appears in astrocytes after neural injury. The authors' laboratory has reported the presence of EGFR in glaucomatous optic nerves. The activation of EGFR is often associated with induction of cyclooxygenase (COX)-2. In this study, the induction of COX-2 pathway in rat...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Neufeld AH

更新日期：2005-06-01 00:00:00

abstract：:The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated ...

journal_title：Investigative ophthalmology & visual science

authors： Gilbard JP,Rossi SR,Gray KL

更新日期：1987-02-01 00:00:00

abstract：PURPOSE:In an earlier study it was reported that thrombin significantly reduces the rate of Na,K-adenosine triphosphatase (ATPase)-mediated ion transport by porcine lens. Because thrombin stimulates the release of endogenous endothelin (ET)-1 stores from some tissues, and because ET-1 can cause Na,K-ATPase inhibition, ...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Mukhopadhyay P,Delamere NA

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To determine the impact of repetitive nonlethal oxidant injury with hydroquinone (HQ) on regulation of cell membrane blebbing and molecules, which are essential in extracellular matrix turnover (ECM) maintenance, especially matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-2, and type IV collagen...

journal_title：Investigative ophthalmology & visual science

authors： Marin-Castaño ME,Striker GE,Alcazar O,Catanuto P,Espinosa-Heidmann DG,Cousins SW

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:In amblyopia, neuronal deficits deteriorate spatial vision including visual acuity, possibly because of a lack of use-dependent fine-tuning of afferents to the visual cortex during infancy; but temporal processing may deteriorate as well. METHODS:Temporal, rather than spatial, resolution was investigated in pa...

journal_title：Investigative ophthalmology & visual science

authors： Spang K,Fahle M

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:In Graves' orbitopathy (GO), inflammation and expansion of the retrobulbar tissue are the result of a pathophysiologic process in which orbital fibroblasts (GO-Fs) are considered the central cell type. However, in a previous study we observed that GO-Fs expressed some of the consensus surface markers described ...

journal_title：Investigative ophthalmology & visual science

authors： Brandau S,Bruderek K,Hestermann K,Görtz GE,Horstmann M,Mattheis S,Lang S,Eckstein A,Berchner-Pfannschmidt U

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

journal_title：Investigative ophthalmology & visual science

authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

更新日期：2015-01-08 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the efficacy of new viscous cysteamine hydrochloride (CH) eye drops (vCH 0.55%) compared with standard CH 0.10% drops treatment. Methods:This was an open-label, phase III, randomized, two-arm multicenter trial conducted at two centers in France. Cystinosis patients ≥2 ...

journal_title：Investigative ophthalmology & visual science

authors： Liang H,Labbé A,Le Mouhaër J,Plisson C,Baudouin C

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To evaluate genotypic and macular morphologic correlations in patients with RPE65-, CEP290-, GUCY2D-, or AIPL1-related Leber congenital amaurosis (LCA) using spectral-domain optical coherence tomography (SD-OCT). METHODS:SD-OCT macular scans were performed in 21 patients, including 10 with RPE65, 7 with CEP290...

journal_title：Investigative ophthalmology & visual science

authors： Pasadhika S,Fishman GA,Stone EM,Lindeman M,Zelkha R,Lopez I,Koenekoop RK,Shahidi M

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS:Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-...

journal_title：Investigative ophthalmology & visual science

authors： Syed R,Sundquist SM,Ratnam K,Zayit-Soudry S,Zhang Y,Crawford JB,MacDonald IM,Godara P,Rha J,Carroll J,Roorda A,Stepien KE,Duncan JL

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort. METHODS:Persons with type 1 diabetes (440 women, 548 men) from the DCCT/EDIC c...

journal_title：Investigative ophthalmology & visual science

authors： Lyons TJ,Jenkins AJ,Zheng D,Lackland DT,McGee D,Garvey WT,Klein RL

更新日期：2004-03-01 00:00:00