Ocular penetration of N-formimidoyl thienamycin (MK-787) and potentiation by dipeptidase inhibitor (MK-791).

abstract：PURPOSE:To determine whether the uniform field and pattern ERGs that are reduced in macaque eyes with experimental glaucoma have the same inner-retinal origins. METHODS:ERGs were recorded from 14 anesthetized adult macaques using DTL electrodes. Six monkeys had laser-induced experimental glaucoma, and two others recei...

journal_title：Investigative ophthalmology & visual science

authors： Viswanathan S,Frishman LJ,Robson JG

更新日期：2000-08-01 00:00:00

abstract：:Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 +/- 0.8 to 7.1 +/- 1.4 mm Hg (P less than 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the ...

journal_title：Investigative ophthalmology & visual science

authors： Toris CB,Pederson JE

更新日期：1985-12-01 00:00:00

abstract：Purpose:The prevalence of age-related macular degeneration (AMD) increases dramatically with age. This large collaborative study investigates the effects of 51 late-AMD-associated genetic variants in different ages, focusing on individuals above the age of 90 years. Methods:The study included 27,996 individuals of the...

journal_title：Investigative ophthalmology & visual science

authors： Schick T,Lorés-Motta L,Altay L,Fritsche LG,den Hollander AI,Fauser S

更新日期：2020-12-01 00:00:00

abstract：Purpose:We assess if α retinal ganglion cells (αRGCs) and intrinsically photosensitive retinal ganglion cells (ipRGCs) survive in mouse models of glaucoma. Methods:Two microliters of N-methyl-D-aspartate (NMDA; 1 mM) or PBS were injected intraocularly 7 days before sacrifice. Immunohistochemical analyses of the retina...

journal_title：Investigative ophthalmology & visual science

authors： Honda S,Namekata K,Kimura A,Guo X,Harada C,Murakami A,Matsuda A,Harada T

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To reveal the effects of minocycline, an anti-inflammatory and neuroprotective agent, on the viability and physiological properties of retinal pigment epithelial (RPE) cells and to compare the effects with those of triamcinolone acetonide. METHODS:The proliferation of human RPE cells in vitro was investigated ...

journal_title：Investigative ophthalmology & visual science

authors： Hollborn M,Wiedemann P,Bringmann A,Kohen L

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

journal_title：Investigative ophthalmology & visual science

authors： Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

更新日期：2006-07-01 00:00:00

abstract：Purpose:Mutations in CACNA2D4, encoding the α2δ4 subunit of retinal voltage-gated calcium channels (Cav), cause a rare type of retinal dysfunction in human, mainly affecting cone vision. Here, we investigate the role of CACNA2D4 in targeting of Cav, its influence on cone-mediated signal transmission, and the cellular a...

journal_title：Investigative ophthalmology & visual science

authors： Schlegel DK,Glasauer SMK,Mateos JM,Barmettler G,Ziegler U,Neuhauss SCF

更新日期：2019-12-02 00:00:00

abstract：PURPOSE:Homocysteine (Hcys), a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM). LOX contributes to the...

journal_title：Investigative ophthalmology & visual science

authors： Coral K,Angayarkanni N,Gomathy N,Bharathselvi M,Pukhraj R,Rupak R

更新日期：2009-08-01 00:00:00

abstract：Purpose:A shortage of human corneal endothelial cells (HCEC) for transplant and current methods of differentiation induction require chemical compounds, which might cast further influences after differentiation induction. Therefore, we developed a simple and straightforward approach to endothelial cell differentiation ...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Wu L,Li Z,Dong Y,Pei X,Huang Y,Wang L

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD:A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subty...

journal_title：Investigative ophthalmology & visual science

authors： Tomlinson A,Khanal S,Ramaesh K,Diaper C,McFadyen A

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To test the hypothesis that changes in the viscoelastic material properties of peripapillary sclera are present within monkey eyes at the onset of early experimental glaucoma detected by confocal scanning laser tomography (CSLT). METHODS:Short-term (3-9 weeks), moderate (< or =44 mm Hg) intraocular pressure (I...

journal_title：Investigative ophthalmology & visual science

authors： Downs JC,Suh JK,Thomas KA,Bellezza AJ,Hart RT,Burgoyne CF

更新日期：2005-02-01 00:00:00

abstract：Purpose:Yap1 encodes an evolutionarily conserved transcriptional coactivator and functions as a down-stream effector of the Hippo signaling pathway that controls tissue size and cell growth. Yap1 contributes to lens epithelial development. However, the effect of Yap1 haplodeficiency on the lens epithelium and its role ...

journal_title：Investigative ophthalmology & visual science

authors： Lu Q,Zhang Y,Kasetti RB,Gaddipati S,Cvm NK,Borchman D,Li Q

更新日期：2020-10-01 00:00:00

abstract：Purpose:There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanic...

journal_title：Investigative ophthalmology & visual science

authors： Blackburn BJ,Gu S,Ford MR,de Stefano V,Jenkins MW,Dupps WJ Jr,Rollins AM

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 during the eye-opening stage when the goblet cells first appear. METHODS:Laser microdissection (LMD) was used to collect conjunctival forniceal cells from postnatal (PN) day 9, PN14 and PN20 wild-type...

journal_title：Investigative ophthalmology & visual science

authors： Gupta D,Harvey SA,Kaminski N,Swamynathan SK

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:Levels of some cytokines are significantly higher in the vitreous fluid of patients with acute uveitis than in normal vitreous fluid. The authors sought to determine which proinflammatory cytokines were upregulated in the vitreous fluid of patients with ocular sarcoidosis. METHODS:Samples of vitreous fluid wer...

journal_title：Investigative ophthalmology & visual science

authors： Nagata K,Maruyama K,Uno K,Shinomiya K,Yoneda K,Hamuro J,Sugita S,Yoshimura T,Sonoda KH,Mochizuki M,Kinoshita S

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:To map the gene for autosomal dominant cataracts (ADC) in an American white family of European descent. METHODS:Ophthalmic examinations and linkage analyses using a variety of polymorphisms were performed; two-point lod scores calculated. RESULTS:Affected individuals (14 studied) exhibited variable expressivi...

journal_title：Investigative ophthalmology & visual science

authors： Bateman JB,Johannes M,Flodman P,Geyer DD,Clancy KP,Heinzmann C,Kojis T,Berry R,Sparkes RS,Spence MA

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:To compare directly the robustness of standard automated perimetry (SAP), short-wavelength automated perimetry (SWAP), frequency-doubling perimetry (FDP), and grating-resolution perimetry (GRP) stimuli to different degrees of intraocular stray light induced by commercially available opacity-containing filters. ...

journal_title：Investigative ophthalmology & visual science

authors： Anderson RS,Redmond T,McDowell DR,Breslin KM,Zlatkova MB

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00

abstract：Purpose:To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant. Methods:This was a retrospective, observational study. The medical records of 53 RP ...

journal_title：Investigative ophthalmology & visual science

authors： Inooka D,Ueno S,Kominami T,Sayo A,Okado S,Ito Y,Terasaki H

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To evaluate the developmental expression of Thy-1 in the retina. Thy-1, the most abundant mammalian neuronal surface glycoprotein, is likely to play a significant role in retinal development. In the mammalian retina, it is found predominantly, if not exclusively, on retinal ganglion cells. METHODS:Rat retinae ...

journal_title：Investigative ophthalmology & visual science

authors： Liu CJ,Chaturvedi N,Barnstable CJ,Dreyer EB

更新日期：1996-06-01 00:00:00

abstract：:The characterization of beta-adrenergic receptors on cultured human trabecular cells and trabecular meshwork from human autopsy eyes was carried out by radioligand binding utilizing (125I)-iodopindolol. In cultured cells, the observed binding of (125I)-iodopindolol was of high affinity (Kd = 43 pM) and saturable. Scat...

journal_title：Investigative ophthalmology & visual science

authors： Wax MB,Molinoff PB,Alvarado J,Polansky J

更新日期：1989-01-01 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods:Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight su...

journal_title：Investigative ophthalmology & visual science

authors： Kim DY,Song J,Kim JY,Choi K,Hyung S,Chae JB

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Retinal neovascularization is one of the leading causes of blindness. A crucial event in this process is the remodeling and penetration of the capillary basement membrane by migrating endothelial cells. This process requires proteolysis of basement membrane components by a variety of proteinases. The objective ...

journal_title：Investigative ophthalmology & visual science

authors： Das A,McGuire PG,Eriqat C,Ober RR,DeJuan E Jr,Williams GA,McLamore A,Biswas J,Johnson DW

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:BM88 is a cell-cycle exit and neuronal differentiation protein that has been used as a marker of surviving retinal ganglion cells (RGCs) after optic nerve injury. Thy1.1 has also been used as a marker for RGC loss, but after optic nerve crush (ONC) a decrease in Thy1.1 expression precedes the loss of RGCs. The ...

journal_title：Investigative ophthalmology & visual science

authors： Siddiqui AM,Sabljic TF,Koeberle PD,Ball AK

更新日期：2014-03-28 00:00:00

abstract：PURPOSE:Corneal crystallins are lost from resident cells of the corneal stroma during wound repair, and this is associated with a loss of cell transparency. The goal of this study was to identify factors inducing loss of the corneal crystallin transketolase (TKT). METHODS:A cell culture model of freshly isolated rabbi...

journal_title：Investigative ophthalmology & visual science

authors： Stramer BM,Fini ME

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test in detecting visual acuity (VA) of >20/200. METHODS:This was a combined retrospective and prospective, noninterventional study. In phase I of the study, data from 168 eyes of 154 subjects who underwent the computerized objective VA tes...

journal_title：Investigative ophthalmology & visual science

authors： Han SB,Yang HK,Hyon JY,Seo JM,Lee JH,Lee IB,Hwang JM

更新日期：2011-09-27 00:00:00

abstract：:The transport rates of radiolabeled ascorbic acid and dehydroascorbic acid, as well as, labeled 3-O-methyl-D-glucose and L-glucose from a central plasma compartment into aqueous and vitreous humors and cerebrospinal fluid were studied in vivo. Normal, male albino Sprague-Dawley rats and English Short Haired guinea pig...

journal_title：Investigative ophthalmology & visual science

authors： DiMattio J

更新日期：1989-11-01 00:00:00