Abstract：
Purpose:To evaluate the microvascular changes in eyes with RP quantitatively using optical coherence tomography angiography (OCTA) and to determine whether the correlations between these indices and the severity of RP are significant. Methods:This was a retrospective, observational study. The medical records of 53 RP patients and 46 controls were reviewed. The OCTA images were obtained with the Cirrus 5000 with Angioplex, and an automated program was used to analyze the microvascular patterns. The perfusion density (PD) and vessel length density (VLD) were used as indices of the microvascular density, whereas the vessel diameter index (VDI) was used as a measure of the caliber of the vessels. The width of the ellipsoid zone (EZ) in the OCT images and the mean deviation (MD) of the Humphry Field Analyzer (HFA) were used to determine the severity of the RP. Student's t-tests and Spearman's correlation tests were used. Results:Both the PD and VLD in the superficial and deep plexuses and the whole retina were significantly reduced, and the VDI was significantly increased in RP patients compared with the corresponding values of the controls (P < 0.001). Spearman's rank tests indicated the RP severity was significantly correlated with the PD and VLD in all three layers (P < 0.001, r ranging from 0.50 to 0.87) and significantly correlated with VDI in the deep and the whole retina (P < 0.001, ranging from -0.64 to -0.73). Conclusions:Quantitative changes in the microvascular density might be useful for examining the pathophysiology of RP.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Inooka D,Ueno S,Kominami T,Sayo A,Okado S,Ito Y,Terasaki Hdoi
10.1167/iovs.17-23202subject
Has Abstractpub_date
2018-01-01 00:00:00pages
433-438issue
1eissn
0146-0404issn
1552-5783pii
2670502journal_volume
59pub_type
杂志文章abstract：PURPOSE:To analyze the patterns of expression of the cryptochromes, CRY1 and CRY2, in the human retina and to correlate expression of these putative blue-light receptors with nonvisual photoreceptor localization. METHODS:CRY1 and CRY2 mRNA expression was analyzed in 4-mm diameter punches of macula and midperipheral hu...
journal_title：Investigative ophthalmology & visual science
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journal_title：Investigative ophthalmology & visual science
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